Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_002221                                                              18    1482
NP_068831                                                              18    1482
XP_006721941                                                           18    1482
XP_006721940                                                           18    1482
XP_006721939                                                           18    1482
XP_006721938                                                           18    1482
XP_006721937                                                           18    1482
XP_006721936                                                           18    1482
XP_006721935                                                           18    1482
XP_006721934                                                           18    1482
XP_005257370                                                           18    1482
NP_001895                                                              18    1935
NP_001091680                                                           18    1935
NP_001091679                                                           18    1935
XP_006713048                                                           18    1935
XP_006713047                                                           18    1935
XP_006713046                                                           18    1935
XP_005264943                                                           18    1935
NP_001177773                                                           17    4312
NP_036485                                                              17    4312
NP_001483                                                              16    5631
NP_660328                                                              16    5631
NP_079239                                                              16    7355
NP_001073865                                                           16    7355
NP_001127951                                                           16    7355
NP_060573                                                              16    7355
NP_061927                                                              16    7355
XP_006717969                                                           16    7355
XP_005269977                                                           16    7355
XP_006717968                                                           16    7355
XP_006717967                                                           16    7355
XP_006717966                                                           16    7355
XP_006717965                                                           16    7355
XP_005249911                                                           16    7355
XP_005249910                                                           16    7355
XP_005271048                                                           16    7355
NP_001360                                                              15    9605
NP_115582                                                              15    9605
NP_112181                                                              15    9605
NP_689838                                                              15    9605
NP_005874                                                              15    9605
XP_006722673                                                           15    9605
XP_006722672                                                           15    9605
XP_006722671                                                           15    9605
XP_006722670                                                           15    9605
XP_005259532                                                           15    9605
XP_005266713                                                           15    9605
XP_006721363                                                           15    9605
XP_005256258                                                           15    9605
XP_005256257                                                           15    9605
XP_005256256                                                           15    9605
XP_005256255                                                           15    9605
XP_006721362                                                           15    9605
XP_006721361                                                           15    9605
XP_005256254                                                           15    9605
XP_005256253                                                           15    9605
XP_005256252                                                           15    9605
XP_005256251                                                           15    9605
XP_006721360                                                           15    9605
XP_005256250                                                           15    9605
XP_005248319                                                           15    9605
NP_055728                                                              15    9605
NP_036497                                                              15    9605
>NP_002221
          Length = 745

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ALVHTVLRA 9
           AL+H +LRA
Sbjct: 437 ALIHAILRA 445
>NP_068831
          Length = 745

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ALVHTVLRA 9
           AL+H +LRA
Sbjct: 437 ALIHAILRA 445
>XP_006721941
          Length = 745

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ALVHTVLRA 9
           AL+H +LRA
Sbjct: 437 ALIHAILRA 445
>XP_006721940
          Length = 745

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ALVHTVLRA 9
           AL+H +LRA
Sbjct: 437 ALIHAILRA 445
>XP_006721939
          Length = 745

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ALVHTVLRA 9
           AL+H +LRA
Sbjct: 437 ALIHAILRA 445
>XP_006721938
          Length = 745

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ALVHTVLRA 9
           AL+H +LRA
Sbjct: 437 ALIHAILRA 445
>XP_006721937
          Length = 745

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ALVHTVLRA 9
           AL+H +LRA
Sbjct: 437 ALIHAILRA 445
>XP_006721936
          Length = 745

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ALVHTVLRA 9
           AL+H +LRA
Sbjct: 437 ALIHAILRA 445
>XP_006721935
          Length = 762

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ALVHTVLRA 9
           AL+H +LRA
Sbjct: 454 ALIHAILRA 462
>XP_006721934
          Length = 783

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ALVHTVLRA 9
           AL+H +LRA
Sbjct: 475 ALIHAILRA 483
>XP_005257370
          Length = 783

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ALVHTVLRA 9
           AL+H +LRA
Sbjct: 475 ALIHAILRA 483
>NP_001895
          Length = 781

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ALVHTVLRA 9
           ALV TVLRA
Sbjct: 446 ALVRTVLRA 454
>NP_001091680
          Length = 781

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ALVHTVLRA 9
           ALV TVLRA
Sbjct: 446 ALVRTVLRA 454
>NP_001091679
          Length = 781

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ALVHTVLRA 9
           ALV TVLRA
Sbjct: 446 ALVRTVLRA 454
>XP_006713048
          Length = 720

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ALVHTVLRA 9
           ALV TVLRA
Sbjct: 446 ALVRTVLRA 454
>XP_006713047
          Length = 774

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ALVHTVLRA 9
           ALV TVLRA
Sbjct: 439 ALVRTVLRA 447
>XP_006713046
          Length = 774

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ALVHTVLRA 9
           ALV TVLRA
Sbjct: 439 ALVRTVLRA 447
>XP_005264943
          Length = 781

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ALVHTVLRA 9
           ALV TVLRA
Sbjct: 446 ALVRTVLRA 454
>NP_001177773
          Length = 291

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LVHTVLRA 9
           L HT+LRA
Sbjct: 168 LTHTLLRA 175
>NP_036485
          Length = 314

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   ALVHTVLRA 9
           AL+HTVL A
Sbjct: 156 ALLHTVLIA 164
>NP_001483
          Length = 372

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   ALVHTVLRA 9
           AL H VLRA
Sbjct: 314 ALNHAVLRA 322
>NP_660328
          Length = 364

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  VHTVLR 8
          VHTVLR
Sbjct: 93 VHTVLR 98
>NP_079239
          Length = 718

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  ALVHTVL 7
          +L+HTVL
Sbjct: 67 SLIHTVL 73
>NP_001073865
          Length = 458

