Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001277144                                                           20     509
NP_001277143                                                           20     509
NP_001077383                                                           20     509
NP_001320                                                              20     509
NP_073713                                                              20     509
XP_005269629                                                           20     509
XP_005269628                                                           20     509
XP_005269627                                                           20     509
XP_005269626                                                           20     509
XP_006717706                                                           20     509
XP_005269625                                                           20     509
XP_005269624                                                           20     509
XP_006717705                                                           20     509
XP_005269622                                                           20     509
XP_005269621                                                           20     509
XP_006717704                                                           20     509
XP_005269619                                                           20     509
XP_005269618                                                           20     509
NP_001319                                                              18    1135
NP_001012632                                                           18    1135
XP_005272320                                                           18    1135
XP_005272319                                                           18    1135
XP_005272318                                                           18    1135
NP_006105                                                              17    4312
NP_001122388                                                           17    4312
NP_001122389                                                           17    4312
NP_005597                                                              17    4312
NP_001008530                                                           17    4312
NP_001273302                                                           17    4312
NP_001273303                                                           17    4312
NP_115550                                                              17    4312
XP_005267920                                                           17    4312
XP_005267919                                                           17    4312
XP_006711638                                                           17    4312
XP_006711637                                                           17    4312
XP_006711636                                                           17    4312
XP_006711635                                                           17    4312
NP_071417                                                              16    5631
NP_003213                                                              16    7355
NP_055160                                                              16    7355
NP_000634                                                              15    9605
NP_000635                                                              15    9605
NP_000636                                                              15    9605
NP_000019                                                              15    9605
NP_000637                                                              15    9605
NP_000633                                                              15    9605
NP_663623                                                              15    9605
NP_113655                                                              15    9605
NP_057223                                                              15    9605
NP_055817                                                              15    9605
NP_296373                                                              15    9605
NP_001245356                                                           15    9605
NP_001245355                                                           15    9605
NP_001245357                                                           15    9605
XP_006714863                                                           15    9605
XP_006714862                                                           15    9605
XP_005268578                                                           15    9605
XP_005270614                                                           15    9605
>NP_001277144
          Length = 445

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  AVGAMMNHT 9
          AVGAMM HT
Sbjct: 76 AVGAMMYHT 84
>NP_001277143
          Length = 445

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  AVGAMMNHT 9
          AVGAMM HT
Sbjct: 76 AVGAMMYHT 84
>NP_001077383
          Length = 445

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  AVGAMMNHT 9
          AVGAMM HT
Sbjct: 76 AVGAMMYHT 84
>NP_001320
          Length = 445

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  AVGAMMNHT 9
          AVGAMM HT
Sbjct: 76 AVGAMMYHT 84
>NP_073713
          Length = 985

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AVGAMMNHT 9
           AVGAMM HT
Sbjct: 616 AVGAMMYHT 624
>XP_005269629
          Length = 445

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  AVGAMMNHT 9
          AVGAMM HT
Sbjct: 76 AVGAMMYHT 84
>XP_005269628
          Length = 445

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  AVGAMMNHT 9
          AVGAMM HT
Sbjct: 76 AVGAMMYHT 84
>XP_005269627
          Length = 445

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  AVGAMMNHT 9
          AVGAMM HT
Sbjct: 76 AVGAMMYHT 84
>XP_005269626
          Length = 445

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  AVGAMMNHT 9
          AVGAMM HT
Sbjct: 76 AVGAMMYHT 84
>XP_006717706
          Length = 445

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  AVGAMMNHT 9
          AVGAMM HT
Sbjct: 76 AVGAMMYHT 84
>XP_005269625
          Length = 445

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  AVGAMMNHT 9
          AVGAMM HT
Sbjct: 76 AVGAMMYHT 84
>XP_005269624
          Length = 445

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  AVGAMMNHT 9
          AVGAMM HT
Sbjct: 76 AVGAMMYHT 84
>XP_006717705
          Length = 445

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  AVGAMMNHT 9
          AVGAMM HT
Sbjct: 76 AVGAMMYHT 84
>XP_005269622
          Length = 445

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  AVGAMMNHT 9
          AVGAMM HT
Sbjct: 76 AVGAMMYHT 84
>XP_005269621
          Length = 445

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  AVGAMMNHT 9
          AVGAMM HT
Sbjct: 76 AVGAMMYHT 84
>XP_006717704
          Length = 445

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  AVGAMMNHT 9
          AVGAMM HT
Sbjct: 76 AVGAMMYHT 84
>XP_005269619
          Length = 445

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  AVGAMMNHT 9
          AVGAMM HT
Sbjct: 76 AVGAMMYHT 84
>XP_005269618
          Length = 445

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  AVGAMMNHT 9
          AVGAMM HT
Sbjct: 76 AVGAMMYHT 84
>NP_001319
          Length = 440

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  AVGAMMNHT 9
          AVGA+M HT
Sbjct: 70 AVGALMYHT 78
>NP_001012632
          Length = 429

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  AVGAMMNHT 9
          AVGA+M HT
Sbjct: 59 AVGALMYHT 67
>XP_005272320
          Length = 430

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  AVGAMMNHT 9
          AVGA+M HT
Sbjct: 59 AVGALMYHT 67
>XP_005272319
          Length = 430

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  AVGAMMNHT 9
          AVGA+M HT
Sbjct: 59 AVGALMYHT 67
>XP_005272318
          Length = 441

