Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004110                                                              18    1935
NP_919420                                                              17    2528
NP_001124506                                                           17    2528
XP_005272332                                                           17    2528
XP_006713941                                                           17    2528
XP_006713940                                                           17    2528
XP_005272331                                                           17    2528
NP_002877                                                              17    4312
NP_056099                                                              17    4312
NP_067006                                                              17    4312
NP_001258115                                                           17    4312
XP_006710564                                                           17    4312
XP_005270743                                                           17    4312
NP_066361                                                              17    4312
NP_001229371                                                           16    7355
XP_005248564                                                           16    7355
NP_005900                                                              16    7355
NP_000350                                                              15    9605
NP_003310                                                              15    9605
NP_597676                                                              15    9605
NP_001243779                                                           15    9605
NP_596869                                                              15    9605
NP_055555                                                              15    9605
NP_004372                                                              15    9605
NP_005821                                                              15    9605
NP_001129625                                                           15    9605
NP_036395                                                              15    9605
NP_075055                                                              15    9605
NP_002245                                                              15    9605
NP_056326                                                              15    9605
NP_001258803                                                           15    9605
XP_006724288                                                           15    9605
XP_006723833                                                           15    9605
XP_005260442                                                           15    9605
XP_006722904                                                           15    9605
XP_005260077                                                           15    9605
XP_005246888                                                           15    9605
XP_006712788                                                           15    9605
XP_006712787                                                           15    9605
XP_006712786                                                           15    9605
XP_005263742                                                           15    9605
XP_005263740                                                           15    9605
XP_005263739                                                           15    9605
XP_005263738                                                           15    9605
XP_005264356                                                           15    9605
NP_001254479                                                           15    9605
NP_597681                                                              15    9605
>NP_004110
          Length = 993

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  AVEVDVSPS 9
          AVEVDVS S
Sbjct: 80 AVEVDVSAS 88
>NP_919420
          Length = 232

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   AVEVDVSPS 9
           ++EVD+SPS
Sbjct: 158 SMEVDLSPS 166
>NP_001124506
          Length = 297

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   AVEVDVSPS 9
           ++EVD+SPS
Sbjct: 158 SMEVDLSPS 166
>XP_005272332
          Length = 192

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   AVEVDVSPS 9
           ++EVD+SPS
Sbjct: 158 SMEVDLSPS 166
>XP_006713941
          Length = 206

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   AVEVDVSPS 9
           ++EVD+SPS
Sbjct: 92  SMEVDLSPS 100
>XP_006713940
          Length = 228

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   AVEVDVSPS 9
           ++EVD+SPS
Sbjct: 114 SMEVDLSPS 122
>XP_005272331
          Length = 272

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   AVEVDVSPS 9
           ++EVD+SPS
Sbjct: 158 SMEVDLSPS 166
>NP_002877
          Length = 183

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  VEVDVSPS 9
          +EVD SPS
Sbjct: 44 IEVDSSPS 51
>NP_056099
          Length = 3375

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VEVDVSPS 9
           +E+D+SPS
Sbjct: 98  IELDLSPS 105
>NP_067006
          Length = 183

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  VEVDVSPS 9
          +EVD SPS
Sbjct: 44 IEVDSSPS 51
>NP_001258115
          Length = 183

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  VEVDVSPS 9
          +EVD SPS
Sbjct: 44 IEVDSSPS 51
>XP_006710564
          Length = 3432

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VEVDVSPS 9
           +E+D+SPS
Sbjct: 98  IELDLSPS 105
>XP_005270743
          Length = 3453

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VEVDVSPS 9
           +E+D+SPS
Sbjct: 119 IELDLSPS 126
>NP_066361
          Length = 183

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  VEVDVSPS 9
          +EVD SPS
Sbjct: 44 IEVDSSPS 51
>NP_001229371
          Length = 555

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  AVEVDVSP 8
          A+E+D+SP
Sbjct: 23 AMELDLSP 30
>XP_005248564
          Length = 2342

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    EVDVSPS 9
            EVD SPS
Sbjct: 1560 EVDYSPS 1566
>NP_005900
          Length = 2468

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    EVDVSPS 9
            EVD SPS
Sbjct: 1686 EVDYSPS 1692
>NP_000350
          Length = 817

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   VEVDVSPS 9
           ++VDV+P+
Sbjct: 782 IQVDVAPA 789
>NP_003310
          Length = 26926

