Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

• Home Page
• Cancer-specific
• Epitope Search
• Data Retrieval
• Browse Gene
• Browse Tissue
• Sequence Similarity
• Partially Personalized
• Submit a Protein
• Vaccine Target
• Proteome Data
• NGS data
• BLAST & Predict
• Fully Personalized
• Proteins Pair
• Proteome Pair
• Advanced Tools
• Epitope Mapping
• Cross Reactivity
• Important Information
• Acknowledgement
• Algorithm
• Help
• Developers
• Contact

Blast-Search of mutated query peptide against human proteome

BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_056106                                                              17    4312
NP_789786                                                              17    4312
XP_005276826                                                           17    4312
XP_005276825                                                           17    4312
XP_005276824                                                           17    4312
XP_005276823                                                           17    4312
XP_005276822                                                           17    4312
XP_006726278                                                           17    4312
XP_005276821                                                           17    4312
XP_006726277                                                           17    4312
XP_005276820                                                           17    4312
XP_005276819                                                           17    4312
XP_005276818                                                           17    4312
XP_005248522                                                           17    4312
XP_005248521                                                           17    4312
XP_005248520                                                           17    4312
XP_005248519                                                           17    4312
XP_005248518                                                           17    4312
XP_006714633                                                           17    4312
XP_005248517                                                           17    4312
XP_006714632                                                           17    4312
XP_005248516                                                           17    4312
XP_005248515                                                           17    4312
XP_005248514                                                           17    4312
NP_001278383                                                           16    5631
NP_055676                                                              16    5631
NP_001273456                                                           16    5631
XP_006721418                                                           16    5631
NP_598397                                                              16    7355
NP_004728                                                              16    7355
XP_006724438                                                           16    7355
XP_005261889                                                           16    7355
XP_005261888                                                           16    7355
NP_001268421                                                           15    9605
NP_000170                                                              15    9605
NP_733468                                                              15    9605
NP_653091                                                              15    9605
NP_001268422                                                           15    9605
NP_001268423                                                           15    9605
NP_055362                                                              15    9605
XP_006720542                                                           15    9605
XP_005264328                                                           15    9605

>NP_056106
          Length = 782

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   NAVVKKNL 9
           NAVV++NL
Sbjct: 231 NAVVRENL 238



>NP_789786
          Length = 511

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   NAVVKKNL 9
           NAV+K+NL
Sbjct: 211 NAVLKENL 218



>XP_005276826
          Length = 348

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   NAVVKKNL 9
           NAV+K+NL
Sbjct: 210 NAVLKENL 217



>XP_005276825
          Length = 349

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   NAVVKKNL 9
           NAV+K+NL
Sbjct: 211 NAVLKENL 218



>XP_005276824
          Length = 386

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  NAVVKKNL 9
          NAV+K+NL
Sbjct: 86 NAVLKENL 93



>XP_005276823
          Length = 386

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  NAVVKKNL 9
          NAV+K+NL
Sbjct: 86 NAVLKENL 93



>XP_005276822
          Length = 421

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   NAVVKKNL 9
           NAV+K+NL
Sbjct: 121 NAVLKENL 128



>XP_006726278
          Length = 434

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   NAVVKKNL 9
           NAV+K+NL
Sbjct: 134 NAVLKENL 141



>XP_005276821
          Length = 438

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   NAVVKKNL 9
           NAV+K+NL
Sbjct: 138 NAVLKENL 145



>XP_006726277
          Length = 506

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   NAVVKKNL 9
           NAV+K+NL
Sbjct: 211 NAVLKENL 218



>XP_005276820
          Length = 510

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   NAVVKKNL 9
           NAV+K+NL
Sbjct: 210 NAVLKENL 217



>XP_005276819
          Length = 511

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   NAVVKKNL 9
           NAV+K+NL
Sbjct: 211 NAVLKENL 218



>XP_005276818
          Length = 511

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   NAVVKKNL 9
           NAV+K+NL
Sbjct: 211 NAVLKENL 218



>XP_005248522
          Length = 348

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   NAVVKKNL 9
           NAV+K+NL
Sbjct: 210 NAVLKENL 217



