Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_064450                                                              22     103
XP_005273257                                                           22     103
NP_003117                                                              18    1135
XP_005247901                                                           18    1135
NP_787063                                                              18    1935
NP_037501                                                              18    1935
XP_006723974                                                           18    1935
NP_054859                                                              17    2528
NP_001120679                                                           17    2528
NP_694953                                                              17    2528
NP_003604                                                              17    2528
XP_006712620                                                           17    2528
XP_005246688                                                           17    2528
XP_005246689                                                           17    2528
NP_009029                                                              17    3301
NP_001826                                                              17    3301
XP_006724391                                                           17    3301
XP_005261338                                                           17    3301
XP_005277858                                                           17    3301
XP_006724390                                                           17    3301
XP_006724389                                                           17    3301
XP_005277857                                                           17    3301
NP_000123                                                              17    4312
NP_940918                                                              17    4312
XP_006718288                                                           17    4312
XP_006718287                                                           17    4312
NP_065681                                                              16    5631
NP_066124                                                              16    5631
XP_005260978                                                           16    5631
XP_006717999                                                           16    5631
XP_005273067                                                           16    5631
NP_006606                                                              16    5631
NP_057536                                                              16    5631
YP_003024028                                                           16    5631
NP_000304                                                              16    7355
NP_001006624                                                           16    7355
NP_005158                                                              16    7355
NP_775864                                                              16    7355
XP_006720788                                                           16    7355
XP_006715787                                                           16    7355
XP_005247683                                                           16    7355
NP_000339                                                              15    9605
NP_071400                                                              15    9605
NP_006080                                                              15    9605
NP_001135796                                                           15    9605
NP_003044                                                              15    9605
NP_001129163                                                           15    9605
NP_055947                                                              15    9605
NP_055796                                                              15    9605
NP_689543                                                              15    9605
NP_001035946                                                           15    9605
NP_001253975                                                           15    9605
XP_006724655                                                           15    9605
XP_006724521                                                           15    9605
XP_006724520                                                           15    9605
XP_005257947                                                           15    9605
XP_006720093                                                           15    9605
XP_006720092                                                           15    9605
XP_005249729                                                           15    9605
NP_065908                                                              15    9605
>NP_064450
          Length = 1722

 Score = 21.9 bits (45), Expect =   103
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    CFLETRAYF 9
            CFLET AYF
Sbjct: 1637 CFLETTAYF 1645
>XP_005273257
          Length = 1726

 Score = 21.9 bits (45), Expect =   103
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    CFLETRAYF 9
            CFLET AYF
Sbjct: 1641 CFLETTAYF 1649
>NP_003117
          Length = 2419

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3    LETRAYF 9
            LETRAYF
Sbjct: 2174 LETRAYF 2180
>XP_005247901
          Length = 663

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  CFLETRAYF 9
          CF+ET A+F
Sbjct: 4  CFVETPAHF 12
>NP_787063
          Length = 386

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   CFLETRAYF 9
           CFL  R YF
Sbjct: 367 CFLPLREYF 375
>NP_037501
          Length = 387

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   CFLETRAYF 9
           CFL  R YF
Sbjct: 368 CFLPLREYF 376
>XP_006723974
          Length = 148

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   CFLETRAYF 9
           CFL  R YF
Sbjct: 129 CFLPLREYF 137
>NP_054859
          Length = 954

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   CFLETRAYF 9
           C L +RAYF
Sbjct: 335 CMLISRAYF 343
>NP_001120679
          Length = 954

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   CFLETRAYF 9
           C L +RAYF
Sbjct: 335 CMLISRAYF 343
>NP_694953
          Length = 1156

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   CFLETRAY 8
           CF++ RAY
Sbjct: 737 CFVKVRAY 744
>NP_003604
          Length = 1184

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   CFLETRAY 8
           CF++ RAY
Sbjct: 752 CFVKVRAY 759
>XP_006712620
          Length = 932

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   CFLETRAYF 9
           C L +RAYF
Sbjct: 335 CMLISRAYF 343
>XP_005246688
          Length = 954

