Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001268421                                                           20     509
NP_000170                                                              20     509
NP_001268422                                                           20     509
NP_001268423                                                           20     509
XP_005264328                                                           20     509
NP_000278                                                              18    1135
XP_005249237                                                           18    1135
NP_734465                                                              18    1935
NP_001231818                                                           18    1935
NP_789791                                                              18    1935
NP_001271189                                                           17    2528
NP_002261                                                              17    3301
NP_694858                                                              17    3301
NP_001129668                                                           17    3301
NP_061928                                                              17    3301
NP_612353                                                              17    3301
NP_001129667                                                           17    3301
NP_001194003                                                           17    3301
NP_001194001                                                           17    3301
NP_038461                                                              17    3301
NP_001194002                                                           17    3301
XP_005271654                                                           17    3301
XP_005271653                                                           17    3301
XP_006718924                                                           17    3301
XP_006717416                                                           17    3301
XP_005248557                                                           17    3301
XP_005248558                                                           17    3301
NP_001194000                                                           17    3301
NP_075463                                                              17    4312
NP_085095                                                              17    4312
NP_085080                                                              17    4312
NP_071436                                                              17    4312
NP_003824                                                              17    4312
XP_005260654                                                           17    4312
XP_006719812                                                           17    4312
NP_001119600                                                           16    5631
NP_068754                                                              16    5631
NP_001844                                                              16    5631
NP_003552                                                              16    5631
XP_006725277                                                           16    5631
XP_006722660                                                           16    5631
XP_006721062                                                           16    5631
XP_006721021                                                           16    5631
NP_000739                                                              16    7355
NP_055365                                                              16    7355
NP_079493                                                              16    7355
NP_002067                                                              16    7355
NP_009194                                                              16    7355
NP_955474                                                              16    7355
NP_001182131                                                           16    7355
XP_005267207                                                           16    7355
XP_006711206                                                           16    7355
NP_066569                                                              15    9605
NP_940988                                                              15    9605
NP_115804                                                              15    9605
NP_060142                                                              15    9605
NP_998820                                                              15    9605
NP_612213                                                              15    9605
NP_542384                                                              15    9605
XP_006724772                                                           15    9605
XP_006721660                                                           15    9605
XP_006720645                                                           15    9605
XP_005254546                                                           15    9605
XP_005254545                                                           15    9605
XP_005254544                                                           15    9605
XP_005254543                                                           15    9605
XP_005248383                                                           15    9605
XP_005264691                                                           15    9605
XP_005264690                                                           15    9605
NP_056499                                                              15    9605
NP_612204                                                              15    9605
NP_005606                                                              15    9605
>NP_001268421
          Length = 1230

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   CRPVILLLE 9
           CRPVILL E
Sbjct: 945 CRPVILLPE 953
>NP_000170
          Length = 1360

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    CRPVILLLE 9
            CRPVILL E
Sbjct: 1075 CRPVILLPE 1083
>NP_001268422
          Length = 1058

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   CRPVILLLE 9
           CRPVILL E
Sbjct: 773 CRPVILLPE 781
>NP_001268423
          Length = 1058

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   CRPVILLLE 9
           CRPVILL E
Sbjct: 773 CRPVILLPE 781
>XP_005264328
          Length = 1261

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   CRPVILLLE 9
           CRPVILL E
Sbjct: 976 CRPVILLPE 984
>NP_000278
          Length = 980

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   CRPVILLL 8
           CRP +LLL
Sbjct: 521 CRPAVLLL 528
>XP_005249237
          Length = 892

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   CRPVILLL 8
           CRP +LLL
Sbjct: 433 CRPAVLLL 440
>NP_734465
          Length = 945

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   CRPVILLL 8
           CRPVIL +
Sbjct: 615 CRPVILTM 622
>NP_001231818
          Length = 934

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   CRPVILLL 8
           CRPVIL +
Sbjct: 604 CRPVILTM 611
>NP_789791
          Length = 655

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   CRPVILLLE 9
           C+ V+LLLE
Sbjct: 208 CKEVVLLLE 216
>NP_001271189
          Length = 482

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   CRPVILLL 8
           CRP +LLL
Sbjct: 255 CRPSLLLL 262
>NP_002261
          Length = 898