>XP_005248521
          Length = 349

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   NAVVKKNL 9
           NAV+K+NL
Sbjct: 211 NAVLKENL 218



>XP_005248520
          Length = 386

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  NAVVKKNL 9
          NAV+K+NL
Sbjct: 86 NAVLKENL 93



>XP_005248519
          Length = 386

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  NAVVKKNL 9
          NAV+K+NL
Sbjct: 86 NAVLKENL 93



>XP_005248518
          Length = 421

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   NAVVKKNL 9
           NAV+K+NL
Sbjct: 121 NAVLKENL 128



>XP_006714633
          Length = 434

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   NAVVKKNL 9
           NAV+K+NL
Sbjct: 134 NAVLKENL 141



>XP_005248517
          Length = 438

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   NAVVKKNL 9
           NAV+K+NL
Sbjct: 138 NAVLKENL 145



>XP_006714632
          Length = 506

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   NAVVKKNL 9
           NAV+K+NL
Sbjct: 211 NAVLKENL 218



>XP_005248516
          Length = 510

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   NAVVKKNL 9
           NAV+K+NL
Sbjct: 210 NAVLKENL 217



>XP_005248515
          Length = 511

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   NAVVKKNL 9
           NAV+K+NL
Sbjct: 211 NAVLKENL 218



>XP_005248514
          Length = 511

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   NAVVKKNL 9
           NAV+K+NL
Sbjct: 211 NAVLKENL 218



>NP_001278383
          Length = 795

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   NAVVKKN 8
           NAV++KN
Sbjct: 293 NAVIRKN 299



>NP_055676
          Length = 946

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   NAVVKKN 8
           NAV++KN
Sbjct: 444 NAVIRKN 450



>NP_001273456
          Length = 975

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   NAVVKKN 8
           NAV++KN
Sbjct: 444 NAVIRKN 450



>XP_006721418
          Length = 972

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   NAVVKKN 8
           NAV++KN
Sbjct: 444 NAVIRKN 450



>NP_598397
          Length = 756

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   NAVVKKN 8
           NAV+K+N
Sbjct: 339 NAVIKQN 345



>NP_004728
          Length = 756

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   NAVVKKN 8
           NAV+K+N
Sbjct: 339 NAVIKQN 345



>XP_006724438
          Length = 577

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   NAVVKKN 8
           NAV+K+N
Sbjct: 339 NAVIKQN 345



>XP_005261889
          Length = 756

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   NAVVKKN 8
           NAV+K+N
Sbjct: 339 NAVIKQN 345



>XP_005261888
          Length = 756

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   NAVVKKN 8
           NAV+K+N
Sbjct: 339 NAVIKQN 345



>NP_001268421
          Length = 1230

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    ANAVVKK 7
            ANAVVK+
Sbjct: 1098 ANAVVKE 1104



>NP_000170
          Length = 1360

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    ANAVVKK 7
            ANAVVK+
Sbjct: 1228 ANAVVKE 1234



>NP_733468
          Length = 2342

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    ANAVVKKNL 9
            AN+V+ KNL
Sbjct: 1832 ANSVLIKNL 1840



>NP_653091
          Length = 2316

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    ANAVVKKNL 9
            AN+V+ KNL
Sbjct: 1806 ANSVLIKNL 1814



>NP_001268422
          Length = 1058

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   ANAVVKK 7
           ANAVVK+
Sbjct: 926 ANAVVKE 932



>NP_001268423
          Length = 1058

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   ANAVVKK 7
           ANAVVK+
Sbjct: 926 ANAVVKE 932



>NP_055362
          Length = 352

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   ANAVVKKN 8
           ANA+ K N
Sbjct: 332 ANAITKNN 339



>XP_006720542
          Length = 352

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   ANAVVKKN 8
           ANA+ K N
Sbjct: 332 ANAITKNN 339



>XP_005264328
          Length = 1261

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    ANAVVKK 7
            ANAVVK+
Sbjct: 1129 ANAVVKE 1135



  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.307    0.118    0.284 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 349,080
Number of extensions: 348
Number of successful extensions: 42
Number of sequences better than 10000.0: 42
Number of HSP's gapped: 42
Number of HSP's successfully gapped: 42
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)