Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_008835                                                              20     299
NP_001075109                                                           20     299
NP_000954                                                              19     665
NP_005018                                                              18    1935
NP_056053                                                              17    3301
NP_000669                                                              17    3301
NP_001155134                                                           17    3301
NP_001155133                                                           17    3301
XP_006714899                                                           17    3301
XP_005265910                                                           17    3301
XP_006714898                                                           17    3301
XP_005265909                                                           17    3301
XP_005265908                                                           17    3301
XP_005265907                                                           17    3301
NP_542158                                                              17    4312
NP_001258297                                                           17    4312
NP_000953                                                              17    4312
NP_001258094                                                           17    4312
NP_001258296                                                           17    4312
NP_001258093                                                           17    4312
NP_001258095                                                           17    4312
NP_653252                                                              17    4312
NP_002949                                                              17    4312
XP_006717255                                                           17    4312
XP_005252162                                                           17    4312
XP_005251225                                                           17    4312
XP_006716483                                                           17    4312
XP_005251224                                                           17    4312
NP_115266                                                              17    4312
NP_061745                                                              17    4312
NP_006132                                                              16    5631
NP_001273086                                                           16    5631
NP_001005861                                                           16    5631
NP_001073867                                                           16    7355
NP_001171890                                                           16    7355
NP_001171891                                                           16    7355
NP_055883                                                              16    7355
NP_001035242                                                           16    7355
NP_001165908                                                           16    7355
NP_001165909                                                           16    7355
NP_114088                                                              16    7355
NP_061721                                                              16    7355
XP_005251911                                                           16    7355
XP_005251910                                                           16    7355
XP_005251909                                                           16    7355
XP_005251908                                                           16    7355
XP_005251907                                                           16    7355
NP_065944                                                              15    9605
NP_005622                                                              15    9605
NP_006835                                                              15    9605
NP_001258767                                                           15    9605
NP_001258763                                                           15    9605
NP_001847                                                              15    9605
NP_057709                                                              15    9605
XP_005259774                                                           15    9605
XP_005247575                                                           15    9605
XP_005247574                                                           15    9605
XP_005247573                                                           15    9605
XP_005247572                                                           15    9605
XP_005270538                                                           15    9605
NP_006840                                                              15    9605
>NP_008835
          Length = 4128

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    AYPALMVEK 9
            AYPAL+VEK
Sbjct: 3441 AYPALVVEK 3449
>NP_001075109
          Length = 4097

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    AYPALMVEK 9
            AYPAL+VEK
Sbjct: 3441 AYPALVVEK 3449
>NP_000954
          Length = 604

 Score = 19.2 bits (38), Expect =   665
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   YPALMVEK 9
           YPAL+VEK
Sbjct: 490 YPALLVEK 497
>NP_005018
          Length = 728

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   YPALMVEK 9
           +PAL+VEK
Sbjct: 279 FPALLVEK 286
>NP_056053
          Length = 1113

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   YPALMVEK 9
           YPAL V+K
Sbjct: 882 YPALKVDK 889
>NP_000669
          Length = 572

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YPALMVEK 9
           YPA+M E+
Sbjct: 204 YPAIMTER 211
>NP_001155134
          Length = 1118

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   YPALMVEK 9
           YPAL V+K
Sbjct: 882 YPALKVDK 889
>NP_001155133
          Length = 1119

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   YPALMVEK 9
           YPAL V+K
Sbjct: 882 YPALKVDK 889
>XP_006714899
          Length = 881

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   YPALMVEK 9
           YPAL V+K
Sbjct: 644 YPALKVDK 651
>XP_005265910
          Length = 1112

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   YPALMVEK 9
           YPAL V+K
Sbjct: 882 YPALKVDK 889
>XP_006714898
          Length = 1117

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   YPALMVEK 9
           YPAL V+K
Sbjct: 887 YPALKVDK 894
>XP_005265909
          Length = 1118

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   YPALMVEK 9
           YPAL V+K
Sbjct: 887 YPALKVDK 894
>XP_005265908
          Length = 1123

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   YPALMVEK 9
           YPAL V+K
Sbjct: 887 YPALKVDK 894
>XP_005265907
          Length = 1124

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   YPALMVEK 9
           YPAL V+K
Sbjct: 887 YPALKVDK 894
>NP_542158
          Length = 562

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YPALMVEK 9
           YP L++EK
Sbjct: 466 YPGLLLEK 473
>NP_001258297
          Length = 537

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YPALMVEK 9
           YP L++EK
Sbjct: 441 YPGLLLEK 448
>NP_000953
          Length = 599

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YPALMVEK 9
           YP L++EK
Sbjct: 503 YPGLLLEK 510
>NP_001258094
          Length = 490

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YPALMVEK 9
           YP L++EK
Sbjct: 394 YPGLLLEK 401
>NP_001258296
          Length = 453

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YPALMVEK 9
           YP L++EK
Sbjct: 357 YPGLLLEK 364
>NP_001258093
          Length = 551

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YPALMVEK 9
           YP L++EK
Sbjct: 455 YPGLLLEK 462
>NP_001258095
          Length = 453

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YPALMVEK 9
           YP L++EK
Sbjct: 357 YPGLLLEK 364
>NP_653252
          Length = 1463

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    YPALMVE 8
            +PALMVE
Sbjct: 1197 WPALMVE 1203
>NP_002949
          Length = 607

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   AYPALMVEK 9
           +YP L +EK
Sbjct: 297 SYPTLRIEK 305
>XP_006717255
          Length = 537

