Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001245210                                                           20     390
NP_000242                                                              20     390
XP_005264389                                                           20     390
NP_000285                                                              17    3301
NP_001165903                                                           17    3301
XP_005255422                                                           17    3301
XP_006721117                                                           17    3301
XP_005255421                                                           17    3301
XP_005255420                                                           17    3301
NP_059138                                                              17    4312
NP_001032360                                                           17    4312
NP_003742                                                              17    4312
NP_001073982                                                           16    5631
NP_071351                                                              16    5631
XP_006726572                                                           16    5631
XP_006726571                                                           16    5631
XP_006726570                                                           16    5631
XP_003960511                                                           16    5631
XP_006717414                                                           16    5631
XP_005269338                                                           16    5631
XP_005269337                                                           16    5631
XP_006710283                                                           16    5631
XP_006710282                                                           16    5631
NP_001005289                                                           16    5631
NP_006517                                                              16    7355
NP_001027549                                                           16    7355
NP_001230352                                                           16    7355
XP_006724219                                                           16    7355
XP_006724218                                                           16    7355
XP_006724217                                                           16    7355
XP_006716981                                                           16    7355
XP_006716980                                                           16    7355
XP_005272572                                                           16    7355
XP_005272573                                                           16    7355
XP_005264365                                                           16    7355
XP_005264364                                                           16    7355
NP_689726                                                              16    7355
NP_149350                                                              16    7355
NP_001267                                                              15    9605
NP_055325                                                              15    9605
NP_149015                                                              15    9605
NP_001127951                                                           15    9605
NP_060573                                                              15    9605
NP_036505                                                              15    9605
XP_005276733                                                           15    9605
XP_005259517                                                           15    9605
XP_006715989                                                           15    9605
XP_005271048                                                           15    9605
>NP_001245210
          Length = 868

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   VSFAHVSN 9
           VSFAHVSN
Sbjct: 540 VSFAHVSN 547
>NP_000242
          Length = 934

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   VSFAHVSN 9
           VSFAHVSN
Sbjct: 606 VSFAHVSN 613
>XP_005264389
          Length = 921

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   VSFAHVSN 9
           VSFAHVSN
Sbjct: 606 VSFAHVSN 613
>NP_000285
          Length = 406

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AVSFAHVSN 9
           AVSF H +N
Sbjct: 140 AVSFLHANN 148
>NP_001165903
          Length = 374

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AVSFAHVSN 9
           AVSF H +N
Sbjct: 140 AVSFLHANN 148
>XP_005255422
          Length = 301

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  AVSFAHVSN 9
          AVSF H +N
Sbjct: 31 AVSFLHANN 39
>XP_006721117
          Length = 301

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  AVSFAHVSN 9
          AVSF H +N
Sbjct: 31 AVSFLHANN 39
>XP_005255421
          Length = 308

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  AVSFAHVSN 9
          AVSF H +N
Sbjct: 38 AVSFLHANN 46
>XP_005255420
          Length = 410

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AVSFAHVSN 9
           AVSF H +N
Sbjct: 140 AVSFLHANN 148
>NP_059138
          Length = 1032

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   VSFAHVS 8
           VSFAH+S
Sbjct: 349 VSFAHLS 355
>NP_001032360
          Length = 814

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AVSFAHVSN 9
           +VSF HV N
Sbjct: 588 SVSFYHVKN 596
>NP_003742
          Length = 814

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AVSFAHVSN 9
           +VSF HV N
Sbjct: 588 SVSFYHVKN 596
>NP_001073982
          Length = 545

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   SFAHVSN 9
           +FAH+SN
Sbjct: 308 TFAHLSN 314
>NP_071351
          Length = 2752

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    AVSFAHVS 8
            AVSF H+S
Sbjct: 1834 AVSFEHLS 1841
>XP_006726572
          Length = 2066

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    AVSFAHV 7
            AVSF HV
Sbjct: 1209 AVSFVHV 1215
>XP_006726571
          Length = 3681

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    AVSFAHV 7
            AVSF HV
Sbjct: 2865 AVSFVHV 2871
>XP_006726570
          Length = 3722

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    AVSFAHV 7
            AVSF HV
Sbjct: 2865 AVSFVHV 2871
>XP_003960511
          Length = 3722

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    AVSFAHV 7
            AVSF HV
Sbjct: 2865 AVSFVHV 2871
>XP_006717414
          Length = 5100

