Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005091                                                              18    1135
NP_653080                                                              18    1135
XP_005267292                                                           18    1135
XP_005267291                                                           18    1135
XP_005267290                                                           18    1135
NP_001230468                                                           17    2528
NP_002180                                                              17    2528
NP_751950                                                              17    2528
NP_001243694                                                           17    2528
NP_004378                                                              17    2528
NP_055816                                                              17    2528
XP_006717510                                                           17    2528
XP_006717509                                                           17    2528
XP_006717508                                                           17    2528
XP_006717507                                                           17    2528
XP_006717506                                                           17    2528
XP_006717505                                                           17    2528
XP_006717504                                                           17    2528
XP_005265877                                                           17    2528
NP_001073280                                                           17    4312
NP_005210                                                              17    4312
NP_940948                                                              17    4312
NP_001136028                                                           17    4312
NP_036616                                                              17    4312
NP_001136029                                                           17    4312
NP_036617                                                              17    4312
XP_005268441                                                           17    4312
XP_005245923                                                           17    4312
NP_000060                                                              16    5631
NP_783202                                                              16    5631
NP_001268412                                                           16    5631
NP_001268411                                                           16    5631
NP_060679                                                              16    5631
XP_006723887                                                           16    5631
XP_006723886                                                           16    5631
XP_005245535                                                           16    5631
NP_001092192                                                           16    7355
NP_001092191                                                           16    7355
NP_004476                                                              16    7355
XP_006711825                                                           16    7355
XP_006711824                                                           16    7355
NP_878918                                                              15    9605
NP_055995                                                              15    9605
NP_065871                                                              15    9605
NP_055136                                                              15    9605
NP_510880                                                              15    9605
NP_976063                                                              15    9605
XP_006720147                                                           15    9605
XP_005267517                                                           15    9605
XP_005267516                                                           15    9605
XP_005267515                                                           15    9605
XP_005267514                                                           15    9605
XP_005267513                                                           15    9605
XP_005267512                                                           15    9605
XP_005267511                                                           15    9605
>NP_005091
          Length = 1782

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AVEMEKMEA 9
           AVE EKMEA
Sbjct: 854 AVEREKMEA 862
>NP_653080
          Length = 1684

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AVEMEKMEA 9
           AVE EKMEA
Sbjct: 756 AVEREKMEA 764
>XP_005267292
          Length = 1677

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AVEMEKMEA 9
           AVE EKMEA
Sbjct: 749 AVEREKMEA 757
>XP_005267291
          Length = 1684

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AVEMEKMEA 9
           AVE EKMEA
Sbjct: 756 AVEREKMEA 764
>XP_005267290
          Length = 1782

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AVEMEKMEA 9
           AVE EKMEA
Sbjct: 854 AVEREKMEA 862
>NP_001230468
          Length = 231

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   AVEMEKMEA 9
           +VEME MEA
Sbjct: 202 SVEMEAMEA 210
>NP_002180
          Length = 267

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   AVEMEKMEA 9
           +VEME MEA
Sbjct: 238 SVEMEAMEA 246
>NP_751950
          Length = 234

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   AVEMEKMEA 9
           +VEME MEA
Sbjct: 205 SVEMEAMEA 213
>NP_001243694
          Length = 353

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   AVEMEKMEA 9
           +VEME MEA
Sbjct: 324 SVEMEAMEA 332
>NP_004378
          Length = 324

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   AVEMEKMEA 9
           AVE+EK EA
Sbjct: 119 AVELEKTEA 127
>NP_055816
          Length = 3664

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   AVEMEKMEA 9
           AV++EK+EA
Sbjct: 975 AVDLEKLEA 983
>XP_006717510
          Length = 227

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   AVEMEKMEA 9
           +VEME MEA
Sbjct: 198 SVEMEAMEA 206
>XP_006717509
          Length = 237

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   AVEMEKMEA 9
           +VEME MEA
Sbjct: 208 SVEMEAMEA 216
>XP_006717508
          Length = 259

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   AVEMEKMEA 9
           +VEME MEA
Sbjct: 230 SVEMEAMEA 238
>XP_006717507
          Length = 260

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   AVEMEKMEA 9
           +VEME MEA
Sbjct: 231 SVEMEAMEA 239
>XP_006717506
          Length = 292

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   AVEMEKMEA 9
           +VEME MEA
Sbjct: 263 SVEMEAMEA 271
>XP_006717505
          Length = 292

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   AVEMEKMEA 9
           +VEME MEA
Sbjct: 263 SVEMEAMEA 271
>XP_006717504
          Length = 325

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   AVEMEKMEA 9
           +VEME MEA
Sbjct: 296 SVEMEAMEA 304
>XP_005265877
          Length = 286

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  AVEMEKMEA 9
          AVE+EK EA
Sbjct: 81 AVELEKTEA 89
>NP_001073280
          Length = 1263

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   VEMEKMEA 9
           VEM+KME+
Sbjct: 491 VEMKKMES 498
>NP_005210
          Length = 1272

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   VEMEKMEA 9
           VEM+KME+
Sbjct: 500 VEMKKMES 507
>NP_940948
          Length = 469

