Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001243398                                                           21     175
NP_036462                                                              21     175
NP_001243397                                                           21     175
XP_005269721                                                           21     175
NP_775082                                                              17    3301
NP_003377                                                              17    3301
NP_003881                                                              17    4312
NP_001622                                                              17    4312
NP_000072                                                              16    5631
NP_055626                                                              16    5631
XP_006719395                                                           16    5631
XP_006717405                                                           16    5631
XP_006717404                                                           16    5631
XP_006717403                                                           16    5631
XP_005263469                                                           16    5631
XP_005263468                                                           16    5631
XP_006711794                                                           16    5631
XP_005273085                                                           16    5631
XP_005273084                                                           16    5631
NP_689850                                                              16    5631
NP_054752                                                              16    5631
NP_000543                                                              16    7355
NP_002448                                                              16    7355
NP_002449                                                              16    7355
NP_689662                                                              16    7355
NP_005952                                                              16    7355
NP_036345                                                              16    7355
NP_005413                                                              16    7355
NP_775871                                                              16    7355
XP_006725823                                                           16    7355
XP_006725595                                                           16    7355
XP_006720458                                                           16    7355
XP_006720457                                                           16    7355
XP_005271710                                                           16    7355
XP_006718462                                                           16    7355
XP_006710008                                                           16    7355
NP_001129386                                                           16    7355
NP_705690                                                              15    9605
NP_036221                                                              15    9605
NP_001171515                                                           15    9605
NP_079533                                                              15    9605
NP_001258740                                                           15    9605
NP_004255                                                              15    9605
NP_919417                                                              15    9605
NP_001103467                                                           15    9605
XP_005256254                                                           15    9605
XP_005267404                                                           15    9605
XP_006711818                                                           15    9605
XP_006711817                                                           15    9605
>NP_001243398
          Length = 1781

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    AQCGMAANF 9
            AQC MAANF
Sbjct: 1475 AQCSMAANF 1483
>NP_036462
          Length = 2073

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    AQCGMAANF 9
            AQC MAANF
Sbjct: 1767 AQCSMAANF 1775
>NP_001243397
          Length = 1890

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    AQCGMAANF 9
            AQC MAANF
Sbjct: 1584 AQCSMAANF 1592
>XP_005269721
          Length = 2073

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    AQCGMAANF 9
            AQC MAANF
Sbjct: 1767 AQCSMAANF 1775
>NP_775082
          Length = 2721

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 3    CGMAANF 9
            CGM  NF
Sbjct: 2066 CGMCGNF 2072
>NP_003377
          Length = 2812

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 3    CGMAANF 9
            CGM  NF
Sbjct: 2066 CGMCGNF 2072
>NP_003881
          Length = 5405

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    AQCGMAANF 9
            A CG+  NF
Sbjct: 998  ALCGLCGNF 1006

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 5/7 (71%)

Query: 3    CGMAANF 9
            CG+  NF
Sbjct: 4983 CGLCGNF 4989
>NP_001622
          Length = 528

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   CGMAANF 9
           CG+ ANF
Sbjct: 120 CGVKANF 126
>NP_000072
          Length = 3801

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    AQCGMAANF 9
            A CG++ NF
Sbjct: 3503 AICGLSRNF 3511
>NP_055626
          Length = 1209

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   AQCGMAANF 9
           A CG+ A+F
Sbjct: 97  AVCGLVADF 105
>XP_006719395
          Length = 244

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 3  CGMAANF 9
          CG  ANF
Sbjct: 79 CGTGANF 85
>XP_006717405
          Length = 1209

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   AQCGMAANF 9
           A CG+ A+F
Sbjct: 97  AVCGLVADF 105
>XP_006717404
          Length = 1209

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   AQCGMAANF 9
           A CG+ A+F
Sbjct: 97  AVCGLVADF 105
>XP_006717403
          Length = 1209

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   AQCGMAANF 9
           A CG+ A+F
Sbjct: 97  AVCGLVADF 105
>XP_005263469
          Length = 1209

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   AQCGMAANF 9
           A CG+ A+F
Sbjct: 97  AVCGLVADF 105
>XP_005263468
          Length = 1209

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   AQCGMAANF 9
           A CG+ A+F
Sbjct: 97  AVCGLVADF 105
>XP_006711794
          Length = 3022

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    AQCGMAANF 9
            A CG++ NF
Sbjct: 2724 AICGLSRNF 2732
>XP_005273085
          Length = 3755

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    AQCGMAANF 9
            A CG++ NF
Sbjct: 3457 AICGLSRNF 3465
>XP_005273084
          Length = 3801

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    AQCGMAANF 9
            A CG++ NF
Sbjct: 3503 AICGLSRNF 3511
>NP_689850
          Length = 244

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 3  CGMAANF 9
          CG  ANF
Sbjct: 79 CGTGANF 85
>NP_054752
          Length = 244

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 3  CGMAANF 9
          CG  ANF
Sbjct: 79 CGTGANF 85
>NP_000543
          Length = 2813

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 5/7 (71%)

Query: 3   CGMAANF 9
           CG+  NF
Sbjct: 159 CGLCGNF 165

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 5/7 (71%)

