Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_006209                                                              20     390
XP_006713721                                                           20     390
XP_005250923                                                           17    3301
NP_055194                                                              17    3301
NP_878918                                                              17    4312
NP_055995                                                              17    4312
XP_006720147                                                           17    4312
XP_005267517                                                           17    4312
XP_005267516                                                           17    4312
XP_005267515                                                           17    4312
XP_005267514                                                           17    4312
XP_005267513                                                           17    4312
XP_005267512                                                           17    4312
XP_005267511                                                           17    4312
NP_001035519                                                           16    5631
NP_071940                                                              16    5631
XP_005268066                                                           16    5631
XP_005266415                                                           16    5631
XP_005266414                                                           16    5631
NP_061744                                                              16    5631
NP_114478                                                              16    5631
NP_065866                                                              16    7355
NP_116586                                                              16    7355
NP_001171809                                                           16    7355
NP_001098713                                                           16    7355
NP_065817                                                              16    7355
NP_998765                                                              16    7355
NP_060824                                                              16    7355
XP_005260805                                                           16    7355
XP_006723650                                                           16    7355
XP_006723649                                                           16    7355
XP_005260804                                                           16    7355
XP_005254329                                                           16    7355
NP_001167535                                                           15    9605
NP_001167534                                                           15    9605
NP_001167536                                                           15    9605
NP_056934                                                              15    9605
NP_006260                                                              15    9605
NP_075598                                                              15    9605
NP_001167538                                                           15    9605
NP_525022                                                              15    9605
NP_001268695                                                           15    9605
NP_872272                                                              15    9605
NP_055401                                                              15    9605
NP_065961                                                              15    9605
NP_004430                                                              15    9605
NP_001158137                                                           15    9605
NP_001268694                                                           15    9605
NP_001268696                                                           15    9605
XP_005256994                                                           15    9605
XP_005256993                                                           15    9605
XP_005256992                                                           15    9605
XP_006721697                                                           15    9605
XP_006721696                                                           15    9605
XP_005256991                                                           15    9605
XP_006716372                                                           15    9605
XP_006716371                                                           15    9605
XP_006716370                                                           15    9605
XP_006716369                                                           15    9605
XP_006716368                                                           15    9605
XP_006716367                                                           15    9605
XP_006716366                                                           15    9605
XP_006716134                                                           15    9605
>NP_006209
          Length = 1068

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ATYVSVNIR 9
           ATYV+VNIR
Sbjct: 341 ATYVNVNIR 349
>XP_006713721
          Length = 1068

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ATYVSVNIR 9
           ATYV+VNIR
Sbjct: 341 ATYVNVNIR 349
>XP_005250923
          Length = 500

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   TYVSVNIR 9
           +Y+SVN+R
Sbjct: 462 SYISVNLR 469
>NP_055194
          Length = 500

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   TYVSVNIR 9
           +Y+SVN+R
Sbjct: 462 SYISVNLR 469
>NP_878918
          Length = 6907

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ATYVSVNI 8
           ATY SVN+
Sbjct: 196 ATYESVNV 203
>NP_055995
          Length = 6885

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ATYVSVNI 8
           ATY SVN+
Sbjct: 196 ATYESVNV 203
>XP_006720147
          Length = 4788

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ATYVSVNI 8
           ATY SVN+
Sbjct: 196 ATYESVNV 203
>XP_005267517
          Length = 6883

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ATYVSVNI 8
           ATY SVN+
Sbjct: 196 ATYESVNV 203
>XP_005267516
          Length = 6884

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ATYVSVNI 8
           ATY SVN+
Sbjct: 196 ATYESVNV 203
>XP_005267515
          Length = 6899

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ATYVSVNI 8
           ATY SVN+
Sbjct: 196 ATYESVNV 203
>XP_005267514
          Length = 6908

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ATYVSVNI 8
           ATY SVN+
Sbjct: 196 ATYESVNV 203
>XP_005267513
          Length = 6921

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ATYVSVNI 8
           ATY SVN+
Sbjct: 196 ATYESVNV 203
>XP_005267512
          Length = 6922

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ATYVSVNI 8
           ATY SVN+
Sbjct: 196 ATYESVNV 203
>XP_005267511
          Length = 6922

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ATYVSVNI 8
           ATY SVN+
Sbjct: 196 ATYESVNV 203
>NP_001035519
          Length = 1159

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   TYVSVN 7
           TYVSVN
Sbjct: 523 TYVSVN 528
>NP_071940
          Length = 938

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TYVSVNIR 9
           TY S+NI+
Sbjct: 441 TYCSINIK 448
>XP_005268066
          Length = 1172

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TYVSVNIR 9
           TY S+NI+
Sbjct: 675 TYCSINIK 682
>XP_005266415
          Length = 1158

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   TYVSVN 7
           TYVSVN
Sbjct: 523 TYVSVN 528
>XP_005266414
          Length = 1159

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   TYVSVN 7
           TYVSVN
Sbjct: 523 TYVSVN 528
>NP_061744
          Length = 932

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ATYVSVN 7
           +TYVS+N
Sbjct: 502 STYVSIN 508
>NP_114478
          Length = 828

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ATYVSVN 7
           +TYVS+N
Sbjct: 502 STYVSIN 508
>NP_065866
          Length = 896

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   TYVSVN 7
           TYVS+N
Sbjct: 514 TYVSIN 519
>NP_116586
          Length = 1040

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   TYVSVN 7
           TYVS+N
Sbjct: 514 TYVSIN 519
>NP_001171809
          Length = 1148

