Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001277144                                                           20     390
NP_001277143                                                           20     390
NP_001319                                                              20     390
NP_001012632                                                           20     390
NP_001077383                                                           20     390
NP_001320                                                              20     390
NP_073713                                                              20     390
XP_005269629                                                           20     390
XP_005269628                                                           20     390
XP_005269627                                                           20     390
XP_005269626                                                           20     390
XP_006717706                                                           20     390
XP_005269625                                                           20     390
XP_005269624                                                           20     390
XP_006717705                                                           20     390
XP_005269622                                                           20     390
XP_005269621                                                           20     390
XP_006717704                                                           20     390
XP_005269619                                                           20     390
XP_005269618                                                           20     390
XP_005272320                                                           20     390
XP_005272319                                                           20     390
XP_005272318                                                           20     390
NP_003282                                                              17    3301
XP_005254130                                                           17    3301
XP_005254129                                                           17    3301
XP_005254128                                                           17    3301
XP_005254127                                                           17    3301
NP_001181927                                                           16    7355
NP_055800                                                              16    7355
NP_004806                                                              16    7355
NP_653223                                                              16    7355
NP_006026                                                              16    7355
NP_001258652                                                           16    7355
NP_110420                                                              16    7355
XP_006720500                                                           16    7355
XP_005268287                                                           16    7355
XP_005268286                                                           16    7355
XP_005268285                                                           16    7355
XP_005268284                                                           16    7355
XP_006714860                                                           16    7355
XP_006714859                                                           16    7355
XP_005268570                                                           16    7355
XP_006711111                                                           16    7355
NP_001622                                                              16    7355
NP_073572                                                              15    9605
NP_001139664                                                           15    9605
NP_003310                                                              15    9605
NP_597676                                                              15    9605
NP_596870                                                              15    9605
NP_001243779                                                           15    9605
NP_596869                                                              15    9605
NP_055785                                                              15    9605
NP_055795                                                              15    9605
NP_115633                                                              15    9605
NP_071335                                                              15    9605
XP_005266697                                                           15    9605
XP_005247964                                                           15    9605
XP_006713889                                                           15    9605
XP_006713888                                                           15    9605
XP_006712787                                                           15    9605
XP_006712786                                                           15    9605
XP_005245027                                                           15    9605
NP_001254479                                                           15    9605
NP_597681                                                              15    9605
>NP_001277144
          Length = 445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   ALDVHESE 8
           ALDVHESE
Sbjct: 294 ALDVHESE 301
>NP_001277143
          Length = 445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   ALDVHESE 8
           ALDVHESE
Sbjct: 294 ALDVHESE 301
>NP_001319
          Length = 440

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   ALDVHESE 8
           ALDVHESE
Sbjct: 288 ALDVHESE 295
>NP_001012632
          Length = 429

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   ALDVHESE 8
           ALDVHESE
Sbjct: 277 ALDVHESE 284
>NP_001077383
          Length = 445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   ALDVHESE 8
           ALDVHESE
Sbjct: 294 ALDVHESE 301
>NP_001320
          Length = 445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   ALDVHESE 8
           ALDVHESE
Sbjct: 294 ALDVHESE 301
>NP_073713
          Length = 985

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   ALDVHESE 8
           ALDVHESE
Sbjct: 834 ALDVHESE 841
>XP_005269629
          Length = 445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   ALDVHESE 8
           ALDVHESE
Sbjct: 294 ALDVHESE 301
>XP_005269628
          Length = 445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   ALDVHESE 8
           ALDVHESE
Sbjct: 294 ALDVHESE 301
>XP_005269627
          Length = 445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   ALDVHESE 8
           ALDVHESE
Sbjct: 294 ALDVHESE 301
>XP_005269626
          Length = 445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   ALDVHESE 8
           ALDVHESE
Sbjct: 294 ALDVHESE 301
>XP_006717706
          Length = 445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   ALDVHESE 8
           ALDVHESE
Sbjct: 294 ALDVHESE 301
>XP_005269625
          Length = 445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   ALDVHESE 8
           ALDVHESE
Sbjct: 294 ALDVHESE 301
>XP_005269624
          Length = 445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   ALDVHESE 8
           ALDVHESE
Sbjct: 294 ALDVHESE 301
>XP_006717705
          Length = 445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   ALDVHESE 8
           ALDVHESE
Sbjct: 294 ALDVHESE 301
>XP_005269622
          Length = 445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   ALDVHESE 8
           ALDVHESE
Sbjct: 294 ALDVHESE 301
>XP_005269621
          Length = 445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   ALDVHESE 8
           ALDVHESE
Sbjct: 294 ALDVHESE 301
>XP_006717704
          Length = 445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   ALDVHESE 8
           ALDVHESE
Sbjct: 294 ALDVHESE 301
>XP_005269619
          Length = 445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   ALDVHESE 8
           ALDVHESE
Sbjct: 294 ALDVHESE 301
>XP_005269618
          Length = 445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   ALDVHESE 8
           ALDVHESE
Sbjct: 294 ALDVHESE 301
>XP_005272320
          Length = 430

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   ALDVHESE 8
           ALDVHESE
Sbjct: 277 ALDVHESE 284
>XP_005272319
          Length = 430

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   ALDVHESE 8
           ALDVHESE
Sbjct: 277 ALDVHESE 284
>XP_005272318
          Length = 441

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   ALDVHESE 8
           ALDVHESE
Sbjct: 288 ALDVHESE 295
>NP_003282
          Length = 1249

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ALDVHESES 9
           +LD+HE+ S
Sbjct: 919 SLDIHENHS 927
>XP_005254130
          Length = 1162

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ALDVHESES 9
           +LD+HE+ S
Sbjct: 919 SLDIHENHS 927
>XP_005254129
          Length = 1262

