Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

XP_005257832                                                           17    4312
NP_001683                                                              16    5631
NP_063946                                                              16    5631
NP_001137446                                                           16    5631
NP_653312                                                              16    5631
NP_056045                                                              16    5631
NP_001186219                                                           16    5631
XP_005262700                                                           16    5631
XP_005262697                                                           16    5631
XP_006714054                                                           16    5631
XP_005262695                                                           16    5631
XP_005264425                                                           16    5631
NP_001004696                                                           16    5631
NP_000085                                                              16    7355
NP_001926                                                              16    7355
NP_001257880                                                           16    7355
NP_001257879                                                           16    7355
NP_003830                                                              16    7355
NP_001131                                                              16    7355
NP_001265197                                                           16    7355
NP_055981                                                              16    7355
NP_851999                                                              16    7355
NP_631941                                                              16    7355
NP_065852                                                              16    7355
NP_001185461                                                           16    7355
NP_115655                                                              16    7355
NP_001185462                                                           16    7355
XP_006716659                                                           16    7355
XP_005251053                                                           16    7355
XP_005251052                                                           16    7355
XP_006716658                                                           16    7355
XP_005251051                                                           16    7355
XP_005251050                                                           16    7355
XP_006716657                                                           16    7355
XP_005247886                                                           16    7355
XP_006713849                                                           16    7355
XP_005246428                                                           16    7355
NP_060472                                                              16    7355
NP_899232                                                              16    7355
NP_001177951                                                           15    9605
NP_006556                                                              15    9605
NP_995322                                                              15    9605
NP_001255979                                                           15    9605
NP_001255983                                                           15    9605
NP_001255971                                                           15    9605
NP_001255970                                                           15    9605
NP_001255978                                                           15    9605
NP_001255972                                                           15    9605
NP_001255981                                                           15    9605
NP_542185                                                              15    9605
NP_001255976                                                           15    9605
NP_001255975                                                           15    9605
NP_001255974                                                           15    9605
NP_001255973                                                           15    9605
NP_001255969                                                           15    9605
NP_001255984                                                           15    9605
NP_001255977                                                           15    9605
NP_001255980                                                           15    9605
NP_940851                                                              15    9605
NP_443117                                                              15    9605
NP_008816                                                              15    9605
NP_001032394                                                           15    9605
NP_001010861                                                           15    9605
NP_060223                                                              15    9605
XP_003960868                                                           15    9605
XP_003846356                                                           15    9605
XP_005256014                                                           15    9605
XP_005255832                                                           15    9605
XP_005254365                                                           15    9605
XP_005268673                                                           15    9605
XP_003846691                                                           15    9605
NP_997182                                                              15    9605
>XP_005257832
          Length = 330

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  CIFITSGQ 8
          C FI+ GQ
Sbjct: 6  CFFISGGQ 13
>NP_001683
          Length = 513

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   FITSGQI 9
           FIT GQI
Sbjct: 365 FITEGQI 371
>NP_063946
          Length = 780

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  IFITSGQI 9
          +FITSG I
Sbjct: 31 LFITSGTI 38
>NP_001137446
          Length = 745

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  IFITSGQI 9
          +FITSG I
Sbjct: 31 LFITSGTI 38
>NP_653312
          Length = 558

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   CIFITSG 7
           CI++T G
Sbjct: 509 CIYVTGG 515
>NP_056045
          Length = 1704

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    CIFITSGQ 8
            C+F T GQ
Sbjct: 1271 CLFQTKGQ 1278
>NP_001186219
          Length = 558

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   CIFITSG 7
           CI++T G
Sbjct: 509 CIYVTGG 515
>XP_005262700
          Length = 907

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   CIFITSGQ 8
           C+F T GQ
Sbjct: 474 CLFQTKGQ 481
>XP_005262697
          Length = 1681

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    CIFITSGQ 8
            C+F T GQ
Sbjct: 1271 CLFQTKGQ 1278
>XP_006714054
          Length = 1693

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    CIFITSGQ 8
            C+F T GQ
Sbjct: 1260 CLFQTKGQ 1267
>XP_005262695
          Length = 1704

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    CIFITSGQ 8
            C+F T GQ
Sbjct: 1271 CLFQTKGQ 1278
>XP_005264425
          Length = 471

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   FITSGQI 9
           FIT GQI
Sbjct: 323 FITEGQI 329
>NP_001004696
          Length = 348

