Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_733751                                                              19     869
XP_006716142                                                           19     869
XP_005250088                                                           19     869
XP_006716141                                                           19     869
XP_005250085                                                           19     869
XP_006716140                                                           19     869
XP_005250084                                                           19     869
XP_005250083                                                           19     869
XP_005250082                                                           19     869
NP_001177344                                                           18    1482
NP_647476                                                              18    1482
NP_005632                                                              18    1482
XP_006716165                                                           18    1482
XP_006716164                                                           18    1482
XP_006716163                                                           18    1482
NP_653229                                                              17    4312
NP_001149946                                                           17    4312
NP_068599                                                              17    4312
XP_006723603                                                           17    4312
XP_005260718                                                           17    4312
XP_005274218                                                           17    4312
NP_006736                                                              16    7355
NP_001017369                                                           16    7355
NP_006284                                                              16    7355
NP_001229338                                                           16    7355
NP_001273879                                                           16    7355
NP_659401                                                              16    7355
NP_001273881                                                           16    7355
NP_001273880                                                           16    7355
NP_001273882                                                           16    7355
NP_001273883                                                           16    7355
NP_073588                                                              16    7355
XP_005251436                                                           16    7355
XP_005251432                                                           16    7355
XP_005251430                                                           16    7355
XP_005263233                                                           16    7355
XP_006711061                                                           16    7355
XP_006711060                                                           16    7355
XP_005244868                                                           16    7355
NP_075391                                                              15    9605
NP_004932                                                              15    9605
NP_001276109                                                           15    9605
NP_001276108                                                           15    9605
NP_001276106                                                           15    9605
NP_653327                                                              15    9605
NP_001186312                                                           15    9605
NP_001186311                                                           15    9605
NP_001186310                                                           15    9605
NP_001186309                                                           15    9605
NP_008869                                                              15    9605
NP_061760                                                              15    9605
XP_006726512                                                           15    9605
XP_005276794                                                           15    9605
XP_006726268                                                           15    9605
XP_006726267                                                           15    9605
XP_005276792                                                           15    9605
XP_005259710                                                           15    9605
XP_006722978                                                           15    9605
XP_005257171                                                           15    9605
XP_005257170                                                           15    9605
XP_005265883                                                           15    9605
XP_005245518                                                           15    9605
XP_006711554                                                           15    9605
XP_006711553                                                           15    9605
XP_005245516                                                           15    9605
NP_061762                                                              15    9605
NP_112186                                                              15    9605
NP_001276107                                                           15    9605
>NP_733751
          Length = 4911

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   LPLETLVS 9
           LPLETLVS
Sbjct: 694 LPLETLVS 701
>XP_006716142
          Length = 4927

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   LPLETLVS 9
           LPLETLVS
Sbjct: 695 LPLETLVS 702
>XP_005250088
          Length = 4928

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   LPLETLVS 9
           LPLETLVS
Sbjct: 695 LPLETLVS 702
>XP_006716141
          Length = 4959

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   LPLETLVS 9
           LPLETLVS
Sbjct: 695 LPLETLVS 702
>XP_005250085
          Length = 4979

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   LPLETLVS 9
           LPLETLVS
Sbjct: 695 LPLETLVS 702
>XP_006716140
          Length = 4982

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   LPLETLVS 9
           LPLETLVS
Sbjct: 695 LPLETLVS 702
>XP_005250084
          Length = 4982

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   LPLETLVS 9
           LPLETLVS
Sbjct: 695 LPLETLVS 702
>XP_005250083
          Length = 4982

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   LPLETLVS 9
           LPLETLVS
Sbjct: 694 LPLETLVS 701
>XP_005250082
          Length = 4983

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   LPLETLVS 9
           LPLETLVS
Sbjct: 695 LPLETLVS 702
>NP_001177344
          Length = 714

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   ALPLETLVS 9
           ALP++TLVS
Sbjct: 551 ALPVQTLVS 559
>NP_647476
          Length = 677

