Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005179                                                              19     869
NP_004044                                                              18    1935
XP_006716415                                                           17    3301
NP_057696                                                              17    3301
NP_115575                                                              17    4312
NP_001231567                                                           17    4312
XP_005252695                                                           17    4312
NP_006014                                                              17    4312
NP_115813                                                              16    5631
NP_000776                                                              16    5631
NP_001269612                                                           16    5631
NP_114403                                                              16    5631
NP_079011                                                              16    5631
XP_005271331                                                           16    5631
XP_006711040                                                           16    5631
XP_006711039                                                           16    5631
NP_079255                                                              16    7355
NP_001007526                                                           16    7355
NP_001277284                                                           16    7355
NP_001106203                                                           16    7355
XP_005268373                                                           16    7355
XP_005268372                                                           16    7355
XP_005268371                                                           16    7355
XP_006720031                                                           16    7355
XP_005268370                                                           16    7355
XP_006720030                                                           16    7355
XP_005268369                                                           16    7355
XP_006720029                                                           16    7355
XP_005268367                                                           16    7355
XP_005268366                                                           16    7355
XP_005268365                                                           16    7355
XP_005268364                                                           16    7355
XP_006714304                                                           16    7355
NP_001013716                                                           16    7355
NP_085131                                                              16    7355
NP_006230                                                              16    7355
NP_060485                                                              15    9605
NP_001171711                                                           15    9605
NP_001274509                                                           15    9605
NP_653184                                                              15    9605
NP_073210                                                              15    9605
NP_001034451                                                           15    9605
NP_071411                                                              15    9605
NP_001166094                                                           15    9605
NP_002490                                                              15    9605
XP_006726466                                                           15    9605
XP_006724394                                                           15    9605
XP_006724393                                                           15    9605
XP_006724392                                                           15    9605
XP_005261339                                                           15    9605
XP_005254473                                                           15    9605
XP_005254472                                                           15    9605
XP_005254471                                                           15    9605
XP_005254470                                                           15    9605
XP_005254469                                                           15    9605
XP_005254468                                                           15    9605
XP_005254467                                                           15    9605
XP_005254465                                                           15    9605
XP_006712969                                                           15    9605
XP_006710208                                                           15    9605
NP_001166095                                                           15    9605
>NP_005179
          Length = 906

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   ARRTLSDI 8
           ARRTLSDI
Sbjct: 786 ARRTLSDI 793
>NP_004044
          Length = 437

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   ARRTLSDI 8
           ARRTL+DI
Sbjct: 143 ARRTLADI 150
>XP_006716415
          Length = 266

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  RRTLSDIF 9
          +RTL+D+F
Sbjct: 57 KRTLNDVF 64
>NP_057696
          Length = 338

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   RRTLSDIF 9
           +RTL+D+F
Sbjct: 129 KRTLNDVF 136
>NP_115575
          Length = 1188

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   RRTLSDIF 9
           R+T++DIF
Sbjct: 766 RKTINDIF 773
>NP_001231567
          Length = 945

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   RRTLSDIF 9
           R+T++DIF
Sbjct: 523 RKTINDIF 530
>XP_005252695
          Length = 304

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  RTLSDIF 9
          +TLSDIF
Sbjct: 93 KTLSDIF 99
>NP_006014
          Length = 336

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   RTLSDIF 9
           +TLSDIF
Sbjct: 125 KTLSDIF 131
>NP_115813
          Length = 629

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RRTLSDIF 9
           + TLSDIF
Sbjct: 405 KSTLSDIF 412
>NP_000776
          Length = 508

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  ARRTLSDI 8
          ARR+L+DI
Sbjct: 33 ARRSLADI 40
>NP_001269612
          Length = 367

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  RTLSDIF 9
          RTL DIF
Sbjct: 84 RTLEDIF 90
>NP_114403
          Length = 167

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  ARRTLSDIF 9
          A RT+ D+F
Sbjct: 83 AERTVEDVF 91
>NP_079011
          Length = 539

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   RTLSDIF 9
           RTL DIF
Sbjct: 256 RTLEDIF 262
>XP_005271331
          Length = 606

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RRTLSDIF 9
           + TLSDIF
Sbjct: 405 KSTLSDIF 412
>XP_006711040
          Length = 629

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RRTLSDIF 9
           + TLSDIF
Sbjct: 405 KSTLSDIF 412
>XP_006711039
          Length = 642

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RRTLSDIF 9
           + TLSDIF
Sbjct: 418 KSTLSDIF 425
>NP_079255
          Length = 1123

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RRTLSDI 8
           +RTLSDI
Sbjct: 141 QRTLSDI 147
>NP_001007526
          Length = 1432

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ARRTLSDI 8
           ARRTLS +
Sbjct: 511 ARRTLSPV 518
>NP_001277284
          Length = 1429

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ARRTLSDI 8
           ARRTLS +
Sbjct: 376 ARRTLSPV 383
>NP_001106203
          Length = 1125

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RRTLSDI 8
           +RTLSDI
Sbjct: 143 QRTLSDI 149
>XP_005268373
          Length = 984

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RRTLSDI 8
           +RTLSDI
Sbjct: 141 QRTLSDI 147
>XP_005268372
          Length = 1043

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RRTLSDI 8
           +RTLSDI
Sbjct: 200 QRTLSDI 206
>XP_005268371
          Length = 1067

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RRTLSDI 8
           +RTLSDI
Sbjct: 147 QRTLSDI 153
>XP_006720031
          Length = 1080

