Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005179                                                              18    1482
NP_056516                                                              18    1935
NP_001120869                                                           18    1935
NP_001120870                                                           18    1935
NP_060773                                                              17    3301
XP_006715205                                                           17    3301
XP_006715204                                                           17    3301
NP_689537                                                              17    4312
NP_060762                                                              16    5631
NP_006763                                                              16    7355
NP_689923                                                              16    7355
NP_443179                                                              16    7355
NP_065746                                                              16    7355
XP_005259656                                                           16    7355
XP_006717762                                                           16    7355
XP_005269672                                                           16    7355
XP_006717761                                                           16    7355
XP_005251814                                                           16    7355
NP_003212                                                              15    9605
NP_055180                                                              15    9605
NP_078858                                                              15    9605
NP_001278232                                                           15    9605
NP_001278214                                                           15    9605
NP_003627                                                              15    9605
NP_001004334                                                           15    9605
NP_001186791                                                           15    9605
NP_001186346                                                           15    9605
NP_742128                                                              15    9605
NP_001186792                                                           15    9605
NP_001186789                                                           15    9605
NP_001186790                                                           15    9605
NP_036430                                                              15    9605
NP_872393                                                              15    9605
NP_775808                                                              15    9605
XP_006725396                                                           15    9605
XP_006725395                                                           15    9605
XP_006725394                                                           15    9605
XP_006725393                                                           15    9605
XP_005257805                                                           15    9605
XP_006722205                                                           15    9605
XP_006722204                                                           15    9605
XP_006722057                                                           15    9605
XP_006722056                                                           15    9605
XP_006722055                                                           15    9605
XP_006722054                                                           15    9605
XP_005277669                                                           15    9605
XP_005277638                                                           15    9605
XP_005277637                                                           15    9605
XP_005277636                                                           15    9605
XP_006715241                                                           15    9605
XP_006715240                                                           15    9605
XP_006715239                                                           15    9605
XP_006712515                                                           15    9605
XP_006712514                                                           15    9605
XP_006712513                                                           15    9605
XP_006712512                                                           15    9605
XP_006712511                                                           15    9605
XP_006712510                                                           15    9605
XP_006712509                                                           15    9605
XP_005246533                                                           15    9605
XP_006712508                                                           15    9605
XP_005263571                                                           15    9605
NP_001155971                                                           15    9605
NP_115893                                                              15    9605
NP_003623                                                              15    9605
NP_061720                                                              15    9605
NP_001003795                                                           15    9605
>NP_005179
          Length = 906

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ALPQLSSEI 9
           A PQLSSEI
Sbjct: 853 ASPQLSSEI 861
>NP_056516
          Length = 483

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  ALPQLSSEI 9
          ALPQLS +I
Sbjct: 33 ALPQLSDDI 41
>NP_001120869
          Length = 457

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  ALPQLSSEI 9
          ALPQLS +I
Sbjct: 33 ALPQLSDDI 41
>NP_001120870
          Length = 429

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  ALPQLSSEI 9
          ALPQLS +I
Sbjct: 33 ALPQLSDDI 41
>NP_060773
          Length = 924

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   ALPQLSS 7
           ALPQLSS
Sbjct: 883 ALPQLSS 889
>XP_006715205
          Length = 924

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   ALPQLSS 7
           ALPQLSS
Sbjct: 883 ALPQLSS 889
>XP_006715204
          Length = 924

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   ALPQLSS 7
           ALPQLSS
Sbjct: 883 ALPQLSS 889
>NP_689537
          Length = 151

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   ALPQLSSE 8
           ALPQ SSE
Sbjct: 96  ALPQKSSE 103
>NP_060762
          Length = 528

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LPQLSSEI 9
           +P+LSSE+
Sbjct: 287 VPELSSEV 294
>NP_006763
          Length = 1343

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LPQLSSE 8
           LPQLS E
Sbjct: 700 LPQLSKE 706
>NP_689923
          Length = 351

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   PQLSSE 8
           PQLSSE
Sbjct: 138 PQLSSE 143
>NP_443179
          Length = 2170

