Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001243398                                                           20     509
NP_036462                                                              20     509
NP_001243397                                                           20     509
XP_005269721                                                           20     509
NP_002567                                                              17    3301
NP_001122092                                                           17    3301
NP_002568                                                              17    3301
NP_002569                                                              17    3301
NP_001121645                                                           17    3301
NP_001121644                                                           17    3301
NP_001121640                                                           17    3301
NP_001121639                                                           17    3301
NP_001121638                                                           17    3301
XP_005262190                                                           17    3301
XP_006724719                                                           17    3301
XP_006724718                                                           17    3301
XP_006724717                                                           17    3301
XP_005262189                                                           17    3301
XP_006718639                                                           17    3301
XP_006718638                                                           17    3301
XP_006718637                                                           17    3301
XP_006718636                                                           17    3301
XP_005274082                                                           17    3301
XP_006718635                                                           17    3301
NP_001276022                                                           16    5631
NP_001276021                                                           16    5631
NP_002100                                                              16    5631
NP_001244970                                                           16    5631
NP_001244969                                                           16    5631
NP_001276023                                                           16    5631
NP_001244971                                                           16    5631
NP_849144                                                              16    5631
XP_006713662                                                           16    5631
XP_006713661                                                           16    5631
XP_006713660                                                           16    5631
XP_005247434                                                           16    5631
XP_006713659                                                           16    5631
NP_002262                                                              16    7355
NP_071445                                                              16    7355
NP_009211                                                              16    7355
NP_001157994                                                           16    7355
XP_006721306                                                           16    7355
XP_006721305                                                           16    7355
XP_005256141                                                           16    7355
XP_005254110                                                           16    7355
XP_005254109                                                           16    7355
XP_005254106                                                           16    7355
NP_796377                                                              16    7355
NP_689935                                                              15    9605
NP_001271165                                                           15    9605
NP_001098721                                                           15    9605
NP_055548                                                              15    9605
NP_001271166                                                           15    9605
XP_005271506                                                           15    9605
XP_006718849                                                           15    9605
XP_005248691                                                           15    9605
XP_005248689                                                           15    9605
>NP_001243398
          Length = 1781

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    AQISPDQS 8
            AQISPDQS
Sbjct: 1335 AQISPDQS 1342
>NP_036462
          Length = 2073

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    AQISPDQS 8
            AQISPDQS
Sbjct: 1627 AQISPDQS 1634
>NP_001243397
          Length = 1890

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    AQISPDQS 8
            AQISPDQS
Sbjct: 1444 AQISPDQS 1451
>XP_005269721
          Length = 2073

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    AQISPDQS 8
            AQISPDQS
Sbjct: 1627 AQISPDQS 1634
>NP_002567
          Length = 545

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   AQISPDQS 8
           AQI+P+QS
Sbjct: 412 AQITPEQS 419
>NP_001122092
          Length = 553

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   AQISPDQS 8
           AQI+P+QS
Sbjct: 412 AQITPEQS 419
>NP_002568
          Length = 524

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   AQISPDQS 8
           AQI+P+QS
Sbjct: 391 AQITPEQS 398
>NP_002569
          Length = 544

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   AQISPDQS 8
           AQI+P+QS
Sbjct: 410 AQITPEQS 417
>NP_001121645
          Length = 559

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   AQISPDQS 8
           AQI+P+QS
Sbjct: 425 AQITPEQS 432
>NP_001121644
          Length = 565

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   AQISPDQS 8
           AQI+P+QS
Sbjct: 431 AQITPEQS 438
>NP_001121640
          Length = 580

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   AQISPDQS 8
           AQI+P+QS
Sbjct: 446 AQITPEQS 453
>NP_001121639
          Length = 544

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   AQISPDQS 8
           AQI+P+QS
Sbjct: 410 AQITPEQS 417
>NP_001121638
          Length = 544

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   AQISPDQS 8
           AQI+P+QS
Sbjct: 410 AQITPEQS 417
>XP_005262190
          Length = 547

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   AQISPDQS 8
           AQI+P+QS
Sbjct: 410 AQITPEQS 417
>XP_006724719
          Length = 559

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   AQISPDQS 8
           AQI+P+QS
Sbjct: 425 AQITPEQS 432
>XP_006724718
          Length = 562

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   AQISPDQS 8
           AQI+P+QS
Sbjct: 425 AQITPEQS 432
>XP_006724717
          Length = 562

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   AQISPDQS 8
           AQI+P+QS
Sbjct: 425 AQITPEQS 432
>XP_005262189
          Length = 562

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   AQISPDQS 8
           AQI+P+QS
Sbjct: 425 AQITPEQS 432
>XP_006718639
          Length = 545

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   AQISPDQS 8
           AQI+P+QS
Sbjct: 412 AQITPEQS 419
>XP_006718638
          Length = 545

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   AQISPDQS 8
           AQI+P+QS
Sbjct: 412 AQITPEQS 419
>XP_006718637
          Length = 545

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   AQISPDQS 8
           AQI+P+QS
Sbjct: 412 AQITPEQS 419
>XP_006718636
          Length = 545

