Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_919047                                                              19     869
XP_005250598                                                           19     869
XP_005271963                                                           18    1482
XP_006714622                                                           18    1482
XP_005271962                                                           18    1482
XP_006714621                                                           18    1482
NP_689761                                                              18    1482
NP_115996                                                              17    2528
NP_001258925                                                           17    2528
NP_001258924                                                           17    2528
NP_443086                                                              17    2528
XP_006718443                                                           17    2528
NP_075561                                                              17    3301
NP_001242910                                                           17    3301
NP_570968                                                              17    3301
NP_001242909                                                           17    3301
NP_001242908                                                           17    3301
NP_001242907                                                           17    3301
XP_005248410                                                           17    3301
XP_006714553                                                           17    3301
XP_005248407                                                           17    3301
XP_005248406                                                           17    3301
XP_005248404                                                           17    3301
XP_005248403                                                           17    3301
XP_006714552                                                           17    3301
XP_005248402                                                           17    3301
XP_006711235                                                           17    3301
NP_114171                                                              17    4312
NP_001177738                                                           16    5631
XP_005264824                                                           16    5631
NP_068750                                                              16    5631
NP_938012                                                              16    5631
NP_006359                                                              16    7355
NP_003329                                                              16    7355
NP_061330                                                              16    7355
NP_057687                                                              16    7355
NP_001095271                                                           16    7355
NP_001095270                                                           16    7355
NP_004873                                                              16    7355
NP_057067                                                              16    7355
NP_715638                                                              16    7355
XP_006715799                                                           16    7355
XP_006715798                                                           16    7355
XP_006715797                                                           16    7355
XP_006714712                                                           16    7355
XP_005272064                                                           16    7355
XP_006714711                                                           16    7355
XP_006714710                                                           16    7355
NP_689629                                                              15    9605
NP_005624                                                              15    9605
NP_068378                                                              15    9605
NP_000432                                                              15    9605
NP_001274141                                                           15    9605
NP_002370                                                              15    9605
NP_057597                                                              15    9605
NP_055735                                                              15    9605
NP_061907                                                              15    9605
NP_065867                                                              15    9605
NP_001116291                                                           15    9605
XP_005250850                                                           15    9605
XP_005250849                                                           15    9605
XP_005250848                                                           15    9605
XP_005250847                                                           15    9605
XP_005250846                                                           15    9605
XP_005250483                                                           15    9605
XP_006716087                                                           15    9605
XP_005250482                                                           15    9605
XP_005264572                                                           15    9605
XP_005246008                                                           15    9605
XP_005246007                                                           15    9605
>NP_919047
          Length = 520

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ALKKIQRKI 9
           ALKKI+RKI
Sbjct: 294 ALKKIRRKI 302
>XP_005250598
          Length = 457

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ALKKIQRKI 9
           ALKKI+RKI
Sbjct: 231 ALKKIRRKI 239
>XP_005271963
          Length = 248

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   LKKIQRKI 9
           LKK+QRKI
Sbjct: 235 LKKLQRKI 242
>XP_006714622
          Length = 266

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   LKKIQRKI 9
           LKK+QRKI
Sbjct: 253 LKKLQRKI 260
>XP_005271962
          Length = 266

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   LKKIQRKI 9
           LKK+QRKI
Sbjct: 253 LKKLQRKI 260
>XP_006714621
          Length = 368

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   LKKIQRKI 9
           LKK+QRKI
Sbjct: 355 LKKLQRKI 362
>NP_689761
          Length = 452

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   LKKIQRKI 9
           LKK+QRKI
Sbjct: 439 LKKLQRKI 446
>NP_115996
          Length = 461

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   LKKIQRKI 9
           LKKI+RKI
Sbjct: 244 LKKIRRKI 251
>NP_001258925
          Length = 459

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   LKKIQRKI 9
           LKKI+RKI
Sbjct: 242 LKKIRRKI 249
>NP_001258924
          Length = 460

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   LKKIQRKI 9
           LKKI+RKI
Sbjct: 243 LKKIRRKI 250
>NP_443086
          Length = 519

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   ALKKIQRKI 9
           ALK+++RKI
Sbjct: 290 ALKRVRRKI 298
>XP_006718443
          Length = 363

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   ALKKIQRKI 9
           ALK+++RKI
Sbjct: 290 ALKRVRRKI 298
>NP_075561
          Length = 3197

