Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001261                                                              19     869
XP_005271924                                                           19     869
XP_005271923                                                           19     869
NP_001171313                                                           17    4312
NP_003130                                                              17    4312
NP_059107                                                              16    5631
NP_075013                                                              16    5631
NP_075014                                                              16    5631
NP_000335                                                              16    5631
NP_075015                                                              16    5631
NP_075012                                                              16    5631
NP_001191676                                                           16    5631
NP_002904                                                              16    5631
XP_005248632                                                           16    5631
XP_005276832                                                           16    5631
XP_006714740                                                           16    5631
NP_060800                                                              16    7355
NP_001120683                                                           16    7355
NP_001245227                                                           16    7355
NP_001245228                                                           16    7355
NP_001245229                                                           16    7355
XP_005270059                                                           16    7355
XP_006717994                                                           16    7355
NP_002878                                                              15    9605
>NP_001261
          Length = 1710

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    AKKNKATKS 9
            AKKNKA KS
Sbjct: 1336 AKKNKAMKS 1344
>XP_005271924
          Length = 1710

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    AKKNKATKS 9
            AKKNKA KS
Sbjct: 1336 AKKNKAMKS 1344
>XP_005271923
          Length = 1798

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    AKKNKATKS 9
            AKKNKA KS
Sbjct: 1336 AKKNKAMKS 1344
>NP_001171313
          Length = 610

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KKNKATKS 9
           K NK+TKS
Sbjct: 199 KSNKSTKS 206
>NP_003130
          Length = 638

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KKNKATKS 9
           K NK+TKS
Sbjct: 227 KSNKSTKS 234
>NP_059107
          Length = 294

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  AKKNKATK 8
          AKKNK+ K
Sbjct: 75 AKKNKSQK 82
>NP_075013
          Length = 282

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  AKKNKATK 8
          AKKNK+ K
Sbjct: 75 AKKNKSQK 82
>NP_075014
          Length = 262

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  AKKNKATK 8
          AKKNK+ K
Sbjct: 75 AKKNKSQK 82
>NP_000335
          Length = 294

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  AKKNKATK 8
          AKKNK+ K
Sbjct: 75 AKKNKSQK 82
>NP_075015
          Length = 250

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  AKKNKATK 8
          AKKNK+ K
Sbjct: 75 AKKNKSQK 82
>NP_075012
          Length = 262

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  AKKNKATK 8
          AKKNK+ K
Sbjct: 75 AKKNKSQK 82
>NP_001191676
          Length = 1148

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  KKNKATKS 9
          KKN+ TKS
Sbjct: 22 KKNEKTKS 29
>NP_002904
          Length = 1147

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  KKNKATKS 9
          KKN+ TKS
Sbjct: 22 KKNEKTKS 29
>XP_005248632
          Length = 282

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  AKKNKATK 8
          AKKNK+ K
Sbjct: 75 AKKNKSQK 82
>XP_005276832
          Length = 282

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  AKKNKATK 8
          AKKNK+ K
Sbjct: 75 AKKNKSQK 82
>XP_006714740
          Length = 282

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  AKKNKATK 8
          AKKNK+ K
Sbjct: 75 AKKNKSQK 82
>NP_060800
          Length = 456

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AKKNKATK 8
           AKK KAT+
Sbjct: 388 AKKEKATQ 395
>NP_001120683
          Length = 631

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AKKNKATK 8
           AKK KAT+
Sbjct: 388 AKKEKATQ 395
>NP_001245227
          Length = 571

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AKKNKATK 8
           AKK KAT+
Sbjct: 328 AKKEKATQ 335
>NP_001245228
          Length = 558

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AKKNKATK 8
           AKK KAT+
Sbjct: 388 AKKEKATQ 395
>NP_001245229
          Length = 498

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AKKNKATK 8
           AKK KAT+
Sbjct: 328 AKKEKATQ 335
>XP_005270059
          Length = 573

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AKKNKATK 8
           AKK KAT+
Sbjct: 388 AKKEKATQ 395
>XP_006717994
          Length = 617

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AKKNKATK 8
           AKK KAT+
Sbjct: 388 AKKEKATQ 395
>NP_002878
          Length = 660

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  AKKNKATKS 9
          A++NK TK+
Sbjct: 64 AERNKPTKN 72
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.278   0.0910    0.202 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 391,402
Number of extensions: 454
Number of successful extensions: 24
Number of sequences better than 10000.0: 24
Number of HSP's gapped: 24
Number of HSP's successfully gapped: 24
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 18 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (14.7 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package