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   CFLETRAYF 9
           C L +RAYF
Sbjct: 335 CMLISRAYF 343
>XP_005246689
          Length = 954

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   CFLETRAYF 9
           C L +RAYF
Sbjct: 335 CMLISRAYF 343
>NP_009029
          Length = 1640

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   CFLETRAYF 9
           CFL   AY+
Sbjct: 892 CFLRENAYY 900

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1    CFLETRAYF 9
            C+ + R YF
Sbjct: 1288 CYYQDRGYF 1296
>NP_001826
          Length = 1583

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   CFLETRAYF 9
           CFL   AY+
Sbjct: 892 CFLRENAYY 900

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1    CFLETRAYF 9
            C+ + R YF
Sbjct: 1288 CYYQDRGYF 1296
>XP_006724391
          Length = 1567

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   CFLETRAYF 9
           CFL   AY+
Sbjct: 913 CFLRENAYY 921

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1    CFLETRAYF 9
            C+ + R YF
Sbjct: 1309 CYYQDRGYF 1317
>XP_005261338
          Length = 1570

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   CFLETRAYF 9
           CFL   AY+
Sbjct: 913 CFLRENAYY 921
>XP_005277858
          Length = 1604

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   CFLETRAYF 9
           CFL   AY+
Sbjct: 913 CFLRENAYY 921

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1    CFLETRAYF 9
            C+ + R YF
Sbjct: 1309 CYYQDRGYF 1317
>XP_006724390
          Length = 1623

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   CFLETRAYF 9
           CFL   AY+
Sbjct: 875 CFLRENAYY 883

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1    CFLETRAYF 9
            C+ + R YF
Sbjct: 1271 CYYQDRGYF 1279
>XP_006724389
          Length = 1653

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   CFLETRAYF 9
           CFL   AY+
Sbjct: 913 CFLRENAYY 921

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1    CFLETRAYF 9
            C+ + R YF
Sbjct: 1309 CYYQDRGYF 1317
>XP_005277857
          Length = 1661

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   CFLETRAYF 9
           CFL   AY+
Sbjct: 913 CFLRENAYY 921

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1    CFLETRAYF 9
            C+ + R YF
Sbjct: 1309 CYYQDRGYF 1317
>NP_000123
          Length = 2351

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  CFLETRAYF 9
          CF  TR Y+
Sbjct: 17 CFSATRRYY 25
>NP_940918
          Length = 607

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   CFLETRAYF 9
           CF+  R YF
Sbjct: 333 CFIVDRQYF 341
>XP_006718288
          Length = 368

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   CFLETRAYF 9
           CF+  R YF
Sbjct: 333 CFIVDRQYF 341
>XP_006718287
          Length = 545

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   CFLETRAYF 9
           CF+  R YF
Sbjct: 333 CFIVDRQYF 341
>NP_065681
          Length = 1072

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   CFLETRAYF 9
           CF ETR  F
Sbjct: 166 CFPETRPSF 174
>NP_066124
          Length = 1114

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   CFLETRAYF 9
           CF ETR  F
Sbjct: 166 CFPETRPSF 174
>XP_005260978
          Length = 483

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FLETRAYF 9
           FL+T AY+
Sbjct: 354 FLDTSAYY 361
>XP_006717999
          Length = 1207

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   CFLETRAYF 9
           CF ETR  F
Sbjct: 259 CFPETRPSF 267
>XP_005273067
          Length = 627

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   CFLETRA 7
           CF++TR+
Sbjct: 169 CFIDTRS 175
>NP_006606
          Length = 690

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   CFLETRA 7
           CF++TR+
Sbjct: 232 CFIDTRS 238
>NP_057536
          Length = 664

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   CFLETRA 7
           CF++TR+
Sbjct: 232 CFIDTRS 238
>YP_003024028
          Length = 513

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LETRAYF 9
           ++TRAYF
Sbjct: 299 VDTRAYF 305
>NP_000304
          Length = 676

