Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000042                                                              20     509
XP_006718908                                                           20     509
XP_005271621                                                           20     509
XP_006718907                                                           20     509
XP_006718906                                                           20     509
XP_005271619                                                           20     509
XP_005271618                                                           20     509
NP_065717                                                              17    3301
XP_005266006                                                           17    3301
XP_005266005                                                           17    3301
XP_006714959                                                           17    3301
XP_006714958                                                           17    3301
XP_005266004                                                           17    3301
NP_443137                                                              17    4312
XP_006712292                                                           17    4312
XP_005246323                                                           17    4312
XP_005246322                                                           17    4312
XP_006712291                                                           17    4312
XP_005246320                                                           17    4312
NP_689831                                                              16    7355
NP_004975                                                              16    7355
NP_004513                                                              16    7355
NP_004512                                                              16    7355
NP_001171478                                                           16    7355
NP_057323                                                              16    7355
XP_005256732                                                           16    7355
NP_002854                                                              15    9605
NP_872434                                                              15    9605
XP_006717006                                                           15    9605
XP_006713686                                                           15    9605
XP_006713685                                                           15    9605
XP_006713684                                                           15    9605
XP_006713683                                                           15    9605
XP_006713682                                                           15    9605
XP_006713681                                                           15    9605
XP_006713680                                                           15    9605
XP_005247488                                                           15    9605
XP_005275805                                                           15    9605
NP_001004701                                                           15    9605
>NP_000042
          Length = 3056

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    ARTLKNTQL 9
            ART KNTQL
Sbjct: 2262 ARTFKNTQL 2270
>XP_006718908
          Length = 1708

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ARTLKNTQL 9
           ART KNTQL
Sbjct: 914 ARTFKNTQL 922
>XP_005271621
          Length = 2708

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    ARTLKNTQL 9
            ART KNTQL
Sbjct: 1914 ARTFKNTQL 1922
>XP_006718907
          Length = 3050

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    ARTLKNTQL 9
            ART KNTQL
Sbjct: 2256 ARTFKNTQL 2264
>XP_006718906
          Length = 3056

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    ARTLKNTQL 9
            ART KNTQL
Sbjct: 2262 ARTFKNTQL 2270
>XP_005271619
          Length = 3056

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    ARTLKNTQL 9
            ART KNTQL
Sbjct: 2262 ARTFKNTQL 2270
>XP_005271618
          Length = 3056

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    ARTLKNTQL 9
            ART KNTQL
Sbjct: 2262 ARTFKNTQL 2270
>NP_065717
          Length = 481

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RTLKNTQL 9
           RTLKNT +
Sbjct: 312 RTLKNTDI 319
>XP_005266006
          Length = 301

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RTLKNTQL 9
           RTLKNT +
Sbjct: 132 RTLKNTDI 139
>XP_005266005
          Length = 301

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RTLKNTQL 9
           RTLKNT +
Sbjct: 132 RTLKNTDI 139
>XP_006714959
          Length = 445

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RTLKNTQL 9
           RTLKNT +
Sbjct: 276 RTLKNTDI 283
>XP_006714958
          Length = 445

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RTLKNTQL 9
           RTLKNT +
Sbjct: 276 RTLKNTDI 283
>XP_005266004
          Length = 484

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RTLKNTQL 9
           RTLKNT +
Sbjct: 315 RTLKNTDI 322
>NP_443137
          Length = 1092

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   RTLKNTQL 9
           RTLKN++L
Sbjct: 207 RTLKNSRL 214
>XP_006712292
          Length = 641

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   RTLKNTQL 9
           RTLKN++L
Sbjct: 207 RTLKNSRL 214
>XP_005246323
          Length = 1069

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   RTLKNTQL 9
           RTLKN++L
Sbjct: 207 RTLKNSRL 214
>XP_005246322
          Length = 1084

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   RTLKNTQL 9
           RTLKN++L
Sbjct: 207 RTLKNSRL 214
>XP_006712291
          Length = 1086

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   RTLKNTQL 9
           RTLKN++L
Sbjct: 207 RTLKNSRL 214
>XP_005246320
          Length = 1087

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   RTLKNTQL 9
           RTLKN++L
Sbjct: 207 RTLKNSRL 214
>NP_689831
          Length = 710

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ARTLKNTQL 9
           +RTLKN+ L
Sbjct: 213 SRTLKNSLL 221
>NP_004975
          Length = 1032

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ARTLKNT 7
           A+T+KNT
Sbjct: 324 AKTIKNT 330
>NP_004513
          Length = 957

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ARTLKNT 7
           A+T+KNT
Sbjct: 324 AKTIKNT 330
>NP_004512
          Length = 963

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ARTLKNT 7
           A+T+KNT
Sbjct: 322 AKTIKNT 328
>NP_001171478
          Length = 710

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ARTLKNTQL 9
           +RTLKN+ L
Sbjct: 213 SRTLKNSLL 221
>NP_057323
          Length = 3530

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    ARTLKNTQL 9
            ARTL  TQL
Sbjct: 2203 ARTLPPTQL 2211
>XP_005256732
          Length = 3531

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    ARTLKNTQL 9
            ARTL  TQL
Sbjct: 2204 ARTLPPTQL 2212
>NP_002854
          Length = 847

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RTLKNTQL 9
           RTL+NT +
Sbjct: 94  RTLQNTMI 101
>NP_872434
          Length = 611

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ARTLKNTQL 9
           + TLK+TQ+
Sbjct: 419 SHTLKHTQI 427
>XP_006717006
          Length = 1760

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  RTLKNTQL 9
          RTLKN+ L
Sbjct: 15 RTLKNSLL 22
>XP_006713686
          Length = 611

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ARTLKNTQL 9
           + TLK+TQ+
Sbjct: 419 SHTLKHTQI 427
>XP_006713685
          Length = 612

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ARTLKNTQL 9
           + TLK+TQ+
Sbjct: 420 SHTLKHTQI 428
>XP_006713684
          Length = 612

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ARTLKNTQL 9
           + TLK+TQ+
Sbjct: 420 SHTLKHTQI 428
>XP_006713683
          Length = 612

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ARTLKNTQL 9
           + TLK+TQ+
Sbjct: 420 SHTLKHTQI 428
>XP_006713682
          Length = 612

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ARTLKNTQL 9
           + TLK+TQ+
Sbjct: 420 SHTLKHTQI 428
>XP_006713681
          Length = 612

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ARTLKNTQL 9
           + TLK+TQ+
Sbjct: 420 SHTLKHTQI 428
>XP_006713680
          Length = 612

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ARTLKNTQL 9
           + TLK+TQ+
Sbjct: 420 SHTLKHTQI 428
>XP_005247488
          Length = 612

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ARTLKNTQL 9
           + TLK+TQ+
Sbjct: 420 SHTLKHTQI 428
>XP_005275805
          Length = 309

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  RTLKNTQ 8
          RTL NTQ
Sbjct: 39 RTLGNTQ 45
>NP_001004701
          Length = 310

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   TLKNTQL 9
           TLKNT++
Sbjct: 286 TLKNTEV 292
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.313    0.119    0.292 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 383,433
Number of extensions: 521
Number of successful extensions: 39
Number of sequences better than 10000.0: 39
Number of HSP's gapped: 39
Number of HSP's successfully gapped: 39
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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