Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_733751                                                              19     869
NP_061878                                                              19     869
XP_006716142                                                           19     869
XP_005250088                                                           19     869
XP_006716141                                                           19     869
XP_005250085                                                           19     869
XP_006716140                                                           19     869
XP_005250084                                                           19     869
XP_005250083                                                           19     869
XP_005250082                                                           19     869
XP_005249839                                                           19     869
XP_005249838                                                           19     869
XP_005249837                                                           19     869
NP_003473                                                              18    1135
XP_006719679                                                           18    1135
XP_005269219                                                           18    1135
XP_006719678                                                           18    1135
XP_006719677                                                           18    1135
XP_006713079                                                           17    2528
XP_006713078                                                           17    2528
NP_000081                                                              17    3301
NP_001438                                                              17    3301
NP_002636                                                              17    3301
XP_005253036                                                           17    3301
XP_005253035                                                           17    3301
XP_005253034                                                           17    3301
XP_006714824                                                           17    3301
NP_055068                                                              16    5631
NP_001156750                                                           16    5631
NP_001156751                                                           16    5631
NP_064455                                                              16    5631
XP_006724788                                                           16    5631
NP_000085                                                              15    9605
NP_005492                                                              15    9605
NP_002195                                                              15    9605
NP_064707                                                              15    9605
NP_001257655                                                           15    9605
NP_055899                                                              15    9605
NP_060191                                                              15    9605
NP_975010                                                              15    9605
NP_001257658                                                           15    9605
NP_056182                                                              15    9605
NP_001257659                                                           15    9605
NP_001257660                                                           15    9605
NP_851607                                                              15    9605
NP_653252                                                              15    9605
NP_006036                                                              15    9605
NP_001712                                                              15    9605
NP_065156                                                              15    9605
NP_001273677                                                           15    9605
XP_006724573                                                           15    9605
XP_006724139                                                           15    9605
XP_005260032                                                           15    9605
XP_005260031                                                           15    9605
XP_005260030                                                           15    9605
XP_005260029                                                           15    9605
XP_005257365                                                           15    9605
XP_005251225                                                           15    9605
XP_006716483                                                           15    9605
XP_005251224                                                           15    9605
XP_005246155                                                           15    9605
XP_006712703                                                           15    9605
XP_005246154                                                           15    9605
XP_006711529                                                           15    9605
XP_006711528                                                           15    9605
>NP_733751
          Length = 4911

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    ASIVQRGE 8
            ASIVQRGE
Sbjct: 4536 ASIVQRGE 4543
>NP_061878
          Length = 875

 Score = 18.9 bits (37), Expect =   869
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SIVQRGEW 9
           S+VQ GEW
Sbjct: 514 SLVQEGEW 521
>XP_006716142
          Length = 4927

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    ASIVQRGE 8
            ASIVQRGE
Sbjct: 4552 ASIVQRGE 4559
>XP_005250088
          Length = 4928

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    ASIVQRGE 8
            ASIVQRGE
Sbjct: 4553 ASIVQRGE 4560
>XP_006716141
          Length = 4959

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    ASIVQRGE 8
            ASIVQRGE
Sbjct: 4584 ASIVQRGE 4591
>XP_005250085
          Length = 4979

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    ASIVQRGE 8
            ASIVQRGE
Sbjct: 4608 ASIVQRGE 4615
>XP_006716140
          Length = 4982

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    ASIVQRGE 8
            ASIVQRGE
Sbjct: 4607 ASIVQRGE 4614
>XP_005250084
          Length = 4982

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    ASIVQRGE 8
            ASIVQRGE
Sbjct: 4607 ASIVQRGE 4614
>XP_005250083
          Length = 4982

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    ASIVQRGE 8
            ASIVQRGE
Sbjct: 4607 ASIVQRGE 4614
>XP_005250082
          Length = 4983

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    ASIVQRGE 8
            ASIVQRGE
Sbjct: 4608 ASIVQRGE 4615
>XP_005249839
          Length = 875

