Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005091                                                              21     229
NP_653080                                                              21     229
XP_005267292                                                           21     229
XP_005267291                                                           21     229
XP_005267290                                                           21     229
NP_006764                                                              17    2528
NP_005227                                                              17    3301
NP_056392                                                              17    4312
NP_001138997                                                           17    4312
NP_001138995                                                           17    4312
NP_001138994                                                           17    4312
NP_001138993                                                           17    4312
NP_001138992                                                           17    4312
XP_006714532                                                           17    4312
NP_056262                                                              16    5631
NP_071933                                                              16    5631
NP_006819                                                              16    5631
XP_005263453                                                           16    5631
XP_006715385                                                           16    5631
NP_689808                                                              16    5631
NP_056327                                                              16    7355
NP_003132                                                              16    7355
NP_001243338                                                           16    7355
NP_443172                                                              16    7355
XP_006718346                                                           16    7355
XP_006713163                                                           16    7355
XP_006710391                                                           16    7355
XP_006710390                                                           16    7355
NP_000072                                                              15    9605
NP_009054                                                              15    9605
NP_996816                                                              15    9605
NP_892006                                                              15    9605
NP_149062                                                              15    9605
NP_057205                                                              15    9605
NP_116247                                                              15    9605
NP_001273306                                                           15    9605
NP_001273307                                                           15    9605
NP_001034568                                                           15    9605
NP_065928                                                              15    9605
NP_001243595                                                           15    9605
NP_001243596                                                           15    9605
NP_001243597                                                           15    9605
XP_005256527                                                           15    9605
XP_005268301                                                           15    9605
XP_006720407                                                           15    9605
XP_006715485                                                           15    9605
XP_006715484                                                           15    9605
XP_006715483                                                           15    9605
XP_006715482                                                           15    9605
XP_006715481                                                           15    9605
XP_006715480                                                           15    9605
XP_006715479                                                           15    9605
XP_006715478                                                           15    9605
XP_006715477                                                           15    9605
XP_006715476                                                           15    9605
XP_006715475                                                           15    9605
XP_006715474                                                           15    9605
XP_006715473                                                           15    9605
XP_006715472                                                           15    9605
XP_006715471                                                           15    9605
XP_006715470                                                           15    9605
XP_006713995                                                           15    9605
XP_006713994                                                           15    9605
XP_006713993                                                           15    9605
XP_005273087                                                           15    9605
XP_006711794                                                           15    9605
XP_005273086                                                           15    9605
XP_005273085                                                           15    9605
XP_005273084                                                           15    9605
XP_006711646                                                           15    9605
XP_006711645                                                           15    9605
XP_005273215                                                           15    9605
XP_005273214                                                           15    9605
XP_005273213                                                           15    9605
NP_003695                                                              15    9605
>NP_005091
          Length = 1782

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   AMVPLSEYD 9
           A+VPLSEYD
Sbjct: 845 AVVPLSEYD 853
>NP_653080
          Length = 1684

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   AMVPLSEYD 9
           A+VPLSEYD
Sbjct: 747 AVVPLSEYD 755
>XP_005267292
          Length = 1677

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   AMVPLSEYD 9
           A+VPLSEYD
Sbjct: 740 AVVPLSEYD 748
>XP_005267291
          Length = 1684

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   AMVPLSEYD 9
           A+VPLSEYD
Sbjct: 747 AVVPLSEYD 755
>XP_005267290
          Length = 1782

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   AMVPLSEYD 9
           A+VPLSEYD
Sbjct: 845 AVVPLSEYD 853
>NP_006764
          Length = 670

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   VPLSEYD 9
           VPLSE+D
Sbjct: 546 VPLSEFD 552
>NP_005227
          Length = 916

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  AMVPLSEYD 9
          AM PL EY+
Sbjct: 11 AMAPLLEYE 19
>NP_056392
          Length = 980

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AMVPLSEYD 9
           AMVP S Y+
Sbjct: 782 AMVPRSSYE 790
>NP_001138997
          Length = 983

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AMVPLSEYD 9
           AMVP S Y+
Sbjct: 785 AMVPRSSYE 793
>NP_001138995
          Length = 972

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AMVPLSEYD 9
           AMVP S Y+
Sbjct: 774 AMVPRSSYE 782
>NP_001138994
          Length = 951

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AMVPLSEYD 9
           AMVP S Y+
Sbjct: 753 AMVPRSSYE 761
>NP_001138993
          Length = 980

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AMVPLSEYD 9
           AMVP S Y+
Sbjct: 782 AMVPRSSYE 790
>NP_001138992
          Length = 980

