Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001243398                                                           22     103
NP_036462                                                              22     103
NP_001243397                                                           22     103
XP_005269721                                                           22     103
NP_001092882                                                           18    1482
NP_006757                                                              18    1482
NP_001092883                                                           18    1482
XP_005273706                                                           18    1482
NP_005952                                                              18    1935
XP_006725823                                                           18    1935
XP_006725595                                                           18    1935
XP_005249641                                                           17    2528
NP_066939                                                              17    2528
NP_000029                                                              16    5631
NP_001120983                                                           16    5631
NP_001120982                                                           16    5631
NP_002784                                                              16    5631
NP_001155018                                                           16    7355
NP_569712                                                              16    7355
NP_085059                                                              16    7355
NP_001420                                                              15    9605
NP_004487                                                              15    9605
NP_277037                                                              15    9605
NP_055872                                                              15    9605
NP_660337                                                              15    9605
NP_001032412                                                           15    9605
NP_001103444                                                           15    9605
NP_001159681                                                           15    9605
NP_001159680                                                           15    9605
NP_009217                                                              15    9605
XP_006724228                                                           15    9605
XP_006720925                                                           15    9605
XP_006720924                                                           15    9605
XP_006720923                                                           15    9605
XP_005255218                                                           15    9605
XP_005255217                                                           15    9605
XP_006719852                                                           15    9605
XP_005266357                                                           15    9605
XP_006719851                                                           15    9605
XP_006719850                                                           15    9605
XP_006719849                                                           15    9605
XP_006719848                                                           15    9605
XP_005266356                                                           15    9605
XP_006719847                                                           15    9605
XP_006719846                                                           15    9605
XP_006719845                                                           15    9605
XP_006719844                                                           15    9605
XP_006719843                                                           15    9605
XP_006719842                                                           15    9605
XP_006715211                                                           15    9605
XP_006715210                                                           15    9605
XP_006715209                                                           15    9605
XP_006715208                                                           15    9605
XP_006715207                                                           15    9605
XP_006715206                                                           15    9605
XP_005249280                                                           15    9605
XP_005268428                                                           15    9605
XP_005268427                                                           15    9605
XP_005268426                                                           15    9605
XP_006714818                                                           15    9605
XP_006710050                                                           15    9605
>NP_001243398
          Length = 1781

 Score = 21.9 bits (45), Expect =   103
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    NMMYTAPG 9
            NMMYTAPG
Sbjct: 1753 NMMYTAPG 1760
>NP_036462
          Length = 2073

 Score = 21.9 bits (45), Expect =   103
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    NMMYTAPG 9
            NMMYTAPG
Sbjct: 2045 NMMYTAPG 2052
>NP_001243397
          Length = 1890

 Score = 21.9 bits (45), Expect =   103
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    NMMYTAPG 9
            NMMYTAPG
Sbjct: 1862 NMMYTAPG 1869
>XP_005269721
          Length = 2073

 Score = 21.9 bits (45), Expect =   103
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    NMMYTAPG 9
            NMMYTAPG
Sbjct: 2045 NMMYTAPG 2052
>NP_001092882
          Length = 2004

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    NMMYTAP 8
            NMMYT P
Sbjct: 1975 NMMYTGP 1981
>NP_006757
          Length = 2004

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    NMMYTAP 8
            NMMYT P
Sbjct: 1975 NMMYTGP 1981
>NP_001092883
          Length = 2004

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    NMMYTAP 8
            NMMYT P
Sbjct: 1975 NMMYTGP 1981
>XP_005273706
          Length = 1997

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    NMMYTAP 8
            NMMYT P
Sbjct: 1968 NMMYTGP 1974
>NP_005952
          Length = 2439

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  ANMMYTAPG 9
          AN  YT+PG
Sbjct: 20 ANTSYTSPG 28
>XP_006725823
          Length = 1825

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  ANMMYTAPG 9
          AN  YT+PG
Sbjct: 20 ANTSYTSPG 28
>XP_006725595
          Length = 1311

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  ANMMYTAPG 9
          AN  YT+PG
Sbjct: 20 ANTSYTSPG 28
>XP_005249641
          Length = 979

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   NMMYTAPG 9
           N++YT PG
Sbjct: 555 NVVYTTPG 562
>NP_066939
          Length = 1119

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   NMMYTAPG 9
           N++YT PG
Sbjct: 555 NVVYTTPG 562
>NP_000029
          Length = 2843

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    MMYTAPG 9
            M YT+PG
Sbjct: 2364 MSYTSPG 2370
>NP_001120983
          Length = 2825

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    MMYTAPG 9
            M YT+PG
Sbjct: 2346 MSYTSPG 2352
>NP_001120982
          Length = 2843

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    MMYTAPG 9
            M YT+PG
Sbjct: 2364 MSYTSPG 2370
>NP_002784
          Length = 241

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  MYTAPG 9
          MY+APG
Sbjct: 7  MYSAPG 12
>NP_001155018
          Length = 1015

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 5  YTAPG 9
          YTAPG
Sbjct: 35 YTAPG 39
>NP_569712
          Length = 1336

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   NMMYTAPG 9
           +++YT PG
Sbjct: 136 SLLYTEPG 143
>NP_085059
          Length = 1516

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   NMMYTAPG 9
           +++YT PG
Sbjct: 316 SLLYTEPG 323
>NP_001420
          Length = 2414

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 2   NMMYTAPG 9
           NM Y  PG
Sbjct: 204 NMQYPNPG 211
>NP_004487
          Length = 472

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 2  NMMYTAPG 9
          NM Y  PG
Sbjct: 65 NMSYANPG 72
>NP_277037
          Length = 1200

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ANMMYTAP 8
           +NMM+ AP
Sbjct: 104 SNMMWGAP 111
>NP_055872
          Length = 4678

