Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004110                                                              21     229
NP_000213                                                              20     390
NP_001087241                                                           20     390
XP_005265799                                                           20     390
XP_005265798                                                           20     390
XP_005265797                                                           20     390
NP_938056                                                              19     869
NP_001243543                                                           19     869
NP_938055                                                              19     869
NP_001243542                                                           19     869
NP_872395                                                              19     869
XP_005247433                                                           19     869
NP_005202                                                              18    1935
NP_001275634                                                           18    1935
NP_000042                                                              16    5631
NP_001073936                                                           16    5631
XP_006718908                                                           16    5631
XP_005271621                                                           16    5631
XP_006718907                                                           16    5631
XP_006718906                                                           16    5631
XP_005271619                                                           16    5631
XP_005271618                                                           16    5631
NP_001107854                                                           16    7355
NP_001070651                                                           16    7355
NP_000539                                                              16    7355
NP_055692                                                              16    7355
XP_006722279                                                           16    7355
XP_006722278                                                           16    7355
XP_005257947                                                           16    7355
XP_005257946                                                           16    7355
XP_005257945                                                           16    7355
XP_006722277                                                           16    7355
XP_005255589                                                           16    7355
XP_005255588                                                           16    7355
XP_005255587                                                           16    7355
XP_005255586                                                           16    7355
XP_005255585                                                           16    7355
XP_005255584                                                           16    7355
XP_006715729                                                           16    7355
XP_006715728                                                           16    7355
XP_006715727                                                           16    7355
XP_006715726                                                           16    7355
NP_872352                                                              16    7355
NP_005674                                                              15    9605
NP_002323                                                              15    9605
NP_001191742                                                           15    9605
NP_002517                                                              15    9605
NP_777577                                                              15    9605
NP_001230208                                                           15    9605
NP_001271245                                                           15    9605
NP_036367                                                              15    9605
NP_001120686                                                           15    9605
XP_005265024                                                           15    9605
XP_006713097                                                           15    9605
XP_005247009                                                           15    9605
>NP_004110
          Length = 993

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ARNVLATHG 9
           ARNVL THG
Sbjct: 814 ARNVLVTHG 822
>NP_000213
          Length = 976

 Score = 20.0 bits (40), Expect =   390
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   ARNVLATHG 9
           ARN+L THG
Sbjct: 795 ARNILLTHG 803
>NP_001087241
          Length = 972

 Score = 20.0 bits (40), Expect =   390
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   ARNVLATHG 9
           ARN+L THG
Sbjct: 791 ARNILLTHG 799
>XP_005265799
          Length = 973

 Score = 20.0 bits (40), Expect =   390
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   ARNVLATHG 9
           ARN+L THG
Sbjct: 792 ARNILLTHG 800
>XP_005265798
          Length = 976

 Score = 20.0 bits (40), Expect =   390
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   ARNVLATHG 9
           ARN+L THG
Sbjct: 795 ARNILLTHG 803
>XP_005265797
          Length = 977

 Score = 20.0 bits (40), Expect =   390
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   ARNVLATHG 9
           ARN+L THG
Sbjct: 796 ARNILLTHG 804
>NP_938056
          Length = 456

 Score = 18.9 bits (37), Expect =   869
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ARNVLATHG 9
           +RN+L THG
Sbjct: 205 SRNILQTHG 213
>NP_001243543
          Length = 482

 Score = 18.9 bits (37), Expect =   869
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ARNVLATHG 9
           +RN+L THG
Sbjct: 231 SRNILQTHG 239
>NP_938055
          Length = 441

 Score = 18.9 bits (37), Expect =   869
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ARNVLATHG 9
           +RN+L THG
Sbjct: 190 SRNILQTHG 198
>NP_001243542
          Length = 456

 Score = 18.9 bits (37), Expect =   869
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ARNVLATHG 9
           +RN+L THG
Sbjct: 205 SRNILQTHG 213
>NP_872395
          Length = 471

 Score = 18.9 bits (37), Expect =   869
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ARNVLATHG 9
           +RN+L THG
Sbjct: 220 SRNILQTHG 228
>XP_005247433
          Length = 374

 Score = 18.9 bits (37), Expect =   869
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ARNVLATHG 9
           +RN+L THG
Sbjct: 134 SRNILQTHG 142
>NP_005202
          Length = 972

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   ARNVLATHG 9
           ARNVL T+G
Sbjct: 781 ARNVLLTNG 789
>NP_001275634
          Length = 972

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   ARNVLATHG 9
           ARNVL T+G
Sbjct: 781 ARNVLLTNG 789
>NP_000042
          Length = 3056

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    RNVLATH 8
            RN+L+TH
Sbjct: 1859 RNLLSTH 1865
>NP_001073936
          Length = 1848

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   ARNVLATH 8
           ARN LA H
Sbjct: 400 ARNALAKH 407
>XP_006718908
          Length = 1708

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RNVLATH 8
           RN+L+TH
Sbjct: 511 RNLLSTH 517
>XP_005271621
          Length = 2708

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    RNVLATH 8
            RN+L+TH
Sbjct: 1511 RNLLSTH 1517
>XP_006718907
          Length = 3050

