Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004324                                                              20     299
XP_005250103                                                           20     299
XP_005250102                                                           20     299
NP_000594                                                              17    3301
NP_001243793                                                           17    3301
NP_006693                                                              17    3301
NP_001159583                                                           17    3301
NP_001159585                                                           17    3301
NP_001243794                                                           17    3301
NP_001159586                                                           17    3301
NP_055602                                                              17    3301
NP_001159584                                                           17    3301
XP_005250117                                                           17    3301
XP_006716064                                                           17    3301
XP_006716063                                                           17    3301
NP_003583                                                              17    3301
NP_001340                                                              17    4312
NP_001258651                                                           17    4312
NP_852478                                                              16    5631
NP_003065                                                              16    5631
NP_001263987                                                           16    5631
NP_003499                                                              16    5631
NP_736609                                                              16    5631
NP_001263988                                                           16    5631
NP_001503                                                              16    7355
NP_001028222                                                           16    7355
NP_079474                                                              16    7355
NP_870987                                                              16    7355
NP_689500                                                              16    7355
NP_001106997                                                           16    7355
XP_005256385                                                           16    7355
XP_006721400                                                           16    7355
XP_005256381                                                           16    7355
XP_006719676                                                           16    7355
XP_006719675                                                           16    7355
XP_006716781                                                           16    7355
XP_005251409                                                           16    7355
XP_005251408                                                           16    7355
XP_006716780                                                           16    7355
XP_005249092                                                           16    7355
NP_056324                                                              16    7355
NP_001367                                                              15    9605
NP_001005619                                                           15    9605
NP_001005731                                                           15    9605
NP_003676                                                              15    9605
NP_000204                                                              15    9605
NP_075561                                                              15    9605
NP_005236                                                              15    9605
NP_001438                                                              15    9605
NP_001129245                                                           15    9605
NP_006029                                                              15    9605
XP_006723957                                                           15    9605
XP_005259725                                                           15    9605
XP_005257369                                                           15    9605
XP_005257368                                                           15    9605
XP_006721933                                                           15    9605
XP_006721932                                                           15    9605
XP_006721931                                                           15    9605
XP_006721930                                                           15    9605
XP_005257366                                                           15    9605
XP_006721929                                                           15    9605
XP_006714824                                                           15    9605
XP_005248410                                                           15    9605
XP_006714553                                                           15    9605
XP_005248407                                                           15    9605
XP_005248406                                                           15    9605
XP_005248404                                                           15    9605
XP_005248403                                                           15    9605
XP_006714552                                                           15    9605
XP_005248402                                                           15    9605
XP_006714202                                                           15    9605
XP_005262892                                                           15    9605
XP_005262891                                                           15    9605
NP_056066                                                              15    9605
>NP_004324
          Length = 766

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   AVYRIQDG 8
           AVYRIQDG
Sbjct: 196 AVYRIQDG 203
>XP_005250103
          Length = 758

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   AVYRIQDG 8
           AVYRIQDG
Sbjct: 196 AVYRIQDG 203
>XP_005250102
          Length = 767

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   AVYRIQDG 8
           AVYRIQDG
Sbjct: 196 AVYRIQDG 203
>NP_000594
          Length = 1203

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   YRIQDGL 9
           YR QDGL
Sbjct: 962 YRTQDGL 968
>NP_001243793
          Length = 970

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   YRIQDG 8
           YR+QDG
Sbjct: 334 YRVQDG 339
>NP_006693
          Length = 1327

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   AVYRIQDGL 9
           ++Y +QDGL
Sbjct: 183 SIYVVQDGL 191
>NP_001159583
          Length = 1375

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   AVYRIQDGL 9
           ++Y +QDGL
Sbjct: 231 SIYVVQDGL 239
>NP_001159585
          Length = 1327

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   AVYRIQDGL 9
           ++Y +QDGL
Sbjct: 183 SIYVVQDGL 191
>NP_001243794
          Length = 900

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   YRIQDG 8
           YR+QDG
Sbjct: 264 YRVQDG 269
>NP_001159586
          Length = 1365

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   AVYRIQDGL 9
           ++Y +QDGL
Sbjct: 222 SIYVVQDGL 230
>NP_055602
          Length = 913

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   YRIQDG 8
           YR+QDG
Sbjct: 277 YRVQDG 282
>NP_001159584
          Length = 1300

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   AVYRIQDGL 9
           ++Y +QDGL
Sbjct: 183 SIYVVQDGL 191
>XP_005250117
          Length = 776

