Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001895                                                              20     509
NP_001091680                                                           20     509
NP_001091679                                                           20     509
XP_006713048                                                           20     509
XP_006713047                                                           20     509
XP_006713046                                                           20     509
XP_005264943                                                           20     509
NP_002221                                                              18    1482
NP_068831                                                              18    1482
XP_006721941                                                           18    1482
XP_006721940                                                           18    1482
XP_006721939                                                           18    1482
XP_006721938                                                           18    1482
XP_006721937                                                           18    1482
XP_006721936                                                           18    1482
XP_006721935                                                           18    1482
XP_006721934                                                           18    1482
XP_005257370                                                           18    1482
NP_005498                                                              17    3301
NP_060233                                                              17    4312
XP_006713184                                                           17    4312
NP_000830                                                              17    4312
NP_005361                                                              16    5631
NP_059344                                                              16    5631
NP_006331                                                              16    5631
NP_059345                                                              16    5631
XP_005257005                                                           16    5631
XP_006721701                                                           16    5631
XP_006721700                                                           16    5631
XP_005257002                                                           16    5631
XP_005257001                                                           16    5631
XP_006721699                                                           16    5631
XP_006721698                                                           16    5631
XP_005257000                                                           16    5631
NP_001138360                                                           16    5631
NP_060546                                                              16    7355
NP_001276949                                                           16    7355
NP_001276950                                                           16    7355
NP_619579                                                              16    7355
NP_068733                                                              16    7355
NP_001230574                                                           16    7355
NP_001135799                                                           16    7355
NP_001135798                                                           16    7355
NP_055866                                                              16    7355
NP_066968                                                              16    7355
XP_005252542                                                           16    7355
XP_006717518                                                           16    7355
XP_006717517                                                           16    7355
XP_006717516                                                           16    7355
XP_006716268                                                           16    7355
XP_006716267                                                           16    7355
XP_006716266                                                           16    7355
XP_005250791                                                           16    7355
XP_006716265                                                           16    7355
XP_006716264                                                           16    7355
XP_006716263                                                           16    7355
XP_006716262                                                           16    7355
XP_006716261                                                           16    7355
XP_006716260                                                           16    7355
NP_066008                                                              15    9605
NP_001758                                                              15    9605
NP_005094                                                              15    9605
XP_005271792                                                           15    9605
XP_005271791                                                           15    9605
XP_005271377                                                           15    9605
XP_005271376                                                           15    9605
>NP_001895
          Length = 781

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   AVLFQMSED 9
           AVLF+MSED
Sbjct: 657 AVLFRMSED 665
>NP_001091680
          Length = 781

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   AVLFQMSED 9
           AVLF+MSED
Sbjct: 657 AVLFRMSED 665
>NP_001091679
          Length = 781

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   AVLFQMSED 9
           AVLF+MSED
Sbjct: 657 AVLFRMSED 665
>XP_006713048
          Length = 720

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   AVLFQMSED 9
           AVLF+MSED
Sbjct: 657 AVLFRMSED 665
>XP_006713047
          Length = 774

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   AVLFQMSED 9
           AVLF+MSED
Sbjct: 650 AVLFRMSED 658
>XP_006713046
          Length = 774

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   AVLFQMSED 9
           AVLF+MSED
Sbjct: 650 AVLFRMSED 658
>XP_005264943
          Length = 781

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   AVLFQMSED 9
           AVLF+MSED
Sbjct: 657 AVLFRMSED 665
>NP_002221
          Length = 745

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   AVLFQMSED 9
           AVLF++SED
Sbjct: 647 AVLFRISED 655
>NP_068831
          Length = 745

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   AVLFQMSED 9
           AVLF++SED
Sbjct: 647 AVLFRISED 655
>XP_006721941
          Length = 745

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   AVLFQMSED 9
           AVLF++SED
Sbjct: 647 AVLFRISED 655
>XP_006721940
          Length = 745