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  VEMEKMEA 9
          +E+EKMEA
Sbjct: 90 LEVEKMEA 97
>NP_001136028
          Length = 725

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   EMEKMEA 9
           E+EKMEA
Sbjct: 112 ELEKMEA 118
>NP_036616
          Length = 724

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   EMEKMEA 9
           E+EKMEA
Sbjct: 111 ELEKMEA 117
>NP_001136029
          Length = 638

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  EMEKMEA 9
          E+EKMEA
Sbjct: 25 ELEKMEA 31
>NP_036617
          Length = 709

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   EMEKMEA 9
           E+EKMEA
Sbjct: 96  ELEKMEA 102
>XP_005268441
          Length = 1250

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   VEMEKMEA 9
           VEM+KME+
Sbjct: 500 VEMKKMES 507
>XP_005245923
          Length = 446

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  VEMEKMEA 9
          +E+EKMEA
Sbjct: 67 LEVEKMEA 74
>NP_000060
          Length = 1873

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    VEMEKMEA 9
            +EME+ME+
Sbjct: 1633 IEMEEMES 1640
>NP_783202
          Length = 414

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  VEMEKMEA 9
          +E+EKM+A
Sbjct: 70 IELEKMKA 77
>NP_001268412
          Length = 361

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  VEMEKMEA 9
          +E+EKM+A
Sbjct: 17 IELEKMKA 24
>NP_001268411
          Length = 403

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  VEMEKMEA 9
          +E+EKM+A
Sbjct: 70 IELEKMKA 77
>NP_060679
          Length = 406

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  VEMEKMEA 9
          +E+EKM+A
Sbjct: 70 IELEKMKA 77
>XP_006723887
          Length = 353

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  VEMEKMEA 9
          +E+EKM+A
Sbjct: 17 IELEKMKA 24
>XP_006723886
          Length = 404

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  VEMEKMEA 9
          +E+EKM+A
Sbjct: 70 IELEKMKA 77
>XP_005245535
          Length = 1854

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    VEMEKMEA 9
            +EME+ME+
Sbjct: 1614 IEMEEMES 1621
>NP_001092192
          Length = 75

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  AVEMEKMEA 9
          AVE  KMEA
Sbjct: 19 AVEQLKMEA 27
>NP_001092191
          Length = 75

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  AVEMEKMEA 9
          AVE  KMEA
Sbjct: 19 AVEQLKMEA 27
>NP_004476
          Length = 75

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  AVEMEKMEA 9
          AVE  KMEA
Sbjct: 19 AVEQLKMEA 27
>XP_006711825
          Length = 75

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  AVEMEKMEA 9
          AVE  KMEA
Sbjct: 19 AVEQLKMEA 27
>XP_006711824
          Length = 75

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  AVEMEKMEA 9
          AVE  KMEA
Sbjct: 19 AVEQLKMEA 27
>NP_878918
          Length = 6907

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    EMEKMEA 9
            E+EKME+
Sbjct: 1923 ELEKMES 1929
>NP_055995
          Length = 6885

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    EMEKMEA 9
            E+EKME+
Sbjct: 1923 ELEKMES 1929
>NP_065871
          Length = 1659

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   EMEKMEA 9
           +MEK+EA
Sbjct: 243 QMEKLEA 249
>NP_055136
          Length = 252

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AVEMEKME 8
           A EMEK+E
Sbjct: 209 AKEMEKVE 216
>NP_510880
          Length = 2054

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    VEMEKMEA 9
            +EME MEA
Sbjct: 1343 MEMEVMEA 1350
>NP_976063
          Length = 2039

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    VEMEKMEA 9
            +EME MEA
Sbjct: 1343 MEMEVMEA 1350
>XP_006720147
          Length = 4788

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    EMEKMEA 9
            E+EKME+
Sbjct: 1923 ELEKMES 1929
>XP_005267517
          Length = 6883

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    EMEKMEA 9
            E+EKME+
Sbjct: 1923 ELEKMES 1929
>XP_005267516
          Length = 6884

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    EMEKMEA 9
            E+EKME+
Sbjct: 1923 ELEKMES 1929
>XP_005267515
          Length = 6899

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    EMEKMEA 9
            E+EKME+
Sbjct: 1923 ELEKMES 1929
>XP_005267514
          Length = 6908

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    EMEKMEA 9
            E+EKME+
Sbjct: 1923 ELEKMES 1929
>XP_005267513
          Length = 6921

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    EMEKMEA 9
            E+EKME+
Sbjct: 1923 ELEKMES 1929
>XP_005267512
          Length = 6922

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    EMEKMEA 9
            E+EKME+
Sbjct: 1923 ELEKMES 1929
>XP_005267511
          Length = 6922

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    EMEKMEA 9
            E+EKME+
Sbjct: 1923 ELEKMES 1929
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.299    0.108    0.237 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 456,283
Number of extensions: 913
Number of successful extensions: 55
Number of sequences better than 10000.0: 55
Number of HSP's gapped: 55
Number of HSP's successfully gapped: 55
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)

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