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   CRPVILLLE 9
           CR +++LLE
Sbjct: 244 CRALVMLLE 252
>NP_694858
          Length = 890

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   CRPVILLLE 9
           CR +++LLE
Sbjct: 236 CRALVMLLE 244
>NP_001129668
          Length = 897

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   CRPVILLLE 9
           CR +++LLE
Sbjct: 234 CRALVMLLE 242
>NP_061928
          Length = 1007

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   RPVILLLE 9
           RPV LLLE
Sbjct: 433 RPVCLLLE 440
>NP_612353
          Length = 354

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   CRPVIL 6
           CRPV+L
Sbjct: 329 CRPVVL 334
>NP_001129667
          Length = 887

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   CRPVILLLE 9
           CR +++LLE
Sbjct: 234 CRALVMLLE 242
>NP_001194003
          Length = 292

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   CRPVIL 6
           CRPV+L
Sbjct: 267 CRPVVL 272
>NP_001194001
          Length = 292

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   CRPVIL 6
           CRPV+L
Sbjct: 267 CRPVVL 272
>NP_038461
          Length = 887

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   CRPVILLLE 9
           CR +++LLE
Sbjct: 234 CRALVMLLE 242
>NP_001194002
          Length = 292

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   CRPVIL 6
           CRPV+L
Sbjct: 267 CRPVVL 272
>XP_005271654
          Length = 862

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   RPVILLLE 9
           RPV LLLE
Sbjct: 288 RPVCLLLE 295
>XP_005271653
          Length = 862

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   RPVILLLE 9
           RPV LLLE
Sbjct: 288 RPVCLLLE 295
>XP_006718924
          Length = 969

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   RPVILLLE 9
           RPV LLLE
Sbjct: 433 RPVCLLLE 440
>XP_006717416
          Length = 624

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   CRPVIL 6
           CRPV+L
Sbjct: 503 CRPVVL 508
>XP_005248557
          Length = 890

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   CRPVILLLE 9
           CR +++LLE
Sbjct: 236 CRALVMLLE 244
>XP_005248558
          Length = 866

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   CRPVILLLE 9
           CR +++LLE
Sbjct: 244 CRALVMLLE 252
>NP_001194000
          Length = 292

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   CRPVIL 6
           CRPV+L
Sbjct: 267 CRPVVL 272
>NP_075463
          Length = 3013

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    CRPVILLLE 9
            C  V+LLLE
Sbjct: 1203 CEVVVLLLE 1211
>NP_085095
          Length = 499

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  CRPVILLL 8
          C PV+LLL
Sbjct: 6  CWPVLLLL 13
>NP_085080
          Length = 540

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  CRPVILLL 8
          C PV+LLL
Sbjct: 6  CWPVLLLL 13
>NP_071436
          Length = 311

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   CRPVILLL 8
           C P+ILLL
Sbjct: 207 CLPLILLL 214
>NP_003824
          Length = 581

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  CRPVILLL 8
          C PV+LLL
Sbjct: 6  CWPVLLLL 13
>XP_005260654
          Length = 581

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  CRPVILLL 8
          C PV+LLL
Sbjct: 6  CWPVLLLL 13
>XP_006719812
          Length = 3019

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    CRPVILLLE 9
            C  V+LLLE
Sbjct: 1200 CEVVVLLLE 1208
>NP_001119600
          Length = 129

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  CRPVILLL 8
          C P++LLL
Sbjct: 6  CAPLLLLL 13
>NP_068754
          Length = 108

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  CRPVILLL 8
          C P++LLL
Sbjct: 6  CAPLLLLL 13
>NP_001844
          Length = 684

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  CRPVILLL 8
          C P++LLL
Sbjct: 7  CAPLLLLL 14
>NP_003552
          Length = 165

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  CRPVILLL 8
          C P++LLL
Sbjct: 7  CLPIMLLL 14
>XP_006725277
          Length = 165

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  CRPVILLL 8
          C P++LLL
Sbjct: 7  CLPIMLLL 14
>XP_006722660
          Length = 550

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   CRPVILLLE 9
           CR V +LLE
Sbjct: 533 CREVAVLLE 541
>XP_006721062
          Length = 408

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  CRPVILLL 8
          C P++LLL
Sbjct: 7  CLPIMLLL 14
>XP_006721021
          Length = 165

