Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_878314                                                              18    1935
NP_005453                                                              17    4312
XP_003846820                                                           17    4312
NP_001258614                                                           16    5631
NP_127493                                                              16    5631
NP_001267729                                                           16    5631
NP_127494                                                              16    5631
NP_001157108                                                           16    5631
NP_001509                                                              16    5631
NP_127492                                                              16    5631
NP_775808                                                              16    5631
XP_005272291                                                           16    5631
XP_005277669                                                           16    5631
XP_005277638                                                           16    5631
XP_005277637                                                           16    5631
XP_005277636                                                           16    5631
XP_006716009                                                           16    5631
XP_005250353                                                           16    5631
XP_006716008                                                           16    5631
XP_006716007                                                           16    5631
XP_006716006                                                           16    5631
XP_006716005                                                           16    5631
XP_006716004                                                           16    5631
XP_006716003                                                           16    5631
XP_006716002                                                           16    5631
XP_005250348                                                           16    5631
NP_001003795                                                           16    5631
NP_059125                                                              16    7355
NP_116254                                                              16    7355
XP_005257801                                                           16    7355
NP_085143                                                              15    9605
NP_004774                                                              15    9605
NP_057235                                                              15    9605
NP_001238972                                                           15    9605
XP_005253545                                                           15    9605
XP_006719218                                                           15    9605
>NP_878314
          Length = 361

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1  ASRSIMSPA 9
          A+RS++SPA
Sbjct: 63 AARSVLSPA 71
>NP_005453
          Length = 1142

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    ASRSIMSPA 9
            AS S+MSP+
Sbjct: 1130 ASSSVMSPS 1138
>XP_003846820
          Length = 1177

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    ASRSIMSPA 9
            AS S+MSP+
Sbjct: 1165 ASSSVMSPS 1173
>NP_001258614
          Length = 367

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1 ASRSIMSP 8
         +SRS++SP
Sbjct: 2 SSRSVLSP 9
>NP_127493
          Length = 978

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ASRSIMSP 8
           A RSI+SP
Sbjct: 204 ADRSILSP 211
>NP_001267729
          Length = 274

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ASRSIMSP 8
           A RSI+SP
Sbjct: 204 ADRSILSP 211
>NP_127494
          Length = 977

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ASRSIMSP 8
           A RSI+SP
Sbjct: 204 ADRSILSP 211
>NP_001157108
          Length = 976

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ASRSIMSP 8
           A RSI+SP
Sbjct: 204 ADRSILSP 211
>NP_001509
          Length = 957

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ASRSIMSP 8
           A RSI+SP
Sbjct: 204 ADRSILSP 211
>NP_127492
          Length = 998

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ASRSIMSP 8
           A RSI+SP
Sbjct: 204 ADRSILSP 211
>NP_775808
          Length = 949

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ASRSIMSPA 9
           A RSI+SP+
Sbjct: 199 AERSIVSPS 207
>XP_005272291
          Length = 537

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ASRSIMSPA 9
           ASR++ SPA
Sbjct: 516 ASRTVESPA 524
>XP_005277669
          Length = 949

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ASRSIMSPA 9
           A RSI+SP+
Sbjct: 199 AERSIVSPS 207
>XP_005277638
          Length = 755

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  ASRSIMSPA 9
          A RSI+SP+
Sbjct: 5  AERSIVSPS 13
>XP_005277637
          Length = 878

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ASRSIMSPA 9
           A RSI+SP+
Sbjct: 128 AERSIVSPS 136
>XP_005277636
          Length = 949

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ASRSIMSPA 9
           A RSI+SP+
Sbjct: 199 AERSIVSPS 207
>XP_006716009
          Length = 596

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ASRSIMSP 8
           A RSI+SP
Sbjct: 216 ADRSILSP 223
>XP_005250353
          Length = 969

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ASRSIMSP 8
           A RSI+SP
Sbjct: 216 ADRSILSP 223
>XP_006716008
          Length = 988

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ASRSIMSP 8
           A RSI+SP
Sbjct: 216 ADRSILSP 223
>XP_006716007
          Length = 989

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ASRSIMSP 8
           A RSI+SP
Sbjct: 216 ADRSILSP 223
>XP_006716006
          Length = 990

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ASRSIMSP 8
           A RSI+SP
Sbjct: 216 ADRSILSP 223
>XP_006716005
          Length = 998

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ASRSIMSP 8
           A RSI+SP
Sbjct: 204 ADRSILSP 211
>XP_006716004
          Length = 1003

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ASRSIMSP 8
           A RSI+SP
Sbjct: 209 ADRSILSP 216
>XP_006716003
          Length = 1009

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ASRSIMSP 8
           A RSI+SP
Sbjct: 216 ADRSILSP 223
>XP_006716002
          Length = 1010

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ASRSIMSP 8
           A RSI+SP
Sbjct: 216 ADRSILSP 223
>XP_005250348
          Length = 1010

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ASRSIMSP 8
           A RSI+SP
Sbjct: 216 ADRSILSP 223
>NP_001003795
          Length = 949

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ASRSIMSPA 9
           A RSI+SP+
Sbjct: 199 AERSIVSPS 207
>NP_059125
          Length = 547

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SRSIMSPA 9
           SRS++SP+
Sbjct: 227 SRSLLSPS 234
>NP_116254
          Length = 715

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ASRSIMSPA 9
           +SRS+ SPA
Sbjct: 303 SSRSLESPA 311
>XP_005257801
          Length = 714

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ASRSIMSPA 9
           +SRS+ SPA
Sbjct: 302 SSRSLESPA 310
>NP_085143
          Length = 665

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ASRSIMSP 8
           A RS++SP
Sbjct: 495 AQRSLLSP 502
>NP_004774
          Length = 1049

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SRSIMSPA 9
           S SIM+PA
Sbjct: 172 SASIMAPA 179
>NP_057235
          Length = 1235

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SRSIMSPA 9
           S SIM+PA
Sbjct: 172 SASIMAPA 179
>NP_001238972
          Length = 1122

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SRSIMSPA 9
           S SIM+PA
Sbjct: 172 SASIMAPA 179
>XP_005253545
          Length = 517

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ASRSIMSP 8
           A RS++SP
Sbjct: 347 AQRSLLSP 354
>XP_006719218
          Length = 665

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ASRSIMSP 8
           A RS++SP
Sbjct: 495 AQRSLLSP 502
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.308    0.108    0.266 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 447,394
Number of extensions: 518
Number of successful extensions: 36
Number of sequences better than 10000.0: 36
Number of HSP's gapped: 36
Number of HSP's successfully gapped: 36
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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