Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001121619                                                           18    1135
NP_000258                                                              18    1135
NP_001035957                                                           18    1135
XP_006721991                                                           18    1135
XP_006721990                                                           18    1135
XP_006721989                                                           18    1135
XP_005258041                                                           18    1135
XP_006721988                                                           18    1135
XP_006721987                                                           18    1135
XP_006721986                                                           18    1135
XP_005258040                                                           18    1135
XP_006721985                                                           18    1135
NP_001153392                                                           17    4312
NP_001001668                                                           16    5631
XP_005258968                                                           16    5631
XP_005258967                                                           16    5631
XP_006723273                                                           16    5631
NP_008900                                                              16    7355
NP_001265381                                                           16    7355
NP_001265380                                                           16    7355
NP_001265382                                                           16    7355
NP_009168                                                              16    7355
NP_001005176                                                           16    7355
XP_006723523                                                           16    7355
XP_006723522                                                           16    7355
XP_006723420                                                           16    7355
XP_006723419                                                           16    7355
XP_006723418                                                           16    7355
XP_006723417                                                           16    7355
XP_005246315                                                           16    7355
XP_006712289                                                           16    7355
XP_005246314                                                           16    7355
XP_005246313                                                           16    7355
XP_005246312                                                           16    7355
XP_005246311                                                           16    7355
XP_005246310                                                           16    7355
XP_006712288                                                           16    7355
XP_006712287                                                           16    7355
XP_005246309                                                           16    7355
XP_006712286                                                           16    7355
NP_001008801                                                           16    7355
NP_002011                                                              15    9605
NP_891555                                                              15    9605
NP_001827                                                              15    9605
NP_073590                                                              15    9605
NP_001243050                                                           15    9605
NP_002431                                                              15    9605
XP_006710883                                                           15    9605
XP_006710882                                                           15    9605
XP_006710881                                                           15    9605
>NP_001121619
          Length = 593

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   AVFSRIST 8
           AVFSRIST
Sbjct: 152 AVFSRIST 159
>NP_000258
          Length = 2818

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   AVFSRIST 8
           AVFSRIST
Sbjct: 152 AVFSRIST 159
>NP_001035957
          Length = 2839

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   AVFSRIST 8
           AVFSRIST
Sbjct: 152 AVFSRIST 159
>XP_006721991
          Length = 1632

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   AVFSRIST 8
           AVFSRIST
Sbjct: 152 AVFSRIST 159
>XP_006721990
          Length = 2823

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   AVFSRIST 8
           AVFSRIST
Sbjct: 152 AVFSRIST 159
>XP_006721989
          Length = 2823

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   AVFSRIST 8
           AVFSRIST
Sbjct: 152 AVFSRIST 159
>XP_005258041
          Length = 2836

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   AVFSRIST 8
           AVFSRIST
Sbjct: 152 AVFSRIST 159
>XP_006721988
          Length = 2846

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   AVFSRIST 8
           AVFSRIST
Sbjct: 152 AVFSRIST 159
>XP_006721987
          Length = 2849

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   AVFSRIST 8
           AVFSRIST
Sbjct: 152 AVFSRIST 159
>XP_006721986
          Length = 2854

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   AVFSRIST 8
           AVFSRIST
Sbjct: 139 AVFSRIST 146
>XP_005258040
          Length = 2857

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   AVFSRIST 8
           AVFSRIST
Sbjct: 152 AVFSRIST 159
>XP_006721985
          Length = 2867

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   AVFSRIST 8
           AVFSRIST
Sbjct: 152 AVFSRIST 159
>NP_001153392
          Length = 687

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   AVFSRIS 7
           AVFSRIS
Sbjct: 664 AVFSRIS 670
>NP_001001668
          Length = 717

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VFSRISTM 9
           +FS+IST+
Sbjct: 236 IFSKISTL 243
>XP_005258968
          Length = 624

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VFSRISTM 9
           +FS+IST+
Sbjct: 236 IFSKISTL 243
>XP_005258967
          Length = 666

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VFSRISTM 9
           +FS+IST+
Sbjct: 185 IFSKISTL 192
>XP_006723273
          Length = 717

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VFSRISTM 9
           +FS+IST+
Sbjct: 236 IFSKISTL 243
>NP_008900
          Length = 718

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VFSRISTM 9
           VF+R+ST+
Sbjct: 363 VFNRLSTL 370
>NP_001265381
          Length = 807

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   AVFSRISTM 9
           A+FSRI+ M
Sbjct: 113 ALFSRINLM 121
>NP_001265380
          Length = 840

