Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_003290                                                              18    1135
NP_001171889                                                           17    3301
NP_114098                                                              17    3301
NP_001019837                                                           17    3301
XP_005274553                                                           17    3301
XP_005274552                                                           17    3301
XP_005274551                                                           17    3301
NP_038479                                                              16    7355
NP_579899                                                              16    7355
NP_002797                                                              16    7355
NP_001229619                                                           16    7355
NP_054786                                                              16    7355
NP_078810                                                              16    7355
XP_005273996                                                           16    7355
XP_006717823                                                           16    7355
XP_005269751                                                           16    7355
XP_005269750                                                           16    7355
NP_001135870                                                           15    9605
NP_065945                                                              15    9605
NP_001018114                                                           15    9605
NP_001013003                                                           15    9605
XP_006713962                                                           15    9605
XP_006713961                                                           15    9605
XP_005272347                                                           15    9605
XP_006713960                                                           15    9605
XP_005273180                                                           15    9605
XP_005245830                                                           15    9605
XP_005245829                                                           15    9605
NP_001193570                                                           15    9605
NP_112485                                                              15    9605
>NP_003290
          Length = 803

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1  ASQIRELR 8
          ASQIRELR
Sbjct: 63 ASQIRELR 70
>NP_001171889
          Length = 427

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   SQIRELRS 9
           +Q+RELRS
Sbjct: 376 TQVRELRS 383
>NP_114098
          Length = 665

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   SQIRELRS 9
           +Q+RELRS
Sbjct: 614 TQVRELRS 621
>NP_001019837
          Length = 628

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   SQIRELRS 9
           +Q+RELRS
Sbjct: 577 TQVRELRS 584
>XP_005274553
          Length = 647

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   SQIRELRS 9
           +Q+RELRS
Sbjct: 596 TQVRELRS 603
>XP_005274552
          Length = 653

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   SQIRELRS 9
           +Q+RELRS
Sbjct: 602 TQVRELRS 609
>XP_005274551
          Length = 690

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   SQIRELRS 9
           +Q+RELRS
Sbjct: 639 TQVRELRS 646
>NP_038479
          Length = 2061

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   SQIRELRS 9
           +QIR+LRS
Sbjct: 720 TQIRKLRS 727
>NP_579899
          Length = 2048

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   SQIRELRS 9
           +QIR+LRS
Sbjct: 707 TQIRKLRS 714
>NP_002797
          Length = 403

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ASQIRELR 8
           + QIRELR
Sbjct: 153 SEQIRELR 160
>NP_001229619
          Length = 563

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   ASQIRELRS 9
           ASQI  LRS
Sbjct: 334 ASQITNLRS 342
>NP_054786
          Length = 325

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   ASQIRELRS 9
           ASQ  ELRS
Sbjct: 237 ASQAAELRS 245
>NP_078810
          Length = 563

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   ASQIRELRS 9
           ASQI  LRS
Sbjct: 334 ASQITNLRS 342
>XP_005273996
          Length = 334

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   ASQIRELRS 9
           ASQ  ELRS
Sbjct: 237 ASQAAELRS 245
>XP_006717823
          Length = 1938

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   SQIRELRS 9
           +QIR+LRS
Sbjct: 578 TQIRKLRS 585
>XP_005269751
          Length = 2067

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   SQIRELRS 9
           +QIR+LRS
Sbjct: 707 TQIRKLRS 714
>XP_005269750
          Length = 2080

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   SQIRELRS 9
           +QIR+LRS
Sbjct: 720 TQIRKLRS 727
>NP_001135870
          Length = 226

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  ASQIRELRS 9
          A  +RE+RS
Sbjct: 28 ADHVREMRS 36
>NP_065945
          Length = 709

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   ASQIRELR 8
           A+Q+R+LR
Sbjct: 461 AAQLRQLR 468
>NP_001018114
          Length = 248

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  ASQIRELRS 9
          A  +RE+RS
Sbjct: 28 ADHVREMRS 36
>NP_001013003
          Length = 125

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  ASQIRELRS 9
          ASQ ++LRS
Sbjct: 76 ASQCKKLRS 84
>XP_006713962
          Length = 613

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   ASQIRELR 8
           A+Q+R+LR
Sbjct: 461 AAQLRQLR 468
>XP_006713961
          Length = 613

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   ASQIRELR 8
           A+Q+R+LR
Sbjct: 461 AAQLRQLR 468
>XP_005272347
          Length = 709

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   ASQIRELR 8
           A+Q+R+LR
Sbjct: 461 AAQLRQLR 468
>XP_006713960
          Length = 709

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   ASQIRELR 8
           A+Q+R+LR
Sbjct: 461 AAQLRQLR 468
>XP_005273180
          Length = 155

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ASQIRELRS 9
           ASQ ++LRS
Sbjct: 106 ASQCKKLRS 114
>XP_005245830
          Length = 782

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SQIRELRS 9
           +Q+RELR+
Sbjct: 770 AQLRELRA 777
>XP_005245829
          Length = 787

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SQIRELRS 9
           +Q+RELR+
Sbjct: 775 AQLRELRA 782
>NP_001193570
          Length = 79

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  ASQIRELRS 9
          ASQ ++LRS
Sbjct: 30 ASQCKKLRS 38
>NP_112485
          Length = 224

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  ASQIRELRS 9
          A  +RE+RS
Sbjct: 28 ADHVREMRS 36
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.313    0.121    0.271 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 376,650
Number of extensions: 486
Number of successful extensions: 30
Number of sequences better than 10000.0: 30
Number of HSP's gapped: 30
Number of HSP's successfully gapped: 30
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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