 Score = 18.9 bits (37), Expect =   869
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SIVQRGEW 9
           S+VQ GEW
Sbjct: 514 SLVQEGEW 521
>XP_005249838
          Length = 875

 Score = 18.9 bits (37), Expect =   869
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SIVQRGEW 9
           S+VQ GEW
Sbjct: 514 SLVQEGEW 521
>XP_005249837
          Length = 875

 Score = 18.9 bits (37), Expect =   869
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SIVQRGEW 9
           S+VQ GEW
Sbjct: 514 SLVQEGEW 521
>NP_003473
          Length = 5537

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1    ASIVQRGE 8
            ASI+QRGE
Sbjct: 5166 ASIIQRGE 5173
>XP_006719679
          Length = 5536

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1    ASIVQRGE 8
            ASI+QRGE
Sbjct: 5165 ASIIQRGE 5172
>XP_005269219
          Length = 5537

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1    ASIVQRGE 8
            ASI+QRGE
Sbjct: 5166 ASIIQRGE 5173
>XP_006719678
          Length = 5539

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1    ASIVQRGE 8
            ASI+QRGE
Sbjct: 5168 ASIIQRGE 5175
>XP_006719677
          Length = 5540

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1    ASIVQRGE 8
            ASI+QRGE
Sbjct: 5169 ASIIQRGE 5176
>XP_006713079
          Length = 364

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   VQRGEW 9
           V+RGEW
Sbjct: 123 VERGEW 128
>XP_006713078
          Length = 371

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   VQRGEW 9
           V+RGEW
Sbjct: 123 VERGEW 128
>NP_000081
          Length = 1466

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  SIVQRGEW 9
          S VQ+G W
Sbjct: 3  SFVQKGSW 10
>NP_001438
          Length = 4349

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4    VQRGEW 9
            +QRG+W
Sbjct: 4039 IQRGDW 4044
>NP_002636
          Length = 1686

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   VQRGEW 9
           +QRG+W
Sbjct: 137 IQRGQW 142
>XP_005253036
          Length = 1686

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   VQRGEW 9
           +QRG+W
Sbjct: 137 IQRGQW 142
>XP_005253035
          Length = 1686

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   VQRGEW 9
           +QRG+W
Sbjct: 137 IQRGQW 142
>XP_005253034
          Length = 1686

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   VQRGEW 9
           +QRG+W
Sbjct: 137 IQRGQW 142
>XP_006714824
          Length = 4349

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4    VQRGEW 9
            +QRG+W
Sbjct: 4039 IQRGDW 4044
>NP_055068
          Length = 2725

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2    SIVQRGEW 9
            + +QRG W
Sbjct: 1852 TFIQRGTW 1859
>NP_001156750
          Length = 2732

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2    SIVQRGEW 9
            + +QRG W
Sbjct: 1859 TFIQRGTW 1866
>NP_001156751
          Length = 2731

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2    SIVQRGEW 9
            + +QRG W
Sbjct: 1858 TFIQRGTW 1865
>NP_064455
          Length = 213

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3  IVQRGEW 9
          ++QRG W
Sbjct: 71 LLQRGSW 77
>XP_006724788
          Length = 2570

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2    SIVQRGEW 9
            + +QRG W
Sbjct: 1697 TFIQRGTW 1704
>NP_000085
          Length = 2944

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   IVQRGE 8
           +VQRGE
Sbjct: 875 VVQRGE 880
>NP_005492
          Length = 1066

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   IVQRGEW 9
           ++QR EW
Sbjct: 226 MIQRKEW 232
>NP_002195
          Length = 1051

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   IVQRGEW 9
           ++QR EW
Sbjct: 226 MIQRKEW 232
>NP_064707
          Length = 362

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2   SIVQRGEW 9
           S+VQ  +W
Sbjct: 103 SLVQHNQW 110
>NP_001257655
          Length = 509

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   IVQRGEW 9
           I+Q+G W
Sbjct: 218 IIQQGGW 224
>NP_055899
          Length = 414

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1 ASIVQRG 7
         ASIV+RG
Sbjct: 3 ASIVRRG 9
>NP_060191
          Length = 951

