Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_115803                                                              21     229
NP_000126                                                              19     869
NP_001273096                                                           19     869
XP_005256351                                                           19     869
XP_006721231                                                           19     869
XP_006721230                                                           19     869
NP_877398                                                              18    1935
NP_056007                                                              18    1935
XP_005260738                                                           18    1935
XP_006723618                                                           18    1935
NP_001139669                                                           18    1935
NP_644809                                                              17    3301
XP_005257884                                                           17    3301
XP_005257882                                                           17    3301
NP_057726                                                              16    5631
NP_001271165                                                           16    5631
NP_001098721                                                           16    5631
NP_055548                                                              16    5631
XP_005254495                                                           16    5631
XP_005248689                                                           16    5631
NP_000072                                                              16    7355
NP_001245134                                                           16    7355
NP_055464                                                              16    7355
NP_659505                                                              16    7355
XP_005273087                                                           16    7355
XP_006711794                                                           16    7355
XP_005273086                                                           16    7355
XP_005273085                                                           16    7355
XP_005273084                                                           16    7355
XP_006711659                                                           16    7355
XP_005277493                                                           16    7355
XP_005277492                                                           16    7355
XP_005277491                                                           16    7355
XP_005277489                                                           16    7355
NP_003628                                                              16    7355
NP_005543                                                              15    9605
NP_001123579                                                           15    9605
NP_891553                                                              15    9605
NP_079350                                                              15    9605
NP_001139280                                                           15    9605
NP_002903                                                              15    9605
NP_001273361                                                           15    9605
NP_001273360                                                           15    9605
NP_000623                                                              15    9605
NP_001275964                                                           15    9605
NP_001275963                                                           15    9605
NP_236914                                                              15    9605
NP_067012                                                              15    9605
NP_958930                                                              15    9605
NP_958929                                                              15    9605
NP_001074                                                              15    9605
NP_001120645                                                           15    9605
NP_958931                                                              15    9605
NP_246273                                                              15    9605
XP_006721108                                                           15    9605
XP_005267148                                                           15    9605
XP_005267147                                                           15    9605
XP_006715607                                                           15    9605
XP_006715606                                                           15    9605
XP_006714380                                                           15    9605
XP_006714379                                                           15    9605
XP_006714378                                                           15    9605
XP_006714377                                                           15    9605
>NP_115803
          Length = 1156

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   AVQNMGMY 8
           AVQNMGMY
Sbjct: 863 AVQNMGMY 870
>NP_000126
          Length = 1455

 Score = 18.9 bits (37), Expect =   869
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   AVQNMGMYE 9
           +++NMG+YE
Sbjct: 524 SIENMGLYE 532
>NP_001273096
          Length = 1424

 Score = 18.9 bits (37), Expect =   869
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   AVQNMGMYE 9
           +++NMG+YE
Sbjct: 524 SIENMGLYE 532
>XP_005256351
          Length = 1463

 Score = 18.9 bits (37), Expect =   869
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   AVQNMGMYE 9
           +++NMG+YE
Sbjct: 524 SIENMGLYE 532
>XP_006721231
          Length = 1114

 Score = 18.9 bits (37), Expect =   869
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   AVQNMGMYE 9
           +++NMG+YE
Sbjct: 183 SIENMGLYE 191
>XP_006721230
          Length = 1412

 Score = 18.9 bits (37), Expect =   869
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   AVQNMGMYE 9
           +++NMG+YE
Sbjct: 524 SIENMGLYE 532
>NP_877398
          Length = 1173

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   NMGMYE 9
           NMGMYE
Sbjct: 636 NMGMYE 641
>NP_056007
          Length = 1216

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   NMGMYE 9
           NMGMYE
Sbjct: 636 NMGMYE 641
>XP_005260738
          Length = 877

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   NMGMYE 9
           NMGMYE
Sbjct: 636 NMGMYE 641
>XP_006723618
          Length = 1173