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   ALPLETLVS 9
           ALP++TLVS
Sbjct: 514 ALPVQTLVS 522
>NP_005632
          Length = 677

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   ALPLETLVS 9
           ALP++TLVS
Sbjct: 514 ALPVQTLVS 522
>XP_006716165
          Length = 667

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   ALPLETLVS 9
           ALP++TLVS
Sbjct: 504 ALPVQTLVS 512
>XP_006716164
          Length = 667

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   ALPLETLVS 9
           ALP++TLVS
Sbjct: 504 ALPVQTLVS 512
>XP_006716163
          Length = 677

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   ALPLETLVS 9
           ALP++TLVS
Sbjct: 514 ALPVQTLVS 522
>NP_653229
          Length = 403

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LPLETLVS 9
           LP ETL+S
Sbjct: 286 LPYETLIS 293
>NP_001149946
          Length = 652

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LPLETLV 8
           LP+ETLV
Sbjct: 222 LPMETLV 228
>NP_068599
          Length = 562

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LPLETLV 8
           LP+ETLV
Sbjct: 132 LPMETLV 138
>XP_006723603
          Length = 341

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LPLETLVS 9
           LP ETL+S
Sbjct: 224 LPYETLIS 231
>XP_005260718
          Length = 403

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LPLETLVS 9
           LP ETL+S
Sbjct: 286 LPYETLIS 293
>XP_005274218
          Length = 604

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LPLETLV 8
           LP+ETLV
Sbjct: 222 LPMETLV 228
>NP_006736
          Length = 293

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ALPLETLV 8
           A PLETL+
Sbjct: 187 AHPLETLI 194
>NP_001017369
          Length = 162

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  ALPLETLV 8
          A PLETL+
Sbjct: 56 AHPLETLI 63
>NP_006284
          Length = 890

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LPLETLV 8
           LPL+TL+
Sbjct: 627 LPLQTLI 633
>NP_001229338
          Length = 876

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  ALPLETLVS 9
          A+PL+ LVS
Sbjct: 20 AVPLDLLVS 28
>NP_001273879
          Length = 256

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   PLETLV 8
           PLETLV
Sbjct: 153 PLETLV 158
>NP_659401
          Length = 316

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   PLETLV 8
           PLETLV
Sbjct: 204 PLETLV 209
>NP_001273881
          Length = 229

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   PLETLV 8
           PLETLV
Sbjct: 126 PLETLV 131
>NP_001273880
          Length = 221

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   PLETLV 8
           PLETLV
Sbjct: 109 PLETLV 114
>NP_001273882
          Length = 196

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  PLETLV 8
          PLETLV
Sbjct: 93 PLETLV 98
>NP_001273883
          Length = 196

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  PLETLV 8
          PLETLV
Sbjct: 93 PLETLV 98
>NP_073588
          Length = 875

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  ALPLETLVS 9
          A+PL+ LVS
Sbjct: 20 AVPLDLLVS 28
>XP_005251436
          Length = 184

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  PLETLV 8
          PLETLV
Sbjct: 72 PLETLV 77
>XP_005251432
          Length = 238

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   PLETLV 8
           PLETLV
Sbjct: 126 PLETLV 131
>XP_005251430
          Length = 307

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   PLETLV 8
           PLETLV
Sbjct: 204 PLETLV 209
>XP_005263233
          Length = 293

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ALPLETLV 8
           A PLETL+
Sbjct: 187 AHPLETLI 194
>XP_006711061
          Length = 1553

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LPLETL 7
           LPLETL
Sbjct: 887 LPLETL 892
>XP_006711060
          Length = 1595

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LPLETL 7
           LPLETL
Sbjct: 929 LPLETL 934
>XP_005244868
          Length = 1639

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LPLETL 7
           LPLETL
Sbjct: 973 LPLETL 978
>NP_075391
          Length = 1042

