Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_060501                                                              17    3301
NP_000284                                                              17    4312
NP_001027005                                                           17    4312
NP_002970                                                              17    4312
NP_001007099                                                           17    4312
NP_001180528                                                           17    4312
NP_001180529                                                           17    4312
NP_001180546                                                           17    4312
XP_005256041                                                           17    4312
XP_005256040                                                           17    4312
XP_005271161                                                           17    4312
XP_005271160                                                           17    4312
NP_000531                                                              16    5631
NP_000208                                                              16    5631
NP_001036188                                                           16    5631
NP_003238                                                              16    5631
XP_006723382                                                           16    5631
XP_006723381                                                           16    5631
XP_006723380                                                           16    5631
NP_001026                                                              16    7355
NP_001129131                                                           16    7355
NP_001275913                                                           16    7355
NP_060585                                                              16    7355
NP_079335                                                              16    7355
NP_001275912                                                           16    7355
XP_006715631                                                           16    7355
XP_005263162                                                           16    7355
XP_005263159                                                           16    7355
XP_006711873                                                           16    7355
XP_006711872                                                           16    7355
XP_006711871                                                           16    7355
XP_006711870                                                           16    7355
XP_006711869                                                           16    7355
XP_006711868                                                           16    7355
XP_006711867                                                           16    7355
XP_006711866                                                           16    7355
XP_006711865                                                           16    7355
NP_597677                                                              15    9605
NP_056199                                                              15    9605
NP_060136                                                              15    9605
XP_006724828                                                           15    9605
XP_005248340                                                           15    9605
XP_005248339                                                           15    9605
XP_005248337                                                           15    9605
XP_006714531                                                           15    9605
XP_006714530                                                           15    9605
>NP_060501
          Length = 1151

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  CLSTSKI 7
          CLSTS+I
Sbjct: 23 CLSTSRI 29
>NP_000284
          Length = 1093

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   CLSTSKI 7
           CL TSKI
Sbjct: 559 CLGTSKI 565
>NP_001027005
          Length = 1086

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   CLSTSKI 7
           CL TSKI
Sbjct: 552 CLGTSKI 558
>NP_002970
          Length = 547

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   CLSTSKILT 9
           C ST+++LT
Sbjct: 307 CFSTNELLT 315
>NP_001007099
          Length = 322

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   CLSTSKILT 9
           C ST+++LT
Sbjct: 263 CFSTNELLT 271
>NP_001180528
          Length = 523

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   CLSTSKILT 9
           C ST+++LT
Sbjct: 283 CFSTNELLT 291
>NP_001180529
          Length = 503

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   CLSTSKILT 9
           C ST+++LT
Sbjct: 263 CFSTNELLT 271
>NP_001180546
          Length = 466

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   CLSTSKILT 9
           C ST+++LT
Sbjct: 226 CFSTNELLT 234
>XP_005256041
          Length = 1086

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   CLSTSKI 7
           CL TSKI
Sbjct: 552 CLGTSKI 558
>XP_005256040
          Length = 1093

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   CLSTSKI 7
           CL TSKI
Sbjct: 559 CLGTSKI 565
>XP_005271161
          Length = 366

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   CLSTSKILT 9
           C ST+++LT
Sbjct: 307 CFSTNELLT 315
>XP_005271160
          Length = 463

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   CLSTSKILT 9
           C ST+++LT
Sbjct: 307 CFSTNELLT 315
>NP_000531
          Length = 5038

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   CLSTSKILT 9
           CL+TS+ +T
Sbjct: 119 CLTTSRSMT 127
>NP_000208
          Length = 495

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   CLSTSKILT 9
           C++ SK+LT
Sbjct: 485 CVNKSKLLT 493
>NP_001036188
          Length = 5033

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   CLSTSKILT 9
           CL+TS+ +T
Sbjct: 119 CLTTSRSMT 127
>NP_003238
          Length = 1172

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   CLSTSKI 7
           C STSK+
Sbjct: 601 CFSTSKV 607
>XP_006723382
          Length = 5027

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   CLSTSKILT 9
           CL+TS+ +T
Sbjct: 119 CLTTSRSMT 127
>XP_006723381
          Length = 5031

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   CLSTSKILT 9
           CL+TS+ +T
Sbjct: 119 CLTTSRSMT 127
>XP_006723380
          Length = 5032