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   NMGMYE 9
           NMGMYE
Sbjct: 636 NMGMYE 641
>NP_001139669
          Length = 7081

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AVQNMGMYE 9
           A QN G+YE
Sbjct: 304 AFQNQGLYE 312
>NP_644809
          Length = 153

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  VQNMGMY 8
          + NMGMY
Sbjct: 55 IHNMGMY 61
>XP_005257884
          Length = 153

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  VQNMGMY 8
          + NMGMY
Sbjct: 55 IHNMGMY 61
>XP_005257882
          Length = 171

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  VQNMGMY 8
          + NMGMY
Sbjct: 73 IHNMGMY 79
>NP_057726
          Length = 3674

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AVQNMGMYE 9
           AVQ +GM E
Sbjct: 465 AVQRLGMLE 473
>NP_001271165
          Length = 1539

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    VQNMGMYE 9
            +QN G+YE
Sbjct: 1295 IQNDGIYE 1302
>NP_001098721
          Length = 1539

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    VQNMGMYE 9
            +QN G+YE
Sbjct: 1295 IQNDGIYE 1302
>NP_055548
          Length = 1539

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    VQNMGMYE 9
            +QN G+YE
Sbjct: 1295 IQNDGIYE 1302
>XP_005254495
          Length = 3694

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AVQNMGMYE 9
           AVQ +GM E
Sbjct: 485 AVQRLGMLE 493
>XP_005248689
          Length = 1539

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    VQNMGMYE 9
            +QN G+YE
Sbjct: 1295 IQNDGIYE 1302
>NP_000072
          Length = 3801

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    VQNMGMYE 9
            V+NMG+++
Sbjct: 2416 VRNMGLFQ 2423
>NP_001245134
          Length = 791

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   QNMGMY 8
           Q+MGMY
Sbjct: 570 QSMGMY 575
>NP_055464
          Length = 953

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VQNMGMYE 9
           +QNMGM +
Sbjct: 123 LQNMGMMD 130
>NP_659505
          Length = 790

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   QNMGMY 8
           Q+MGMY
Sbjct: 570 QSMGMY 575
>XP_005273087
          Length = 2788

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    VQNMGMYE 9
            V+NMG+++
Sbjct: 2416 VRNMGLFQ 2423
>XP_006711794
          Length = 3022

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    VQNMGMYE 9
            V+NMG+++
Sbjct: 1637 VRNMGLFQ 1644
>XP_005273086
          Length = 3264

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    VQNMGMYE 9
            V+NMG+++
Sbjct: 2416 VRNMGLFQ 2423
>XP_005273085
          Length = 3755

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    VQNMGMYE 9
            V+NMG+++
Sbjct: 2370 VRNMGLFQ 2377
>XP_005273084
          Length = 3801

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    VQNMGMYE 9
            V+NMG+++
Sbjct: 2416 VRNMGLFQ 2423
>XP_006711659
          Length = 1046

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VQNMGMY 8
           VQN+G Y
Sbjct: 853 VQNLGCY 859
>XP_005277493
          Length = 1105

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VQNMGMY 8
           VQN+G Y
Sbjct: 912 VQNLGCY 918
>XP_005277492
          Length = 1119

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VQNMGMY 8
           VQN+G Y
Sbjct: 926 VQNLGCY 932
>XP_005277491
          Length = 1143

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VQNMGMY 8
           VQN+G Y
Sbjct: 988 VQNLGCY 994
>XP_005277489
          Length = 1181

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VQNMGMY 8
           VQN+G Y
Sbjct: 988 VQNLGCY 994
>NP_003628
          Length = 1167

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VQNMGMY 8
           VQN+G Y
Sbjct: 974 VQNLGCY 980
>NP_005543
          Length = 560

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 3   QNMGMYE 9
           QN G YE
Sbjct: 350 QNQGKYE 356
>NP_001123579
          Length = 618

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 3   QNMGMYE 9
           QN G YE
Sbjct: 350 QNQGKYE 356
>NP_891553
          Length = 573