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    NMMYTAPG 9
            NM++ +PG
Sbjct: 3181 NMIFPSPG 3188
>NP_660337
          Length = 1748

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    ANMMYTAPG 9
            A +MY  PG
Sbjct: 1646 ALLMYVGPG 1654
>NP_001032412
          Length = 2649

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2   NMMYTAPG 9
           NM++  PG
Sbjct: 382 NMLFAPPG 389
>NP_001103444
          Length = 685

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   MYTAPG 9
           +YT+PG
Sbjct: 623 LYTSPG 628
>NP_001159681
          Length = 929

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   MYTAPG 9
           +YT+PG
Sbjct: 867 LYTSPG 872
>NP_001159680
          Length = 929

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   MYTAPG 9
           +YT+PG
Sbjct: 867 LYTSPG 872
>NP_009217
          Length = 903

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   MYTAPG 9
           +YT+PG
Sbjct: 623 LYTSPG 628
>XP_006724228
          Length = 2388

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 2   NMMYTAPG 9
           NM Y  PG
Sbjct: 204 NMQYPNPG 211
>XP_006720925
          Length = 1674

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    ANMMYTAPG 9
            A +MY  PG
Sbjct: 1649 ALLMYVGPG 1657
>XP_006720924
          Length = 1679

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    ANMMYTAPG 9
            A +MY  PG
Sbjct: 1577 ALLMYVGPG 1585
>XP_006720923
          Length = 1738

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    ANMMYTAPG 9
            A +MY  PG
Sbjct: 1636 ALLMYVGPG 1644
>XP_005255218
          Length = 1750

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    ANMMYTAPG 9
            A +MY  PG
Sbjct: 1648 ALLMYVGPG 1656
>XP_005255217
          Length = 1751

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    ANMMYTAPG 9
            A +MY  PG
Sbjct: 1649 ALLMYVGPG 1657
>XP_006719852
          Length = 4752

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    NMMYTAPG 9
            NM++ +PG
Sbjct: 3258 NMIFPSPG 3265
>XP_005266357
          Length = 4600

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    NMMYTAPG 9
            NM++ +PG
Sbjct: 3106 NMIFPSPG 3113
>XP_006719851
          Length = 4689

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    NMMYTAPG 9
            NM++ +PG
Sbjct: 3192 NMIFPSPG 3199
>XP_006719850
          Length = 4697

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    NMMYTAPG 9
            NM++ +PG
Sbjct: 3200 NMIFPSPG 3207
>XP_006719849
          Length = 4703

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    NMMYTAPG 9
            NM++ +PG
Sbjct: 3206 NMIFPSPG 3213
>XP_006719848
          Length = 4737

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    NMMYTAPG 9
            NM++ +PG
Sbjct: 3240 NMIFPSPG 3247
>XP_005266356
          Length = 4755

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    NMMYTAPG 9
            NM++ +PG
Sbjct: 3258 NMIFPSPG 3265
>XP_006719847
          Length = 4761

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    NMMYTAPG 9
            NM++ +PG
Sbjct: 3264 NMIFPSPG 3271
>XP_006719846
          Length = 4763

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    NMMYTAPG 9
            NM++ +PG
Sbjct: 3266 NMIFPSPG 3273
>XP_006719845
          Length = 4772

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    NMMYTAPG 9
            NM++ +PG
Sbjct: 3275 NMIFPSPG 3282
>XP_006719844
          Length = 4789

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    NMMYTAPG 9
            NM++ +PG
Sbjct: 3292 NMIFPSPG 3299
>XP_006719843
          Length = 4794

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    NMMYTAPG 9
            NM++ +PG
Sbjct: 3300 NMIFPSPG 3307
>XP_006719842
          Length = 4797

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    NMMYTAPG 9
            NM++ +PG
Sbjct: 3300 NMIFPSPG 3307
>XP_006715211
          Length = 1117

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ANMMYTAP 8
           +NMM+ AP
Sbjct: 104 SNMMWGAP 111
>XP_006715210
          Length = 1129

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ANMMYTAP 8
           +NMM+ AP
Sbjct: 104 SNMMWGAP 111
>XP_006715209
          Length = 1131

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ANMMYTAP 8
           +NMM+ AP
Sbjct: 104 SNMMWGAP 111
>XP_006715208
          Length = 1200

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ANMMYTAP 8
           +NMM+ AP
Sbjct: 104 SNMMWGAP 111
>XP_006715207
          Length = 1212

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ANMMYTAP 8
           +NMM+ AP
Sbjct: 104 SNMMWGAP 111
>XP_006715206
          Length = 1220

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ANMMYTAP 8
           +NMM+ AP
Sbjct: 104 SNMMWGAP 111
>XP_005249280
          Length = 1220

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ANMMYTAP 8
           +NMM+ AP
Sbjct: 104 SNMMWGAP 111
>XP_005268428
          Length = 903

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   MYTAPG 9
           +YT+PG
Sbjct: 623 LYTSPG 628
>XP_005268427
          Length = 903

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   MYTAPG 9
           +YT+PG
Sbjct: 623 LYTSPG 628
>XP_005268426
          Length = 903

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   MYTAPG 9
           +YT+PG
Sbjct: 623 LYTSPG 628
>XP_006714818
          Length = 1147

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   MYTAPG 9
           +YT+PG
Sbjct: 867 LYTSPG 872
>XP_006710050
          Length = 320

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   MYTAPG 9
           MY APG
Sbjct: 160 MYEAPG 165
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.316    0.124    0.382 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 724,979
Number of extensions: 956
Number of successful extensions: 61
Number of sequences better than 10000.0: 61
Number of HSP's gapped: 61
Number of HSP's successfully gapped: 61
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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