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   LPLETLV 8
           +PLET++
Sbjct: 819 IPLETII 825
>NP_004932
          Length = 1220

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ALPLETLVS 9
           A P+ETL++
Sbjct: 948 APPMETLIT 956
>NP_001276109
          Length = 479

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LPLETLV 8
           +P+ETLV
Sbjct: 340 IPVETLV 346
>NP_001276108
          Length = 638

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LPLETLV 8
           +P+ETLV
Sbjct: 527 IPVETLV 533
>NP_001276106
          Length = 666

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LPLETLV 8
           +P+ETLV
Sbjct: 527 IPVETLV 533
>NP_653327
          Length = 691

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LPLETLV 8
           +PLET+V
Sbjct: 191 VPLETIV 197
>NP_001186312
          Length = 663

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LPLETLV 8
           +PLET+V
Sbjct: 163 VPLETIV 169
>NP_001186311
          Length = 677

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LPLETLV 8
           +PLET+V
Sbjct: 177 VPLETIV 183
>NP_001186310
          Length = 680

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LPLETLV 8
           +PLET+V
Sbjct: 180 VPLETIV 186
>NP_001186309
          Length = 693

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LPLETLV 8
           +PLET+V
Sbjct: 193 VPLETIV 199
>NP_008869
          Length = 119

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  ALPLETLV 8
          +LPL+TL+
Sbjct: 73 SLPLDTLL 80
>NP_061760
          Length = 796

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LPLETLVS 9
           LPL +LVS
Sbjct: 498 LPLSSLVS 505
>XP_006726512
          Length = 335

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ALPLETLV 8
           A PL+TL+
Sbjct: 176 AAPLQTLI 183
>XP_005276794
          Length = 555

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   LPLETLV 8
           +PLET++
Sbjct: 332 IPLETII 338
>XP_006726268
          Length = 621

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   LPLETLV 8
           +PLET++
Sbjct: 332 IPLETII 338
>XP_006726267
          Length = 1053

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   LPLETLV 8
           +PLET++
Sbjct: 764 IPLETII 770
>XP_005276792
          Length = 1108

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   LPLETLV 8
           +PLET++
Sbjct: 819 IPLETII 825
>XP_005259710
          Length = 566

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LPLETLV 8
           +P+ETLV
Sbjct: 527 IPVETLV 533
>XP_006722978
          Length = 651

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LPLETLV 8
           +P+ETLV
Sbjct: 527 IPVETLV 533
>XP_005257171
          Length = 1181

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ALPLETLVS 9
           A P+ETL++
Sbjct: 948 APPMETLIT 956
>XP_005257170
          Length = 1218

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ALPLETLVS 9
           A P+ETL++
Sbjct: 946 APPMETLIT 954
>XP_005265883
          Length = 679

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LPLETLV 8
           +PLET+V
Sbjct: 179 VPLETIV 185
>XP_005245518
          Length = 555

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   LPLETLV 8
           +PLET++
Sbjct: 332 IPLETII 338
>XP_006711554
          Length = 621

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   LPLETLV 8
           +PLET++
Sbjct: 332 IPLETII 338
>XP_006711553
          Length = 1053

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   LPLETLV 8
           +PLET++
Sbjct: 764 IPLETII 770
>XP_005245516
          Length = 1108

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   LPLETLV 8
           +PLET++
Sbjct: 819 IPLETII 825
>NP_061762
          Length = 794

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LPLETLVS 9
           LPL +LVS
Sbjct: 496 LPLSSLVS 503
>NP_112186
          Length = 666

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LPLETLV 8
           +P+ETLV
Sbjct: 527 IPVETLV 533
>NP_001276107
          Length = 666

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LPLETLV 8
           +P+ETLV
Sbjct: 527 IPVETLV 533
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.312    0.130    0.328 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 594,247
Number of extensions: 893
Number of successful extensions: 68
Number of sequences better than 10000.0: 68
Number of HSP's gapped: 68
Number of HSP's successfully gapped: 68
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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