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   PQLSSE 8
           PQLSSE
Sbjct: 297 PQLSSE 302
>NP_065746
          Length = 1221

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ALPQLSSE 8
           ALP LSS+
Sbjct: 542 ALPSLSSD 549
>XP_005259656
          Length = 1373

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ALPQLSSE 8
           ALP LSS+
Sbjct: 542 ALPSLSSD 549
>XP_006717762
          Length = 315

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  PQLSSE 8
          PQLSSE
Sbjct: 19 PQLSSE 24
>XP_005269672
          Length = 351

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   PQLSSE 8
           PQLSSE
Sbjct: 138 PQLSSE 143
>XP_006717761
          Length = 383

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   PQLSSE 8
           PQLSSE
Sbjct: 138 PQLSSE 143
>XP_005251814
          Length = 839

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LPQLSSEI 9
           LP L+SEI
Sbjct: 824 LPSLNSEI 831
>NP_003212
          Length = 460

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   ALPQLS 6
           ALPQLS
Sbjct: 128 ALPQLS 133
>NP_055180
          Length = 196

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  ALPQLSS 7
          ALP+LSS
Sbjct: 52 ALPRLSS 58
>NP_078858
          Length = 4981

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LPQLSSEI 9
           +PQLSS +
Sbjct: 973 VPQLSSSV 980
>NP_001278232
          Length = 4983

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LPQLSSEI 9
           +PQLSS +
Sbjct: 973 VPQLSSSV 980
>NP_001278214
          Length = 4982

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LPQLSSEI 9
           +PQLSS +
Sbjct: 973 VPQLSSSV 980
>NP_003627
          Length = 367

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LPQLSSEI 9
           LP+LSS I
Sbjct: 340 LPKLSSSI 347
>NP_001004334
          Length = 2367

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  ALPQLSSEI 9
          +LP LSS++
Sbjct: 34 SLPPLSSQV 42
>NP_001186791
          Length = 415

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LPQLSSEI 9
           LP+LSS I
Sbjct: 388 LPKLSSSI 395
>NP_001186346
          Length = 1491

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   ALPQLSSE 8
           A P LSSE
Sbjct: 256 AFPHLSSE 263
>NP_742128
          Length = 353

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LPQLSSEI 9
           LP+LSS I
Sbjct: 326 LPKLSSSI 333
>NP_001186792
          Length = 300

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LPQLSSEI 9
           LP+LSS I
Sbjct: 273 LPKLSSSI 280
>NP_001186789
          Length = 367

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LPQLSSEI 9
           LP+LSS I
Sbjct: 340 LPKLSSSI 347
>NP_001186790
          Length = 367

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LPQLSSEI 9
           LP+LSS I
Sbjct: 340 LPKLSSSI 347
>NP_036430
          Length = 1119

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  LPQLSS 7
          LPQLSS
Sbjct: 88 LPQLSS 93
>NP_872393
          Length = 3234

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ALPQLSSEI 9
           A+P LSS++
Sbjct: 430 AVPDLSSDL 438
>NP_775808
          Length = 949

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LPQLSS 7
           LPQLSS
Sbjct: 741 LPQLSS 746
>XP_006725396
          Length = 1144

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   ALPQLSSE 8
           A P LSSE
Sbjct: 256 AFPHLSSE 263
>XP_006725395
          Length = 1249

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   ALPQLSSE 8
           A P LSSE
Sbjct: 256 AFPHLSSE 263
>XP_006725394
          Length = 1408

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   ALPQLSSE 8
           A P LSSE
Sbjct: 256 AFPHLSSE 263
>XP_006725393
          Length = 1473

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   ALPQLSSE 8
           A P LSSE
Sbjct: 238 AFPHLSSE 245
>XP_005257805
          Length = 1308

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    ALPQLSSEI 9
            A+P+L SE+
Sbjct: 1176 AMPRLVSEV 1184
>XP_006722205
          Length = 1384

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    ALPQLSSEI 9
            A+P+L SE+
Sbjct: 1252 AMPRLVSEV 1260
>XP_006722204
          Length = 1384