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ALDVHESES 9
           +LD+HE+ S
Sbjct: 919 SLDIHENHS 927
>XP_005254128
          Length = 1291

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ALDVHESES 9
           +LD+HE+ S
Sbjct: 919 SLDIHENHS 927
>XP_005254127
          Length = 1304

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ALDVHESES 9
           +LD+HE+ S
Sbjct: 919 SLDIHENHS 927
>NP_001181927
          Length = 1710

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LDVHESES 9
           +D+H SES
Sbjct: 344 VDLHHSES 351
>NP_055800
          Length = 1654

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LDVHESES 9
           +D+H SES
Sbjct: 344 VDLHHSES 351
>NP_004806
          Length = 1261

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   DVHESES 9
           D+H SES
Sbjct: 933 DIHTSES 939
>NP_653223
          Length = 773

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ALDVHESES 9
           A+D+HE+ S
Sbjct: 305 AMDLHEAVS 313
>NP_006026
          Length = 1711

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   DVHESES 9
           +VH+SES
Sbjct: 718 EVHDSES 724
>NP_001258652
          Length = 943

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ALDVHESES 9
           ++ VH+SES
Sbjct: 592 SITVHDSES 600
>NP_110420
          Length = 1113

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ALDVHESES 9
           ++ VH+SES
Sbjct: 592 SITVHDSES 600
>XP_006720500
          Length = 1710

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LDVHESES 9
           +D+H SES
Sbjct: 344 VDLHHSES 351
>XP_005268287
          Length = 1490

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   DVHESES 9
           +VH+SES
Sbjct: 718 EVHDSES 724
>XP_005268286
          Length = 1685

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   DVHESES 9
           +VH+SES
Sbjct: 718 EVHDSES 724
>XP_005268285
          Length = 1702

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   DVHESES 9
           +VH+SES
Sbjct: 718 EVHDSES 724
>XP_005268284
          Length = 1728

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   DVHESES 9
           +VH+SES
Sbjct: 718 EVHDSES 724
>XP_006714860
          Length = 1146

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ALDVHESES 9
           ++ VH+SES
Sbjct: 592 SITVHDSES 600
>XP_006714859
          Length = 1188

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ALDVHESES 9
           ++ VH+SES
Sbjct: 592 SITVHDSES 600
>XP_005268570
          Length = 1188

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ALDVHESES 9
           ++ VH+SES
Sbjct: 592 SITVHDSES 600
>XP_006711111
          Length = 1197

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   DVHESES 9
           D+H SES
Sbjct: 869 DIHTSES 875
>NP_001622
          Length = 528

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   DVHESES 9
           DV+ESES
Sbjct: 427 DVNESES 433
>NP_073572
          Length = 528

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ALDVHESES 9
           A+ VH SES
Sbjct: 442 AVSVHVSES 450
>NP_001139664
          Length = 255

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   LDVHESES 9
           LDVHE  +
Sbjct: 232 LDVHEQST 239
>NP_003310
          Length = 26926

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    ALDVHESES 9
            A+D+ ESE+
Sbjct: 1234 AVDISESEA 1242
>NP_597676
          Length = 27051

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    ALDVHESES 9
            A+D+ ESE+
Sbjct: 1234 AVDISESEA 1242
>NP_596870
          Length = 5604

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    ALDVHESES 9
            A+D+ ESE+
Sbjct: 1280 AVDISESEA 1288
>NP_001243779
          Length = 34350

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    ALDVHESES 9
            A+D+ ESE+
Sbjct: 1280 AVDISESEA 1288
>NP_596869
          Length = 33423

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    ALDVHESES 9
            A+D+ ESE+
Sbjct: 1280 AVDISESEA 1288
>NP_055785
          Length = 792

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  LDVHESE 8
          +DVH SE
Sbjct: 18 IDVHPSE 24
>NP_055795
          Length = 1186

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   LDVHES 7
           +D+HES
Sbjct: 405 MDIHES 410
>NP_115633
          Length = 365

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   LDVHESES 9
           LDVHE  +
Sbjct: 342 LDVHEQST 349
>NP_071335
          Length = 531

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   ALDVHE 6
           +LDVHE
Sbjct: 250 SLDVHE 255
>XP_005266697
          Length = 1077

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  ALDVHESE 8
          +LD+ ESE
Sbjct: 37 SLDIQESE 44
>XP_005247964
          Length = 1162

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   LDVHES 7
           +D+HES
Sbjct: 405 MDIHES 410
>XP_006713889
          Length = 1186

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   LDVHES 7
           +D+HES
Sbjct: 405 MDIHES 410
>XP_006713888
          Length = 1186

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   LDVHES 7
           +D+HES
Sbjct: 405 MDIHES 410
>XP_006712787
          Length = 33978

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    ALDVHESES 9
            A+D+ ESE+
Sbjct: 1281 AVDISESEA 1289
>XP_006712786
          Length = 35484

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    ALDVHESES 9
            A+D+ ESE+
Sbjct: 1281 AVDISESEA 1289
>XP_005245027
          Length = 794

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  LDVHESE 8
          +DVH SE
Sbjct: 18 IDVHPSE 24
>NP_001254479
          Length = 35991

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    ALDVHESES 9
            A+D+ ESE+
Sbjct: 1280 AVDISESEA 1288
>NP_597681
          Length = 27118

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    ALDVHESES 9
            A+D+ ESE+
Sbjct: 1234 AVDISESEA 1242
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.294    0.112    0.274 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 655,143
Number of extensions: 870
Number of successful extensions: 65
Number of sequences better than 10000.0: 65
Number of HSP's gapped: 65
Number of HSP's successfully gapped: 65
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.0 bits)
S2: 28 (15.4 bits)

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