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   VYRIQDGL 9
           V RIQDGL
Sbjct: 326 VSRIQDGL 333
>XP_006716064
          Length = 997

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   YRIQDGL 9
           YR QDGL
Sbjct: 756 YRTQDGL 762
>XP_006716063
          Length = 1203

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   YRIQDGL 9
           YR QDGL
Sbjct: 962 YRTQDGL 968
>NP_003583
          Length = 776

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   VYRIQDGL 9
           V RIQDGL
Sbjct: 326 VSRIQDGL 333
>NP_001340
          Length = 501

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   AVYRIQDGL 9
           AV+R+Q G+
Sbjct: 194 AVFRLQSGI 202
>NP_001258651
          Length = 134

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  AVYRIQDG 8
          AVYR +DG
Sbjct: 86 AVYRKEDG 93
>NP_852478
          Length = 1179

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   VYRIQDG 8
           +YR++DG
Sbjct: 467 IYRMEDG 473
>NP_003065
          Length = 1105

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  AVYRIQDG 8
          AVYR +DG
Sbjct: 29 AVYRRKDG 36
>NP_001263987
          Length = 1061

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   AVYRIQDG 8
           A Y IQDG
Sbjct: 529 AAYLIQDG 536
>NP_003499
          Length = 591

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   AVYRIQDGL 9
           A+Y IQ+GL
Sbjct: 300 ALYVIQEGL 308
>NP_736609
          Length = 593

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  AVYRIQDG 8
          A Y IQDG
Sbjct: 61 AAYLIQDG 68
>NP_001263988
          Length = 1061

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   AVYRIQDG 8
           A Y IQDG
Sbjct: 529 AAYLIQDG 536
>NP_001503
          Length = 222

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2  VYRIQDG 8
          +Y++QDG
Sbjct: 41 LYKLQDG 47
>NP_001028222
          Length = 385

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   YRIQDG 8
           YRI+DG
Sbjct: 342 YRIKDG 347
>NP_079474
          Length = 385

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   YRIQDG 8
           YRI+DG
Sbjct: 342 YRIKDG 347
>NP_870987
          Length = 561

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RIQDGL 9
           R+QDGL
Sbjct: 382 RVQDGL 387
>NP_689500
          Length = 539

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AVYRIQDGL 9
           AVYR  DG+
Sbjct: 368 AVYRGADGM 376
>NP_001106997
          Length = 614

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AVYRIQDGL 9
           AVYR  DG+
Sbjct: 443 AVYRGADGM 451
>XP_005256385
          Length = 400

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AVYRIQDGL 9
           AVYR  DG+
Sbjct: 229 AVYRGADGM 237
>XP_006721400
          Length = 539

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AVYRIQDGL 9
           AVYR  DG+
Sbjct: 368 AVYRGADGM 376
>XP_005256381
          Length = 597

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AVYRIQDGL 9
           AVYR  DG+
Sbjct: 426 AVYRGADGM 434
>XP_006719676
          Length = 385

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   YRIQDG 8
           YRI+DG
Sbjct: 342 YRIKDG 347
>XP_006719675
          Length = 385

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   YRIQDG 8
           YRI+DG
Sbjct: 342 YRIKDG 347
>XP_006716781
          Length = 387

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RIQDGL 9
           R+QDGL
Sbjct: 208 RVQDGL 213
>XP_005251409
          Length = 561

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RIQDGL 9
           R+QDGL
Sbjct: 382 RVQDGL 387
>XP_005251408
          Length = 561

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RIQDGL 9
           R+QDGL
Sbjct: 382 RVQDGL 387
>XP_006716780
          Length = 561

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RIQDGL 9
           R+QDGL
Sbjct: 382 RVQDGL 387
>XP_005249092
          Length = 222

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2  VYRIQDG 8
          +Y++QDG
Sbjct: 41 LYKLQDG 47
>NP_056324
          Length = 275

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  VYRIQDG 8
          V RIQDG
Sbjct: 93 VIRIQDG 99
>NP_001367
          Length = 4646

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   AVYRIQD 7
           A+YRIQ+
Sbjct: 284 ALYRIQE 290
>NP_001005619
          Length = 1805

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3    YRIQDG 8
            YR QDG
Sbjct: 1026 YRTQDG 1031
>NP_001005731
          Length = 1752

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3    YRIQDG 8
            YR QDG
Sbjct: 1026 YRTQDG 1031
>NP_003676
          Length = 711

