Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005091                                                              19     869
NP_653080                                                              19     869
XP_005267292                                                           19     869
XP_005267291                                                           19     869
XP_005267290                                                           19     869
NP_112599                                                              17    4312
NP_066976                                                              16    5631
NP_001257957                                                           16    5631
XP_006722504                                                           16    5631
XP_006722503                                                           16    5631
NP_775897                                                              16    7355
NP_001159821                                                           16    7355
NP_001159820                                                           16    7355
NP_001159819                                                           16    7355
XP_006721897                                                           16    7355
XP_006721896                                                           16    7355
NP_005426                                                              15    9605
NP_000287                                                              15    9605
NP_001009944                                                           15    9605
NP_002798                                                              15    9605
NP_001177966                                                           15    9605
NP_001003702                                                           15    9605
NP_079032                                                              15    9605
NP_005957                                                              15    9605
NP_113609                                                              15    9605
XP_006726571                                                           15    9605
XP_006726570                                                           15    9605
XP_003960511                                                           15    9605
XP_006726519                                                           15    9605
XP_006723226                                                           15    9605
XP_006722192                                                           15    9605
XP_005255427                                                           15    9605
XP_006720956                                                           15    9605
XP_006720955                                                           15    9605
XP_006720954                                                           15    9605
XP_006720953                                                           15    9605
XP_006720952                                                           15    9605
XP_005270210                                                           15    9605
XP_006718033                                                           15    9605
XP_006717414                                                           15    9605
XP_006716191                                                           15    9605
XP_006716190                                                           15    9605
XP_005246644                                                           15    9605
XP_005246643                                                           15    9605
XP_005246642                                                           15    9605
XP_005246641                                                           15    9605
XP_005246640                                                           15    9605
XP_005246638                                                           15    9605
XP_005246639                                                           15    9605
XP_005246636                                                           15    9605
XP_005246637                                                           15    9605
XP_006712603                                                           15    9605
XP_006710284                                                           15    9605
>NP_005091
          Length = 1782

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    AVGQARSDI 9
            AVGQA SDI
Sbjct: 1622 AVGQAHSDI 1630
>NP_653080
          Length = 1684

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    AVGQARSDI 9
            AVGQA SDI
Sbjct: 1524 AVGQAHSDI 1532
>XP_005267292
          Length = 1677

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    AVGQARSDI 9
            AVGQA SDI
Sbjct: 1517 AVGQAHSDI 1525
>XP_005267291
          Length = 1684

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    AVGQARSDI 9
            AVGQA SDI
Sbjct: 1524 AVGQAHSDI 1532
>XP_005267290
          Length = 1782

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    AVGQARSDI 9
            AVGQA SDI
Sbjct: 1622 AVGQAHSDI 1630
>NP_112599
          Length = 348

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  AVGQARSDI 9
          A G+ARSD+
Sbjct: 23 AYGRARSDL 31
>NP_066976
          Length = 772

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  VGQARSDI 9
          +GQ RSD+
Sbjct: 63 IGQLRSDL 70
>NP_001257957
          Length = 490

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  VGQARSDI 9
          +GQ RSD+
Sbjct: 63 IGQLRSDL 70
>XP_006722504
          Length = 613

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  VGQARSDI 9
          +GQ RSD+
Sbjct: 63 IGQLRSDL 70
>XP_006722503
          Length = 772

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  VGQARSDI 9
          +GQ RSD+
Sbjct: 63 IGQLRSDL 70
>NP_775897
          Length = 606

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  AVGQARS 7
          A+GQARS
Sbjct: 7  ALGQARS 13
>NP_001159821
          Length = 606

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  AVGQARS 7
          A+GQARS
Sbjct: 7  ALGQARS 13
>NP_001159820
          Length = 606

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  AVGQARS 7
          A+GQARS
Sbjct: 7  ALGQARS 13
>NP_001159819
          Length = 606

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  AVGQARS 7
          A+GQARS
Sbjct: 7  ALGQARS 13
>XP_006721897
          Length = 630

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  AVGQARS 7
          A+GQARS
Sbjct: 7  ALGQARS 13
>XP_006721896
          Length = 630

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  AVGQARS 7
          A+GQARS
Sbjct: 7  ALGQARS 13
>NP_005426
          Length = 1597

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   AVGQARS 7
           AVG+ARS
Sbjct: 389 AVGRARS 395
>NP_000287
          Length = 4302

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    VGQARSDI 9
            VGQ +SD+
Sbjct: 3392 VGQMKSDL 3399
>NP_001009944
          Length = 4303

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    VGQARSDI 9
            VGQ +SD+
Sbjct: 3393 VGQMKSDL 3400
>NP_002798
          Length = 953

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   AVGQARSDI 9
           A+G AR D+
Sbjct: 485 AMGTARQDV 493
>NP_001177966
          Length = 922

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   AVGQARSDI 9
           A+G AR D+
Sbjct: 485 AMGTARQDV 493
>NP_001003702
          Length = 484