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    ALKKIQRKI 9
            ALK++QR I
Sbjct: 1418 ALKRVQRNI 1426
>NP_001242910
          Length = 375

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LKKIQRKI 9
           LKK++RKI
Sbjct: 198 LKKVRRKI 205
>NP_570968
          Length = 395

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LKKIQRKI 9
           LKK++RKI
Sbjct: 218 LKKVRRKI 225
>NP_001242909
          Length = 375

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LKKIQRKI 9
           LKK++RKI
Sbjct: 198 LKKVRRKI 205
>NP_001242908
          Length = 395

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LKKIQRKI 9
           LKK++RKI
Sbjct: 218 LKKVRRKI 225
>NP_001242907
          Length = 395

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LKKIQRKI 9
           LKK++RKI
Sbjct: 218 LKKVRRKI 225
>XP_005248410
          Length = 2132

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ALKKIQRKI 9
           ALK++QR I
Sbjct: 299 ALKRVQRNI 307
>XP_006714553
          Length = 2792

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    ALKKIQRKI 9
            ALK++QR I
Sbjct: 1418 ALKRVQRNI 1426
>XP_005248407
          Length = 3208

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    ALKKIQRKI 9
            ALK++QR I
Sbjct: 1375 ALKRVQRNI 1383
>XP_005248406
          Length = 3214

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    ALKKIQRKI 9
            ALK++QR I
Sbjct: 1418 ALKRVQRNI 1426
>XP_005248404
          Length = 3250

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    ALKKIQRKI 9
            ALK++QR I
Sbjct: 1418 ALKRVQRNI 1426
>XP_005248403
          Length = 3250

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    ALKKIQRKI 9
            ALK++QR I
Sbjct: 1418 ALKRVQRNI 1426
>XP_006714552
          Length = 3251

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    ALKKIQRKI 9
            ALK++QR I
Sbjct: 1418 ALKRVQRNI 1426
>XP_005248402
          Length = 3251

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    ALKKIQRKI 9
            ALK++QR I
Sbjct: 1418 ALKRVQRNI 1426
>XP_006711235
          Length = 375

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LKKIQRKI 9
           LKK++RKI
Sbjct: 198 LKKVRRKI 205
>NP_114171
          Length = 798

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   ALKKIQRKI 9
           A+K+I+RKI
Sbjct: 766 AMKQIKRKI 774
>NP_001177738
          Length = 672

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LKKIQRK 8
           LKKIQ+K
Sbjct: 161 LKKIQKK 167
>XP_005264824
          Length = 560

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LKKIQRK 8
           LK+IQRK
Sbjct: 490 LKRIQRK 496
>NP_068750
          Length = 703

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LKKIQRK 8
           LKKIQ+K
Sbjct: 192 LKKIQKK 198
>NP_938012
          Length = 560

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LKKIQRK 8
           LK+IQRK
Sbjct: 490 LKRIQRK 496
>NP_006359
          Length = 371

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LKKIQRKI 9
           LK+++RKI
Sbjct: 151 LKRVRRKI 158
>NP_003329
          Length = 147

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  ALKKIQRKI 9
          ALK+IQ+++
Sbjct: 2  ALKRIQKEL 10
>NP_061330
          Length = 511

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LKKIQRK 8
           LKKI+RK
Sbjct: 140 LKKIRRK 146
>NP_057687
          Length = 915

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LKKIQRKI 9
           +KK+Q+KI
Sbjct: 573 VKKLQKKI 580
>NP_001095271
          Length = 791

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LKKIQRKI 9
           +KK+Q+KI
Sbjct: 477 VKKLQKKI 484
>NP_001095270
          Length = 887

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LKKIQRKI 9
           +KK+Q+KI
Sbjct: 573 VKKLQKKI 580
>NP_004873
          Length = 450

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   KKIQRK 8
           KKIQRK
Sbjct: 287 KKIQRK 292
>NP_057067
          Length = 147

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  ALKKIQRKI 9
          ALK+IQ+++
Sbjct: 2  ALKRIQKEL 10
>NP_715638
          Length = 182

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  ALKKIQRK 8
          ALKK+Q++
Sbjct: 83 ALKKLQKR 90
>XP_006715799
          Length = 157

