Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000537                                                              19     665
NP_001263689                                                           19     665
NP_001119584                                                           19     665
NP_001119586                                                           19     665
NP_001263625                                                           19     665
NP_001119590                                                           19     665
NP_001263690                                                           19     665
NP_001119585                                                           19     665
NP_001263624                                                           19     665
NP_001119588                                                           19     665
NP_001119587                                                           19     665
NP_001119589                                                           19     665
NP_001263627                                                           18    1935
NP_001263628                                                           18    1935
NP_001263626                                                           18    1935
NP_004332                                                              16    5631
XP_005264615                                                           16    5631
XP_006712164                                                           16    5631
XP_005264614                                                           16    5631
XP_005264613                                                           16    5631
XP_005264612                                                           16    5631
NP_001164663                                                           16    7355
NP_001003698                                                           15    9605
NP_001161816                                                           15    9605
NP_001003699                                                           15    9605
NP_001003700                                                           15    9605
XP_006715224                                                           15    9605
XP_005249329                                                           15    9605
XP_006715223                                                           15    9605
XP_006715222                                                           15    9605
XP_005249333                                                           15    9605
XP_006715221                                                           15    9605
XP_006715220                                                           15    9605
XP_005249332                                                           15    9605
XP_006715219                                                           15    9605
>NP_000537
          Length = 393

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   AMAIHKQSQ 9
           AMAI+KQSQ
Sbjct: 159 AMAIYKQSQ 167
>NP_001263689
          Length = 354

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   AMAIHKQSQ 9
           AMAI+KQSQ
Sbjct: 120 AMAIYKQSQ 128
>NP_001119584
          Length = 393

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   AMAIHKQSQ 9
           AMAI+KQSQ
Sbjct: 159 AMAIYKQSQ 167
>NP_001119586
          Length = 341

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   AMAIHKQSQ 9
           AMAI+KQSQ
Sbjct: 159 AMAIYKQSQ 167
>NP_001263625
          Length = 302

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   AMAIHKQSQ 9
           AMAI+KQSQ
Sbjct: 120 AMAIYKQSQ 128
>NP_001119590
          Length = 354

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   AMAIHKQSQ 9
           AMAI+KQSQ
Sbjct: 120 AMAIYKQSQ 128
>NP_001263690
          Length = 354

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   AMAIHKQSQ 9
           AMAI+KQSQ
Sbjct: 120 AMAIYKQSQ 128
>NP_001119585
          Length = 346

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   AMAIHKQSQ 9
           AMAI+KQSQ
Sbjct: 159 AMAIYKQSQ 167
>NP_001263624
          Length = 307

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   AMAIHKQSQ 9
           AMAI+KQSQ
Sbjct: 120 AMAIYKQSQ 128
>NP_001119588
          Length = 209

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  AMAIHKQSQ 9
          AMAI+KQSQ
Sbjct: 27 AMAIYKQSQ 35
>NP_001119587
          Length = 261

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  AMAIHKQSQ 9
          AMAI+KQSQ
Sbjct: 27 AMAIYKQSQ 35
>NP_001119589
          Length = 214

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  AMAIHKQSQ 9
          AMAI+KQSQ
Sbjct: 27 AMAIYKQSQ 35
>NP_001263627
          Length = 182

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2 MAIHKQSQ 9
         MAI+KQSQ
Sbjct: 1 MAIYKQSQ 8
>NP_001263628
          Length = 187

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2 MAIHKQSQ 9
         MAI+KQSQ
Sbjct: 1 MAIYKQSQ 8
>NP_001263626
          Length = 234

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2 MAIHKQSQ 9
         MAI+KQSQ
Sbjct: 1 MAIYKQSQ 8
>NP_004332
          Length = 2225

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    AMAIHKQ 7
            AMA+H+Q
Sbjct: 1024 AMALHRQ 1030
>XP_005264615
          Length = 2162

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   AMAIHKQ 7
           AMA+H+Q
Sbjct: 961 AMALHRQ 967
>XP_006712164
          Length = 2179

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   AMAIHKQ 7
           AMA+H+Q
Sbjct: 961 AMALHRQ 967
>XP_005264614
          Length = 2191

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    AMAIHKQ 7
            AMA+H+Q
Sbjct: 1024 AMALHRQ 1030
>XP_005264613
          Length = 2208

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    AMAIHKQ 7
            AMA+H+Q
Sbjct: 1024 AMALHRQ 1030
>XP_005264612
          Length = 2242

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    AMAIHKQ 7
            AMA+H+Q
Sbjct: 1024 AMALHRQ 1030
>NP_001164663
          Length = 590

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   AMAIHKQS 8
           AMA+HK +
Sbjct: 486 AMALHKDN 493
>NP_001003698
          Length = 1687

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   AMAIHKQS 8
           ++A+HKQ+
Sbjct: 330 SLALHKQT 337
>NP_001161816
          Length = 1687

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   AMAIHKQS 8
           ++A+HKQ+
Sbjct: 330 SLALHKQT 337
>NP_001003699
          Length = 1742

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   AMAIHKQS 8
           ++A+HKQ+
Sbjct: 330 SLALHKQT 337
>NP_001003700
          Length = 1476

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   AMAIHKQS 8
           ++A+HKQ+
Sbjct: 330 SLALHKQT 337
>XP_006715224
          Length = 1742

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   AMAIHKQS 8
           ++A+HKQ+
Sbjct: 330 SLALHKQT 337
>XP_005249329
          Length = 1742

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   AMAIHKQS 8
           ++A+HKQ+
Sbjct: 330 SLALHKQT 337
>XP_006715223
          Length = 1742

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   AMAIHKQS 8
           ++A+HKQ+
Sbjct: 330 SLALHKQT 337
>XP_006715222
          Length = 1742

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   AMAIHKQS 8
           ++A+HKQ+
Sbjct: 330 SLALHKQT 337
>XP_005249333
          Length = 1742

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   AMAIHKQS 8
           ++A+HKQ+
Sbjct: 330 SLALHKQT 337
>XP_006715221
          Length = 1742

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   AMAIHKQS 8
           ++A+HKQ+
Sbjct: 330 SLALHKQT 337
>XP_006715220
          Length = 1742

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   AMAIHKQS 8
           ++A+HKQ+
Sbjct: 330 SLALHKQT 337
>XP_005249332
          Length = 1742

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   AMAIHKQS 8
           ++A+HKQ+
Sbjct: 330 SLALHKQT 337
>XP_006715219
          Length = 1742

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   AMAIHKQS 8
           ++A+HKQ+
Sbjct: 330 SLALHKQT 337
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.316    0.110    0.279 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 496,960
Number of extensions: 506
Number of successful extensions: 35
Number of sequences better than 10000.0: 35
Number of HSP's gapped: 35
Number of HSP's successfully gapped: 35
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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