Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005742                                                              18    1935
NP_671714                                                              18    1935
XP_006715890                                                           18    1935
XP_005250160                                                           18    1935
XP_005250159                                                           18    1935
NP_114104                                                              17    4312
NP_002842                                                              17    4312
XP_005250576                                                           17    4312
NP_078966                                                              16    5631
NP_640337                                                              16    7355
NP_001121187                                                           16    7355
NP_001275707                                                           16    7355
NP_075463                                                              16    7355
NP_004415                                                              16    7355
XP_006720921                                                           16    7355
XP_006720920                                                           16    7355
XP_005255213                                                           16    7355
XP_005255212                                                           16    7355
XP_006719812                                                           16    7355
XP_006715402                                                           16    7355
NP_740754                                                              15    9605
NP_061336                                                              15    9605
NP_055591                                                              15    9605
NP_631940                                                              15    9605
NP_476511                                                              15    9605
NP_001128686                                                           15    9605
NP_001128685                                                           15    9605
NP_476510                                                              15    9605
XP_006721701                                                           15    9605
XP_006719777                                                           15    9605
XP_006719776                                                           15    9605
XP_006719775                                                           15    9605
XP_006719774                                                           15    9605
XP_006719773                                                           15    9605
XP_005254057                                                           15    9605
XP_006719772                                                           15    9605
XP_006719771                                                           15    9605
XP_006719770                                                           15    9605
XP_005254054                                                           15    9605
>NP_005742
          Length = 3907

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    AVSESTVLP 9
            AVSESTV P
Sbjct: 1374 AVSESTVPP 1382
>NP_671714
          Length = 3899

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    AVSESTVLP 9
            AVSESTV P
Sbjct: 1374 AVSESTVPP 1382
>XP_006715890
          Length = 3860

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    AVSESTVLP 9
            AVSESTV P
Sbjct: 1374 AVSESTVPP 1382
>XP_005250160
          Length = 3939

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    AVSESTVLP 9
            AVSESTV P
Sbjct: 1374 AVSESTVPP 1382
>XP_005250159
          Length = 3952

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    AVSESTVLP 9
            AVSESTV P
Sbjct: 1374 AVSESTVPP 1382
>NP_114104
          Length = 490

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  VSESTVLP 9
          VSE+T+LP
Sbjct: 75 VSENTMLP 82
>NP_002842
          Length = 2315

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    SESTVLP 9
            SESTV+P
Sbjct: 1066 SESTVMP 1072
>XP_005250576
          Length = 2308

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    SESTVLP 9
            SESTV+P
Sbjct: 1066 SESTVMP 1072
>NP_078966
          Length = 14507

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    SESTVLP 9
            S+STVLP
Sbjct: 7000 SQSTVLP 7006
>NP_640337
          Length = 1115

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VSESTVLP 9
           +SE TV+P
Sbjct: 699 ISEGTVVP 706
>NP_001121187
          Length = 1151

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VSESTVLP 9
           +SE TV+P
Sbjct: 699 ISEGTVVP 706
>NP_001275707
          Length = 607

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AVSESTVL 8
           A+SE TVL
Sbjct: 553 AISEGTVL 560
>NP_075463
          Length = 3013

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AVSESTVLP 9
           AVS+S  LP
Sbjct: 803 AVSDSATLP 811
>NP_004415
          Length = 784

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AVSESTVL 8
           A+SE TVL
Sbjct: 730 AISEGTVL 737
>XP_006720921
          Length = 783

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AVSESTVL 8
           A+SE TVL
Sbjct: 729 AISEGTVL 736
>XP_006720920
          Length = 785

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AVSESTVL 8
           A+SE TVL
Sbjct: 731 AISEGTVL 738
>XP_005255213
          Length = 836

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AVSESTVL 8
           A+SE TVL
Sbjct: 782 AISEGTVL 789
>XP_005255212
          Length = 837

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AVSESTVL 8
           A+SE TVL
Sbjct: 783 AISEGTVL 790
>XP_006719812
          Length = 3019

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AVSESTVLP 9
           AVS+S  LP
Sbjct: 800 AVSDSATLP 808
>XP_006715402
          Length = 1135

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VSESTVLP 9
           +SE TV+P
Sbjct: 699 ISEGTVVP 706
>NP_740754
          Length = 570

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VSESTVLP 9
           V +STVLP
Sbjct: 209 VIDSTVLP 216
>NP_061336
          Length = 570

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VSESTVLP 9
           V +STVLP
Sbjct: 209 VIDSTVLP 216
>NP_055591
          Length = 679

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VSESTVLP 9
           V+E+TV+P
Sbjct: 308 VTETTVVP 315
>NP_631940
          Length = 471

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VSESTVLP 9
           V+E+TV+P
Sbjct: 308 VTETTVVP 315
>NP_476511
          Length = 631

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VSESTVLP 9
           V+E+TV+P
Sbjct: 308 VTETTVVP 315
>NP_001128686
          Length = 729

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VSESTVLP 9
           V+E+TV+P
Sbjct: 308 VTETTVVP 315
>NP_001128685
          Length = 681

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VSESTVLP 9
           V+E+TV+P
Sbjct: 310 VTETTVVP 317
>NP_476510
          Length = 759

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VSESTVLP 9
           V+E+TV+P
Sbjct: 308 VTETTVVP 315
>XP_006721701
          Length = 529

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  SESTVLP 9
          SES++LP
Sbjct: 21 SESSILP 27
>XP_006719777
          Length = 421

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VSESTVLP 9
           V+E+TV+P
Sbjct: 308 VTETTVVP 315
>XP_006719776
          Length = 456

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VSESTVLP 9
           V+E+TV+P
Sbjct: 308 VTETTVVP 315
>XP_006719775
          Length = 596

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VSESTVLP 9
           V+E+TV+P
Sbjct: 308 VTETTVVP 315
>XP_006719774
          Length = 626

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VSESTVLP 9
           V+E+TV+P
Sbjct: 308 VTETTVVP 315
>XP_006719773
          Length = 674

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VSESTVLP 9
           V+E+TV+P
Sbjct: 308 VTETTVVP 315
>XP_005254057
          Length = 708

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VSESTVLP 9
           V+E+TV+P
Sbjct: 307 VTETTVVP 314
>XP_006719772
          Length = 709

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VSESTVLP 9
           V+E+TV+P
Sbjct: 308 VTETTVVP 315
>XP_006719771
          Length = 714

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VSESTVLP 9
           V+E+TV+P
Sbjct: 308 VTETTVVP 315
>XP_006719770
          Length = 744

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VSESTVLP 9
           V+E+TV+P
Sbjct: 308 VTETTVVP 315
>XP_005254054
          Length = 758

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VSESTVLP 9
           V+E+TV+P
Sbjct: 307 VTETTVVP 314
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.298    0.112    0.271 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 322,595
Number of extensions: 470
Number of successful extensions: 39
Number of sequences better than 10000.0: 39
Number of HSP's gapped: 39
Number of HSP's successfully gapped: 39
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.2 bits)
S2: 28 (15.4 bits)

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