Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004110                                                              20     509
XP_005266922                                                           18    1482
NP_001025029                                                           18    1482
NP_061985                                                              17    3301
NP_689914                                                              17    3301
XP_006722681                                                           17    3301
XP_006722680                                                           17    3301
XP_006722679                                                           17    3301
NP_001783                                                              16    5631
NP_001139317                                                           16    5631
NP_598334                                                              16    5631
NP_002932                                                              16    5631
NP_001239268                                                           16    5631
NP_001239267                                                           16    5631
NP_001785                                                              16    5631
NP_001161052                                                           16    5631
NP_055663                                                              16    5631
XP_005258239                                                           16    5631
XP_005258238                                                           16    5631
XP_005255055                                                           16    5631
XP_005255054                                                           16    5631
XP_006713341                                                           16    5631
XP_006713340                                                           16    5631
XP_006713339                                                           16    5631
NP_006197                                                              16    7355
NP_002600                                                              16    7355
NP_653327                                                              16    7355
NP_001186312                                                           16    7355
NP_001186311                                                           16    7355
NP_001186310                                                           16    7355
NP_001186309                                                           16    7355
XP_005265883                                                           16    7355
XP_005268521                                                           16    7355
XP_006714104                                                           16    7355
XP_005265800                                                           16    7355
XP_006714103                                                           16    7355
XP_006714102                                                           16    7355
NP_001073935                                                           16    7355
NP_037514                                                              15    9605
NP_000213                                                              15    9605
NP_001087241                                                           15    9605
NP_065071                                                              15    9605
NP_653223                                                              15    9605
NP_000129                                                              15    9605
XP_006717988                                                           15    9605
XP_006717987                                                           15    9605
XP_006717986                                                           15    9605
XP_005270044                                                           15    9605
XP_005270045                                                           15    9605
XP_005265799                                                           15    9605
XP_005265798                                                           15    9605
XP_005265797                                                           15    9605
>NP_004110
          Length = 993

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ATAYGISNT 9
           ATAYGIS T
Sbjct: 627 ATAYGISKT 635
>XP_005266922
          Length = 408

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   ATAYGISN 8
           AT YGISN
Sbjct: 227 ATLYGISN 234
>NP_001025029
          Length = 408

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   ATAYGISN 8
           AT YGISN
Sbjct: 227 ATLYGISN 234
>NP_061985
          Length = 2146

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    TAYGISNT 9
            T YGIS+T
Sbjct: 1130 TGYGISDT 1137
>NP_689914
          Length = 5058

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    TAYGISNT 9
            T YGIS+T
Sbjct: 4142 TGYGISDT 4149
>XP_006722681
          Length = 1365

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TAYGISNT 9
           T YGIS+T
Sbjct: 349 TGYGISDT 356
>XP_006722680
          Length = 1636

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    TAYGISNT 9
            T YGIS+T
Sbjct: 1130 TGYGISDT 1137
>XP_006722679
          Length = 2128

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    TAYGISNT 9
            T YGIS+T
Sbjct: 1130 TGYGISDT 1137
>NP_001783
          Length = 906

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   YGISNT 9
           YG+SNT
Sbjct: 360 YGLSNT 365
>NP_001139317
          Length = 1551

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ATAYGISN 8
           A AYGIS+
Sbjct: 601 ANAYGISD 608
>NP_598334
          Length = 1606

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ATAYGISN 8
           A AYGIS+
Sbjct: 601 ANAYGISD 608
>NP_002932
          Length = 1651

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ATAYGISN 8
           A AYGIS+
Sbjct: 637 ANAYGISD 644
>NP_001239268
          Length = 842

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   YGISNT 9
           YG+SNT
Sbjct: 296 YGLSNT 301
>NP_001239267
          Length = 879

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   YGISNT 9
           YG+SNT
Sbjct: 333 YGLSNT 338
>NP_001785
          Length = 916

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   YGISNT 9
           YG+SNT
Sbjct: 370 YGLSNT 375
>NP_001161052
          Length = 532

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ATAYGISN 8
           ATA+GI N
Sbjct: 473 ATAFGILN 480
>NP_055663
          Length = 683

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ATAYGISN 8
           ATA+GI N
Sbjct: 624 ATAFGILN 631
>XP_005258239
          Length = 875

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   YGISNT 9
           YG+SNT
Sbjct: 329 YGLSNT 334
>XP_005258238
          Length = 888

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   YGISNT 9
           YG+SNT
Sbjct: 342 YGLSNT 347
>XP_005255055
          Length = 683

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ATAYGISN 8
           ATA+GI N
Sbjct: 624 ATAFGILN 631
>XP_005255054
          Length = 683