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   AVLFQMSED 9
           AVLF++SED
Sbjct: 647 AVLFRISED 655
>XP_006721939
          Length = 745

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   AVLFQMSED 9
           AVLF++SED
Sbjct: 647 AVLFRISED 655
>XP_006721938
          Length = 745

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   AVLFQMSED 9
           AVLF++SED
Sbjct: 647 AVLFRISED 655
>XP_006721937
          Length = 745

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   AVLFQMSED 9
           AVLF++SED
Sbjct: 647 AVLFRISED 655
>XP_006721936
          Length = 745

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   AVLFQMSED 9
           AVLF++SED
Sbjct: 647 AVLFRISED 655
>XP_006721935
          Length = 762

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   AVLFQMSED 9
           AVLF++SED
Sbjct: 664 AVLFRISED 672
>XP_006721934
          Length = 783

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   AVLFQMSED 9
           AVLF++SED
Sbjct: 685 AVLFRISED 693
>XP_005257370
          Length = 783

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   AVLFQMSED 9
           AVLF++SED
Sbjct: 685 AVLFRISED 693
>NP_005498
          Length = 166

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  AVLFQMSED 9
          AVLF +SED
Sbjct: 35 AVLFCLSED 43
>NP_060233
          Length = 783

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   AVLFQMSED 9
           AVLF ++ED
Sbjct: 136 AVLFDITED 144
>XP_006713184
          Length = 872

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   AVLFQMSED 9
           AVLF  SED
Sbjct: 266 AVLFTRSED 274
>NP_000830
          Length = 872

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   AVLFQMSED 9
           AVLF  SED
Sbjct: 266 AVLFTRSED 274
>NP_005361
          Length = 207

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  VLFQMSED 9
          VLF+ SED
Sbjct: 24 VLFRFSED 31
>NP_059344
          Length = 521

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  VLFQMSE 8
          VLFQM+E
Sbjct: 75 VLFQMAE 81
>NP_006331
          Length = 520

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  VLFQMSE 8
          VLFQM+E
Sbjct: 75 VLFQMAE 81
>NP_059345
          Length = 552

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  VLFQMSE 8
          VLFQM+E
Sbjct: 75 VLFQMAE 81
>XP_005257005
          Length = 522

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  VLFQMSE 8
          VLFQM+E
Sbjct: 75 VLFQMAE 81
>XP_006721701
          Length = 529

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  VLFQMSE 8
          VLFQM+E
Sbjct: 69 VLFQMAE 75
>XP_006721700
          Length = 535

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  VLFQMSE 8
          VLFQM+E
Sbjct: 75 VLFQMAE 81
>XP_005257002
          Length = 553

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   VLFQMSE 8
           VLFQM+E
Sbjct: 108 VLFQMAE 114
>XP_005257001
          Length = 554

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   VLFQMSE 8
           VLFQM+E
Sbjct: 108 VLFQMAE 114
>XP_006721699
          Length = 554

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   VLFQMSE 8
           VLFQM+E
Sbjct: 108 VLFQMAE 114
>XP_006721698
          Length = 555

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   VLFQMSE 8
           VLFQM+E
Sbjct: 108 VLFQMAE 114
>XP_005257000
          Length = 567

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   VLFQMSE 8
           VLFQM+E
Sbjct: 108 VLFQMAE 114
>NP_001138360
          Length = 534

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  VLFQMSE 8
          VLFQM+E
Sbjct: 75 VLFQMAE 81
>NP_060546
          Length = 1044

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LFQMSED 9
           L+Q+SED
Sbjct: 987 LYQLSED 993
>NP_001276949
          Length = 1044

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LFQMSED 9
           L+Q+SED
Sbjct: 987 LYQLSED 993
>NP_001276950
          Length = 612

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LFQMSED 9
           L+Q+SED
Sbjct: 512 LYQLSED 518
>NP_619579
          Length = 166

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  AVLFQMSED 9
          AVLF +S+D
Sbjct: 35 AVLFCLSDD 43
>NP_068733
          Length = 166