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  AVGAMMNHT 9
          AVGA+M HT
Sbjct: 70 AVGALMYHT 78
>NP_006105
          Length = 361

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   AVGAMMNH 8
           A+GA +NH
Sbjct: 340 ALGAFLNH 347
>NP_001122388
          Length = 361

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   AVGAMMNH 8
           A+GA +NH
Sbjct: 340 ALGAFLNH 347
>NP_001122389
          Length = 361

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   AVGAMMNH 8
           A+GA +NH
Sbjct: 340 ALGAFLNH 347
>NP_005597
          Length = 433

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   GAMMNH 8
           G+MMNH
Sbjct: 192 GSMMNH 197
>NP_001008530
          Length = 433

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   GAMMNH 8
           G+MMNH
Sbjct: 192 GSMMNH 197
>NP_001273302
          Length = 274

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   AVGAMMNH 8
           A+GA +NH
Sbjct: 253 ALGAFLNH 260
>NP_001273303
          Length = 243

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   AVGAMMNH 8
           A+GA +NH
Sbjct: 222 ALGAFLNH 229
>NP_115550
          Length = 308

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   AVGAMMNH 8
           A+GA +NH
Sbjct: 287 ALGAFLNH 294
>XP_005267920
          Length = 372

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   GAMMNH 8
           G+MMNH
Sbjct: 192 GSMMNH 197
>XP_005267919
          Length = 376

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   GAMMNH 8
           G+MMNH
Sbjct: 192 GSMMNH 197
>XP_006711638
          Length = 221

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   AVGAMMNH 8
           A+GA +NH
Sbjct: 200 ALGAFLNH 207
>XP_006711637
          Length = 255

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   AVGAMMNH 8
           A+GA +NH
Sbjct: 234 ALGAFLNH 241
>XP_006711636
          Length = 291

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   AVGAMMNH 8
           A+GA +NH
Sbjct: 270 ALGAFLNH 277
>XP_006711635
          Length = 308

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   AVGAMMNH 8
           A+GA +NH
Sbjct: 287 ALGAFLNH 294
>NP_071417
          Length = 398

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   GAMMNHT 9
           GA+ NHT
Sbjct: 326 GALKNHT 332
>NP_003213
          Length = 450

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VGAMMNHT 9
           VGA+MN T
Sbjct: 214 VGAVMNPT 221
>NP_055160
          Length = 2279

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    VGAMMNHT 9
            VGA+ +HT
Sbjct: 2266 VGAIQDHT 2273
>NP_000634
          Length = 1532

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   AVGAMMNH 8
           AVG + NH
Sbjct: 859 AVGILRNH 866
>NP_000635
          Length = 1532

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   AVGAMMNH 8
           AVG + NH
Sbjct: 859 AVGILRNH 866
>NP_000636
          Length = 1515

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   AVGAMMNH 8
           AVG + NH
Sbjct: 842 AVGILRNH 849
>NP_000019
          Length = 1532

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   AVGAMMNH 8
           AVG + NH
Sbjct: 859 AVGILRNH 866
>NP_000637
          Length = 1516

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   AVGAMMNH 8
           AVG + NH
Sbjct: 843 AVGILRNH 850
>NP_000633
          Length = 1532

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   AVGAMMNH 8
           AVG + NH
Sbjct: 859 AVGILRNH 866
>NP_663623
          Length = 577

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   AVGAMMNHT 9
           A+G M +HT
Sbjct: 514 AIGWMSSHT 522
>NP_113655
          Length = 959

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AVGAMMNHT 9
           AVG M+N T
Sbjct: 519 AVGKMLNLT 527
>NP_057223
          Length = 151

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  AVGAMMNHT 9
          AVG+ + HT
Sbjct: 67 AVGSAVGHT 75
>NP_055817
          Length = 621

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   AVGAMMNHT 9
           AVG ++ HT
Sbjct: 460 AVGYLVQHT 468
>NP_296373
          Length = 628

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   AVGAMMNHT 9
           AVG ++ HT
Sbjct: 467 AVGYLVQHT 475
>NP_001245356
          Length = 896

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AVGAMMNHT 9
           AVG M+N T
Sbjct: 519 AVGKMLNLT 527
>NP_001245355
          Length = 945

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AVGAMMNHT 9
           AVG M+N T
Sbjct: 508 AVGKMLNLT 516
>NP_001245357
          Length = 983

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AVGAMMNHT 9
           AVG M+N T
Sbjct: 543 AVGKMLNLT 551
>XP_006714863
          Length = 921

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AVGAMMNHT 9
           AVG M+N T
Sbjct: 481 AVGKMLNLT 489
>XP_006714862
          Length = 956

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AVGAMMNHT 9
           AVG M+N T
Sbjct: 519 AVGKMLNLT 527
>XP_005268578
          Length = 959

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AVGAMMNHT 9
           AVG M+N T
Sbjct: 519 AVGKMLNLT 527
>XP_005270614
          Length = 1532

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   AVGAMMNH 8
           AVG + NH
Sbjct: 859 AVGILRNH 866
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.322    0.119    0.349 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 407,927
Number of extensions: 595
Number of successful extensions: 58
Number of sequences better than 10000.0: 58
Number of HSP's gapped: 58
Number of HSP's successfully gapped: 58
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)

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