Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004351                                                              19     869
NP_078858                                                              17    3301
NP_001278232                                                           17    3301
NP_001278214                                                           17    3301
NP_001438                                                              17    3301
XP_006714824                                                           17    3301
NP_001783                                                              17    4312
XP_005258239                                                           17    4312
XP_005258238                                                           17    4312
NP_005236                                                              16    5631
XP_006714202                                                           16    5631
XP_005262892                                                           16    5631
XP_005262891                                                           16    5631
NP_002244                                                              16    7355
NP_001239268                                                           16    7355
NP_001239267                                                           16    7355
NP_001785                                                              16    7355
NP_060109                                                              16    7355
NP_001004480                                                           16    7355
NP_001136245                                                           15    9605
NP_001136239                                                           15    9605
NP_001136236                                                           15    9605
NP_001136244                                                           15    9605
NP_001136238                                                           15    9605
NP_001136240                                                           15    9605
NP_001136243                                                           15    9605
NP_001136242                                                           15    9605
NP_001136235                                                           15    9605
NP_001136237                                                           15    9605
NP_001136241                                                           15    9605
NP_149045                                                              15    9605
NP_001784                                                              15    9605
NP_001185463                                                           15    9605
NP_001098991                                                           15    9605
NP_003276                                                              15    9605
NP_055061                                                              15    9605
NP_061763                                                              15    9605
XP_006724446                                                           15    9605
XP_006718013                                                           15    9605
XP_006717843                                                           15    9605
XP_005252734                                                           15    9605
XP_005252733                                                           15    9605
XP_005252732                                                           15    9605
XP_005252731                                                           15    9605
XP_005252730                                                           15    9605
XP_005252729                                                           15    9605
NP_061822                                                              15    9605
>NP_004351
          Length = 882

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   YTLVVQAA 9
           YTLVVQAA
Sbjct: 341 YTLVVQAA 348
>NP_078858
          Length = 4981

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    AYTLVVQA 8
            AY+LV+QA
Sbjct: 1280 AYSLVIQA 1287
>NP_001278232
          Length = 4983

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    AYTLVVQA 8
            AY+LV+QA
Sbjct: 1280 AYSLVIQA 1287
>NP_001278214
          Length = 4982

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    AYTLVVQA 8
            AY+LV+QA
Sbjct: 1280 AYSLVIQA 1287
>NP_001438
          Length = 4349

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   AYTLVVQA 8
           +YTL++QA
Sbjct: 114 SYTLIIQA 121
>XP_006714824
          Length = 4349

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   AYTLVVQA 8
           +YTL++QA
Sbjct: 114 SYTLIIQA 121
>NP_001783
          Length = 906

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   YTLVVQA 8
           YTL++QA
Sbjct: 345 YTLIIQA 351
>XP_005258239
          Length = 875

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   YTLVVQA 8
           YTL++QA
Sbjct: 314 YTLIIQA 320
>XP_005258238
          Length = 888

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   YTLVVQA 8
           YTL++QA
Sbjct: 327 YTLIIQA 333
>NP_005236
          Length = 4588

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    YTLVVQAA 9
            YTL VQA+
Sbjct: 3406 YTLTVQAS 3413
>XP_006714202
          Length = 4588

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    YTLVVQAA 9
            YTL VQA+
Sbjct: 3406 YTLTVQAS 3413
>XP_005262892
          Length = 4600

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    YTLVVQAA 9
            YTL VQA+
Sbjct: 3406 YTLTVQAS 3413
>XP_005262891
          Length = 4600

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    YTLVVQAA 9
            YTL VQA+
Sbjct: 3406 YTLTVQAS 3413
>NP_002244
          Length = 1356

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   TLVVQAA 9
           TLV+QAA
Sbjct: 516 TLVIQAA 522
>NP_001239268
          Length = 842

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   YTLVVQA 8
           YT++VQA
Sbjct: 281 YTVIVQA 287
>NP_001239267
          Length = 879

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   YTLVVQA 8
           YT++VQA
Sbjct: 318 YTVIVQA 324
>NP_001785
          Length = 916

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   YTLVVQA 8
           YT++VQA
Sbjct: 355 YTVIVQA 361
>NP_060109
          Length = 2916

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    AYTLVVQA 8
            +Y+L+VQA
Sbjct: 1857 SYSLIVQA 1864
>NP_001004480
          Length = 330