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LVHTVLRA 9
           L+HTVL A
Sbjct: 426 LLHTVLTA 433
>NP_001127951
          Length = 858

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   ALVHTVL 7
           AL+HT++
Sbjct: 169 ALIHTII 175
>NP_060573
          Length = 858

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   ALVHTVL 7
           AL+HT++
Sbjct: 169 ALIHTII 175
>NP_061927
          Length = 835

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LVHTVLR 8
           LVH VLR
Sbjct: 595 LVHAVLR 601
>XP_006717969
          Length = 439

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LVHTVLR 8
           LVH VLR
Sbjct: 130 LVHAVLR 136
>XP_005269977
          Length = 555

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LVHTVLR 8
           LVH VLR
Sbjct: 246 LVHAVLR 252
>XP_006717968
          Length = 952

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LVHTVLR 8
           LVH VLR
Sbjct: 643 LVHAVLR 649
>XP_006717967
          Length = 952

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LVHTVLR 8
           LVH VLR
Sbjct: 643 LVHAVLR 649
>XP_006717966
          Length = 952

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LVHTVLR 8
           LVH VLR
Sbjct: 643 LVHAVLR 649
>XP_006717965
          Length = 958

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LVHTVLR 8
           LVH VLR
Sbjct: 649 LVHAVLR 655
>XP_005249911
          Length = 672

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  ALVHTVL 7
          +L+HTVL
Sbjct: 67 SLIHTVL 73
>XP_005249910
          Length = 801

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  ALVHTVL 7
          +L+HTVL
Sbjct: 67 SLIHTVL 73
>XP_005271048
          Length = 858

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   ALVHTVL 7
           AL+HT++
Sbjct: 169 ALIHTII 175
>NP_001360
          Length = 4624

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3    VHTVLRA 9
            +HT++RA
Sbjct: 2272 IHTLMRA 2278
>NP_115582
          Length = 1866

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VHTVLRA 9
           VH VLRA
Sbjct: 915 VHCVLRA 921
>NP_112181
          Length = 615

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   VHTVLRA 9
           VH +LRA
Sbjct: 95  VHAILRA 101
>NP_689838
          Length = 744

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LVHTVLRA 9
           L+HT +RA
Sbjct: 469 LIHTNIRA 476
>NP_005874
          Length = 2303

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   ALVHTVLRA 9
           ALV  VLRA
Sbjct: 536 ALVQCVLRA 544
>XP_006722673
          Length = 2302

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   ALVHTVLRA 9
           ALV  VLRA
Sbjct: 535 ALVQCVLRA 543
>XP_006722672
          Length = 2303

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   ALVHTVLRA 9
           ALV  VLRA
Sbjct: 536 ALVQCVLRA 544
>XP_006722671
          Length = 2303

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   ALVHTVLRA 9
           ALV  VLRA
Sbjct: 536 ALVQCVLRA 544
>XP_006722670
          Length = 2326

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   ALVHTVLRA 9
           ALV  VLRA
Sbjct: 559 ALVQCVLRA 567
>XP_005259532
          Length = 2327

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   ALVHTVLRA 9
           ALV  VLRA
Sbjct: 560 ALVQCVLRA 568
>XP_005266713
          Length = 1131

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VHTVLRA 9
           VHTVL++
Sbjct: 904 VHTVLKS 910
>XP_006721363
          Length = 1385

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VHTVLRA 9
           VH VLRA
Sbjct: 915 VHCVLRA 921
>XP_005256258
          Length = 1397

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VHTVLRA 9
           VH VLRA
Sbjct: 915 VHCVLRA 921
>XP_005256257
          Length = 1405

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VHTVLRA 9
           VH VLRA
Sbjct: 915 VHCVLRA 921
>XP_005256256
          Length = 1427

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VHTVLRA 9
           VH VLRA
Sbjct: 915 VHCVLRA 921
>XP_005256255
          Length = 1809

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VHTVLRA 9
           VH VLRA
Sbjct: 915 VHCVLRA 921
>XP_006721362
          Length = 1810

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VHTVLRA 9
           VH VLRA
Sbjct: 915 VHCVLRA 921
>XP_006721361
          Length = 1836

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VHTVLRA 9
           VH VLRA
Sbjct: 915 VHCVLRA 921
>XP_005256254
          Length = 1837

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VHTVLRA 9
           VH VLRA
Sbjct: 915 VHCVLRA 921
>XP_005256253
          Length = 1838

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VHTVLRA 9
           VH VLRA
Sbjct: 887 VHCVLRA 893
>XP_005256252
          Length = 1865

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VHTVLRA 9
           VH VLRA
Sbjct: 915 VHCVLRA 921
>XP_005256251
          Length = 1866

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VHTVLRA 9
           VH VLRA
Sbjct: 915 VHCVLRA 921
>XP_006721360
          Length = 1866

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VHTVLRA 9
           VH VLRA
Sbjct: 915 VHCVLRA 921
>XP_005256250
          Length = 1866

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VHTVLRA 9
           VH VLRA
Sbjct: 915 VHCVLRA 921
>XP_005248319
          Length = 4609

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3    VHTVLRA 9
            +HT++RA
Sbjct: 2257 IHTLMRA 2263
>NP_055728
          Length = 1131

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VHTVLRA 9
           VHTVL++
Sbjct: 904 VHTVLKS 910
>NP_036497
          Length = 311

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   ALVHTVL 7
           ALVH VL
Sbjct: 156 ALVHVVL 162
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.338    0.136    0.369 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 482,655
Number of extensions: 527
Number of successful extensions: 63
Number of sequences better than 10000.0: 63
Number of HSP's gapped: 63
Number of HSP's successfully gapped: 63
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.5 bits)
S2: 28 (15.4 bits)

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