Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005742                                                              20     299
NP_671714                                                              20     299
XP_006715890                                                           20     299
XP_005250160                                                           20     299
XP_005250159                                                           20     299
NP_001245200                                                           17    3301
NP_000240                                                              17    3301
NP_001161089                                                           17    3301
NP_000528                                                              17    4312
NP_002847                                                              16    7355
NP_001036189                                                           16    7355
NP_078948                                                              16    7355
NP_065770                                                              16    7355
NP_001017930                                                           16    7355
XP_006724409                                                           16    7355
XP_005261851                                                           16    7355
XP_005261850                                                           16    7355
XP_005263278                                                           16    7355
XP_005263277                                                           16    7355
NP_001130005                                                           16    7355
NP_005753                                                              16    7355
NP_001138678                                                           16    7355
NP_067642                                                              15    9605
NP_055845                                                              15    9605
NP_787078                                                              15    9605
NP_001137310                                                           15    9605
NP_808218                                                              15    9605
NP_056280                                                              15    9605
NP_001271439                                                           15    9605
NP_001271438                                                           15    9605
NP_001269468                                                           15    9605
NP_002065                                                              15    9605
NP_060688                                                              15    9605
NP_001239085                                                           15    9605
XP_006721567                                                           15    9605
XP_005248150                                                           15    9605
XP_005248148                                                           15    9605
XP_005248147                                                           15    9605
XP_005248146                                                           15    9605
XP_005248145                                                           15    9605
XP_005248144                                                           15    9605
XP_005248143                                                           15    9605
XP_005248142                                                           15    9605
XP_005248141                                                           15    9605
XP_005248140                                                           15    9605
XP_005248139                                                           15    9605
XP_005247749                                                           15    9605
XP_006713784                                                           15    9605
XP_005246148                                                           15    9605
XP_005246145                                                           15    9605
XP_006712675                                                           15    9605
>NP_005742
          Length = 3907

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    CEDATLAL 8
            CEDATLAL
Sbjct: 3732 CEDATLAL 3739
>NP_671714
          Length = 3899

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    CEDATLAL 8
            CEDATLAL
Sbjct: 3724 CEDATLAL 3731
>XP_006715890
          Length = 3860

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    CEDATLAL 8
            CEDATLAL
Sbjct: 3685 CEDATLAL 3692
>XP_005250160
          Length = 3939

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    CEDATLAL 8
            CEDATLAL
Sbjct: 3764 CEDATLAL 3771
>XP_005250159
          Length = 3952

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    CEDATLAL 8
            CEDATLAL
Sbjct: 3777 CEDATLAL 3784
>NP_001245200
          Length = 687

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   CEDATLA 7
           CED TLA
Sbjct: 233 CEDKTLA 239
>NP_000240
          Length = 756

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   CEDATLA 7
           CED TLA
Sbjct: 233 CEDKTLA 239
>NP_001161089
          Length = 658

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   CEDATLA 7
           CED TLA
Sbjct: 135 CEDKTLA 141
>NP_000528
          Length = 406

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   CEDATLAL 8
           CED  LAL
Sbjct: 283 CEDGCLAL 290
>NP_002847
          Length = 479

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   EDATLAL 8
           +DATLAL
Sbjct: 121 QDATLAL 127
>NP_001036189
          Length = 538

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   EDATLAL 8
           +DATLAL
Sbjct: 121 QDATLAL 127
>NP_078948
          Length = 903

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   CEDATLALF 9
           CED   AL+
Sbjct: 732 CEDCITALY 740
>NP_065770
          Length = 2036

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    CEDATLAL 8
            C D TLA+
Sbjct: 1985 CRDQTLAI 1992
>NP_001017930
          Length = 600

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   CEDATLAL 8
           C D+TLA+
Sbjct: 251 CGDSTLAM 258
>XP_006724409
          Length = 1806

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   EDATLAL 8
           ED+TLAL
Sbjct: 446 EDSTLAL 452
>XP_005261851
          Length = 1806

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   EDATLAL 8
           ED+TLAL
Sbjct: 446 EDSTLAL 452
>XP_005261850
          Length = 1806

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   EDATLAL 8
           ED+TLAL
Sbjct: 446 EDSTLAL 452
>XP_005263278
          Length = 620

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   CEDATLALF 9
           CED   AL+
Sbjct: 449 CEDCITALY 457
>XP_005263277
          Length = 759

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   CEDATLALF 9
           CED   AL+
Sbjct: 588 CEDCITALY 596
>NP_001130005
          Length = 631

