Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_722576                                                              19     869
XP_005262424                                                           19     869
XP_005268438                                                           17    2528
NP_001025040                                                           17    2528
NP_002151                                                              15    9605
NP_001192273                                                           15    9605
NP_001703                                                              15    9605
NP_001020083                                                           15    9605
NP_006302                                                              15    9605
NP_001268695                                                           15    9605
NP_872272                                                              15    9605
NP_001186794                                                           15    9605
NP_001186795                                                           15    9605
NP_078980                                                              15    9605
NP_004430                                                              15    9605
NP_001268694                                                           15    9605
NP_001268696                                                           15    9605
XP_005260812                                                           15    9605
XP_006723651                                                           15    9605
XP_005260811                                                           15    9605
XP_005260810                                                           15    9605
XP_005260809                                                           15    9605
XP_005260808                                                           15    9605
XP_005260807                                                           15    9605
XP_005256932                                                           15    9605
XP_006721667                                                           15    9605
XP_005256931                                                           15    9605
XP_005256930                                                           15    9605
XP_006721666                                                           15    9605
XP_005256929                                                           15    9605
XP_005256928                                                           15    9605
XP_006721665                                                           15    9605
XP_005256925                                                           15    9605
XP_005256924                                                           15    9605
XP_006721664                                                           15    9605
XP_005256923                                                           15    9605
XP_005252032                                                           15    9605
XP_006717164                                                           15    9605
XP_005252031                                                           15    9605
XP_005252030                                                           15    9605
XP_006717163                                                           15    9605
XP_006717162                                                           15    9605
XP_006717161                                                           15    9605
XP_006717160                                                           15    9605
XP_005252029                                                           15    9605
XP_006717159                                                           15    9605
XP_005265710                                                           15    9605
>NP_722576
          Length = 3080

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    ASSKTTITA 9
            ASS+TTITA
Sbjct: 2107 ASSRTTITA 2115
>XP_005262424
          Length = 2875

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    ASSKTTITA 9
            ASS+TTITA
Sbjct: 1902 ASSRTTITA 1910
>XP_005268438
          Length = 157

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  ASSKTTITA 9
          AS +TTITA
Sbjct: 36 ASGRTTITA 44
>NP_001025040
          Length = 177

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  ASSKTTITA 9
          AS +TTITA
Sbjct: 56 ASGRTTITA 64
>NP_002151
          Length = 2201

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   ASSKTTIT 8
           A++KTT+T
Sbjct: 946 ATTKTTLT 953
>NP_001192273
          Length = 468

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   SSKTTIT 8
           +SKTT+T
Sbjct: 332 ASKTTVT 338
>NP_001703
          Length = 526

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   SSKTTIT 8
           +SKTT+T
Sbjct: 332 ASKTTVT 338
>NP_001020083
          Length = 464

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   SSKTTIT 8
           +SKTT+T
Sbjct: 332 ASKTTVT 338
>NP_006302
          Length = 2440

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    KTTITA 9
            KTTITA
Sbjct: 1924 KTTITA 1929
>NP_001268695
          Length = 1016

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SSKTTITA 9
           S +TTITA
Sbjct: 520 SKETTITA 527
>NP_872272
          Length = 1015

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SSKTTITA 9
           S +TTITA
Sbjct: 520 SKETTITA 527
>NP_001186794
          Length = 1266

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  SKTTIT 8
          SKTTIT
Sbjct: 31 SKTTIT 36
>NP_001186795
          Length = 1392

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  SKTTIT 8
          SKTTIT
Sbjct: 31 SKTTIT 36
>NP_078980
          Length = 1317

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  SKTTIT 8
          SKTTIT
Sbjct: 31 SKTTIT 36
>NP_004430
          Length = 1037

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SSKTTITA 9
           S +TTITA
Sbjct: 520 SKETTITA 527
>NP_001268694
          Length = 1038

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SSKTTITA 9
           S +TTITA
Sbjct: 520 SKETTITA 527
>NP_001268696
          Length = 1004

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SSKTTITA 9
           S +TTITA
Sbjct: 520 SKETTITA 527
>XP_005260812
          Length = 1277

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  SKTTIT 8
          SKTTIT
Sbjct: 31 SKTTIT 36
>XP_006723651
          Length = 1287

