Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001261                                                              19     665
XP_005271924                                                           19     665
XP_005271923                                                           19     665
NP_001379                                                              18    1482
XP_006721531                                                           18    1482
XP_005256556                                                           18    1482
NP_004138                                                              18    1482
NP_001243481                                                           16    5631
NP_078884                                                              16    5631
XP_006720745                                                           16    5631
XP_005254716                                                           16    5631
XP_006720744                                                           16    5631
XP_006720743                                                           16    5631
XP_006720742                                                           16    5631
XP_006720741                                                           16    5631
XP_006720740                                                           16    5631
NP_060800                                                              15    9605
NP_001120683                                                           15    9605
NP_055895                                                              15    9605
NP_620060                                                              15    9605
NP_620063                                                              15    9605
NP_001245227                                                           15    9605
NP_001245228                                                           15    9605
NP_001245229                                                           15    9605
XP_006718812                                                           15    9605
XP_005274463                                                           15    9605
XP_006718811                                                           15    9605
XP_006718810                                                           15    9605
XP_006718809                                                           15    9605
XP_006718808                                                           15    9605
XP_006718807                                                           15    9605
XP_006718806                                                           15    9605
XP_006718805                                                           15    9605
XP_005274459                                                           15    9605
XP_005274458                                                           15    9605
XP_005274457                                                           15    9605
XP_005270059                                                           15    9605
XP_006717994                                                           15    9605
NP_005314                                                              15    9605
>NP_001261
          Length = 1710

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    ARAKKNKA 8
            ARAKKNKA
Sbjct: 1334 ARAKKNKA 1341
>XP_005271924
          Length = 1710

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    ARAKKNKA 8
            ARAKKNKA
Sbjct: 1334 ARAKKNKA 1341
>XP_005271923
          Length = 1798

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    ARAKKNKA 8
            ARAKKNKA
Sbjct: 1334 ARAKKNKA 1341
>NP_001379
          Length = 364

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  ARAKKNKAT 9
          AR +KNKAT
Sbjct: 15 ARTQKNKAT 23
>XP_006721531
          Length = 312

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  ARAKKNKAT 9
          AR +KNKAT
Sbjct: 15 ARTQKNKAT 23
>XP_005256556
          Length = 385

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  ARAKKNKAT 9
          AR +KNKAT
Sbjct: 15 ARTQKNKAT 23
>NP_004138
          Length = 367

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  ARAKKNKAT 9
          AR +KNKAT
Sbjct: 16 ARTQKNKAT 24
>NP_001243481
          Length = 476

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ARAKKNKAT 9
           +R KK+KAT
Sbjct: 381 SRKKKSKAT 389
>NP_078884
          Length = 390

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ARAKKNKAT 9
           +R KK+KAT
Sbjct: 295 SRKKKSKAT 303
>XP_006720745
          Length = 390

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ARAKKNKAT 9
           +R KK+KAT
Sbjct: 295 SRKKKSKAT 303
>XP_005254716
          Length = 390

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ARAKKNKAT 9
           +R KK+KAT
Sbjct: 295 SRKKKSKAT 303
>XP_006720744
          Length = 390

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ARAKKNKAT 9
           +R KK+KAT
Sbjct: 295 SRKKKSKAT 303
>XP_006720743
          Length = 390

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ARAKKNKAT 9
           +R KK+KAT
Sbjct: 295 SRKKKSKAT 303
>XP_006720742
          Length = 433

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ARAKKNKAT 9
           +R KK+KAT
Sbjct: 338 SRKKKSKAT 346
>XP_006720741
          Length = 436

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ARAKKNKAT 9
           +R KK+KAT
Sbjct: 341 SRKKKSKAT 349
>XP_006720740
          Length = 467

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ARAKKNKAT 9
           +R KK+KAT
Sbjct: 372 SRKKKSKAT 380
>NP_060800
          Length = 456

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   AKKNKAT 9
           AKK KAT
Sbjct: 388 AKKEKAT 394
>NP_001120683
          Length = 631

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   AKKNKAT 9
           AKK KAT
Sbjct: 388 AKKEKAT 394
>NP_055895
          Length = 1712

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    ARAKKNK 7
            ++AKKNK
Sbjct: 1700 SKAKKNK 1706
>NP_620060
          Length = 1642

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    ARAKKNK 7
            ++AKKNK
Sbjct: 1630 SKAKKNK 1636
>NP_620063
          Length = 666

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ARAKKNK 7
           ++AKKNK
Sbjct: 654 SKAKKNK 660
>NP_001245227
          Length = 571

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   AKKNKAT 9
           AKK KAT
Sbjct: 328 AKKEKAT 334
>NP_001245228
          Length = 558

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   AKKNKAT 9
           AKK KAT
Sbjct: 388 AKKEKAT 394
>NP_001245229
          Length = 498

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   AKKNKAT 9
           AKK KAT
Sbjct: 328 AKKEKAT 334
>XP_006718812
          Length = 1226

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    ARAKKNK 7
            ++AKKNK
Sbjct: 1214 SKAKKNK 1220
>XP_005274463
          Length = 974

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ARAKKNK 7
           ++AKKNK
Sbjct: 962 SKAKKNK 968
>XP_006718811
          Length = 1420

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    ARAKKNK 7
            ++AKKNK
Sbjct: 1408 SKAKKNK 1414
>XP_006718810
          Length = 1450

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    ARAKKNK 7
            ++AKKNK
Sbjct: 1438 SKAKKNK 1444
>XP_006718809
          Length = 1450

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    ARAKKNK 7
            ++AKKNK
Sbjct: 1438 SKAKKNK 1444
>XP_006718808
          Length = 1454

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    ARAKKNK 7
            ++AKKNK
Sbjct: 1442 SKAKKNK 1448
>XP_006718807
          Length = 1464

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    ARAKKNK 7
            ++AKKNK
Sbjct: 1452 SKAKKNK 1458
>XP_006718806
          Length = 1474

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    ARAKKNK 7
            ++AKKNK
Sbjct: 1462 SKAKKNK 1468
>XP_006718805
          Length = 1484

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    ARAKKNK 7
            ++AKKNK
Sbjct: 1472 SKAKKNK 1478
>XP_005274459
          Length = 1503

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    ARAKKNK 7
            ++AKKNK
Sbjct: 1491 SKAKKNK 1497
>XP_005274458
          Length = 1511

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    ARAKKNK 7
            ++AKKNK
Sbjct: 1499 SKAKKNK 1505
>XP_005274457
          Length = 1705

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    ARAKKNK 7
            ++AKKNK
Sbjct: 1693 SKAKKNK 1699
>XP_005270059
          Length = 573

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   AKKNKAT 9
           AKK KAT
Sbjct: 388 AKKEKAT 394
>XP_006717994
          Length = 617

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   AKKNKAT 9
           AKK KAT
Sbjct: 388 AKKEKAT 394
>NP_005314
          Length = 207

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RAKKNKAT 9
           RAKK +AT
Sbjct: 152 RAKKPRAT 159

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ARAKKNKAT 9
           ARA K+K T
Sbjct: 185 ARASKSKLT 193
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.297    0.101    0.239 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 387,647
Number of extensions: 371
Number of successful extensions: 40
Number of sequences better than 10000.0: 39
Number of HSP's gapped: 40
Number of HSP's successfully gapped: 40
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)

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