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  AVLFQMSED 9
          AVLF +S+D
Sbjct: 35 AVLFCLSDD 43
>NP_001230574
          Length = 149

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  AVLFQMSED 9
          AVLF +S+D
Sbjct: 18 AVLFCLSDD 26
>NP_001135799
          Length = 760

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   VLFQMSED 9
           ++F+MS+D
Sbjct: 183 IIFEMSKD 190
>NP_001135798
          Length = 672

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   VLFQMSED 9
           ++F+MS+D
Sbjct: 95  IIFEMSKD 102
>NP_055866
          Length = 406

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   VLFQMSED 9
           +LF M ED
Sbjct: 265 ILFHMKED 272
>NP_066968
          Length = 760

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   VLFQMSED 9
           ++F+MS+D
Sbjct: 183 IIFEMSKD 190
>XP_005252542
          Length = 736

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LFQMSED 9
           L+Q+SED
Sbjct: 679 LYQLSED 685
>XP_006717518
          Length = 736

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LFQMSED 9
           L+Q+SED
Sbjct: 679 LYQLSED 685
>XP_006717517
          Length = 927

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LFQMSED 9
           L+Q+SED
Sbjct: 870 LYQLSED 876
>XP_006717516
          Length = 1012

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LFQMSED 9
           L+Q+SED
Sbjct: 955 LYQLSED 961
>XP_006716268
          Length = 715

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   VLFQMSED 9
           ++F+MS+D
Sbjct: 183 IIFEMSKD 190
>XP_006716267
          Length = 726

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   VLFQMSED 9
           ++F+MS+D
Sbjct: 142 IIFEMSKD 149
>XP_006716266
          Length = 726

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   VLFQMSED 9
           ++F+MS+D
Sbjct: 142 IIFEMSKD 149
>XP_005250791
          Length = 760

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   VLFQMSED 9
           ++F+MS+D
Sbjct: 183 IIFEMSKD 190
>XP_006716265
          Length = 760

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   VLFQMSED 9
           ++F+MS+D
Sbjct: 183 IIFEMSKD 190
>XP_006716264
          Length = 767

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   VLFQMSED 9
           ++F+MS+D
Sbjct: 183 IIFEMSKD 190
>XP_006716263
          Length = 767

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   VLFQMSED 9
           ++F+MS+D
Sbjct: 183 IIFEMSKD 190
>XP_006716262
          Length = 767

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   VLFQMSED 9
           ++F+MS+D
Sbjct: 183 IIFEMSKD 190
>XP_006716261
          Length = 767

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   VLFQMSED 9
           ++F+MS+D
Sbjct: 183 IIFEMSKD 190
>XP_006716260
          Length = 767

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   VLFQMSED 9
           ++F+MS+D
Sbjct: 183 IIFEMSKD 190
>NP_066008
          Length = 776

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LFQMSED 9
           LFQ SED
Sbjct: 281 LFQPSED 287
>NP_001758
          Length = 351

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  FQMSED 9
          FQMS+D
Sbjct: 48 FQMSDD 53
>NP_005094
          Length = 392

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   VLFQMSED 9
           +LF M ED
Sbjct: 366 ILFAMKED 373
>XP_005271792
          Length = 392

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   VLFQMSED 9
           +LF M ED
Sbjct: 366 ILFAMKED 373
>XP_005271791
          Length = 392

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   VLFQMSED 9
           +LF M ED
Sbjct: 366 ILFAMKED 373
>XP_005271377
          Length = 310

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  FQMSED 9
          FQMS+D
Sbjct: 48 FQMSDD 53
>XP_005271376
          Length = 377

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  FQMSED 9
          FQMS+D
Sbjct: 48 FQMSDD 53
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.323    0.130    0.327 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 440,400
Number of extensions: 914
Number of successful extensions: 66
Number of sequences better than 10000.0: 66
Number of HSP's gapped: 66
Number of HSP's successfully gapped: 66
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package