Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001895                                                              19     869
NP_001091680                                                           19     869
NP_001091679                                                           19     869
XP_006713048                                                           19     869
XP_006713047                                                           19     869
XP_006713046                                                           19     869
XP_005264943                                                           19     869
NP_002221                                                              18    1482
NP_068831                                                              18    1482
XP_006721941                                                           18    1482
XP_006721940                                                           18    1482
XP_006721939                                                           18    1482
XP_006721938                                                           18    1482
XP_006721937                                                           18    1482
XP_006721936                                                           18    1482
XP_006721935                                                           18    1482
XP_006721934                                                           18    1482
XP_005257370                                                           18    1482
NP_004414                                                              17    4312
XP_005247229                                                           17    4312
NP_057095                                                              16    5631
XP_005245942                                                           16    5631
XP_005257608                                                           15    9605
XP_005257606                                                           15    9605
>NP_001895
          Length = 781

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ALVKMLASP 9
           ALVKML SP
Sbjct: 239 ALVKMLGSP 247
>NP_001091680
          Length = 781

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ALVKMLASP 9
           ALVKML SP
Sbjct: 239 ALVKMLGSP 247
>NP_001091679
          Length = 781

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ALVKMLASP 9
           ALVKML SP
Sbjct: 239 ALVKMLGSP 247
>XP_006713048
          Length = 720

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ALVKMLASP 9
           ALVKML SP
Sbjct: 239 ALVKMLGSP 247
>XP_006713047
          Length = 774

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ALVKMLASP 9
           ALVKML SP
Sbjct: 232 ALVKMLGSP 240
>XP_006713046
          Length = 774

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ALVKMLASP 9
           ALVKML SP
Sbjct: 232 ALVKMLGSP 240
>XP_005264943
          Length = 781

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ALVKMLASP 9
           ALVKML SP
Sbjct: 239 ALVKMLGSP 247
>NP_002221
          Length = 745

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   ALVKMLASP 9
           ALV+ML+SP
Sbjct: 230 ALVRMLSSP 238
>NP_068831
          Length = 745

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   ALVKMLASP 9
           ALV+ML+SP
Sbjct: 230 ALVRMLSSP 238
>XP_006721941
          Length = 745

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   ALVKMLASP 9
           ALV+ML+SP
Sbjct: 230 ALVRMLSSP 238
>XP_006721940
          Length = 745

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   ALVKMLASP 9
           ALV+ML+SP
Sbjct: 230 ALVRMLSSP 238
>XP_006721939
          Length = 745

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   ALVKMLASP 9
           ALV+ML+SP
Sbjct: 230 ALVRMLSSP 238
>XP_006721938
          Length = 745

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   ALVKMLASP 9
           ALV+ML+SP
Sbjct: 230 ALVRMLSSP 238
>XP_006721937
          Length = 745

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   ALVKMLASP 9
           ALV+ML+SP
Sbjct: 230 ALVRMLSSP 238
>XP_006721936
          Length = 745

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   ALVKMLASP 9
           ALV+ML+SP
Sbjct: 230 ALVRMLSSP 238
>XP_006721935
          Length = 762

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   ALVKMLASP 9
           ALV+ML+SP
Sbjct: 247 ALVRMLSSP 255
>XP_006721934
          Length = 783

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   ALVKMLASP 9
           ALV+ML+SP
Sbjct: 268 ALVRMLSSP 276
>XP_005257370
          Length = 783

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   ALVKMLASP 9
           ALV+ML+SP
Sbjct: 268 ALVRMLSSP 276
>NP_004414
          Length = 716

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ALVKMLASP 9
           A+VK +ASP
Sbjct: 414 AIVKAMASP 422
>XP_005247229
          Length = 718

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ALVKMLASP 9
           A+VK +ASP
Sbjct: 414 AIVKAMASP 422
>NP_057095
          Length = 373

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  VKMLASP 9
          VKMLA+P
Sbjct: 75 VKMLAAP 81
>XP_005245942
          Length = 401

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   VKMLASP 9
           VKMLA+P
Sbjct: 103 VKMLAAP 109
>XP_005257608
          Length = 147

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LVKMLASP 9
           L+K LA+P
Sbjct: 136 LIKFLANP 143
>XP_005257606
          Length = 219

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LVKMLASP 9
           L+K LA+P
Sbjct: 208 LIKFLANP 215
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.321    0.126    0.323 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 380,172
Number of extensions: 464
Number of successful extensions: 24
Number of sequences better than 10000.0: 24
Number of HSP's gapped: 24
Number of HSP's successfully gapped: 24
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package