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    RNVLATH 8
            RN+L+TH
Sbjct: 1853 RNLLSTH 1859
>XP_006718906
          Length = 3056

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    RNVLATH 8
            RN+L+TH
Sbjct: 1859 RNLLSTH 1865
>XP_005271619
          Length = 3056

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    RNVLATH 8
            RN+L+TH
Sbjct: 1859 RNLLSTH 1865
>XP_005271618
          Length = 3056

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    RNVLATH 8
            RN+L+TH
Sbjct: 1859 RNLLSTH 1865
>NP_001107854
          Length = 1784

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   RNVLATH 8
           RN+L TH
Sbjct: 261 RNLLGTH 267
>NP_001070651
          Length = 1740

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   RNVLATH 8
           RN+L TH
Sbjct: 261 RNLLGTH 267
>NP_000539
          Length = 1807

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   RNVLATH 8
           RN+L TH
Sbjct: 261 RNLLGTH 267
>NP_055692
          Length = 1942

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    NVLATHG 9
            N+L THG
Sbjct: 1238 NLLQTHG 1244
>XP_006722279
          Length = 1578

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   NVLATHG 9
           N+L THG
Sbjct: 874 NLLQTHG 880
>XP_006722278
          Length = 1735

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    NVLATHG 9
            N+L THG
Sbjct: 1031 NLLQTHG 1037
>XP_005257947
          Length = 1935

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    NVLATHG 9
            N+L THG
Sbjct: 1231 NLLQTHG 1237
>XP_005257946
          Length = 1943

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    NVLATHG 9
            N+L THG
Sbjct: 1239 NLLQTHG 1245
>XP_005257945
          Length = 1969

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    NVLATHG 9
            N+L THG
Sbjct: 1265 NLLQTHG 1271
>XP_006722277
          Length = 1970

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    NVLATHG 9
            N+L THG
Sbjct: 1266 NLLQTHG 1272
>XP_005255589
          Length = 1831

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   RNVLATH 8
           RN+L TH
Sbjct: 352 RNLLGTH 358
>XP_005255588
          Length = 1832

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   RNVLATH 8
           RN+L TH
Sbjct: 352 RNLLGTH 358
>XP_005255587
          Length = 1854

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   RNVLATH 8
           RN+L TH
Sbjct: 352 RNLLGTH 358
>XP_005255586
          Length = 1855

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   RNVLATH 8
           RN+L TH
Sbjct: 352 RNLLGTH 358
>XP_005255585
          Length = 1875

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   RNVLATH 8
           RN+L TH
Sbjct: 352 RNLLGTH 358
>XP_005255584
          Length = 1898

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   RNVLATH 8
           RN+L TH
Sbjct: 352 RNLLGTH 358
>XP_006715729
          Length = 226

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  RNVLATHG 9
          RNV AT G
Sbjct: 34 RNVTATEG 41
>XP_006715728
          Length = 228

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  RNVLATHG 9
          RNV AT G
Sbjct: 34 RNVTATEG 41
>XP_006715727
          Length = 240

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  RNVLATHG 9
          RNV AT G
Sbjct: 34 RNVTATEG 41
>XP_006715726
          Length = 309

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  RNVLATHG 9
          RNV AT G
Sbjct: 34 RNVTATEG 41
>NP_872352
          Length = 236

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  RNVLATHG 9
          RNV AT G
Sbjct: 34 RNVTATEG 41
>NP_005674
          Length = 319

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  NVLATHG 9
          N+LA HG
Sbjct: 38 NLLAIHG 44
>NP_002323
          Length = 4544

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    ARNVLATH 8
            ARN + TH
Sbjct: 3850 ARNFMKTH 3857
>NP_001191742
          Length = 524

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   NVLATHG 9
           NV+++HG
Sbjct: 299 NVISSHG 305
>NP_002517
          Length = 574

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   NVLATHG 9
           NV+++HG
Sbjct: 299 NVISSHG 305
>NP_777577
          Length = 576

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ARNVLATH 8
           ARNVLA +
Sbjct: 537 ARNVLAPY 544
>NP_001230208
          Length = 576

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ARNVLATH 8
           ARNVLA +
Sbjct: 537 ARNVLAPY 544
>NP_001271245
          Length = 311

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ARNVLATH 8
           ARNVLA +
Sbjct: 272 ARNVLAPY 279
>NP_036367
          Length = 1279

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   RNVLATHG 9
           RN+L  HG
Sbjct: 161 RNLLPEHG 168
>NP_001120686
          Length = 576

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ARNVLATH 8
           ARNVLA +
Sbjct: 537 ARNVLAPY 544
>XP_005265024
          Length = 1278

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   RNVLATHG 9
           RN+L  HG
Sbjct: 161 RNLLPEHG 168
>XP_006713097
          Length = 1279

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   RNVLATHG 9
           RN+L  HG
Sbjct: 161 RNLLPEHG 168
>XP_005247009
          Length = 319

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  NVLATHG 9
          N+LA HG
Sbjct: 38 NLLAIHG 44
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.320    0.128    0.373 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 486,770
Number of extensions: 801
Number of successful extensions: 55
Number of sequences better than 10000.0: 55
Number of HSP's gapped: 55
Number of HSP's successfully gapped: 55
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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