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  CRPVILLL 8
          C P++LLL
Sbjct: 7  CLPIMLLL 14
>NP_000739
          Length = 502

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  CRPVILLL 8
          C PV LLL
Sbjct: 5  CGPVALLL 12
>NP_055365
          Length = 1032

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RPVILLLE 9
           RPV+LL E
Sbjct: 846 RPVVLLPE 853
>NP_079493
          Length = 246

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  CRPVILLL 8
          C P++LLL
Sbjct: 12 CLPLLLLL 19
>NP_002067
          Length = 552

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  CRPVILLL 8
          C P +LLL
Sbjct: 22 CSPALLLL 29
>NP_009194
          Length = 308

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   CRPVILLL 8
           C P +LLL
Sbjct: 212 CSPTLLLL 219
>NP_955474
          Length = 257

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   CRPVILLL 8
           C P +LLL
Sbjct: 161 CSPTLLLL 168
>NP_001182131
          Length = 137

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RPVILLLE 9
           RP I+LLE
Sbjct: 124 RPFIVLLE 131
>XP_005267207
          Length = 246

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  CRPVILLL 8
          C P++LLL
Sbjct: 12 CLPLLLLL 19
>XP_006711206
          Length = 502

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  CRPVILLL 8
          C PV LLL
Sbjct: 5  CGPVALLL 12
>NP_066569
          Length = 444

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  RPVILLL 8
          RP++LLL
Sbjct: 66 RPLVLLL 72
>NP_940988
          Length = 395

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  CRPVILLLE 9
          C PV+ L+E
Sbjct: 83 CLPVLHLIE 91
>NP_115804
          Length = 1810

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   RPVILLLE 9
           +P++LL+E
Sbjct: 465 KPLVLLME 472
>NP_060142
          Length = 1865

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   PVILLLE 9
           P ILLLE
Sbjct: 769 PAILLLE 775
>NP_998820
          Length = 2634

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   CRPVILLL 8
           C P+ LLL
Sbjct: 723 CVPIFLLL 730
>NP_612213
          Length = 409

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   RPVILLL 8
           RP ILLL
Sbjct: 139 RPTILLL 145
>NP_542384
          Length = 226

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   CRPVILLL 8
           CRP  LLL
Sbjct: 136 CRPQDLLL 143
>XP_006724772
          Length = 1605

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   RPVILLLE 9
           +P++LL+E
Sbjct: 260 KPLVLLME 267
>XP_006721660
          Length = 260

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   RPVILLLE 9
           RP  LLLE
Sbjct: 189 RPAALLLE 196
>XP_006720645
          Length = 1060

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   PVILLLE 9
           P ILLLE
Sbjct: 769 PAILLLE 775
>XP_005254546
          Length = 1443

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   PVILLLE 9
           P ILLLE
Sbjct: 327 PAILLLE 333
>XP_005254545
          Length = 1864

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   PVILLLE 9
           P ILLLE
Sbjct: 769 PAILLLE 775
>XP_005254544
          Length = 1884

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   PVILLLE 9
           P ILLLE
Sbjct: 769 PAILLLE 775
>XP_005254543
          Length = 1885

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   PVILLLE 9
           P ILLLE
Sbjct: 769 PAILLLE 775
>XP_005248383
          Length = 350

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   CRPVILLL 8
           CRP  LLL
Sbjct: 343 CRPSELLL 350
>XP_005264691
          Length = 226

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   CRPVILLL 8
           CRP  LLL
Sbjct: 136 CRPQDLLL 143
>XP_005264690
          Length = 226

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   CRPVILLL 8
           CRP  LLL
Sbjct: 136 CRPQDLLL 143
>NP_056499
          Length = 136

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   PVILLLE 9
           P++LL+E
Sbjct: 124 PIVLLIE 130
>NP_612204
          Length = 154

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  CRPVILLL 8
          C P++LLL
Sbjct: 8  CCPLLLLL 15
>NP_005606
          Length = 150

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  CRPVILLL 8
          C P++LLL
Sbjct: 4  CFPLLLLL 11
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.340    0.160    0.524 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 596,223
Number of extensions: 1173
Number of successful extensions: 72
Number of sequences better than 10000.0: 72
Number of HSP's gapped: 72
Number of HSP's successfully gapped: 72
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.4 bits)
S2: 28 (15.4 bits)

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