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    AVSFAHV 7
            AVSF HV
Sbjct: 4243 AVSFVHV 4249
>XP_005269338
          Length = 545

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   SFAHVSN 9
           +FAH+SN
Sbjct: 308 TFAHLSN 314
>XP_005269337
          Length = 545

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   SFAHVSN 9
           +FAH+SN
Sbjct: 308 TFAHLSN 314
>XP_006710283
          Length = 2066

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    AVSFAHV 7
            AVSF HV
Sbjct: 1209 AVSFVHV 1215
>XP_006710282
          Length = 2621

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    AVSFAHV 7
            AVSF HV
Sbjct: 1764 AVSFVHV 1770
>NP_001005289
          Length = 320

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   AVSFAHV 7
           AVS+AH+
Sbjct: 223 AVSYAHI 229
>NP_006517
          Length = 1048

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    VSFAHVSN 9
            VS+ H+SN
Sbjct: 1017 VSYQHLSN 1024
>NP_001027549
          Length = 265

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   AVSFAHVSN 9
           AVSF H  N
Sbjct: 108 AVSFLHFHN 116
>NP_001230352
          Length = 70

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  VSFAHVSN 9
          V+ AH+SN
Sbjct: 51 VTVAHISN 58
>XP_006724219
          Length = 1157

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    AVSFAHVSN 9
            AVS +H+ N
Sbjct: 1149 AVSLSHIRN 1157
>XP_006724218
          Length = 1200

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    AVSFAHVSN 9
            AVS +H+ N
Sbjct: 1192 AVSLSHIRN 1200
>XP_006724217
          Length = 1235

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    AVSFAHVSN 9
            AVS +H+ N
Sbjct: 1227 AVSLSHIRN 1235
>XP_006716981
          Length = 1053

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   SFAHVS 8
           SFAH+S
Sbjct: 632 SFAHIS 637
>XP_006716980
          Length = 1059

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   SFAHVS 8
           SFAH+S
Sbjct: 638 SFAHIS 643
>XP_005272572
          Length = 1059

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   SFAHVS 8
           SFAH+S
Sbjct: 638 SFAHIS 643
>XP_005272573
          Length = 1059

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   SFAHVS 8
           SFAH+S
Sbjct: 638 SFAHIS 643
>XP_005264365
          Length = 198

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  AVSFAHVSN 9
          AVSF H  N
Sbjct: 41 AVSFLHFHN 49
>XP_005264364
          Length = 288

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   AVSFAHVSN 9
           AVSF H  N
Sbjct: 131 AVSFLHFHN 139
>NP_689726
          Length = 1274

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    AVSFAHVSN 9
            AVS +H+ N
Sbjct: 1266 AVSLSHIRN 1274
>NP_149350
          Length = 1059

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   SFAHVS 8
           SFAH+S
Sbjct: 638 SFAHIS 643
>NP_001267
          Length = 383

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  SFAHVSN 9
          SFA++SN
Sbjct: 57 SFANISN 63
>NP_055325
          Length = 4935

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    VSFAHVSN 9
            VSF+H S+
Sbjct: 4326 VSFSHASS 4333
>NP_149015
          Length = 5142

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    VSFAHVSN 9
            VSF+H S+
Sbjct: 4326 VSFSHASS 4333
>NP_001127951
          Length = 858

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   AVSFAHV 7
           A+SF HV
Sbjct: 332 AISFEHV 338
>NP_060573
          Length = 858

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   AVSFAHV 7
           A+SF HV
Sbjct: 332 AISFEHV 338
>NP_036505
          Length = 321

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   AVSFAHV 7
           +VS+AHV
Sbjct: 224 SVSYAHV 230
>XP_005276733
          Length = 330

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  SFAHVSN 9
          SFAH+S+
Sbjct: 65 SFAHLSS 71
>XP_005259517
          Length = 330

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  SFAHVSN 9
          SFAH+S+
Sbjct: 65 SFAHLSS 71
>XP_006715989
          Length = 5148

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    VSFAHVSN 9
            VSF+H S+
Sbjct: 4326 VSFSHASS 4333
>XP_005271048
          Length = 858

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   AVSFAHV 7
           A+SF HV
Sbjct: 332 AISFEHV 338
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.319    0.116    0.317 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 450,055
Number of extensions: 683
Number of successful extensions: 48
Number of sequences better than 10000.0: 48
Number of HSP's gapped: 48
Number of HSP's successfully gapped: 48
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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