Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_006715                                                              19     869
NP_005913                                                              19     869
XP_005267046                                                           19     869
XP_005267045                                                           19     869
NP_001229285                                                           17    3301
NP_001229286                                                           17    3301
NP_004820                                                              17    3301
NP_001138929                                                           17    3301
NP_001138930                                                           17    3301
NP_065194                                                              16    5631
NP_001128360                                                           16    5631
NP_443070                                                              16    5631
NP_958815                                                              16    7355
XP_005255486                                                           16    7355
XP_005255485                                                           16    7355
XP_005255484                                                           16    7355
XP_006720966                                                           16    7355
NP_689935                                                              15    9605
NP_001139281                                                           15    9605
NP_001077422                                                           15    9605
NP_001070654                                                           15    9605
NP_079005                                                              15    9605
NP_071348                                                              15    9605
XP_006726466                                                           15    9605
XP_006723449                                                           15    9605
XP_005271506                                                           15    9605
XP_006718849                                                           15    9605
XP_006712969                                                           15    9605
XP_006712132                                                           15    9605
XP_006712131                                                           15    9605
XP_006712130                                                           15    9605
XP_006712129                                                           15    9605
XP_006712128                                                           15    9605
XP_006712127                                                           15    9605
XP_006712126                                                           15    9605
XP_006712125                                                           15    9605
XP_006712124                                                           15    9605
XP_005275995                                                           15    9605
>NP_006715
          Length = 1558

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ARERASRAL 9
           ARERAS+AL
Sbjct: 808 ARERASKAL 816
>NP_005913
          Length = 1608

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ARERASRAL 9
           ARERAS+AL
Sbjct: 808 ARERASKAL 816
>XP_005267046
          Length = 1554

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ARERASRAL 9
           ARERAS+AL
Sbjct: 808 ARERASKAL 816
>XP_005267045
          Length = 1604

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ARERASRAL 9
           ARERAS+AL
Sbjct: 808 ARERASKAL 816
>NP_001229285
          Length = 209

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   RERASRA 8
           RERASRA
Sbjct: 189 RERASRA 195
>NP_001229286
          Length = 192

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   RERASRA 8
           RERASRA
Sbjct: 172 RERASRA 178
>NP_004820
          Length = 304

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   RERASRA 8
           RERASRA
Sbjct: 284 RERASRA 290
>NP_001138929
          Length = 303

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   RERASRA 8
           RERASRA
Sbjct: 283 RERASRA 289
>NP_001138930
          Length = 287

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   RERASRA 8
           RERASRA
Sbjct: 267 RERASRA 273
>NP_065194
          Length = 1819

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   ARERASRAL 9
           ARE ASR L
Sbjct: 676 AREAASRVL 684
>NP_001128360
          Length = 1358

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1    ARERASRAL 9
            +RE+A+RAL
Sbjct: 1310 SREQAARAL 1318
>NP_443070
          Length = 414

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   ARERASRA 8
           AR+RASR+
Sbjct: 349 ARDRASRS 356
>NP_958815
          Length = 371

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   ARERASR 7
           +RERASR
Sbjct: 327 SRERASR 333
>XP_005255486
          Length = 285

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   ARERASR 7
           +RERASR
Sbjct: 241 SRERASR 247
>XP_005255485
          Length = 285

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   ARERASR 7
           +RERASR
Sbjct: 241 SRERASR 247
>XP_005255484
          Length = 318

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   ARERASR 7
           +RERASR
Sbjct: 274 SRERASR 280
>XP_006720966
          Length = 318

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   ARERASR 7
           +RERASR
Sbjct: 274 SRERASR 280
>NP_689935
          Length = 416

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  ARERASRAL 9
          A  RASRAL
Sbjct: 7  ALSRASRAL 15
>NP_001139281
          Length = 2036

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    RERASRAL 9
            RER +RAL
Sbjct: 1537 REREARAL 1544
>NP_001077422
          Length = 1953

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    ARERASRAL 9
            +RE A+RAL
Sbjct: 1362 SREMAARAL 1370
>NP_001070654
          Length = 2003

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    RERASRAL 9
            RER +RAL
Sbjct: 1504 REREARAL 1511
>NP_079005
          Length = 1995

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    RERASRAL 9
            RER +RAL
Sbjct: 1496 REREARAL 1503
>NP_071348
          Length = 1953

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    ARERASRAL 9
            +RE A+RAL
Sbjct: 1362 SREMAARAL 1370
>XP_006726466
          Length = 1310

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RERASRAL 9
           RER+ RAL
Sbjct: 135 RERSCRAL 142
>XP_006723449
          Length = 2003

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    RERASRAL 9
            RER +RAL
Sbjct: 1504 REREARAL 1511
>XP_005271506
          Length = 415

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  ARERASRAL 9
          A  RASRAL
Sbjct: 7  ALSRASRAL 15
>XP_006718849
          Length = 423

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  ARERASRAL 9
          A  RASRAL
Sbjct: 7  ALSRASRAL 15
>XP_006712969
          Length = 1310

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RERASRAL 9
           RER+ RAL
Sbjct: 135 RERSCRAL 142
>XP_006712132
          Length = 1136

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ARERASRAL 9
           +RE A+RAL
Sbjct: 545 SREMAARAL 553
>XP_006712131
          Length = 1453

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    ARERASRAL 9
            +RE A+RAL
Sbjct: 1362 SREMAARAL 1370
>XP_006712130
          Length = 1831

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    ARERASRAL 9
            +RE A+RAL
Sbjct: 1240 SREMAARAL 1248
>XP_006712129
          Length = 1832

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    ARERASRAL 9
            +RE A+RAL
Sbjct: 1241 SREMAARAL 1249
>XP_006712128
          Length = 1879

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    ARERASRAL 9
            +RE A+RAL
Sbjct: 1288 SREMAARAL 1296
>XP_006712127
          Length = 1909

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    ARERASRAL 9
            +RE A+RAL
Sbjct: 1362 SREMAARAL 1370
>XP_006712126
          Length = 1913

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    ARERASRAL 9
            +RE A+RAL
Sbjct: 1322 SREMAARAL 1330
>XP_006712125
          Length = 1952

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    ARERASRAL 9
            +RE A+RAL
Sbjct: 1361 SREMAARAL 1369
>XP_006712124
          Length = 1953

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    ARERASRAL 9
            +RE A+RAL
Sbjct: 1362 SREMAARAL 1370
>XP_005275995
          Length = 488

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RERASRAL 9
           RER+ RAL
Sbjct: 135 RERSCRAL 142
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.321    0.119    0.280 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 293,954
Number of extensions: 290
Number of successful extensions: 38
Number of sequences better than 10000.0: 38
Number of HSP's gapped: 38
Number of HSP's successfully gapped: 38
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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