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 3   QNMGMYE 9
           QN G YE
Sbjct: 350 QNQGKYE 356
>NP_079350
          Length = 4012

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    VQNMGM 7
            VQN+GM
Sbjct: 2315 VQNLGM 2320
>NP_001139280
          Length = 1153

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   QNMGMYE 9
           QN GM+E
Sbjct: 437 QNTGMWE 443
>NP_002903
          Length = 3130

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    VQNMGMYE 9
            V+N+G Y+
Sbjct: 2637 VENLGKYD 2644
>NP_001273361
          Length = 3052

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    VQNMGMYE 9
            V+N+G Y+
Sbjct: 2559 VENLGKYD 2566
>NP_001273360
          Length = 3052

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    VQNMGMYE 9
            V+N+G Y+
Sbjct: 2559 VENLGKYD 2566
>NP_000623
          Length = 1152

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   QNMGMYE 9
           QN GM+E
Sbjct: 437 QNTGMWE 443
>NP_001275964
          Length = 542

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 3   QNMGMYE 9
           QN G YE
Sbjct: 271 QNQGKYE 277
>NP_001275963
          Length = 619

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 3   QNMGMYE 9
           QN G YE
Sbjct: 348 QNQGKYE 354
>NP_236914
          Length = 833

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   VQNMGMYE 9
           +QN  MYE
Sbjct: 461 IQNTQMYE 468
>NP_067012
          Length = 432

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   AVQNMGMYE 9
           A  NMG Y+
Sbjct: 335 ATSNMGSYK 343
>NP_958930
          Length = 619

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 3   QNMGMYE 9
           QN G YE
Sbjct: 348 QNQGKYE 354
>NP_958929
          Length = 619

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 3   QNMGMYE 9
           QN G YE
Sbjct: 348 QNQGKYE 354
>NP_001074
          Length = 875

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   VQNMGMYE 9
           +QN  MYE
Sbjct: 503 IQNTQMYE 510
>NP_001120645
          Length = 398

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   AVQNMGMYE 9
           A  NMG Y+
Sbjct: 301 ATSNMGSYK 309
>NP_958931
          Length = 637

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 3   QNMGMYE 9
           QN G YE
Sbjct: 366 QNQGKYE 372
>NP_246273
          Length = 823

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   VQNMGMYE 9
           +QN  MYE
Sbjct: 451 IQNTQMYE 458
>XP_006721108
          Length = 613

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   QNMGMYE 9
           QN GM+E
Sbjct: 437 QNTGMWE 443
>XP_005267148
          Length = 2679

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    VQNMGMYE 9
            V+N+G Y+
Sbjct: 2637 VENLGKYD 2644
>XP_005267147
          Length = 2689

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    VQNMGMYE 9
            V+N+G Y+
Sbjct: 2637 VENLGKYD 2644
>XP_006715607
          Length = 3052

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    VQNMGMYE 9
            V+N+G Y+
Sbjct: 2559 VENLGKYD 2566
>XP_006715606
          Length = 3130

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    VQNMGMYE 9
            V+N+G Y+
Sbjct: 2637 VENLGKYD 2644
>XP_006714380
          Length = 3897

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    VQNMGM 7
            VQN+GM
Sbjct: 2200 VQNLGM 2205
>XP_006714379
          Length = 3936

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    VQNMGM 7
            VQN+GM
Sbjct: 2315 VQNLGM 2320
>XP_006714378
          Length = 3965

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    VQNMGM 7
            VQN+GM
Sbjct: 2268 VQNLGM 2273
>XP_006714377
          Length = 4010

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    VQNMGM 7
            VQN+GM
Sbjct: 2313 VQNLGM 2318
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.316    0.125    0.345 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 416,297
Number of extensions: 639
Number of successful extensions: 63
Number of sequences better than 10000.0: 63
Number of HSP's gapped: 63
Number of HSP's successfully gapped: 63
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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