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    ALPQLSSEI 9
            A+P+L SE+
Sbjct: 1252 AMPRLVSEV 1260
>XP_006722057
          Length = 1144

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   ALPQLSSE 8
           A P LSSE
Sbjct: 256 AFPHLSSE 263
>XP_006722056
          Length = 1249

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   ALPQLSSE 8
           A P LSSE
Sbjct: 256 AFPHLSSE 263
>XP_006722055
          Length = 1408

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   ALPQLSSE 8
           A P LSSE
Sbjct: 256 AFPHLSSE 263
>XP_006722054
          Length = 1473

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   ALPQLSSE 8
           A P LSSE
Sbjct: 238 AFPHLSSE 245
>XP_005277669
          Length = 949

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LPQLSS 7
           LPQLSS
Sbjct: 741 LPQLSS 746
>XP_005277638
          Length = 755

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LPQLSS 7
           LPQLSS
Sbjct: 547 LPQLSS 552
>XP_005277637
          Length = 878

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LPQLSS 7
           LPQLSS
Sbjct: 670 LPQLSS 675
>XP_005277636
          Length = 949

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LPQLSS 7
           LPQLSS
Sbjct: 741 LPQLSS 746
>XP_006715241
          Length = 442

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   ALPQLS 6
           ALPQLS
Sbjct: 110 ALPQLS 115
>XP_006715240
          Length = 449

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   ALPQLS 6
           ALPQLS
Sbjct: 110 ALPQLS 115
>XP_006715239
          Length = 467

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   ALPQLS 6
           ALPQLS
Sbjct: 128 ALPQLS 133
>XP_006712515
          Length = 3232

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ALPQLSSEI 9
           A+P LSS++
Sbjct: 430 AVPDLSSDL 438
>XP_006712514
          Length = 2496

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ALPQLSSEI 9
           A+P LSS++
Sbjct: 430 AVPDLSSDL 438
>XP_006712513
          Length = 3220

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ALPQLSSEI 9
           A+P LSS++
Sbjct: 430 AVPDLSSDL 438
>XP_006712512
          Length = 3237

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ALPQLSSEI 9
           A+P LSS++
Sbjct: 430 AVPDLSSDL 438
>XP_006712511
          Length = 3256

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ALPQLSSEI 9
           A+P LSS++
Sbjct: 430 AVPDLSSDL 438
>XP_006712510
          Length = 3305

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ALPQLSSEI 9
           A+P LSS++
Sbjct: 430 AVPDLSSDL 438
>XP_006712509
          Length = 3319

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ALPQLSSEI 9
           A+P LSS++
Sbjct: 430 AVPDLSSDL 438
>XP_005246533
          Length = 3323

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ALPQLSSEI 9
           A+P LSS++
Sbjct: 430 AVPDLSSDL 438
>XP_006712508
          Length = 3324

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ALPQLSSEI 9
           A+P LSS++
Sbjct: 430 AVPDLSSDL 438
>XP_005263571
          Length = 353

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LPQLSSEI 9
           LP+LSS I
Sbjct: 326 LPKLSSSI 333
>NP_001155971
          Length = 1236

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LPQLSS 7
           LPQLSS
Sbjct: 181 LPQLSS 186
>NP_115893
          Length = 3258

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ALPQLSSEI 9
           A+P LSS++
Sbjct: 430 AVPDLSSDL 438
>NP_003623
          Length = 1384

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    ALPQLSSEI 9
            A+P+L SE+
Sbjct: 1252 AMPRLVSEV 1260
>NP_061720
          Length = 4024

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  ALPQLS 6
          ALPQLS
Sbjct: 41 ALPQLS 46
>NP_001003795
          Length = 949

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LPQLSS 7
           LPQLSS
Sbjct: 741 LPQLSS 746
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.305    0.122    0.297 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 616,516
Number of extensions: 799
Number of successful extensions: 67
Number of sequences better than 10000.0: 67
Number of HSP's gapped: 67
Number of HSP's successfully gapped: 67
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)

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