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   CIFITSG 7
           C+F++SG
Sbjct: 173 CLFLSSG 179
>NP_000085
          Length = 2944

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   CIFITSGQ 8
           CI IT G+
Sbjct: 144 CILITDGK 151
>NP_001926
          Length = 766

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1   CIFITSG 7
           C FIT G
Sbjct: 394 CTFITKG 400
>NP_001257880
          Length = 299

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   FITSGQI 9
           FI+SGQ+
Sbjct: 216 FISSGQV 222
>NP_001257879
          Length = 337

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   FITSGQI 9
           FI+SGQ+
Sbjct: 254 FISSGQV 260
>NP_003830
          Length = 616

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   FITSGQI 9
           FI+SGQ+
Sbjct: 533 FISSGQV 539
>NP_001131
          Length = 662

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   CIFITSGQ 8
           CIF  +GQ
Sbjct: 532 CIFTCTGQ 539
>NP_001265197
          Length = 602

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   FITSGQI 9
           FI+SGQ+
Sbjct: 519 FISSGQV 525
>NP_055981
          Length = 377

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1  CIFITSG 7
          C+ +TSG
Sbjct: 61 CLLVTSG 67
>NP_851999
          Length = 839

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   CIFITSGQ 8
           C +ITSG+
Sbjct: 211 CKYITSGK 218
>NP_631941
          Length = 377

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1  CIFITSG 7
          C+ +TSG
Sbjct: 61 CLLVTSG 67
>NP_065852
          Length = 414

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   CIFITSGQI 9
           C F TSG I
Sbjct: 183 CWFCTSGPI 191
>NP_001185461
          Length = 874

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   CIFITSGQ 8
           C +ITSG+
Sbjct: 219 CKYITSGK 226
>NP_115655
          Length = 1196

 Score = 15.8 bits (29), Expect =  7355
 Identities = 3/8 (37%), Positives = 7/8 (87%)

Query: 1   CIFITSGQ 8
           C+++ SG+
Sbjct: 418 CVYVLSGE 425
>NP_001185462
          Length = 873

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   CIFITSGQ 8
           C +ITSG+
Sbjct: 218 CKYITSGK 225
>XP_006716659
          Length = 653

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   CIFITSGQ 8
           C +ITSG+
Sbjct: 219 CKYITSGK 226
>XP_005251053
          Length = 826

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   CIFITSGQ 8
           C +ITSG+
Sbjct: 149 CKYITSGK 156
>XP_005251052
          Length = 828

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   CIFITSGQ 8
           C +ITSG+
Sbjct: 151 CKYITSGK 158
>XP_006716658
          Length = 847

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   CIFITSGQ 8
           C +ITSG+
Sbjct: 219 CKYITSGK 226
>XP_005251051
          Length = 888

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   CIFITSGQ 8
           C +ITSG+
Sbjct: 211 CKYITSGK 218
>XP_005251050
          Length = 895

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   CIFITSGQ 8
           C +ITSG+
Sbjct: 218 CKYITSGK 225
>XP_006716657
          Length = 896

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   CIFITSGQ 8
           C +ITSG+
Sbjct: 219 CKYITSGK 226
>XP_005247886
          Length = 1127

 Score = 15.8 bits (29), Expect =  7355
 Identities = 3/8 (37%), Positives = 7/8 (87%)

Query: 1   CIFITSGQ 8
           C+++ SG+
Sbjct: 418 CVYVLSGE 425
>XP_006713849
          Length = 1147

 Score = 15.8 bits (29), Expect =  7355
 Identities = 3/8 (37%), Positives = 7/8 (87%)

Query: 1   CIFITSGQ 8
           C+++ SG+
Sbjct: 369 CVYVLSGE 376
>XP_005246428
          Length = 765

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1   CIFITSG 7
           C FIT G
Sbjct: 393 CTFITKG 399
>NP_060472
          Length = 846

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   CIFITSGQ 8
           C +ITSG+
Sbjct: 218 CKYITSGK 225
>NP_899232
          Length = 418

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   CIFITSGQI 9
           C F TSG +
Sbjct: 187 CWFFTSGPV 195
>NP_001177951
          Length = 399

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3 FITSGQI 9
         F+TSG++
Sbjct: 3 FVTSGEL 9
>NP_006556
          Length = 727

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   FITSGQI 9
           F+TSG++
Sbjct: 331 FVTSGEL 337
>NP_995322
          Length = 500