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   YRIQDGL 9
           YR+ DG+
Sbjct: 149 YRVPDGM 155
>NP_000204
          Length = 1822

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3    YRIQDG 8
            YR QDG
Sbjct: 1026 YRTQDG 1031
>NP_075561
          Length = 3197

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    AVYRIQD 7
            ++Y+IQD
Sbjct: 1684 SIYKIQD 1690
>NP_005236
          Length = 4588

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    VYRIQDG 8
            VY I+DG
Sbjct: 1698 VYEIKDG 1704
>NP_001438
          Length = 4349

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   AVYRIQ 6
           AVYR+Q
Sbjct: 365 AVYRVQ 370
>NP_001129245
          Length = 520

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   AVYRIQDGL 9
           A YR QD L
Sbjct: 345 ATYRRQDAL 353
>NP_006029
          Length = 520

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   AVYRIQDGL 9
           A YR QD L
Sbjct: 345 ATYRRQDAL 353
>XP_006723957
          Length = 520

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   AVYRIQDGL 9
           A YR QD L
Sbjct: 345 ATYRRQDAL 353
>XP_005259725
          Length = 747

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   YRIQDGL 9
           YR+ DG+
Sbjct: 149 YRVPDGM 155
>XP_005257369
          Length = 1752

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3    YRIQDG 8
            YR QDG
Sbjct: 1026 YRTQDG 1031
>XP_005257368
          Length = 1875

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3    YRIQDG 8
            YR QDG
Sbjct: 1026 YRTQDG 1031
>XP_006721933
          Length = 1787

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3    YRIQDG 8
            YR QDG
Sbjct: 1061 YRTQDG 1066
>XP_006721932
          Length = 1821

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3   YRIQDG 8
           YR QDG
Sbjct: 972 YRTQDG 977
>XP_006721931
          Length = 1840

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3    YRIQDG 8
            YR QDG
Sbjct: 1061 YRTQDG 1066
>XP_006721930
          Length = 1857

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3    YRIQDG 8
            YR QDG
Sbjct: 1061 YRTQDG 1066
>XP_005257366
          Length = 1875

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3    YRIQDG 8
            YR QDG
Sbjct: 1026 YRTQDG 1031
>XP_006721929
          Length = 1910

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3    YRIQDG 8
            YR QDG
Sbjct: 1061 YRTQDG 1066
>XP_006714824
          Length = 4349

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   AVYRIQ 6
           AVYR+Q
Sbjct: 365 AVYRVQ 370
>XP_005248410
          Length = 2132

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   AVYRIQD 7
           ++Y+IQD
Sbjct: 565 SIYKIQD 571
>XP_006714553
          Length = 2792

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    AVYRIQD 7
            ++Y+IQD
Sbjct: 1684 SIYKIQD 1690
>XP_005248407
          Length = 3208

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    AVYRIQD 7
            ++Y+IQD
Sbjct: 1641 SIYKIQD 1647
>XP_005248406
          Length = 3214

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    AVYRIQD 7
            ++Y+IQD
Sbjct: 1684 SIYKIQD 1690
>XP_005248404
          Length = 3250

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    AVYRIQD 7
            ++Y+IQD
Sbjct: 1684 SIYKIQD 1690
>XP_005248403
          Length = 3250

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    AVYRIQD 7
            ++Y+IQD
Sbjct: 1684 SIYKIQD 1690
>XP_006714552
          Length = 3251

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    AVYRIQD 7
            ++Y+IQD
Sbjct: 1684 SIYKIQD 1690
>XP_005248402
          Length = 3251

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    AVYRIQD 7
            ++Y+IQD
Sbjct: 1684 SIYKIQD 1690
>XP_006714202
          Length = 4588

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    VYRIQDG 8
            VY I+DG
Sbjct: 1698 VYEIKDG 1704
>XP_005262892
          Length = 4600

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    VYRIQDG 8
            VY I+DG
Sbjct: 1698 VYEIKDG 1704
>XP_005262891
          Length = 4600

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    VYRIQDG 8
            VY I+DG
Sbjct: 1698 VYEIKDG 1704
>NP_056066
          Length = 823

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   YRIQDGL 9
           +R+QDG+
Sbjct: 109 HRLQDGI 115
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.329    0.150    0.426 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 576,474
Number of extensions: 989
Number of successful extensions: 74
Number of sequences better than 10000.0: 74
Number of HSP's gapped: 74
Number of HSP's successfully gapped: 74
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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