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AMVPLSEYD 9
           AMVP S Y+
Sbjct: 782 AMVPRSSYE 790
>XP_006714532
          Length = 980

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AMVPLSEYD 9
           AMVP S Y+
Sbjct: 782 AMVPRSSYE 790
>NP_056262
          Length = 1602

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  MVPLSEYD 9
          +VPL  YD
Sbjct: 26 LVPLDRYD 33
>NP_071933
          Length = 314

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   AMVPLSEYD 9
           A++P  EYD
Sbjct: 299 AVIPTIEYD 307
>NP_006819
          Length = 2202

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    AMVPLSEYD 9
            AM+P  +YD
Sbjct: 1902 AMLPCPDYD 1910
>XP_005263453
          Length = 1613

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  MVPLSEYD 9
          +VPL  YD
Sbjct: 26 LVPLDRYD 33
>XP_006715385
          Length = 1866

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    AMVPLSEYD 9
            AM+P  +YD
Sbjct: 1566 AMLPCPDYD 1574
>NP_689808
          Length = 585

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  AMVPLSEYD 9
          AM+P   YD
Sbjct: 79 AMIPRQRYD 87
>NP_056327
          Length = 4265

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   AMVPLSEY 8
           AM+PL  Y
Sbjct: 740 AMIPLQAY 747
>NP_003132
          Length = 475

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   AMVPLSE 7
           AMVPL E
Sbjct: 124 AMVPLEE 130
>NP_001243338
          Length = 428

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   VPLSEYD 9
           VPL E+D
Sbjct: 291 VPLKEFD 297
>NP_443172
          Length = 428

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   VPLSEYD 9
           VPL E+D
Sbjct: 291 VPLKEFD 297
>XP_006718346
          Length = 398

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   AMVPLSE 7
           AMVPL E
Sbjct: 124 AMVPLEE 130
>XP_006713163
          Length = 4265

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   AMVPLSEY 8
           AM+PL  Y
Sbjct: 740 AMIPLQAY 747
>XP_006710391
          Length = 428

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   VPLSEYD 9
           VPL E+D
Sbjct: 291 VPLKEFD 297
>XP_006710390
          Length = 428

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   VPLSEYD 9
           VPL E+D
Sbjct: 291 VPLKEFD 297
>NP_000072
          Length = 3801

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3    VPLSEY 8
            +P+SEY
Sbjct: 2488 IPMSEY 2493
>NP_009054
          Length = 1546

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    MVPLSEYD 9
            +VP ++YD
Sbjct: 1210 LVPFAKYD 1217
>NP_996816
          Length = 5202

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    MVPLSEYD 9
            +VP ++YD
Sbjct: 1210 LVPFAKYD 1217
>NP_892006
          Length = 8797

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    MVPLSEYD 9
            +VP+SE D
Sbjct: 8764 LVPMSEED 8771
>NP_149062
          Length = 8749

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    MVPLSEYD 9
            +VP+SE D
Sbjct: 8716 LVPMSEED 8723
>NP_057205
          Length = 815

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   MVPLSEYD 9
           +VP++ YD
Sbjct: 315 VVPITSYD 322
>NP_116247
          Length = 434

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   AMVPLSEYD 9
           A VPL +Y+
Sbjct: 321 AHVPLQDYE 329
>NP_001273306
          Length = 403

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   AMVPLSEYD 9
           A VPL +Y+
Sbjct: 290 AHVPLQDYE 298
>NP_001273307
          Length = 378

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   AMVPLSEYD 9
           A VPL +Y+
Sbjct: 265 AHVPLQDYE 273
>NP_001034568
          Length = 823

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   MVPLSEYD 9
           +VP  EYD
Sbjct: 189 IVPRDEYD 196
>NP_065928
          Length = 4427

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    MVPLSEY 8
            +VPL EY
Sbjct: 2275 LVPLPEY 2281
>NP_001243595
          Length = 1265

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   PLSEYD 9
           PLS YD
Sbjct: 310 PLSNYD 315
>NP_001243596
          Length = 1246

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   PLSEYD 9
           PLS YD
Sbjct: 332 PLSNYD 337
>NP_001243597
          Length = 1211

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   PLSEYD 9
           PLS YD
Sbjct: 310 PLSNYD 315
>XP_005256527
          Length = 4427

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    MVPLSEY 8
            +VPL EY
Sbjct: 2275 LVPLPEY 2281
>XP_005268301
          Length = 662

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  MVPLSEYD 9
          +VP  EYD
Sbjct: 28 IVPRDEYD 35
>XP_006720407
          Length = 813

