Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results 
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done




                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_055874                                                              17    3301
XP_006720784                                                           17    3301
XP_006720783                                                           17    3301
XP_006720782                                                           17    3301
XP_006720781                                                           17    3301
XP_005254772                                                           17    3301
XP_005254771                                                           17    3301
XP_006720780                                                           17    3301
XP_005254769                                                           17    3301
XP_005254770                                                           17    3301
XP_005254765                                                           17    3301
XP_005254767                                                           17    3301
XP_006720779                                                           17    3301
XP_005254768                                                           17    3301
XP_005254764                                                           17    3301
NP_001004462                                                           17    4312
NP_001004463                                                           17    4312
NP_001004464                                                           17    4312
NP_775869                                                              16    5631
NP_000169                                                              16    5631
XP_006725527                                                           16    5631
XP_005260463                                                           16    5631
XP_006719420                                                           16    5631
XP_006714809                                                           16    5631
NP_783853                                                              16    7355
NP_001230028                                                           16    7355
NP_000555                                                              16    7355
NP_001683                                                              15    9605
NP_001684                                                              15    9605
XP_005264425                                                           15    9605
NP_006824                                                              15    9605



>NP_055874
          Length = 2542

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    HVLIILSK 9
            HVL+IL K
Sbjct: 2254 HVLVILQK 2261





>XP_006720784
          Length = 2502

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    HVLIILSK 9
            HVL+IL K
Sbjct: 2214 HVLVILQK 2221





>XP_006720783
          Length = 2512

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    HVLIILSK 9
            HVL+IL K
Sbjct: 2209 HVLVILQK 2216





>XP_006720782
          Length = 2517

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    HVLIILSK 9
            HVL+IL K
Sbjct: 2214 HVLVILQK 2221





>XP_006720781
          Length = 2542

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    HVLIILSK 9
            HVL+IL K
Sbjct: 2254 HVLVILQK 2261





>XP_005254772
          Length = 2557

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    HVLIILSK 9
            HVL+IL K
Sbjct: 2254 HVLVILQK 2261





>XP_005254771
          Length = 2557

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    HVLIILSK 9
            HVL+IL K
Sbjct: 2254 HVLVILQK 2261





>XP_006720780
          Length = 2557

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    HVLIILSK 9
            HVL+IL K
Sbjct: 2254 HVLVILQK 2261





>XP_005254769
          Length = 2557

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    HVLIILSK 9
            HVL+IL K
Sbjct: 2254 HVLVILQK 2261





>XP_005254770
          Length = 2557

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    HVLIILSK 9
            HVL+IL K
Sbjct: 2254 HVLVILQK 2261





>XP_005254765
          Length = 2557

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    HVLIILSK 9
            HVL+IL K
Sbjct: 2254 HVLVILQK 2261





>XP_005254767
          Length = 2557

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    HVLIILSK 9
            HVL+IL K
Sbjct: 2254 HVLVILQK 2261





>XP_006720779
          Length = 2557

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    HVLIILSK 9
            HVL+IL K
Sbjct: 2254 HVLVILQK 2261





>XP_005254768
          Length = 2557

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    HVLIILSK 9
            HVL+IL K
Sbjct: 2254 HVLVILQK 2261





>XP_005254764
          Length = 2557

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    HVLIILSK 9
            HVL+IL K
Sbjct: 2254 HVLVILQK 2261





>NP_001004462
          Length = 311

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   CHVLIILS 8
           C VLI+LS
Sbjct: 209 CFVLIVLS 216





>NP_001004463
          Length = 311

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   CHVLIILS 8
           C VLI+LS
Sbjct: 209 CFVLIVLS 216





>NP_001004464
          Length = 311

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   CHVLIILS 8
           C VLI+LS
Sbjct: 209 CFVLIVLS 216





>NP_775869
          Length = 921

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   CHVLII 6
           CH+LII
Sbjct: 427 CHLLII 432





>NP_000169
          Length = 474

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   HVLIILSK 9
           HVL +LSK
Sbjct: 165 HVLSVLSK 172





>XP_006725527
          Length = 1322

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  CHVLIILS 8
          C +L+ILS
Sbjct: 81 CSILVILS 88





>XP_005260463
          Length = 474

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   HVLIILSK 9
           HVL +LSK
Sbjct: 165 HVLSVLSK 172





>XP_006719420
          Length = 949

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   CHVLII 6
           CH+LII
Sbjct: 456 CHLLII 461





>XP_006714809
          Length = 1574

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  CHVLIILS 8
          C +L+ILS
Sbjct: 81 CSILVILS 88





>NP_783853
          Length = 420

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   CHVLIILS 8
           C +L+ILS
Sbjct: 352 CFILLILS 359





>NP_001230028
          Length = 378

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   CHVLIILS 8
           C +L+ILS
Sbjct: 352 CFILLILS 359





>NP_000555
          Length = 420

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   CHVLIILS 8
           C +L+ILS
Sbjct: 352 CFILLILS 359





>NP_001683
          Length = 513

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   HVLIILS 8
           HVL+IL+
Sbjct: 286 HVLVILT 292





>NP_001684
          Length = 511

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   HVLIILS 8
           HVL+IL+
Sbjct: 292 HVLVILT 298





>XP_005264425
          Length = 471

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   HVLIILS 8
           HVL+IL+
Sbjct: 244 HVLVILT 250





>NP_006824
          Length = 327

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   CHVLIILS 8
           CH L +LS
Sbjct: 264 CHCLPVLS 271





  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.343    0.151    0.486 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 394,122
Number of extensions: 692
Number of successful extensions: 31
Number of sequences better than 10000.0: 31
Number of HSP's gapped: 31
Number of HSP's successfully gapped: 31
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.6 bits)
S2: 28 (15.4 bits)

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