Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001129119                                                           16    5631
NP_057689                                                              16    5631
NP_982271                                                              16    5631
NP_001271230                                                           16    5631
NP_001153774                                                           16    5631
NP_001271231                                                           16    5631
NP_003886                                                              16    5631
NP_061155                                                              16    5631
NP_001153778                                                           16    5631
XP_005261137                                                           16    5631
XP_006724126                                                           16    5631
XP_006724125                                                           16    5631
XP_006724124                                                           16    5631
XP_005261133                                                           16    5631
XP_006724123                                                           16    5631
XP_006724122                                                           16    5631
XP_006724121                                                           16    5631
XP_006715810                                                           16    5631
XP_006715809                                                           16    5631
NP_148934                                                              16    7355
NP_071285                                                              16    7355
NP_003880                                                              16    7355
NP_058628                                                              16    7355
XP_005264157                                                           16    7355
NP_001243143                                                           15    9605
NP_689509                                                              15    9605
NP_001243142                                                           15    9605
NP_060209                                                              15    9605
NP_001277059                                                           15    9605
NP_001277058                                                           15    9605
NP_008832                                                              15    9605
NP_079067                                                              15    9605
NP_001161940                                                           15    9605
NP_001275701                                                           15    9605
NP_004561                                                              15    9605
NP_001230695                                                           15    9605
NP_001275703                                                           15    9605
XP_005259010                                                           15    9605
XP_005258481                                                           15    9605
XP_006720604                                                           15    9605
XP_005254461                                                           15    9605
XP_006720603                                                           15    9605
XP_006720602                                                           15    9605
XP_005253450                                                           15    9605
XP_006719151                                                           15    9605
XP_006710819                                                           15    9605
XP_006710818                                                           15    9605
XP_005271067                                                           15    9605
>NP_001129119
          Length = 392

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   CLKDTAR 7
           CL++TAR
Sbjct: 315 CLQETAR 321
>NP_057689
          Length = 392

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   CLKDTAR 7
           CL++TAR
Sbjct: 315 CLQETAR 321
>NP_982271
          Length = 1350

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   LKDTARSV 9
           LKD ARSV
Sbjct: 491 LKDGARSV 498
>NP_001271230
          Length = 1087

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LKDTARS 8
           LKDT+RS
Sbjct: 596 LKDTSRS 602
>NP_001153774
          Length = 1295

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   LKDTARSV 9
           LKD ARSV
Sbjct: 452 LKDGARSV 459
>NP_001271231
          Length = 1086

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LKDTARS 8
           LKDT+RS
Sbjct: 595 LKDTSRS 601
>NP_003886
          Length = 1612

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   LKDTARSV 9
           LKD ARSV
Sbjct: 491 LKDGARSV 498
>NP_061155
          Length = 1124

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LKDTARS 8
           LKDT+RS
Sbjct: 633 LKDTSRS 639
>NP_001153778
          Length = 1526

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   LKDTARSV 9
           LKD ARSV
Sbjct: 455 LKDGARSV 462
>XP_005261137
          Length = 1264

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   LKDTARSV 9
           LKD ARSV
Sbjct: 455 LKDGARSV 462
>XP_006724126
          Length = 1313

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   LKDTARSV 9
           LKD ARSV
Sbjct: 455 LKDGARSV 462
>XP_006724125
          Length = 1313

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   LKDTARSV 9
           LKD ARSV
Sbjct: 455 LKDGARSV 462
>XP_006724124
          Length = 1534

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   LKDTARSV 9
           LKD ARSV
Sbjct: 455 LKDGARSV 462
>XP_005261133
          Length = 1557

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   LKDTARSV 9
           LKD ARSV
Sbjct: 452 LKDGARSV 459
>XP_006724123
          Length = 1560

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   LKDTARSV 9
           LKD ARSV
Sbjct: 455 LKDGARSV 462
>XP_006724122
          Length = 1568

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   LKDTARSV 9
           LKD ARSV
Sbjct: 455 LKDGARSV 462
>XP_006724121
          Length = 1576

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   LKDTARSV 9
           LKD ARSV
Sbjct: 455 LKDGARSV 462
>XP_006715810
          Length = 1105

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LKDTARS 8
           LKDT+RS
Sbjct: 596 LKDTSRS 602
>XP_006715809
          Length = 1142

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LKDTARS 8
           LKDT+RS
Sbjct: 633 LKDTSRS 639
>NP_148934
          Length = 397