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   MVPLSEYD 9
           +VP  EYD
Sbjct: 179 IVPRDEYD 186
>XP_006715485
          Length = 8793

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    MVPLSEYD 9
            +VP+SE D
Sbjct: 8760 LVPMSEED 8767
>XP_006715484
          Length = 8794

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    MVPLSEYD 9
            +VP+SE D
Sbjct: 8761 LVPMSEED 8768
>XP_006715483
          Length = 8795

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    MVPLSEYD 9
            +VP+SE D
Sbjct: 8762 LVPMSEED 8769
>XP_006715482
          Length = 8797

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    MVPLSEYD 9
            +VP+SE D
Sbjct: 8764 LVPMSEED 8771
>XP_006715481
          Length = 8799

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    MVPLSEYD 9
            +VP+SE D
Sbjct: 8766 LVPMSEED 8773
>XP_006715480
          Length = 8799

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    MVPLSEYD 9
            +VP+SE D
Sbjct: 8766 LVPMSEED 8773
>XP_006715479
          Length = 8804

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    MVPLSEYD 9
            +VP+SE D
Sbjct: 8771 LVPMSEED 8778
>XP_006715478
          Length = 8809

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    MVPLSEYD 9
            +VP+SE D
Sbjct: 8776 LVPMSEED 8783
>XP_006715477
          Length = 8822

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    MVPLSEYD 9
            +VP+SE D
Sbjct: 8789 LVPMSEED 8796
>XP_006715476
          Length = 8823

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    MVPLSEYD 9
            +VP+SE D
Sbjct: 8790 LVPMSEED 8797
>XP_006715475
          Length = 8827

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    MVPLSEYD 9
            +VP+SE D
Sbjct: 8794 LVPMSEED 8801
>XP_006715474
          Length = 8829

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    MVPLSEYD 9
            +VP+SE D
Sbjct: 8796 LVPMSEED 8803
>XP_006715473
          Length = 8832

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    MVPLSEYD 9
            +VP+SE D
Sbjct: 8799 LVPMSEED 8806
>XP_006715472
          Length = 8839

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    MVPLSEYD 9
            +VP+SE D
Sbjct: 8806 LVPMSEED 8813
>XP_006715471
          Length = 8842

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    MVPLSEYD 9
            +VP+SE D
Sbjct: 8809 LVPMSEED 8816
>XP_006715470
          Length = 8846

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    MVPLSEYD 9
            +VP+SE D
Sbjct: 8813 LVPMSEED 8820
>XP_006713995
          Length = 1448

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   PLSEYD 9
           PLS YD
Sbjct: 534 PLSNYD 539
>XP_006713994
          Length = 1004

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   PLSEYD 9
           PLS YD
Sbjct: 510 PLSNYD 515
>XP_006713993
          Length = 1424

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   PLSEYD 9
           PLS YD
Sbjct: 510 PLSNYD 515
>XP_005273087
          Length = 2788

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3    VPLSEY 8
            +P+SEY
Sbjct: 2488 IPMSEY 2493
>XP_006711794
          Length = 3022

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3    VPLSEY 8
            +P+SEY
Sbjct: 1709 IPMSEY 1714
>XP_005273086
          Length = 3264

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3    VPLSEY 8
            +P+SEY
Sbjct: 2488 IPMSEY 2493
>XP_005273085
          Length = 3755

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3    VPLSEY 8
            +P+SEY
Sbjct: 2442 IPMSEY 2447
>XP_005273084
          Length = 3801

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3    VPLSEY 8
            +P+SEY
Sbjct: 2488 IPMSEY 2493
>XP_006711646
          Length = 419

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   AMVPLSEYD 9
           A VPL +Y+
Sbjct: 306 AHVPLQDYE 314
>XP_006711645
          Length = 420

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   AMVPLSEYD 9
           A VPL +Y+
Sbjct: 307 AHVPLQDYE 315
>XP_005273215
          Length = 713

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   MVPLSEYD 9
           +VP++ YD
Sbjct: 213 VVPITSYD 220
>XP_005273214
          Length = 788

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   MVPLSEYD 9
           +VP++ YD
Sbjct: 288 VVPITSYD 295
>XP_005273213
          Length = 813

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   MVPLSEYD 9
           +VP++ YD
Sbjct: 315 VVPITSYD 322
>NP_003695
          Length = 1224

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   PLSEYD 9
           PLS YD
Sbjct: 310 PLSNYD 315
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.313    0.130    0.365 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 625,522
Number of extensions: 1028
Number of successful extensions: 75
Number of sequences better than 10000.0: 75
Number of HSP's gapped: 75
Number of HSP's successfully gapped: 75
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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