Query: 3   CGMAANF 9
           CG+  NF
Sbjct: 993 CGLCGNF 999
>NP_002448
          Length = 5179

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 5/7 (71%)

Query: 3   CGMAANF 9
           CG+  NF
Sbjct: 989 CGLCGNF 995
>NP_002449
          Length = 5762

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 5/7 (71%)

Query: 3   CGMAANF 9
           CG+  NF
Sbjct: 559 CGLCGNF 565

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 5/7 (71%)

Query: 3    CGMAANF 9
            CG+  NF
Sbjct: 1023 CGLCGNF 1029
>NP_689662
          Length = 297

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  QCGMAAN 8
          +C MAAN
Sbjct: 59 RCSMAAN 65
>NP_005952
          Length = 2439

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 5/7 (71%)

Query: 3   CGMAANF 9
           CG+  NF
Sbjct: 173 CGLCGNF 179

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 5/7 (71%)

Query: 3    CGMAANF 9
            CG+  NF
Sbjct: 999  CGLCGNF 1005
>NP_036345
          Length = 493

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   CGMAANF 9
           CG+ AN+
Sbjct: 448 CGLMANY 454
>NP_005413
          Length = 2155

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 5/7 (71%)

Query: 3    CGMAANF 9
            CG+  NF
Sbjct: 1619 CGLCGNF 1625
>NP_775871
          Length = 8384

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 5/7 (71%)

Query: 3   CGMAANF 9
           CG+  NF
Sbjct: 603 CGLCGNF 609
>XP_006725823
          Length = 1825

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 5/7 (71%)

Query: 3   CGMAANF 9
           CG+  NF
Sbjct: 173 CGLCGNF 179

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 5/7 (71%)

Query: 3    CGMAANF 9
            CG+  NF
Sbjct: 999  CGLCGNF 1005
>XP_006725595
          Length = 1311

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 5/7 (71%)

Query: 3   CGMAANF 9
           CG+  NF
Sbjct: 173 CGLCGNF 179

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 5/7 (71%)

Query: 3    CGMAANF 9
            CG+  NF
Sbjct: 999  CGLCGNF 1005
>XP_006720458
          Length = 297

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  QCGMAAN 8
          +C MAAN
Sbjct: 59 RCSMAAN 65
>XP_006720457
          Length = 297

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  QCGMAAN 8
          +C MAAN
Sbjct: 59 RCSMAAN 65
>XP_005271710
          Length = 2150

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 5/7 (71%)

Query: 3    CGMAANF 9
            CG+  NF
Sbjct: 1619 CGLCGNF 1625
>XP_006718462
          Length = 4966

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 5/7 (71%)

Query: 3   CGMAANF 9
           CG+  NF
Sbjct: 568 CGLCGNF 574

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 5/7 (71%)

Query: 3    CGMAANF 9
            CG+  NF
Sbjct: 1033 CGLCGNF 1039
>XP_006710008
          Length = 2014

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 5/7 (71%)

Query: 3   CGMAANF 9
           CG+  NF
Sbjct: 568 CGLCGNF 574

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 5/7 (71%)

Query: 3    CGMAANF 9
            CG+  NF
Sbjct: 1033 CGLCGNF 1039
>NP_001129386
          Length = 1503

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 5/7 (71%)

Query: 3    CGMAANF 9
            CG+  NF
Sbjct: 1279 CGLCGNF 1285
>NP_705690
          Length = 507

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 3   CGMAA 7
           CGMAA
Sbjct: 165 CGMAA 169
>NP_036221
          Length = 738

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3   CGMAAN 8
           CG AAN
Sbjct: 224 CGAAAN 229
>NP_001171515
          Length = 668

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 1  AQCGMAAN 8
          A CGM  N
Sbjct: 73 AYCGMGEN 80
>NP_079533
          Length = 710

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 1  AQCGMAAN 8
          A CGM  N
Sbjct: 73 AYCGMGEN 80
>NP_001258740
          Length = 68

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  QCGMAANF 9
          QCG  A+F
Sbjct: 28 QCGPPASF 35
>NP_004255
          Length = 144

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  QCGMAANF 9
          QCG  A+F
Sbjct: 28 QCGPPASF 35
>NP_919417
          Length = 484

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 3   CGMAA 7
           CGMAA
Sbjct: 165 CGMAA 169
>NP_001103467
          Length = 533

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   AQCGMAAN 8
           A+C +AAN
Sbjct: 140 ARCWLAAN 147
>XP_005256254
          Length = 1837

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3    CGMAAN 8
            CG++AN
Sbjct: 1219 CGLSAN 1224
>XP_005267404
          Length = 797

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   AQCGMAAN 8
           A+C +AAN
Sbjct: 404 ARCWLAAN 411
>XP_006711818
          Length = 559

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3  CGMAAN 8
          CG AAN
Sbjct: 45 CGAAAN 50
>XP_006711817
          Length = 559

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3  CGMAAN 8
          CG AAN
Sbjct: 45 CGAAAN 50
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.332    0.127    0.432 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 536,918
Number of extensions: 592
Number of successful extensions: 57
Number of sequences better than 10000.0: 49
Number of HSP's gapped: 57
Number of HSP's successfully gapped: 57
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.4 bits)
S2: 28 (15.4 bits)

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