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   CLKDTA 6
           CL+DTA
Sbjct: 270 CLEDTA 275
>NP_071285
          Length = 473

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   CLKDTA 6
           CL+DTA
Sbjct: 346 CLEDTA 351
>NP_003880
          Length = 434

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   CLKDTA 6
           CL+DTA
Sbjct: 307 CLEDTA 312
>NP_058628
          Length = 291

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   CLKDTARSV 9
           C K+ +RSV
Sbjct: 130 CFKEKSRSV 138
>XP_005264157
          Length = 293

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   CLKDTARSV 9
           C K+ +RSV
Sbjct: 130 CFKEKSRSV 138
>NP_001243143
          Length = 1026

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   CLKDTARSV 9
           C++ TAR V
Sbjct: 252 CVEGTARGV 260
>NP_689509
          Length = 1013

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   CLKDTARSV 9
           C++ TAR V
Sbjct: 239 CVEGTARGV 247
>NP_001243142
          Length = 1024

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   CLKDTARSV 9
           C++ TAR V
Sbjct: 250 CVEGTARGV 258
>NP_060209
          Length = 660

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LKDTARSV 9
           LKDTA+++
Sbjct: 185 LKDTAKAL 192
>NP_001277059
          Length = 517

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  LKDTARSV 9
          LKDTA+++
Sbjct: 42 LKDTAKAL 49
>NP_001277058
          Length = 638

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LKDTARSV 9
           LKDTA+++
Sbjct: 163 LKDTAKAL 170
>NP_008832
          Length = 2548

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    CLKDTAR 7
            CLK TA+
Sbjct: 2041 CLKTTAK 2047
>NP_079067
          Length = 491

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   CLKDTARSV 9
           CLK  ARS+
Sbjct: 461 CLKLAARSL 469
>NP_001161940
          Length = 505

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   CLKDTARSV 9
           CLK  ARS+
Sbjct: 475 CLKLAARSL 483
>NP_001275701
          Length = 1486

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    CLKDTARSV 9
            CL  T RS+
Sbjct: 1238 CLLSTTRSI 1246
>NP_004561
          Length = 1445

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    CLKDTARSV 9
            CL  T RS+
Sbjct: 1197 CLLSTTRSI 1205
>NP_001230695
          Length = 748

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LKDTARSV 9
           LKDTA+++
Sbjct: 185 LKDTAKAL 192
>NP_001275703
          Length = 1264

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    CLKDTARSV 9
            CL  T RS+
Sbjct: 1016 CLLSTTRSI 1024
>XP_005259010
          Length = 1261

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   CLKDTARSV 9
           C++ TAR V
Sbjct: 239 CVEGTARGV 247
>XP_005258481
          Length = 898

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LKDTARSV 9
          LK+T RS+
Sbjct: 48 LKETGRSI 55
>XP_006720604
          Length = 1677

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    CLKDTAR 7
            CLK TA+
Sbjct: 1170 CLKTTAK 1176
>XP_005254461
          Length = 2600

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    CLKDTAR 7
            CLK TA+
Sbjct: 2093 CLKTTAK 2099
>XP_006720603
          Length = 2619

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    CLKDTAR 7
            CLK TA+
Sbjct: 2112 CLKTTAK 2118
>XP_006720602
          Length = 2619

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    CLKDTAR 7
            CLK TA+
Sbjct: 2112 CLKTTAK 2118
>XP_005253450
          Length = 1486

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    CLKDTARSV 9
            CL  T RS+
Sbjct: 1238 CLLSTTRSI 1246
>XP_006719151
          Length = 1486

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    CLKDTARSV 9
            CL  T RS+
Sbjct: 1238 CLLSTTRSI 1246
>XP_006710819
          Length = 748

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LKDTARSV 9
           LKDTA+++
Sbjct: 185 LKDTAKAL 192
>XP_006710818
          Length = 718

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LKDTARSV 9
           LKDTA+++
Sbjct: 185 LKDTAKAL 192
>XP_005271067
          Length = 718

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LKDTARSV 9
           LKDTA+++
Sbjct: 185 LKDTAKAL 192
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.323    0.127    0.381 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 492,984
Number of extensions: 537
Number of successful extensions: 48
Number of sequences better than 10000.0: 48
Number of HSP's gapped: 48
Number of HSP's successfully gapped: 48
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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