Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

• Home Page
• Cancer-specific
• Epitope Search
• Data Retrieval
• Browse Gene
• Browse Tissue
• Sequence Similarity
• Partially Personalized
• Submit a Protein
• Vaccine Target
• Proteome Data
• NGS data
• BLAST & Predict
• Fully Personalized
• Proteins Pair
• Proteome Pair
• Advanced Tools
• Epitope Mapping
• Cross Reactivity
• Important Information
• Acknowledgement
• Algorithm
• Help
• Developers
• Contact

Blast-Search of mutated query peptide against human proteome

BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000258                                                              18    1482
NP_001035957                                                           18    1482
XP_006721990                                                           18    1482
XP_006721989                                                           18    1482
XP_005258041                                                           18    1482
XP_006721988                                                           18    1482
XP_006721987                                                           18    1482
XP_006721986                                                           18    1482
XP_005258040                                                           18    1482
XP_006721985                                                           18    1482
XP_005264952                                                           16    5631
NP_055872                                                              15    9605
NP_055478                                                              15    9605
XP_006719852                                                           15    9605
XP_005266357                                                           15    9605
XP_006719851                                                           15    9605
XP_006719850                                                           15    9605
XP_006719849                                                           15    9605
XP_006719848                                                           15    9605
XP_005266356                                                           15    9605
XP_006719847                                                           15    9605
XP_006719846                                                           15    9605
XP_006719845                                                           15    9605
XP_006719844                                                           15    9605
XP_006719843                                                           15    9605
XP_006719842                                                           15    9605
XP_005271413                                                           15    9605
XP_005271412                                                           15    9605
XP_005271411                                                           15    9605

>NP_000258
          Length = 2818

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    AKRQRVIAI 9
            AKRQRV AI
Sbjct: 1945 AKRQRVTAI 1953



>NP_001035957
          Length = 2839

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    AKRQRVIAI 9
            AKRQRV AI
Sbjct: 1966 AKRQRVTAI 1974



>XP_006721990
          Length = 2823

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    AKRQRVIAI 9
            AKRQRV AI
Sbjct: 1976 AKRQRVTAI 1984



>XP_006721989
          Length = 2823

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    AKRQRVIAI 9
            AKRQRV AI
Sbjct: 1976 AKRQRVTAI 1984



>XP_005258041
          Length = 2836

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    AKRQRVIAI 9
            AKRQRV AI
Sbjct: 1945 AKRQRVTAI 1953



>XP_006721988
          Length = 2846

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    AKRQRVIAI 9
            AKRQRV AI
Sbjct: 1955 AKRQRVTAI 1963



>XP_006721987
          Length = 2849

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    AKRQRVIAI 9
            AKRQRV AI
Sbjct: 1976 AKRQRVTAI 1984



>XP_006721986
          Length = 2854

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    AKRQRVIAI 9
            AKRQRV AI
Sbjct: 1963 AKRQRVTAI 1971



>XP_005258040
          Length = 2857

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    AKRQRVIAI 9
            AKRQRV AI
Sbjct: 1966 AKRQRVTAI 1974



>XP_006721985
          Length = 2867

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    AKRQRVIAI 9
            AKRQRV AI
Sbjct: 1976 AKRQRVTAI 1984



>XP_005264952
          Length = 257

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  KRQRVIAI 9
          KR+RV+A+
Sbjct: 54 KRERVLAV 61



>NP_055872
          Length = 4678

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   KRQRVI 7
           KRQRVI
Sbjct: 862 KRQRVI 867



>NP_055478
          Length = 1064

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    KRQRVI 7
            KRQRVI
Sbjct: 1040 KRQRVI 1045



>XP_006719852
          Length = 4752

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   KRQRVI 7
           KRQRVI
Sbjct: 862 KRQRVI 867



>XP_005266357
          Length = 4600

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   KRQRVI 7
           KRQRVI
Sbjct: 862 KRQRVI 867



>XP_006719851
          Length = 4689

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   KRQRVI 7
           KRQRVI
Sbjct: 862 KRQRVI 867



>XP_006719850
          Length = 4697

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   KRQRVI 7
           KRQRVI
Sbjct: 862 KRQRVI 867



>XP_006719849
          Length = 4703

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   KRQRVI 7
           KRQRVI
Sbjct: 862 KRQRVI 867



>XP_006719848
          Length = 4737

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   KRQRVI 7
           KRQRVI
Sbjct: 862 KRQRVI 867



>XP_005266356
          Length = 4755

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   KRQRVI 7
           KRQRVI
Sbjct: 862 KRQRVI 867



>XP_006719847
          Length = 4761

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   KRQRVI 7
           KRQRVI
Sbjct: 862 KRQRVI 867



>XP_006719846
          Length = 4763

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   KRQRVI 7
           KRQRVI
Sbjct: 862 KRQRVI 867



>XP_006719845
          Length = 4772

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   KRQRVI 7
           KRQRVI
Sbjct: 862 KRQRVI 867



>XP_006719844
          Length = 4789

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   KRQRVI 7
           KRQRVI
Sbjct: 862 KRQRVI 867



>XP_006719843
          Length = 4794

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   KRQRVI 7
           KRQRVI
Sbjct: 862 KRQRVI 867



>XP_006719842
          Length = 4797

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   KRQRVI 7
           KRQRVI
Sbjct: 862 KRQRVI 867



>XP_005271413
          Length = 973

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   KRQRVI 7
           KRQRVI
Sbjct: 949 KRQRVI 954



>XP_005271412
          Length = 1064

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    KRQRVI 7
            KRQRVI
Sbjct: 1040 KRQRVI 1045



>XP_005271411
          Length = 1064

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    KRQRVI 7
            KRQRVI
Sbjct: 1040 KRQRVI 1045



  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.339    0.141    0.337 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 387,055
Number of extensions: 457
Number of successful extensions: 29
Number of sequences better than 10000.0: 29
Number of HSP's gapped: 29
Number of HSP's successfully gapped: 29
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.5 bits)
S2: 28 (15.4 bits)