Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_078914                                                              17    2528
NP_001243764                                                           17    2528
NP_001093890                                                           17    4312
NP_059143                                                              17    4312
NP_001093891                                                           17    4312
NP_004757                                                              16    5631
NP_001231643                                                           16    5631
NP_005277                                                              16    5631
NP_005329                                                              16    7355
NP_003836                                                              16    7355
NP_001230127                                                           16    7355
NP_054825                                                              16    7355
NP_001269215                                                           16    7355
NP_001269214                                                           16    7355
XP_005250362                                                           16    7355
XP_005250361                                                           16    7355
XP_006712519                                                           16    7355
XP_006712518                                                           16    7355
NP_694958                                                              16    7355
NP_001128130                                                           16    7355
NP_001028747                                                           16    7355
NP_001053                                                              16    7355
NP_001193985                                                           15    9605
NP_065988                                                              15    9605
NP_002979                                                              15    9605
NP_001164120                                                           15    9605
NP_001164121                                                           15    9605
NP_112483                                                              15    9605
NP_064547                                                              15    9605
NP_001243496                                                           15    9605
NP_065777                                                              15    9605
NP_001186628                                                           15    9605
NP_060089                                                              15    9605
NP_061903                                                              15    9605
XP_005262364                                                           15    9605
XP_005262358                                                           15    9605
XP_005267986                                                           15    9605
XP_006719830                                                           15    9605
XP_005248616                                                           15    9605
XP_006714716                                                           15    9605
NP_002539                                                              15    9605
NP_001004479                                                           15    9605
>NP_078914
          Length = 415

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  CLIYTKS 7
          CL+YTK+
Sbjct: 33 CLLYTKT 39
>NP_001243764
          Length = 427

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  CLIYTKS 7
          CL+YTK+
Sbjct: 45 CLLYTKT 51
>NP_001093890
          Length = 297

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  LIYTKSLR 9
          L++TKSLR
Sbjct: 49 LLHTKSLR 56
>NP_059143
          Length = 296

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  LIYTKSLR 9
          L++TKSLR
Sbjct: 49 LLHTKSLR 56
>NP_001093891
          Length = 221

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  LIYTKSLR 9
          L++TKSLR
Sbjct: 49 LLHTKSLR 56
>NP_004757
          Length = 906

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   CLIYTKSL 8
           C IYT S+
Sbjct: 533 CFIYTSSV 540
>NP_001231643
          Length = 463

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  CLIYTKSLR 9
          C + TK+LR
Sbjct: 62 CCVVTKNLR 70
>NP_005277
          Length = 333

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   CLIYTKSLR 9
           C++YT  LR
Sbjct: 229 CVLYTDLLR 237
>NP_005329
          Length = 1037

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   CLIYTKSLR 9
           C IY K LR
Sbjct: 139 CSIYLKLLR 147
>NP_003836
          Length = 520

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   CLIYTKSLR 9
           CL++  SLR
Sbjct: 380 CLVWEPSLR 388
>NP_001230127
          Length = 986

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   CLIYTKSLR 9
           C IY K LR
Sbjct: 139 CSIYLKLLR 147
>NP_054825
          Length = 691

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   CLIYTKSLR 9
           C++ TKS R
Sbjct: 190 CVLCTKSFR 198
>NP_001269215
          Length = 233

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   CLIYTKSLR 9
           CL++  SLR
Sbjct: 94  CLVWEPSLR 102
>NP_001269214
          Length = 234

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   CLIYTKSLR 9
           CL++  SLR
Sbjct: 94  CLVWEPSLR 102
>XP_005250362
          Length = 1003

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   CLIYTKSLR 9
           C IY K LR
Sbjct: 105 CSIYLKLLR 113
>XP_005250361
          Length = 1008

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   CLIYTKSLR 9
           C IY K LR
Sbjct: 110 CSIYLKLLR 118
>XP_006712519
          Length = 176