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   AVGQARS 7
           AVG+ARS
Sbjct: 389 AVGRARS 395
>NP_079032
          Length = 949

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   VGQARSDI 9
           VGQ R D+
Sbjct: 304 VGQLRQDV 311
>NP_005957
          Length = 487

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   AVGQARSDI 9
           ++GQ +SD+
Sbjct: 138 SLGQGKSDV 146
>NP_113609
          Length = 672

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   GQARSDI 9
           G+ARSD+
Sbjct: 572 GKARSDL 578
>XP_006726571
          Length = 3681

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   AVGQARSDI 9
           AVG+ R D+
Sbjct: 707 AVGEDRQDV 715
>XP_006726570
          Length = 3722

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   AVGQARSDI 9
           AVG+ R D+
Sbjct: 707 AVGEDRQDV 715
>XP_003960511
          Length = 3722

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   AVGQARSDI 9
           AVG+ R D+
Sbjct: 707 AVGEDRQDV 715
>XP_006726519
          Length = 1493

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   AVGQARS 7
           AVG+ARS
Sbjct: 370 AVGRARS 376
>XP_006723226
          Length = 403

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   AVGQAR 6
           AVGQAR
Sbjct: 316 AVGQAR 321
>XP_006722192
          Length = 509

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   GQARSDI 9
           G+ARSD+
Sbjct: 409 GKARSDL 415
>XP_005255427
          Length = 3288

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    VGQARSDI 9
            VGQ +SD+
Sbjct: 2378 VGQMKSDL 2385
>XP_006720956
          Length = 3895

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    VGQARSDI 9
            VGQ +SD+
Sbjct: 2985 VGQMKSDL 2992
>XP_006720955
          Length = 4279

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    VGQARSDI 9
            VGQ +SD+
Sbjct: 3369 VGQMKSDL 3376
>XP_006720954
          Length = 4334

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    VGQARSDI 9
            VGQ +SD+
Sbjct: 3424 VGQMKSDL 3431
>XP_006720953
          Length = 4339

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    VGQARSDI 9
            VGQ +SD+
Sbjct: 3429 VGQMKSDL 3436
>XP_006720952
          Length = 4340

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    VGQARSDI 9
            VGQ +SD+
Sbjct: 3430 VGQMKSDL 3437
>XP_005270210
          Length = 888

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   VGQARSDI 9
           VGQ R D+
Sbjct: 243 VGQLRQDV 250
>XP_006718033
          Length = 888

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   VGQARSDI 9
           VGQ R D+
Sbjct: 243 VGQLRQDV 250
>XP_006717414
          Length = 5100

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    AVGQARSDI 9
            AVG+ R D+
Sbjct: 2085 AVGEDRQDV 2093
>XP_006716191
          Length = 1543

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   AVGQARS 7
           AVG+ARS
Sbjct: 389 AVGRARS 395
>XP_006716190
          Length = 1597

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   AVGQARS 7
           AVG+ARS
Sbjct: 389 AVGRARS 395
>XP_005246644
          Length = 457

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   AVGQARSDI 9
           ++GQ +SD+
Sbjct: 138 SLGQGKSDV 146
>XP_005246643
          Length = 486

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   AVGQARSDI 9
           ++GQ +SD+
Sbjct: 138 SLGQGKSDV 146
>XP_005246642
          Length = 487

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   AVGQARSDI 9
           ++GQ +SD+
Sbjct: 138 SLGQGKSDV 146
>XP_005246641
          Length = 487

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   AVGQARSDI 9
           ++GQ +SD+
Sbjct: 138 SLGQGKSDV 146
>XP_005246640
          Length = 487

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   AVGQARSDI 9
           ++GQ +SD+
Sbjct: 138 SLGQGKSDV 146
>XP_005246638
          Length = 487

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   AVGQARSDI 9
           ++GQ +SD+
Sbjct: 138 SLGQGKSDV 146
>XP_005246639
          Length = 487

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   AVGQARSDI 9
           ++GQ +SD+
Sbjct: 138 SLGQGKSDV 146
>XP_005246636
          Length = 487

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   AVGQARSDI 9
           ++GQ +SD+
Sbjct: 138 SLGQGKSDV 146
>XP_005246637
          Length = 487

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   AVGQARSDI 9
           ++GQ +SD+
Sbjct: 138 SLGQGKSDV 146
>XP_006712603
          Length = 487

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   AVGQARSDI 9
           ++GQ +SD+
Sbjct: 138 SLGQGKSDV 146
>XP_006710284
          Length = 945

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   AVGQARSDI 9
           AVG+ R D+
Sbjct: 711 AVGEDRQDV 719
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.315    0.127    0.324 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 411,552
Number of extensions: 521
Number of successful extensions: 53
Number of sequences better than 10000.0: 53
Number of HSP's gapped: 53
Number of HSP's successfully gapped: 53
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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