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   IVQRGEW 9
           I+QR +W
Sbjct: 883 IMQRSQW 889
>NP_975010
          Length = 675

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   IVQRGEW 9
           +VQ G+W
Sbjct: 430 VVQLGKW 436
>NP_001257658
          Length = 323

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3  IVQRGEW 9
          I+Q+G W
Sbjct: 32 IIQQGGW 38
>NP_056182
          Length = 485

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   IVQRGEW 9
           I+Q+G W
Sbjct: 194 IIQQGGW 200
>NP_001257659
          Length = 323

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3  IVQRGEW 9
          I+Q+G W
Sbjct: 32 IIQQGGW 38
>NP_001257660
          Length = 323

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3  IVQRGEW 9
          I+Q+G W
Sbjct: 32 IIQQGGW 38
>NP_851607
          Length = 742

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   SIVQRGE 8
           S+VQRG+
Sbjct: 624 SLVQRGD 630
>NP_653252
          Length = 1463

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    ASIVQRG 7
            A+I+QRG
Sbjct: 1139 ATIIQRG 1145
>NP_006036
          Length = 1047

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   ASIVQRGEW 9
           A IVQ  +W
Sbjct: 575 AGIVQYNDW 583
>NP_001712
          Length = 675

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   IVQRGEW 9
           +VQ G+W
Sbjct: 430 VVQLGKW 436
>NP_065156
          Length = 688

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   SIVQRGE 8
           S+VQRG+
Sbjct: 570 SLVQRGD 576
>NP_001273677
          Length = 428

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1 ASIVQRG 7
         ASIV+RG
Sbjct: 3 ASIVRRG 9
>XP_006724573
          Length = 674

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   IVQRGEW 9
           +VQ G+W
Sbjct: 429 VVQLGKW 435
>XP_006724139
          Length = 323

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3  IVQRGEW 9
          I+Q+G W
Sbjct: 32 IIQQGGW 38
>XP_005260032
          Length = 946

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   IVQRGEW 9
           I+QR +W
Sbjct: 878 IMQRSQW 884
>XP_005260031
          Length = 947

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   IVQRGEW 9
           I+QR +W
Sbjct: 879 IMQRSQW 885
>XP_005260030
          Length = 950

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   IVQRGEW 9
           I+QR +W
Sbjct: 882 IMQRSQW 888
>XP_005260029
          Length = 950

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   IVQRGEW 9
           I+QR +W
Sbjct: 882 IMQRSQW 888
>XP_005257365
          Length = 916

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   IVQRGEW 9
           ++QR EW
Sbjct: 226 MIQRKEW 232
>XP_005251225
          Length = 848

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ASIVQRG 7
           A+I+QRG
Sbjct: 524 ATIIQRG 530
>XP_006716483
          Length = 1367

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    ASIVQRG 7
            A+I+QRG
Sbjct: 1043 ATIIQRG 1049
>XP_005251224
          Length = 1439

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    ASIVQRG 7
            A+I+QRG
Sbjct: 1115 ATIIQRG 1121
>XP_005246155
          Length = 362

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2   SIVQRGEW 9
           S+VQ  +W
Sbjct: 103 SLVQHNQW 110
>XP_006712703
          Length = 362

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2   SIVQRGEW 9
           S+VQ  +W
Sbjct: 103 SLVQHNQW 110
>XP_005246154
          Length = 362

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2   SIVQRGEW 9
           S+VQ  +W
Sbjct: 103 SLVQHNQW 110
>XP_006711529
          Length = 546

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   SIVQRGE 8
           S+VQRG+
Sbjct: 428 SLVQRGD 434
>XP_006711528
          Length = 742

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   SIVQRGE 8
           S+VQRG+
Sbjct: 624 SLVQRGD 630
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.317    0.129    0.438 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 514,673
Number of extensions: 648
Number of successful extensions: 65
Number of sequences better than 10000.0: 65
Number of HSP's gapped: 65
Number of HSP's successfully gapped: 65
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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