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   CLIYTKSLR 9
           CL+Y K+ R
Sbjct: 99  CLVYCKNGR 107
>XP_006712518
          Length = 176

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   CLIYTKSLR 9
           CL+Y K+ R
Sbjct: 99  CLVYCKNGR 107
>NP_694958
          Length = 364

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   CLIYTKS 7
           CLIY K+
Sbjct: 114 CLIYRKT 120
>NP_001128130
          Length = 365

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   CLIYTKS 7
           CLIY K+
Sbjct: 115 CLIYRKT 121
>NP_001028747
          Length = 176

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   CLIYTKSLR 9
           CL+Y K+ R
Sbjct: 99  CLVYCKNGR 107
>NP_001053
          Length = 433

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   IYTKSL 8
           IYTKSL
Sbjct: 219 IYTKSL 224
>NP_001193985
          Length = 694

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  LIYTKSLR 9
          L YT+SLR
Sbjct: 64 LSYTQSLR 71
>NP_065988
          Length = 2048

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    IYTKSLR 9
            IY KSLR
Sbjct: 1564 IYMKSLR 1570
>NP_002979
          Length = 89

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/5 (80%), Positives = 5/5 (100%)

Query: 1  CLIYT 5
          CL+YT
Sbjct: 31 CLVYT 35
>NP_001164120
          Length = 717

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   CLIYTKS 7
           C IYT+S
Sbjct: 487 CSIYTQS 493
>NP_001164121
          Length = 675

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   CLIYTKS 7
           C IYT+S
Sbjct: 445 CSIYTQS 451
>NP_112483
          Length = 734

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   CLIYTKS 7
           C IYT+S
Sbjct: 504 CSIYTQS 510
>NP_064547
          Length = 707

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   CLIYTKSL 8
           C++YT+ L
Sbjct: 665 CVVYTELL 672
>NP_001243496
          Length = 231

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LIYTKSLR 9
           ++Y KSLR
Sbjct: 116 VLYNKSLR 123
>NP_065777
          Length = 704

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  CLIYTKSLR 9
          CL+  +SLR
Sbjct: 5  CLLAVRSLR 13
>NP_001186628
          Length = 534

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   CLIYTKSL 8
           C++YT+ L
Sbjct: 492 CVVYTELL 499
>NP_060089
          Length = 517

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   CLIYTKSL 8
           C IY K+L
Sbjct: 420 CRIYVKNL 427
>NP_061903
          Length = 1369

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    LIYTKSL 8
            +IYTKS+
Sbjct: 1231 IIYTKSV 1237
>XP_005262364
          Length = 432

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   CLIYTKS 7
           C IYT+S
Sbjct: 202 CSIYTQS 208
>XP_005262358
          Length = 733

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   CLIYTKS 7
           C IYT+S
Sbjct: 504 CSIYTQS 510
>XP_005267986
          Length = 2022

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    IYTKSLR 9
            IY KSLR
Sbjct: 1538 IYMKSLR 1544
>XP_006719830
          Length = 428

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   CLIYTK 6
           CLIY K
Sbjct: 402 CLIYLK 407
>XP_005248616
          Length = 686

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  CLIYTKSLR 9
          CL+  +SLR
Sbjct: 5  CLLAVRSLR 13
>XP_006714716
          Length = 1318

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    LIYTKSL 8
            +IYTKS+
Sbjct: 1180 IIYTKSV 1186
>NP_002539
          Length = 312

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 1   CLIYTKSL 8
           C++Y K L
Sbjct: 256 CMVYLKPL 263
>NP_001004479
          Length = 324

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   CLIYTKS 7
           C+ YT+S
Sbjct: 207 CIFYTQS 213
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.337    0.144    0.457 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 442,738
Number of extensions: 595
Number of successful extensions: 42
Number of sequences better than 10000.0: 42
Number of HSP's gapped: 42
Number of HSP's successfully gapped: 42
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.4 bits)
S2: 28 (15.4 bits)

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