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ATAYGISN 8
           ATA+GI N
Sbjct: 624 ATAFGILN 631
>XP_006713341
          Length = 1600

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ATAYGISN 8
           A AYGIS+
Sbjct: 586 ANAYGISD 593
>XP_006713340
          Length = 1615

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ATAYGISN 8
           A AYGIS+
Sbjct: 601 ANAYGISD 608
>XP_006713339
          Length = 1616

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ATAYGISN 8
           A AYGIS+
Sbjct: 602 ANAYGISD 609
>NP_006197
          Length = 1089

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TAYGISNT 9
           TAYG+S +
Sbjct: 611 TAYGLSRS 618
>NP_002600
          Length = 1106

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   ATAYGISNT 9
           ATA+G+S++
Sbjct: 617 ATAHGLSHS 625
>NP_653327
          Length = 691

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   AYGISNT 9
           AYG+S T
Sbjct: 499 AYGVSET 505
>NP_001186312
          Length = 663

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   AYGISNT 9
           AYG+S T
Sbjct: 471 AYGVSET 477
>NP_001186311
          Length = 677

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   AYGISNT 9
           AYG+S T
Sbjct: 485 AYGVSET 491
>NP_001186310
          Length = 680

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   AYGISNT 9
           AYG+S T
Sbjct: 488 AYGVSET 494
>NP_001186309
          Length = 693

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   AYGISNT 9
           AYG+S T
Sbjct: 501 AYGVSET 507
>XP_005265883
          Length = 679

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   AYGISNT 9
           AYG+S T
Sbjct: 487 AYGVSET 493
>XP_005268521
          Length = 1042

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   ATAYGISNT 9
           ATA+G+S++
Sbjct: 553 ATAHGLSHS 561
>XP_006714104
          Length = 832

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TAYGISNT 9
           TAYG+S +
Sbjct: 636 TAYGLSRS 643
>XP_005265800
          Length = 1089

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TAYGISNT 9
           TAYG+S +
Sbjct: 611 TAYGLSRS 618
>XP_006714103
          Length = 1111

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TAYGISNT 9
           TAYG+S +
Sbjct: 633 TAYGLSRS 640
>XP_006714102
          Length = 1114

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TAYGISNT 9
           TAYG+S +
Sbjct: 636 TAYGLSRS 643
>NP_001073935
          Length = 478

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ATAYGISN 8
           AT YG+S+
Sbjct: 142 ATKYGVSS 149
>NP_037514
          Length = 750

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   TAYGISNT 9
           T YGI+ T
Sbjct: 440 TGYGINGT 447
>NP_000213
          Length = 976

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   ATAYGI 6
           ATAYG+
Sbjct: 606 ATAYGL 611
>NP_001087241
          Length = 972

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   ATAYGI 6
           ATAYG+
Sbjct: 602 ATAYGL 607
>NP_065071
          Length = 1067

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   TAYGISNT 9
           T +G++NT
Sbjct: 169 TVWGVTNT 176
>NP_653223
          Length = 773

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  ATAYGI 6
          ATAYG+
Sbjct: 37 ATAYGL 42
>NP_000129
          Length = 2871

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    AYGISNT 9
            +YG SNT
Sbjct: 2660 SYGCSNT 2666
>XP_006717988
          Length = 986

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   TAYGISNT 9
           T +G++NT
Sbjct: 169 TVWGVTNT 176
>XP_006717987
          Length = 1073

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   TAYGISNT 9
           T +G++NT
Sbjct: 169 TVWGVTNT 176
>XP_006717986
          Length = 1073

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   TAYGISNT 9
           T +G++NT
Sbjct: 169 TVWGVTNT 176
>XP_005270044
          Length = 1073

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   TAYGISNT 9
           T +G++NT
Sbjct: 169 TVWGVTNT 176
>XP_005270045
          Length = 1073

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   TAYGISNT 9
           T +G++NT
Sbjct: 169 TVWGVTNT 176
>XP_005265799
          Length = 973

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   ATAYGI 6
           ATAYG+
Sbjct: 603 ATAYGL 608
>XP_005265798
          Length = 976

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   ATAYGI 6
           ATAYG+
Sbjct: 607 ATAYGL 612
>XP_005265797
          Length = 977

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   ATAYGI 6
           ATAYG+
Sbjct: 607 ATAYGL 612
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.303    0.115    0.305 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 432,632
Number of extensions: 678
Number of successful extensions: 52
Number of sequences better than 10000.0: 52
Number of HSP's gapped: 52
Number of HSP's successfully gapped: 52
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.4 bits)
S2: 28 (15.4 bits)

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