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    AVEVDVS 7
            AVE+DVS
Sbjct: 8606 AVELDVS 8612
>NP_597676
          Length = 27051

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    AVEVDVS 7
            AVE+DVS
Sbjct: 8731 AVELDVS 8737
>NP_001243779
          Length = 34350

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1     AVEVDVS 7
             AVE+DVS
Sbjct: 16030 AVELDVS 16036
>NP_596869
          Length = 33423

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1     AVEVDVS 7
             AVE+DVS
Sbjct: 15103 AVELDVS 15109
>NP_055555
          Length = 411

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  EVDVSPS 9
          EVDV+P+
Sbjct: 33 EVDVTPT 39
>NP_004372
          Length = 703

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  VEVDVSPS 9
          V +DVSPS
Sbjct: 65 VGMDVSPS 72
>NP_005821
          Length = 395

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   AVEVDVSPS 9
           A E D SPS
Sbjct: 268 APETDTSPS 276
>NP_001129625
          Length = 700

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  VEVDVSPS 9
          V +DVSPS
Sbjct: 62 VGMDVSPS 69
>NP_036395
          Length = 423

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VEVDVSPS 9
           +EV+ SPS
Sbjct: 325 IEVNASPS 332
>NP_075055
          Length = 1011

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VEVDVSPS 9
           V+VD +PS
Sbjct: 685 VDVDAAPS 692
>NP_002245
          Length = 793

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VEVDVSP 8
           +E+DVSP
Sbjct: 712 LELDVSP 718
>NP_056326
          Length = 384

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   EVDVSPS 9
           EVD+SP+
Sbjct: 97  EVDLSPA 103
>NP_001258803
          Length = 384

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   EVDVSPS 9
           EVD+SP+
Sbjct: 97  EVDLSPA 103
>XP_006724288
          Length = 326

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VEVDVSPS 9
           +EV+ SPS
Sbjct: 228 IEVNASPS 235
>XP_006723833
          Length = 384

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   EVDVSPS 9
           EVD+SP+
Sbjct: 97  EVDLSPA 103
>XP_005260442
          Length = 384

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   EVDVSPS 9
           EVD+SP+
Sbjct: 97  EVDLSPA 103
>XP_006722904
          Length = 546

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VEVDVSPS 9
           V+VD +PS
Sbjct: 220 VDVDAAPS 227
>XP_005260077
          Length = 1005

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VEVDVSPS 9
           V+VD +PS
Sbjct: 679 VDVDAAPS 686
>XP_005246888
          Length = 22663

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    AVEVDVS 7
            AVE+DVS
Sbjct: 4343 AVELDVS 4349
>XP_006712788
          Length = 24022

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    AVEVDVS 7
            AVE+DVS
Sbjct: 5702 AVELDVS 5708
>XP_006712787
          Length = 33978

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1     AVEVDVS 7
             AVE+DVS
Sbjct: 15658 AVELDVS 15664
>XP_006712786
          Length = 35484

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1     AVEVDVS 7
             AVE+DVS
Sbjct: 17164 AVELDVS 17170
>XP_005263742
          Length = 1043

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   EVDVSPS 9
           E+D+SPS
Sbjct: 130 ELDLSPS 136
>XP_005263740
          Length = 1441

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   EVDVSPS 9
           E+D+SPS
Sbjct: 130 ELDLSPS 136
>XP_005263739
          Length = 1839

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   EVDVSPS 9
           E+D+SPS
Sbjct: 130 ELDLSPS 136
>XP_005263738
          Length = 1876

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   EVDVSPS 9
           E+D+SPS
Sbjct: 130 ELDLSPS 136
>XP_005264356
          Length = 792

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VEVDVSP 8
           +E+DVSP
Sbjct: 711 LELDVSP 717
>NP_001254479
          Length = 35991

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1     AVEVDVS 7
             AVE+DVS
Sbjct: 17671 AVELDVS 17677
>NP_597681
          Length = 27118

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    AVEVDVS 7
            AVE+DVS
Sbjct: 8798 AVELDVS 8804
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.297    0.116    0.288 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 754,097
Number of extensions: 993
Number of successful extensions: 47
Number of sequences better than 10000.0: 47
Number of HSP's gapped: 47
Number of HSP's successfully gapped: 47
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.1 bits)
S2: 28 (15.4 bits)

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