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YPALMVEK 9
           YP L++EK
Sbjct: 441 YPGLLLEK 448
>XP_005252162
          Length = 574

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YPALMVEK 9
           YP L++EK
Sbjct: 478 YPGLLLEK 485
>XP_005251225
          Length = 848

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   YPALMVE 8
           +PALMVE
Sbjct: 582 WPALMVE 588
>XP_006716483
          Length = 1367

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    YPALMVE 8
            +PALMVE
Sbjct: 1101 WPALMVE 1107
>XP_005251224
          Length = 1439

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    YPALMVE 8
            +PALMVE
Sbjct: 1173 WPALMVE 1179
>NP_115266
          Length = 810

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YPALMVEK 9
           YP L++EK
Sbjct: 188 YPVLLLEK 195
>NP_061745
          Length = 927

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YPALMVEK 9
           YP L++EK
Sbjct: 188 YPVLLLEK 195
>NP_006132
          Length = 492

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   PALMVEK 9
           PAL+VEK
Sbjct: 299 PALVVEK 305
>NP_001273086
          Length = 415

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   PALMVEK 9
           PAL+VEK
Sbjct: 222 PALVVEK 228
>NP_001005861
          Length = 610

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   YPALMVEK 9
           YP L +EK
Sbjct: 301 YPTLRIEK 308
>NP_001073867
          Length = 2017

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   YPALMVEK 9
           YP L VEK
Sbjct: 279 YPRLPVEK 286
>NP_001171890
          Length = 742

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   YPALMVE 8
           YPA M+E
Sbjct: 181 YPAFMME 187
>NP_001171891
          Length = 359

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   YPALMVE 8
           YPA M+E
Sbjct: 181 YPAFMME 187
>NP_055883
          Length = 708

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   YPALMVE 8
           YPA M+E
Sbjct: 147 YPAFMME 153
>NP_001035242
          Length = 325

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   YPALMVE 8
           YPA M+E
Sbjct: 147 YPAFMME 153
>NP_001165908
          Length = 784

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   YPALMVE 8
           YPA M+E
Sbjct: 223 YPAFMME 229
>NP_001165909
          Length = 401

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   YPALMVE 8
           YPA M+E
Sbjct: 223 YPAFMME 229
>NP_114088
          Length = 818

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YPALMVEK 9
           YP L++EK
Sbjct: 182 YPELVLEK 189
>NP_061721
          Length = 963

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YPALMVEK 9
           YP L++EK
Sbjct: 182 YPELVLEK 189
>XP_005251911
          Length = 1839

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   YPALMVEK 9
           YP L VEK
Sbjct: 101 YPRLPVEK 108
>XP_005251910
          Length = 1839

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   YPALMVEK 9
           YP L VEK
Sbjct: 101 YPRLPVEK 108
>XP_005251909
          Length = 1839

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   YPALMVEK 9
           YP L VEK
Sbjct: 101 YPRLPVEK 108
>XP_005251908
          Length = 1839

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   YPALMVEK 9
           YP L VEK
Sbjct: 101 YPRLPVEK 108
>XP_005251907
          Length = 1845

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   YPALMVEK 9
           YP L VEK
Sbjct: 107 YPRLPVEK 114
>NP_065944
          Length = 1701

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   YPALMVEK 9
           YPA+M+++
Sbjct: 613 YPAIMLKE 620
>NP_005622
          Length = 787

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   PALMVEK 9
           P+L+VEK
Sbjct: 513 PSLLVEK 519
>NP_006835
          Length = 632

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   YPALMVEK 9
           YP  MV+K
Sbjct: 214 YPYFMVQK 221
>NP_001258767
          Length = 334

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   AYPALMVEK 9
           A+P L +EK
Sbjct: 301 AHPNLFIEK 309
>NP_001258763
          Length = 276

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   AYPALMVEK 9
           A+P L +EK
Sbjct: 243 AHPNLFIEK 251
>NP_001847
          Length = 1604

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   AYPALMVEK 9
           A+P  +VEK
Sbjct: 965 AHPGYLVEK 973
>NP_057709
          Length = 334

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   AYPALMVEK 9
           A+P L +EK
Sbjct: 301 AHPNLFIEK 309
>XP_005259774
          Length = 632

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   YPALMVEK 9
           YP  MV+K
Sbjct: 214 YPYFMVQK 221
>XP_005247575
          Length = 336

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   AYPALMVEK 9
           A+P L +EK
Sbjct: 303 AHPNLFIEK 311
>XP_005247574
          Length = 336

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   AYPALMVEK 9
           A+P L +EK
Sbjct: 303 AHPNLFIEK 311
>XP_005247573
          Length = 336

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   AYPALMVEK 9
           A+P L +EK
Sbjct: 303 AHPNLFIEK 311
>XP_005247572
          Length = 336

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   AYPALMVEK 9
           A+P L +EK
Sbjct: 303 AHPNLFIEK 311
>XP_005270538
          Length = 1588

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   AYPALMVEK 9
           A+P  +VEK
Sbjct: 949 AHPGYLVEK 957
>NP_006840
          Length = 525

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  YPALMVE 8
          +PAL+VE
Sbjct: 59 HPALLVE 65
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.318    0.129    0.360 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 434,683
Number of extensions: 318
Number of successful extensions: 61
Number of sequences better than 10000.0: 61
Number of HSP's gapped: 61
Number of HSP's successfully gapped: 61
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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