Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000236                                                              20     509
NP_001120972                                                           20     509
XP_006716052                                                           20     509
XP_006716051                                                           20     509
NP_612138                                                              17    4312
NP_001925                                                              17    4312
NP_055714                                                              17    4312
NP_659489                                                              16    7355
NP_001241667                                                           16    7355
NP_001136197                                                           16    7355
NP_542394                                                              16    7355
NP_001002913                                                           16    7355
NP_005159                                                              16    7355
XP_006717018                                                           16    7355
NP_055490                                                              15    9605
NP_037397                                                              15    9605
NP_112190                                                              15    9605
NP_005415                                                              15    9605
NP_057715                                                              15    9605
NP_037461                                                              15    9605
NP_079467                                                              15    9605
NP_065728                                                              15    9605
NP_001240286                                                           15    9605
XP_006725302                                                           15    9605
XP_006725301                                                           15    9605
XP_006725300                                                           15    9605
XP_006725299                                                           15    9605
XP_006724130                                                           15    9605
XP_006724129                                                           15    9605
XP_006720969                                                           15    9605
XP_006720968                                                           15    9605
XP_005255504                                                           15    9605
XP_005255503                                                           15    9605
XP_005245556                                                           15    9605
XP_006711123                                                           15    9605
XP_006711122                                                           15    9605
XP_006711121                                                           15    9605
XP_006711120                                                           15    9605
XP_006711119                                                           15    9605
XP_006710932                                                           15    9605
XP_005271220                                                           15    9605
NP_115976                                                              15    9605
>NP_000236
          Length = 1390

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   AQLARQLGA 9
           AQLARQ+GA
Sbjct: 327 AQLARQIGA 335
>NP_001120972
          Length = 1408

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   AQLARQLGA 9
           AQLARQ+GA
Sbjct: 327 AQLARQIGA 335
>XP_006716052
          Length = 1409

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   AQLARQLGA 9
           AQLARQ+GA
Sbjct: 346 AQLARQIGA 354
>XP_006716051
          Length = 1427

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   AQLARQLGA 9
           AQLARQ+GA
Sbjct: 346 AQLARQIGA 354
>NP_612138
          Length = 240

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   AQLARQLG 8
           AQLA QLG
Sbjct: 148 AQLAAQLG 155
>NP_001925
          Length = 168

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1  AQLARQLG 8
          AQLA QLG
Sbjct: 76 AQLAAQLG 83
>NP_055714
          Length = 611

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   QLARQLGA 9
           QLA++LGA
Sbjct: 163 QLAKELGA 170
>NP_659489
          Length = 309

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   QLARQLGA 9
           +L+RQ+GA
Sbjct: 101 ELSRQIGA 108
>NP_001241667
          Length = 244

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   AQLARQLGA 9
           A +A+Q+GA
Sbjct: 163 ANMAKQIGA 171
>NP_001136197
          Length = 691

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  QLARQLG 8
          +LARQLG
Sbjct: 5  RLARQLG 11
>NP_542394
          Length = 328

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  QLARQLG 8
          +LARQLG
Sbjct: 5  RLARQLG 11
>NP_001002913
          Length = 214

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  QLARQLG 8
          QLAR+LG
Sbjct: 55 QLARRLG 61
>NP_005159
          Length = 244

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   AQLARQLGA 9
           A +A+Q+GA
Sbjct: 163 ANMAKQIGA 171
>XP_006717018
          Length = 196

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  QLARQLG 8
          QLAR+LG
Sbjct: 68 QLARRLG 74
>NP_055490
          Length = 2017

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   AQLARQL 7
           AQL+RQL
Sbjct: 837 AQLSRQL 843
>NP_037397
          Length = 782

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AQLARQLGA 9
           A  ARQLG+
Sbjct: 338 AAFARQLGS 346
>NP_112190
          Length = 546

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   QLARQLGA 9
           Q AR+LGA
Sbjct: 128 QRARELGA 135
>NP_005415
          Length = 1138

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    AQLARQLG 8
            AQ+A QLG
Sbjct: 1101 AQIALQLG 1108
>NP_057715
          Length = 917

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   QLARQLG 8
           Q+AR+LG
Sbjct: 233 QMARELG 239
>NP_037461
          Length = 815

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   QLARQLG 8
           Q+AR+LG
Sbjct: 233 QMARELG 239
>NP_079467
          Length = 932

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   QLARQLG 8
           Q+A+QLG
Sbjct: 181 QMAKQLG 187
>NP_065728
          Length = 299

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AQLARQLG 8
           A LAR+LG
Sbjct: 98  ADLARRLG 105
>NP_001240286
          Length = 1093

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    AQLARQLG 8
            AQ+A QLG
Sbjct: 1056 AQIALQLG 1063
>XP_006725302
          Length = 235

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  AQLARQLG 8
          A LAR+LG
Sbjct: 34 ADLARRLG 41
>XP_006725301
          Length = 236

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  AQLARQLG 8
          A LAR+LG
Sbjct: 35 ADLARRLG 42
>XP_006725300
          Length = 299

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AQLARQLG 8
           A LAR+LG
Sbjct: 98  ADLARRLG 105
>XP_006725299
          Length = 299

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AQLARQLG 8
           A LAR+LG
Sbjct: 98  ADLARRLG 105
>XP_006724130
          Length = 757

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   QLARQLG 8
           Q+AR+LG
Sbjct: 233 QMARELG 239
>XP_006724129
          Length = 882

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   QLARQLG 8
           Q+AR+LG
Sbjct: 233 QMARELG 239
>XP_006720969
          Length = 235

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  AQLARQLG 8
          A LAR+LG
Sbjct: 34 ADLARRLG 41
>XP_006720968
          Length = 236

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  AQLARQLG 8
          A LAR+LG
Sbjct: 35 ADLARRLG 42
>XP_005255504
          Length = 299

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AQLARQLG 8
           A LAR+LG
Sbjct: 98  ADLARRLG 105
>XP_005255503
          Length = 299

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AQLARQLG 8
           A LAR+LG
Sbjct: 98  ADLARRLG 105
>XP_005245556
          Length = 933

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   QLARQLG 8
           Q+A+QLG
Sbjct: 181 QMAKQLG 187
>XP_006711123
          Length = 1737

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   AQLARQL 7
           AQL+RQL
Sbjct: 799 AQLSRQL 805
>XP_006711122
          Length = 1918

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   AQLARQL 7
           AQL+RQL
Sbjct: 799 AQLSRQL 805
>XP_006711121
          Length = 1945

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   AQLARQL 7
           AQL+RQL
Sbjct: 765 AQLSRQL 771
>XP_006711120
          Length = 1972

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   AQLARQL 7
           AQL+RQL
Sbjct: 799 AQLSRQL 805
>XP_006711119
          Length = 1979

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   AQLARQL 7
           AQL+RQL
Sbjct: 799 AQLSRQL 805
>XP_006710932
          Length = 783

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AQLARQLG 8
           AQ+A QLG
Sbjct: 746 AQIALQLG 753
>XP_005271220
          Length = 1095

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    AQLARQLG 8
            AQ+A QLG
Sbjct: 1058 AQIALQLG 1065
>NP_115976
          Length = 1037

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AQLARQLG 8
           A LAR+LG
Sbjct: 647 AALARELG 654
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.322    0.127    0.320 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 306,922
Number of extensions: 611
Number of successful extensions: 42
Number of sequences better than 10000.0: 42
Number of HSP's gapped: 42
Number of HSP's successfully gapped: 42
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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