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  SKTTIT 8
          SKTTIT
Sbjct: 31 SKTTIT 36
>XP_005260811
          Length = 1298

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  SKTTIT 8
          SKTTIT
Sbjct: 31 SKTTIT 36
>XP_005260810
          Length = 1328

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  SKTTIT 8
          SKTTIT
Sbjct: 31 SKTTIT 36
>XP_005260809
          Length = 1832

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  SKTTIT 8
          SKTTIT
Sbjct: 31 SKTTIT 36
>XP_005260808
          Length = 1872

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  SKTTIT 8
          SKTTIT
Sbjct: 31 SKTTIT 36
>XP_005260807
          Length = 1883

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  SKTTIT 8
          SKTTIT
Sbjct: 31 SKTTIT 36
>XP_005256932
          Length = 2448

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    KTTITA 9
            KTTITA
Sbjct: 1932 KTTITA 1937
>XP_006721667
          Length = 2456

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    KTTITA 9
            KTTITA
Sbjct: 1940 KTTITA 1945
>XP_005256931
          Length = 2466

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    KTTITA 9
            KTTITA
Sbjct: 1950 KTTITA 1955
>XP_005256930
          Length = 2508

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    KTTITA 9
            KTTITA
Sbjct: 1992 KTTITA 1997
>XP_006721666
          Length = 2511

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    KTTITA 9
            KTTITA
Sbjct: 2008 KTTITA 2013
>XP_005256929
          Length = 2514

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    KTTITA 9
            KTTITA
Sbjct: 1998 KTTITA 2003
>XP_005256928
          Length = 2515

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    KTTITA 9
            KTTITA
Sbjct: 1999 KTTITA 2004
>XP_006721665
          Length = 2523

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    KTTITA 9
            KTTITA
Sbjct: 2007 KTTITA 2012
>XP_005256925
          Length = 2523

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    KTTITA 9
            KTTITA
Sbjct: 2007 KTTITA 2012
>XP_005256924
          Length = 2524

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    KTTITA 9
            KTTITA
Sbjct: 2008 KTTITA 2013
>XP_006721664
          Length = 2524

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    KTTITA 9
            KTTITA
Sbjct: 2008 KTTITA 2013
>XP_005256923
          Length = 2524

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    KTTITA 9
            KTTITA
Sbjct: 2008 KTTITA 2013
>XP_005252032
          Length = 1564

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   ASSKTTIT 8
           A++KTT+T
Sbjct: 946 ATTKTTLT 953
>XP_006717164
          Length = 1655

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   ASSKTTIT 8
           A++KTT+T
Sbjct: 946 ATTKTTLT 953
>XP_005252031
          Length = 1655

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   ASSKTTIT 8
           A++KTT+T
Sbjct: 946 ATTKTTLT 953
>XP_005252030
          Length = 1837

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   ASSKTTIT 8
           A++KTT+T
Sbjct: 946 ATTKTTLT 953
>XP_006717163
          Length = 1928

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   ASSKTTIT 8
           A++KTT+T
Sbjct: 946 ATTKTTLT 953
>XP_006717162
          Length = 1928

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   ASSKTTIT 8
           A++KTT+T
Sbjct: 946 ATTKTTLT 953
>XP_006717161
          Length = 2019

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   ASSKTTIT 8
           A++KTT+T
Sbjct: 946 ATTKTTLT 953
>XP_006717160
          Length = 2110

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   ASSKTTIT 8
           A++KTT+T
Sbjct: 946 ATTKTTLT 953
>XP_005252029
          Length = 2110

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   ASSKTTIT 8
           A++KTT+T
Sbjct: 946 ATTKTTLT 953
>XP_006717159
          Length = 2293

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   ASSKTTIT 8
           A++KTT+T
Sbjct: 946 ATTKTTLT 953
>XP_005265710
          Length = 874

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SSKTTITA 9
           S +TTITA
Sbjct: 356 SKETTITA 363
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.285   0.0898    0.191 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 256,475
Number of extensions: 296
Number of successful extensions: 47
Number of sequences better than 10000.0: 47
Number of HSP's gapped: 47
Number of HSP's successfully gapped: 47
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 18 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.0 bits)
S2: 28 (15.4 bits)

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