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   TYVSVN 7
           TYVS+N
Sbjct: 504 TYVSIN 509
>NP_001098713
          Length = 1101

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   TYVSVN 7
           TYVS+N
Sbjct: 504 TYVSIN 509
>NP_065817
          Length = 1100

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   TYVSVN 7
           TYVS+N
Sbjct: 504 TYVSIN 509
>NP_998765
          Length = 849

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   YVSVNIR 9
           Y SVN+R
Sbjct: 496 YTSVNVR 502
>NP_060824
          Length = 256

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TYVSVNIR 9
           TY S+N+R
Sbjct: 219 TYGSINLR 226
>XP_005260805
          Length = 232

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TYVSVNIR 9
           TY S+N+R
Sbjct: 195 TYGSINLR 202
>XP_006723650
          Length = 232

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TYVSVNIR 9
           TY S+N+R
Sbjct: 195 TYGSINLR 202
>XP_006723649
          Length = 256

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TYVSVNIR 9
           TY S+N+R
Sbjct: 219 TYGSINLR 226
>XP_005260804
          Length = 256

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TYVSVNIR 9
           TY S+N+R
Sbjct: 219 TYGSINLR 226
>XP_005254329
          Length = 481

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   YVSVNIR 9
           Y SVN+R
Sbjct: 128 YTSVNVR 134
>NP_001167535
          Length = 812

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   TYVSVNI 8
           TY SVN+
Sbjct: 104 TYFSVNV 110
>NP_001167534
          Length = 820

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   TYVSVNI 8
           TY SVN+
Sbjct: 112 TYFSVNV 118
>NP_001167536
          Length = 820

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   TYVSVNI 8
           TY SVN+
Sbjct: 112 TYFSVNV 118
>NP_056934
          Length = 820

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   TYVSVNI 8
           TY SVN+
Sbjct: 112 TYFSVNV 118
>NP_006260
          Length = 2156

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    TYVSVNI 8
            TYV VN+
Sbjct: 1332 TYVPVNV 1338
>NP_075598
          Length = 822

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   TYVSVNI 8
           TY SVN+
Sbjct: 112 TYFSVNV 118
>NP_001167538
          Length = 853

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   TYVSVNI 8
           TY SVN+
Sbjct: 145 TYFSVNV 151
>NP_525022
          Length = 1624

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   YVSVNI 8
           YVSVN+
Sbjct: 240 YVSVNV 245
>NP_001268695
          Length = 1016

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   YVSVNI 8
           YVSVN+
Sbjct: 457 YVSVNV 462
>NP_872272
          Length = 1015

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   YVSVNI 8
           YVSVN+
Sbjct: 457 YVSVNV 462
>NP_055401
          Length = 714

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TYVSVNIR 9
           TYV+ N+R
Sbjct: 102 TYVTKNLR 109
>NP_065961
          Length = 1934

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   ATYVSV 6
           ATYVSV
Sbjct: 140 ATYVSV 145
>NP_004430
          Length = 1037

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   YVSVNI 8
           YVSVN+
Sbjct: 457 YVSVNV 462
>NP_001158137
          Length = 1950

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   ATYVSV 6
           ATYVSV
Sbjct: 140 ATYVSV 145
>NP_001268694
          Length = 1038

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   YVSVNI 8
           YVSVN+
Sbjct: 457 YVSVNV 462
>NP_001268696
          Length = 1004

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   YVSVNI 8
           YVSVN+
Sbjct: 457 YVSVNV 462
>XP_005256994
          Length = 1443

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   YVSVNI 8
           YVSVN+
Sbjct: 248 YVSVNV 253
>XP_005256993
          Length = 1543

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   YVSVNI 8
           YVSVN+
Sbjct: 159 YVSVNV 164
>XP_005256992
          Length = 1543

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   YVSVNI 8
           YVSVN+
Sbjct: 159 YVSVNV 164
>XP_006721697
          Length = 1625

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   YVSVNI 8
           YVSVN+
Sbjct: 248 YVSVNV 253
>XP_006721696
          Length = 1632

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   YVSVNI 8
           YVSVN+
Sbjct: 248 YVSVNV 253
>XP_005256991
          Length = 1632

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   YVSVNI 8
           YVSVN+
Sbjct: 248 YVSVNV 253
>XP_006716372
          Length = 824

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   TYVSVNI 8
           TY SVN+
Sbjct: 104 TYFSVNV 110
>XP_006716371
          Length = 830

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   TYVSVNI 8
           TY SVN+
Sbjct: 112 TYFSVNV 118
>XP_006716370
          Length = 830

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   TYVSVNI 8
           TY SVN+
Sbjct: 112 TYFSVNV 118
>XP_006716369
          Length = 830

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   TYVSVNI 8
           TY SVN+
Sbjct: 112 TYFSVNV 118
>XP_006716368
          Length = 832

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   TYVSVNI 8
           TY SVN+
Sbjct: 112 TYFSVNV 118
>XP_006716367
          Length = 832

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   TYVSVNI 8
           TY SVN+
Sbjct: 112 TYFSVNV 118
>XP_006716366
          Length = 832

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   TYVSVNI 8
           TY SVN+
Sbjct: 112 TYFSVNV 118
>XP_006716134
          Length = 1847

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  ATYVSV 6
          ATYVSV
Sbjct: 64 ATYVSV 69
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.322    0.128    0.332 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 383,964
Number of extensions: 432
Number of successful extensions: 63
Number of sequences better than 10000.0: 63
Number of HSP's gapped: 63
Number of HSP's successfully gapped: 63
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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