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   CLSTSKILT 9
           CL+TS+ +T
Sbjct: 119 CLTTSRSMT 127
>NP_001026
          Length = 4967

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   CLSTSKILT 9
           CLSTS+  T
Sbjct: 132 CLSTSRSST 140
>NP_001129131
          Length = 1547

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   CLSTSKILT 9
           C++T+K LT
Sbjct: 281 CINTAKPLT 289
>NP_001275913
          Length = 590

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LSTSKILT 9
           +STS++LT
Sbjct: 448 ISTSRVLT 455
>NP_060585
          Length = 687

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LSTSKILT 9
           +STS++LT
Sbjct: 545 ISTSRVLT 552
>NP_079335
          Length = 715

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   LSTSKILT 9
           LSTSKI T
Sbjct: 115 LSTSKIRT 122
>NP_001275912
          Length = 650

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LSTSKILT 9
           +STS++LT
Sbjct: 508 ISTSRVLT 515
>XP_006715631
          Length = 648

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   LSTSKILT 9
           LSTSKI T
Sbjct: 115 LSTSKIRT 122
>XP_005263162
          Length = 590

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LSTSKILT 9
           +STS++LT
Sbjct: 448 ISTSRVLT 455
>XP_005263159
          Length = 662

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LSTSKILT 9
           +STS++LT
Sbjct: 520 ISTSRVLT 527
>XP_006711873
          Length = 4954

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   CLSTSKILT 9
           CLSTS+  T
Sbjct: 132 CLSTSRSST 140
>XP_006711872
          Length = 2735

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   CLSTSKILT 9
           CLSTS+  T
Sbjct: 132 CLSTSRSST 140
>XP_006711871
          Length = 4906

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   CLSTSKILT 9
           CLSTS+  T
Sbjct: 132 CLSTSRSST 140
>XP_006711870
          Length = 4965

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   CLSTSKILT 9
           CLSTS+  T
Sbjct: 132 CLSTSRSST 140
>XP_006711869
          Length = 4973

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   CLSTSKILT 9
           CLSTS+  T
Sbjct: 132 CLSTSRSST 140
>XP_006711868
          Length = 4975

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   CLSTSKILT 9
           CLSTS+  T
Sbjct: 132 CLSTSRSST 140
>XP_006711867
          Length = 4977

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   CLSTSKILT 9
           CLSTS+  T
Sbjct: 132 CLSTSRSST 140
>XP_006711866
          Length = 4984

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   CLSTSKILT 9
           CLSTS+  T
Sbjct: 132 CLSTSRSST 140
>XP_006711865
          Length = 4985

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   CLSTSKILT 9
           CLSTS+  T
Sbjct: 132 CLSTSRSST 140
>NP_597677
          Length = 2804

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    CLSTSKILT 9
            CL+T  I+T
Sbjct: 1311 CLTTINIMT 1319
>NP_056199
          Length = 2697

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    CLSTSKILT 9
            CL+T  I+T
Sbjct: 1311 CLTTINIMT 1319
>NP_060136
          Length = 737

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   CLSTSKIL 8
           C S SK+L
Sbjct: 318 CFSCSKVL 325
>XP_006724828
          Length = 688

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   CLSTSKIL 8
           C S SK+L
Sbjct: 318 CFSCSKVL 325
>XP_005248340
          Length = 2265

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   CLSTSKILT 9
           CL+T  I+T
Sbjct: 772 CLTTINIMT 780
>XP_005248339
          Length = 2584

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    CLSTSKILT 9
            CL+T  I+T
Sbjct: 1091 CLTTINIMT 1099
>XP_005248337
          Length = 2698

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    CLSTSKILT 9
            CL+T  I+T
Sbjct: 1311 CLTTINIMT 1319
>XP_006714531
          Length = 2738

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    CLSTSKILT 9
            CL+T  I+T
Sbjct: 1245 CLTTINIMT 1253
>XP_006714530
          Length = 2755

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    CLSTSKILT 9
            CL+T  I+T
Sbjct: 1311 CLTTINIMT 1319
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.321    0.124    0.349 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 436,459
Number of extensions: 785
Number of successful extensions: 46
Number of sequences better than 10000.0: 46
Number of HSP's gapped: 46
Number of HSP's successfully gapped: 46
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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