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   LETRAYF 9
           LET+ YF
Sbjct: 421 LETKVYF 427
>NP_001006624
          Length = 257

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 5/9 (55%)

Query: 1   CFLETRAYF 9
           CF   R YF
Sbjct: 244 CFHHCRCYF 252
>NP_005158
          Length = 505

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 1   CFLETRAY 8
           CF E R Y
Sbjct: 403 CFPEVRVY 410
>NP_775864
          Length = 998

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   CFLETRAYF 9
           CF +  AY+
Sbjct: 392 CFYQENAYY 400
>XP_006720788
          Length = 222

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   CFLETR 6
           CF ETR
Sbjct: 95  CFYETR 100
>XP_006715787
          Length = 249

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   CFLETRAY 8
           C LET+ Y
Sbjct: 231 CLLETQFY 238
>XP_005247683
          Length = 708

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   LETRAYF 9
           LET+ YF
Sbjct: 453 LETKVYF 459
>NP_000339
          Length = 254

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   CFLETRAY 8
           CFL  RA+
Sbjct: 222 CFLGLRAF 229
>NP_071400
          Length = 693

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   FLETRAYF 9
           F+ET  YF
Sbjct: 455 FMETTDYF 462
>NP_006080
          Length = 700

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   CFLETRAYF 9
           C LET+  F
Sbjct: 402 CALETKTVF 410
>NP_001135796
          Length = 493

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   CFLETRAY 8
           C +ETR Y
Sbjct: 463 CPMETRMY 470
>NP_003044
          Length = 525

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   CFLETRAY 8
           C +ETR Y
Sbjct: 495 CPMETRMY 502
>NP_001129163
          Length = 525

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   CFLETRAY 8
           C +ETR Y
Sbjct: 495 CPMETRMY 502
>NP_055947
          Length = 957

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   FLETRAY 8
           FLE +AY
Sbjct: 672 FLENKAY 678
>NP_055796
          Length = 1946

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  CFLETRAYF 9
          C L  RA+F
Sbjct: 5  CLLTFRAFF 13
>NP_689543
          Length = 614

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 5/9 (55%)

Query: 1   CFLETRAYF 9
           C L   AYF
Sbjct: 137 CVLREEAYF 145
>NP_001035946
          Length = 614

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 5/9 (55%)

Query: 1   CFLETRAYF 9
           C L   AYF
Sbjct: 137 CVLREEAYF 145
>NP_001253975
          Length = 622

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 5/9 (55%)

Query: 1   CFLETRAYF 9
           C L   AYF
Sbjct: 145 CVLREEAYF 153
>XP_006724655
          Length = 694

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   FLETRAYF 9
           F+ET  YF
Sbjct: 455 FMETTDYF 462
>XP_006724521
          Length = 609

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   CFLETRAYF 9
           C LET+  F
Sbjct: 402 CALETKTVF 410
>XP_006724520
          Length = 617

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   CFLETRAYF 9
           C LET+  F
Sbjct: 402 CALETKTVF 410
>XP_005257947
          Length = 1935

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   ETRAYF 9
           ETR YF
Sbjct: 717 ETRVYF 722
>XP_006720093
          Length = 614

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 5/9 (55%)

Query: 1   CFLETRAYF 9
           C L   AYF
Sbjct: 137 CVLREEAYF 145
>XP_006720092
          Length = 622

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 5/9 (55%)

Query: 1   CFLETRAYF 9
           C L   AYF
Sbjct: 145 CVLREEAYF 153
>XP_005249729
          Length = 968

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   FLETRAY 8
           FLE +AY
Sbjct: 683 FLENKAY 689
>NP_065908
          Length = 973

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   CFLETRAYF 9
           C+  T++YF
Sbjct: 445 CYALTQSYF 453
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.348    0.151    0.551 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 469,634
Number of extensions: 981
Number of successful extensions: 67
Number of sequences better than 10000.0: 60
Number of HSP's gapped: 67
Number of HSP's successfully gapped: 67
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 14 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.8 bits)
S2: 28 (15.4 bits)

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