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   AQISPDQS 8
           AQI+P+QS
Sbjct: 412 AQITPEQS 419
>XP_005274082
          Length = 545

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   AQISPDQS 8
           AQI+P+QS
Sbjct: 412 AQITPEQS 419
>XP_006718635
          Length = 607

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   AQISPDQS 8
           AQI+P+QS
Sbjct: 474 AQITPEQS 481
>NP_001276022
          Length = 395

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  AQISPDQS 8
          AQ+ PD+S
Sbjct: 43 AQLGPDES 50
>NP_001276021
          Length = 435

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  AQISPDQS 8
          AQ+ PD+S
Sbjct: 43 AQLGPDES 50
>NP_002100
          Length = 509

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  AQISPDQS 8
          AQ+ PD+S
Sbjct: 43 AQLGPDES 50
>NP_001244970
          Length = 489

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  AQISPDQS 8
          AQ+ PD+S
Sbjct: 43 AQLGPDES 50
>NP_001244969
          Length = 469

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  AQISPDQS 8
          AQ+ PD+S
Sbjct: 43 AQLGPDES 50
>NP_001276023
          Length = 480

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  AQISPDQS 8
          AQ+ PD+S
Sbjct: 14 AQLGPDES 21
>NP_001244971
          Length = 449

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  AQISPDQS 8
          AQ+ PD+S
Sbjct: 43 AQLGPDES 50
>NP_849144
          Length = 2623

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    ISPDQS 8
            ISPDQS
Sbjct: 1360 ISPDQS 1365
>XP_006713662
          Length = 1846

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    ISPDQS 8
            ISPDQS
Sbjct: 1432 ISPDQS 1437
>XP_006713661
          Length = 1860

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    ISPDQS 8
            ISPDQS
Sbjct: 1432 ISPDQS 1437
>XP_006713660
          Length = 2623

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    ISPDQS 8
            ISPDQS
Sbjct: 1360 ISPDQS 1365
>XP_005247434
          Length = 2623

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    ISPDQS 8
            ISPDQS
Sbjct: 1360 ISPDQS 1365
>XP_006713659
          Length = 2695

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    ISPDQS 8
            ISPDQS
Sbjct: 1432 ISPDQS 1437
>NP_002262
          Length = 1115

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    AQISPDQ 7
            AQ+SP+Q
Sbjct: 1098 AQLSPEQ 1104
>NP_071445
          Length = 1040

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   AQISPD 6
           AQ+SPD
Sbjct: 573 AQVSPD 578
>NP_009211
          Length = 229

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   AQISPDQS 8
           ++++PDQS
Sbjct: 218 SEVTPDQS 225
>NP_001157994
          Length = 199

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   QISPDQS 8
           ++SPDQS
Sbjct: 188 KLSPDQS 194
>XP_006721306
          Length = 793

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   AQISPD 6
           AQ+SPD
Sbjct: 546 AQVSPD 551
>XP_006721305
          Length = 985

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   AQISPD 6
           AQ+SPD
Sbjct: 546 AQVSPD 551
>XP_005256141
          Length = 1013

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   AQISPD 6
           AQ+SPD
Sbjct: 546 AQVSPD 551
>XP_005254110
          Length = 1115

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    AQISPDQ 7
            AQ+SP+Q
Sbjct: 1098 AQLSPEQ 1104
>XP_005254109
          Length = 1115

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    AQISPDQ 7
            AQ+SP+Q
Sbjct: 1098 AQLSPEQ 1104
>XP_005254106
          Length = 1115

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    AQISPDQ 7
            AQ+SP+Q
Sbjct: 1098 AQLSPEQ 1104
>NP_796377
          Length = 199

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   QISPDQS 8
           ++SPDQS
Sbjct: 188 KLSPDQS 194
>NP_689935
          Length = 416

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   ISPDQSV 9
           +SPDQ V
Sbjct: 195 LSPDQKV 201
>NP_001271165
          Length = 1539

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QISPDQSV 9
           +I PDQ+V
Sbjct: 455 KIDPDQTV 462
>NP_001098721
          Length = 1539

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QISPDQSV 9
           +I PDQ+V
Sbjct: 455 KIDPDQTV 462
>NP_055548
          Length = 1539

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QISPDQSV 9
           +I PDQ+V
Sbjct: 455 KIDPDQTV 462
>NP_001271166
          Length = 809

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QISPDQSV 9
           +I PDQ+V
Sbjct: 455 KIDPDQTV 462
>XP_005271506
          Length = 415

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   ISPDQSV 9
           +SPDQ V
Sbjct: 195 LSPDQKV 201
>XP_006718849
          Length = 423

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   ISPDQSV 9
           +SPDQ V
Sbjct: 195 LSPDQKV 201
>XP_005248691
          Length = 816

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QISPDQSV 9
           +I PDQ+V
Sbjct: 455 KIDPDQTV 462
>XP_005248689
          Length = 1539

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QISPDQSV 9
           +I PDQ+V
Sbjct: 455 KIDPDQTV 462
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.301    0.115    0.289 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 714,846
Number of extensions: 749
Number of successful extensions: 57
Number of sequences better than 10000.0: 57
Number of HSP's gapped: 57
Number of HSP's successfully gapped: 57
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)

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