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  RRTLSDI 8
          +RTLSDI
Sbjct: 73 QRTLSDI 79
>XP_005268370
          Length = 1112

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RRTLSDI 8
           +RTLSDI
Sbjct: 105 QRTLSDI 111
>XP_006720030
          Length = 1128

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RRTLSDI 8
           +RTLSDI
Sbjct: 121 QRTLSDI 127
>XP_005268369
          Length = 1132

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RRTLSDI 8
           +RTLSDI
Sbjct: 125 QRTLSDI 131
>XP_006720029
          Length = 1150

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RRTLSDI 8
           +RTLSDI
Sbjct: 143 QRTLSDI 149
>XP_005268367
          Length = 1154

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RRTLSDI 8
           +RTLSDI
Sbjct: 147 QRTLSDI 153
>XP_005268366
          Length = 1180

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RRTLSDI 8
           +RTLSDI
Sbjct: 173 QRTLSDI 179
>XP_005268365
          Length = 1182

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RRTLSDI 8
           +RTLSDI
Sbjct: 200 QRTLSDI 206
>XP_005268364
          Length = 1207

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RRTLSDI 8
           +RTLSDI
Sbjct: 200 QRTLSDI 206
>XP_006714304
          Length = 598

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   RTLSDIF 9
           RTL D+F
Sbjct: 269 RTLQDVF 275
>NP_001013716
          Length = 339

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   TLSDIF 9
           TLSDIF
Sbjct: 103 TLSDIF 108
>NP_085131
          Length = 1019

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ARRTLSDIF 9
           A RTL DI+
Sbjct: 185 ATRTLMDIY 193
>NP_006230
          Length = 753

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   RTLSDIF 9
           RTL D+F
Sbjct: 269 RTLQDVF 275
>NP_060485
          Length = 855

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ARRTLSD 7
           AR+T+SD
Sbjct: 672 ARKTISD 678
>NP_001171711
          Length = 758

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ARRTLSD 7
           AR+T+SD
Sbjct: 575 ARKTISD 581
>NP_001274509
          Length = 255

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TLSDIF 9
           TLSD+F
Sbjct: 124 TLSDVF 129
>NP_653184
          Length = 381

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   RTLSDI 8
           RTLSDI
Sbjct: 163 RTLSDI 168
>NP_073210
          Length = 476

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   ARRTLSDIF 9
           ARR  SD F
Sbjct: 468 ARRKASDFF 476
>NP_001034451
          Length = 427

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   RTLSDI 8
           RTLSDI
Sbjct: 163 RTLSDI 168
>NP_071411
          Length = 322

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TLSDIF 9
           TLSD+F
Sbjct: 191 TLSDVF 196
>NP_001166094
          Length = 1408

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ARRTLSDI 8
           A RTLSD+
Sbjct: 625 AVRTLSDV 632
>NP_002490
          Length = 1461

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ARRTLSDI 8
           A RTLSD+
Sbjct: 625 AVRTLSDV 632
>XP_006726466
          Length = 1310

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   ARRTLSD 7
           ARR LSD
Sbjct: 724 ARRALSD 730
>XP_006724394
          Length = 397

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   ARRTLSDIF 9
           ARR  SD F
Sbjct: 389 ARRKASDFF 397
>XP_006724393
          Length = 398

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   ARRTLSDIF 9
           ARR  SD F
Sbjct: 390 ARRKASDFF 398
>XP_006724392
          Length = 398

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   ARRTLSDIF 9
           ARR  SD F
Sbjct: 390 ARRKASDFF 398
>XP_005261339
          Length = 477

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   ARRTLSDIF 9
           ARR  SD F
Sbjct: 469 ARRKASDFF 477
>XP_005254473
          Length = 1408

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ARRTLSDI 8
           A RTLSD+
Sbjct: 625 AVRTLSDV 632
>XP_005254472
          Length = 1428

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ARRTLSDI 8
           A RTLSD+
Sbjct: 645 AVRTLSDV 652
>XP_005254471
          Length = 1450

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ARRTLSDI 8
           A RTLSD+
Sbjct: 625 AVRTLSDV 632
>XP_005254470
          Length = 1454

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ARRTLSDI 8
           A RTLSD+
Sbjct: 645 AVRTLSDV 652
>XP_005254469
          Length = 1461

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ARRTLSDI 8
           A RTLSD+
Sbjct: 625 AVRTLSDV 632
>XP_005254468
          Length = 1465

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ARRTLSDI 8
           A RTLSD+
Sbjct: 645 AVRTLSDV 652
>XP_005254467
          Length = 1470

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ARRTLSDI 8
           A RTLSD+
Sbjct: 645 AVRTLSDV 652
>XP_005254465
          Length = 1481

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ARRTLSDI 8
           A RTLSD+
Sbjct: 645 AVRTLSDV 652
>XP_006712969
          Length = 1310

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   ARRTLSD 7
           ARR LSD
Sbjct: 724 ARRALSD 730
>XP_006710208
          Length = 666

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  ARRTLSD 7
          ARR LSD
Sbjct: 80 ARRALSD 86
>NP_001166095
          Length = 1450

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ARRTLSDI 8
           A RTLSD+
Sbjct: 625 AVRTLSDV 632
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.338    0.143    0.388 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 385,796
Number of extensions: 655
Number of successful extensions: 61
Number of sequences better than 10000.0: 61
Number of HSP's gapped: 61
Number of HSP's successfully gapped: 61
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.5 bits)
S2: 28 (15.4 bits)

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