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   IFITSGQI 9
           +FIT G I
Sbjct: 130 VFITKGDI 137
>NP_001255979
          Length = 422

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   FITSGQI 9
           F+TSG++
Sbjct: 117 FVTSGEL 123
>NP_001255983
          Length = 403

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3  FITSGQI 9
          F+TSG++
Sbjct: 60 FVTSGEL 66
>NP_001255971
          Length = 662

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   FITSGQI 9
           F+TSG++
Sbjct: 322 FVTSGEL 328
>NP_001255970
          Length = 663

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   FITSGQI 9
           F+TSG++
Sbjct: 322 FVTSGEL 328
>NP_001255978
          Length = 460

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   FITSGQI 9
           F+TSG++
Sbjct: 117 FVTSGEL 123
>NP_001255972
          Length = 700

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   FITSGQI 9
           F+TSG++
Sbjct: 322 FVTSGEL 328
>NP_001255981
          Length = 404

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   FITSGQI 9
           F+TSG++
Sbjct: 322 FVTSGEL 328
>NP_542185
          Length = 663

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   FITSGQI 9
           F+TSG++
Sbjct: 322 FVTSGEL 328
>NP_001255976
          Length = 573

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   FITSGQI 9
           F+TSG++
Sbjct: 322 FVTSGEL 328
>NP_001255975
          Length = 613

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   FITSGQI 9
           F+TSG++
Sbjct: 322 FVTSGEL 328
>NP_001255974
          Length = 627

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   FITSGQI 9
           F+TSG++
Sbjct: 322 FVTSGEL 328
>NP_001255973
          Length = 665

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   FITSGQI 9
           F+TSG++
Sbjct: 322 FVTSGEL 328
>NP_001255969
          Length = 663

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   FITSGQI 9
           F+TSG++
Sbjct: 322 FVTSGEL 328
>NP_001255984
          Length = 299

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3  FITSGQI 9
          F+TSG++
Sbjct: 60 FVTSGEL 66
>NP_001255977
          Length = 483

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   FITSGQI 9
           F+TSG++
Sbjct: 322 FVTSGEL 328
>NP_001255980
          Length = 404

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   FITSGQI 9
           F+TSG++
Sbjct: 322 FVTSGEL 328
>NP_940851
          Length = 327

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  CIFITSGQI 9
          C F TSG +
Sbjct: 88 CQFTTSGDL 96
>NP_443117
          Length = 648

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   IFITSGQ 8
           +FIT GQ
Sbjct: 214 LFITGGQ 220
>NP_008816
          Length = 3703

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 1   CIFITSGQ 8
           C++  SGQ
Sbjct: 701 CVYCKSGQ 708
>NP_001032394
          Length = 321

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   IFITSGQI 9
           IF+ +GQ+
Sbjct: 135 IFVNAGQV 142
>NP_001010861
          Length = 316

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   IFITSGQI 9
           IF+ +GQ+
Sbjct: 135 IFVNAGQV 142
>NP_060223
          Length = 325

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   IFITSGQI 9
           IF+ +GQ+
Sbjct: 140 IFVNAGQV 147
>XP_003960868
          Length = 208

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1   CIFITSG 7
           CIF T G
Sbjct: 173 CIFSTDG 179
>XP_003846356
          Length = 208

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1   CIFITSG 7
           CIF T G
Sbjct: 173 CIFSTDG 179
>XP_005256014
          Length = 3702

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 1   CIFITSGQ 8
           C++  SGQ
Sbjct: 701 CVYCKSGQ 708
>XP_005255832
          Length = 725

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   FITSGQI 9
           F+TSG++
Sbjct: 331 FVTSGEL 337
>XP_005254365
          Length = 500

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   IFITSGQI 9
           +FIT G I
Sbjct: 130 VFITKGDI 137
>XP_005268673
          Length = 555

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   IFITSGQ 8
           +FIT GQ
Sbjct: 214 LFITGGQ 220
>XP_003846691
          Length = 208

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1   CIFITSG 7
           CIF T G
Sbjct: 173 CIFSTDG 179
>NP_997182
          Length = 325

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   IFITSGQI 9
           IF+ +GQ+
Sbjct: 140 IFVNAGQV 147
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.341    0.151    0.495 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 532,192
Number of extensions: 1127
Number of successful extensions: 72
Number of sequences better than 10000.0: 72
Number of HSP's gapped: 72
Number of HSP's successfully gapped: 72
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.5 bits)
S2: 28 (15.4 bits)

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