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   AVFSRISTM 9
           A+FSRI+ M
Sbjct: 113 ALFSRINLM 121
>NP_001265382
          Length = 753

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   AVFSRISTM 9
           A+FSRI+ M
Sbjct: 113 ALFSRINLM 121
>NP_009168
          Length = 867

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   AVFSRISTM 9
           A+FSRI+ M
Sbjct: 113 ALFSRINLM 121
>NP_001005176
          Length = 172

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   AVFSRISTM 9
           A+FSRI+ M
Sbjct: 113 ALFSRINLM 121
>XP_006723523
          Length = 469

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VFSRISTM 9
           VF+R+ST+
Sbjct: 310 VFNRLSTL 317
>XP_006723522
          Length = 541

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VFSRISTM 9
           VF+R+ST+
Sbjct: 382 VFNRLSTL 389
>XP_006723420
          Length = 606

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VFSRISTM 9
           VF+R+ST+
Sbjct: 251 VFNRLSTL 258
>XP_006723419
          Length = 634

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VFSRISTM 9
           VF+R+ST+
Sbjct: 363 VFNRLSTL 370
>XP_006723418
          Length = 662

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VFSRISTM 9
           VF+R+ST+
Sbjct: 363 VFNRLSTL 370
>XP_006723417
          Length = 704

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VFSRISTM 9
           VF+R+ST+
Sbjct: 349 VFNRLSTL 356
>XP_005246315
          Length = 675

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   AVFSRISTM 9
           A+FSRI+ M
Sbjct: 113 ALFSRINLM 121
>XP_006712289
          Length = 750

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   AVFSRISTM 9
           A+FSRI+ M
Sbjct: 113 ALFSRINLM 121
>XP_005246314
          Length = 789

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   AVFSRISTM 9
           A+FSRI+ M
Sbjct: 113 ALFSRINLM 121
>XP_005246313
          Length = 806

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   AVFSRISTM 9
           A+FSRI+ M
Sbjct: 113 ALFSRINLM 121
>XP_005246312
          Length = 817

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   AVFSRISTM 9
           A+FSRI+ M
Sbjct: 113 ALFSRINLM 121
>XP_005246311
          Length = 833

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   AVFSRISTM 9
           A+FSRI+ M
Sbjct: 113 ALFSRINLM 121
>XP_005246310
          Length = 841

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   AVFSRISTM 9
           A+FSRI+ M
Sbjct: 113 ALFSRINLM 121
>XP_006712288
          Length = 845

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   AVFSRISTM 9
           A+FSRI+ M
Sbjct: 113 ALFSRINLM 121
>XP_006712287
          Length = 847

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   AVFSRISTM 9
           A+FSRI+ M
Sbjct: 93  ALFSRINLM 101
>XP_005246309
          Length = 864

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   AVFSRISTM 9
           A+FSRI+ M
Sbjct: 113 ALFSRINLM 121
>XP_006712286
          Length = 867

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   AVFSRISTM 9
           A+FSRI+ M
Sbjct: 113 ALFSRINLM 121
>NP_001008801
          Length = 522

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VFSRISTM 9
           VF+R+ST+
Sbjct: 363 VFNRLSTL 370
>NP_002011
          Length = 1298

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    FSRISTM 9
            FS++STM
Sbjct: 1199 FSQVSTM 1205
>NP_891555
          Length = 1363

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    FSRISTM 9
            FS++STM
Sbjct: 1199 FSQVSTM 1205
>NP_001827
          Length = 247

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   AVFSRIS 7
           AVF+RIS
Sbjct: 228 AVFTRIS 234
>NP_073590
          Length = 408

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   AVFSRIS 7
           +VFSRIS
Sbjct: 236 SVFSRIS 242
>NP_001243050
          Length = 408

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   AVFSRIS 7
           +VFSRIS
Sbjct: 236 SVFSRIS 242
>NP_002431
          Length = 936

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VFSRIST 8
           +F+RIST
Sbjct: 719 IFTRIST 725
>XP_006710883
          Length = 342

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   AVFSRIS 7
           +VFSRIS
Sbjct: 236 SVFSRIS 242
>XP_006710882
          Length = 349

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   AVFSRIS 7
           +VFSRIS
Sbjct: 236 SVFSRIS 242
>XP_006710881
          Length = 407

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   AVFSRIS 7
           +VFSRIS
Sbjct: 236 SVFSRIS 242
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.337    0.129    0.317 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 311,309
Number of extensions: 814
Number of successful extensions: 50
Number of sequences better than 10000.0: 50
Number of HSP's gapped: 50
Number of HSP's successfully gapped: 50
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.6 bits)
S2: 28 (15.4 bits)

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