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  ALKKIQRKI 9
          ALK+IQ+++
Sbjct: 2  ALKRIQKEL 10
>XP_006715798
          Length = 158

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  ALKKIQRKI 9
          ALK+IQ+++
Sbjct: 2  ALKRIQKEL 10
>XP_006715797
          Length = 171

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  ALKKIQRKI 9
          ALK+IQ+++
Sbjct: 2  ALKRIQKEL 10
>XP_006714712
          Length = 819

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LKKIQRKI 9
           +KK+Q+KI
Sbjct: 477 VKKLQKKI 484
>XP_005272064
          Length = 909

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LKKIQRKI 9
           +KK+Q+KI
Sbjct: 595 VKKLQKKI 602
>XP_006714711
          Length = 937

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LKKIQRKI 9
           +KK+Q+KI
Sbjct: 595 VKKLQKKI 602
>XP_006714710
          Length = 937

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LKKIQRKI 9
           +KK+Q+KI
Sbjct: 595 VKKLQKKI 602
>NP_689629
          Length = 333

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LKKIQR 7
           LKKIQR
Sbjct: 298 LKKIQR 303
>NP_005624
          Length = 1333

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  ALKKIQRKI 9
          ALKK+Q ++
Sbjct: 26 ALKKVQGQV 34
>NP_068378
          Length = 147

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  ALKKIQRK 8
          ALK+++RK
Sbjct: 70 ALKRLRRK 77
>NP_000432
          Length = 780

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ALKKIQRKI 9
           AL+KIQ+ I
Sbjct: 584 ALRKIQKLI 592
>NP_001274141
          Length = 929

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LKKIQRKI 9
           L+K+QRK+
Sbjct: 715 LEKMQRKL 722
>NP_002370
          Length = 496

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   KKIQRKI 9
           KK+Q+KI
Sbjct: 445 KKLQKKI 451
>NP_057597
          Length = 632

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  ALKKIQRK 8
          A+KK++RK
Sbjct: 31 AIKKMKRK 38
>NP_055735
          Length = 632

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  ALKKIQRK 8
          A+KK++RK
Sbjct: 31 AIKKMKRK 38
>NP_061907
          Length = 211

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ALKKIQRK 8
           ALKK QR+
Sbjct: 195 ALKKAQRQ 202
>NP_065867
          Length = 1029

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LKKIQRKI 9
           L+K+QRK+
Sbjct: 815 LEKMQRKL 822
>NP_001116291
          Length = 1028

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LKKIQRKI 9
           L+K+QRK+
Sbjct: 815 LEKMQRKL 822
>XP_005250850
          Length = 181

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LKKIQR 7
           LKKIQR
Sbjct: 146 LKKIQR 151
>XP_005250849
          Length = 181

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LKKIQR 7
           LKKIQR
Sbjct: 146 LKKIQR 151
>XP_005250848
          Length = 181

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LKKIQR 7
           LKKIQR
Sbjct: 146 LKKIQR 151
>XP_005250847
          Length = 222

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LKKIQR 7
           LKKIQR
Sbjct: 187 LKKIQR 192
>XP_005250846
          Length = 241

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LKKIQR 7
           LKKIQR
Sbjct: 206 LKKIQR 211
>XP_005250483
          Length = 367

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ALKKIQRKI 9
           AL+KIQ+ I
Sbjct: 171 ALRKIQKLI 179
>XP_006716087
          Length = 780

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ALKKIQRKI 9
           AL+KIQ+ I
Sbjct: 584 ALRKIQKLI 592
>XP_005250482
          Length = 780

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ALKKIQRKI 9
           AL+KIQ+ I
Sbjct: 584 ALRKIQKLI 592
>XP_005264572
          Length = 1318

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  ALKKIQRKI 9
          ALKK+Q ++
Sbjct: 26 ALKKVQGQV 34
>XP_005246008
          Length = 984

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LKKIQRKI 9
           L+K+QRK+
Sbjct: 815 LEKMQRKL 822
>XP_005246007
          Length = 985

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LKKIQRKI 9
           L+K+QRK+
Sbjct: 815 LEKMQRKL 822
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.328    0.139    0.329 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 426,920
Number of extensions: 1190
Number of successful extensions: 70
Number of sequences better than 10000.0: 70
Number of HSP's gapped: 70
Number of HSP's successfully gapped: 70
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)

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