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   AYTLVVQA 8
           +YTLV++A
Sbjct: 235 SYTLVIRA 242
>NP_001136245
          Length = 1932

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   YTLVVQAA 9
           Y L VQAA
Sbjct: 557 YALTVQAA 564
>NP_001136239
          Length = 1915

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   YTLVVQAA 9
           Y L VQAA
Sbjct: 542 YALTVQAA 549
>NP_001136236
          Length = 1957

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   YTLVVQAA 9
           Y L VQAA
Sbjct: 579 YALTVQAA 586
>NP_001136244
          Length = 1677

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   YTLVVQAA 9
           Y L VQAA
Sbjct: 579 YALTVQAA 586
>NP_001136238
          Length = 1952

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   YTLVVQAA 9
           Y L VQAA
Sbjct: 579 YALTVQAA 586
>NP_001136240
          Length = 1935

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   YTLVVQAA 9
           Y L VQAA
Sbjct: 557 YALTVQAA 564
>NP_001136243
          Length = 1682

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   YTLVVQAA 9
           Y L VQAA
Sbjct: 584 YALTVQAA 591
>NP_001136242
          Length = 1539

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   YTLVVQAA 9
           Y L VQAA
Sbjct: 579 YALTVQAA 586
>NP_001136235
          Length = 1962

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   YTLVVQAA 9
           Y L VQAA
Sbjct: 584 YALTVQAA 591
>NP_001136237
          Length = 1886

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   YTLVVQAA 9
           Y L VQAA
Sbjct: 579 YALTVQAA 586
>NP_001136241
          Length = 1790

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   YTLVVQAA 9
           Y L VQAA
Sbjct: 591 YALTVQAA 598
>NP_149045
          Length = 1955

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   YTLVVQAA 9
           Y L VQAA
Sbjct: 579 YALTVQAA 586
>NP_001784
          Length = 829

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   YTLVVQA 8
           YTL +QA
Sbjct: 294 YTLTIQA 300
>NP_001185463
          Length = 243

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  YTLVVQAA 9
          YTLVV  A
Sbjct: 20 YTLVVSVA 27
>NP_001098991
          Length = 844

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AYTLVVQA 8
           A TLV+QA
Sbjct: 171 ALTLVIQA 178
>NP_003276
          Length = 1358

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    YTLVVQAA 9
            YT+++QAA
Sbjct: 1105 YTVLLQAA 1112
>NP_055061
          Length = 3014

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    YTLVVQA 8
            Y LVVQA
Sbjct: 1070 YVLVVQA 1076
>NP_061763
          Length = 793

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   YTLVVQA 8
           YTL +QA
Sbjct: 315 YTLTIQA 321
>XP_006724446
          Length = 3019

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    YTLVVQA 8
            Y LVVQA
Sbjct: 1070 YVLVVQA 1076
>XP_006718013
          Length = 1778

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   YTLVVQAA 9
           Y L VQAA
Sbjct: 579 YALTVQAA 586
>XP_006717843
          Length = 844

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AYTLVVQA 8
           A TLV+QA
Sbjct: 171 ALTLVIQA 178
>XP_005252734
          Length = 846

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AYTLVVQA 8
           A TLV+QA
Sbjct: 171 ALTLVIQA 178
>XP_005252733
          Length = 916

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AYTLVVQA 8
           A TLV+QA
Sbjct: 171 ALTLVIQA 178
>XP_005252732
          Length = 976

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AYTLVVQA 8
           A TLV+QA
Sbjct: 171 ALTLVIQA 178
>XP_005252731
          Length = 988

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AYTLVVQA 8
           A TLV+QA
Sbjct: 171 ALTLVIQA 178
>XP_005252730
          Length = 990

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AYTLVVQA 8
           A TLV+QA
Sbjct: 171 ALTLVIQA 178
>XP_005252729
          Length = 990

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AYTLVVQA 8
           A TLV+QA
Sbjct: 171 ALTLVIQA 178
>NP_061822
          Length = 389

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  AYTLVV 6
          AYTLVV
Sbjct: 70 AYTLVV 75
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.324    0.122    0.304 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 275,333
Number of extensions: 366
Number of successful extensions: 47
Number of sequences better than 10000.0: 47
Number of HSP's gapped: 47
Number of HSP's successfully gapped: 47
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)

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