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   CEDATLAL 8
           C D+TLA+
Sbjct: 283 CGDSTLAM 290
>NP_005753
          Length = 835

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   CEDATLALF 9
           CE   LALF
Sbjct: 704 CERVLLALF 712
>NP_001138678
          Length = 1806

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   EDATLAL 8
           ED+TLAL
Sbjct: 446 EDSTLAL 452
>NP_067642
          Length = 340

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1  CEDATL 6
          C DATL
Sbjct: 25 CNDATL 30
>NP_055845
          Length = 3013

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    EDATLAL 8
            ED TLAL
Sbjct: 2621 EDVTLAL 2627
>NP_787078
          Length = 684

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1   CEDATLA 7
           C D TLA
Sbjct: 129 CSDTTLA 135
>NP_001137310
          Length = 522

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   DATLALF 9
           DAT+A+F
Sbjct: 356 DATVAIF 362
>NP_808218
          Length = 568

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   DATLALF 9
           DAT+A+F
Sbjct: 356 DATVAIF 362
>NP_056280
          Length = 1508

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    CEDATLAL 8
            C D TLA+
Sbjct: 1205 CHDLTLAV 1212
>NP_001271439
          Length = 525

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   DATLALF 9
           DAT+A+F
Sbjct: 313 DATVAIF 319
>NP_001271438
          Length = 551

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   DATLALF 9
           DAT+A+F
Sbjct: 339 DATVAIF 345
>NP_001269468
          Length = 340

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  CEDATLA 7
          C DATL+
Sbjct: 25 CADATLS 31
>NP_002065
          Length = 340

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  CEDATLA 7
          C DATL+
Sbjct: 25 CADATLS 31
>NP_060688
          Length = 1247

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    EDATLA 7
            EDATLA
Sbjct: 1005 EDATLA 1010
>NP_001239085
          Length = 1507

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    CEDATLAL 8
            C D TLA+
Sbjct: 1204 CHDLTLAV 1211
>XP_006721567
          Length = 531

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   DATLALF 9
           DAT+A+F
Sbjct: 319 DATVAIF 325
>XP_005248150
          Length = 2044

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    EDATLAL 8
            ED TLAL
Sbjct: 1652 EDVTLAL 1658
>XP_005248148
          Length = 3028

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    EDATLAL 8
            ED TLAL
Sbjct: 2636 EDVTLAL 2642
>XP_005248147
          Length = 3028

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    EDATLAL 8
            ED TLAL
Sbjct: 2636 EDVTLAL 2642
>XP_005248146
          Length = 3073

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    EDATLAL 8
            ED TLAL
Sbjct: 2681 EDVTLAL 2687
>XP_005248145
          Length = 3079

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    EDATLAL 8
            ED TLAL
Sbjct: 2687 EDVTLAL 2693
>XP_005248144
          Length = 3099

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    EDATLAL 8
            ED TLAL
Sbjct: 2713 EDVTLAL 2719
>XP_005248143
          Length = 3105

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    EDATLAL 8
            ED TLAL
Sbjct: 2713 EDVTLAL 2719
>XP_005248142
          Length = 3114

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    EDATLAL 8
            ED TLAL
Sbjct: 2728 EDVTLAL 2734
>XP_005248141
          Length = 3119

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    EDATLAL 8
            ED TLAL
Sbjct: 2727 EDVTLAL 2733
>XP_005248140
          Length = 3119

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    EDATLAL 8
            ED TLAL
Sbjct: 2727 EDVTLAL 2733
>XP_005248139
          Length = 3120

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    EDATLAL 8
            ED TLAL
Sbjct: 2728 EDVTLAL 2734
>XP_005247749
          Length = 340

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1  CEDATL 6
          C DATL
Sbjct: 25 CNDATL 30
>XP_006713784
          Length = 340

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1  CEDATL 6
          C DATL
Sbjct: 25 CNDATL 30
>XP_005246148
          Length = 1108

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   EDATLA 7
           EDATLA
Sbjct: 866 EDATLA 871
>XP_005246145
          Length = 1236

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   EDATLA 7
           EDATLA
Sbjct: 994 EDATLA 999
>XP_006712675
          Length = 1248

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    EDATLA 7
            EDATLA
Sbjct: 1006 EDATLA 1011
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.332    0.139    0.442 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 472,737
Number of extensions: 560
Number of successful extensions: 51
Number of sequences better than 10000.0: 51
Number of HSP's gapped: 51
Number of HSP's successfully gapped: 51
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.3 bits)
S2: 28 (15.4 bits)

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