Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000213                                                              17    2528
NP_001087241                                                           17    2528
XP_005265799                                                           17    2528
XP_005265798                                                           17    2528
XP_005265797                                                           17    2528
NP_001131145                                                           16    5631
NP_703194                                                              16    5631
NP_060090                                                              16    5631
NP_036350                                                              16    5631
NP_004507                                                              16    5631
NP_055523                                                              16    5631
NP_001273142                                                           16    5631
NP_001273141                                                           16    5631
NP_115632                                                              16    5631
XP_006722805                                                           16    5631
XP_006719769                                                           16    5631
NP_005202                                                              16    7355
NP_001275634                                                           16    7355
NP_001726                                                              16    7355
NP_001007526                                                           16    7355
NP_001277284                                                           16    7355
NP_653267                                                              16    7355
XP_006717373                                                           16    7355
XP_005265662                                                           16    7355
NP_001239                                                              16    7355
NP_005290                                                              15    9605
NP_006019                                                              15    9605
NP_073751                                                              15    9605
NP_060004                                                              15    9605
NP_808211                                                              15    9605
NP_803545                                                              15    9605
NP_001093582                                                           15    9605
NP_003703                                                              15    9605
XP_006726450                                                           15    9605
XP_005258189                                                           15    9605
XP_006722402                                                           15    9605
XP_006712223                                                           15    9605
XP_006710190                                                           15    9605
NP_001129386                                                           15    9605
>NP_000213
          Length = 976

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AKCMAFLAS 9
           AK MAFLAS
Sbjct: 777 AKGMAFLAS 785
>NP_001087241
          Length = 972

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AKCMAFLAS 9
           AK MAFLAS
Sbjct: 773 AKGMAFLAS 781
>XP_005265799
          Length = 973

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AKCMAFLAS 9
           AK MAFLAS
Sbjct: 774 AKGMAFLAS 782
>XP_005265798
          Length = 976

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AKCMAFLAS 9
           AK MAFLAS
Sbjct: 777 AKGMAFLAS 785
>XP_005265797
          Length = 977

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AKCMAFLAS 9
           AK MAFLAS
Sbjct: 778 AKGMAFLAS 786
>NP_001131145
          Length = 706

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KCMAFLAS 9
           KC+A LAS
Sbjct: 202 KCLAALAS 209
>NP_703194
          Length = 690

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KCMAFLAS 9
           KC+A LAS
Sbjct: 202 KCLAALAS 209
>NP_060090
          Length = 898

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KCMAFLAS 9
           KC+A LAS
Sbjct: 202 KCLAALAS 209
>NP_036350
          Length = 894

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KCMAFLAS 9
           KC+A LAS
Sbjct: 202 KCLAALAS 209
>NP_004507
          Length = 702

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KCMAFLAS 9
           KC+A LAS
Sbjct: 202 KCLAALAS 209
>NP_055523
          Length = 2209

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    KCMAFLAS 9
            +C+ FLAS
Sbjct: 1918 RCITFLAS 1925
>NP_001273142
          Length = 370

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KCMAFLAS 9
           KC+AF+ S
Sbjct: 249 KCLAFVPS 256
>NP_001273141
          Length = 410

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KCMAFLAS 9
           KC+AF+ S
Sbjct: 289 KCLAFVPS 296
>NP_115632
          Length = 514

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KCMAFLAS 9
           KC+AF+ S
Sbjct: 393 KCLAFVPS 400
>XP_006722805
          Length = 855

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KCMAFLAS 9
           KC+A LAS
Sbjct: 202 KCLAALAS 209
>XP_006719769
          Length = 2209

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    KCMAFLAS 9
            +C+ FLAS
Sbjct: 1918 RCITFLAS 1925
>NP_005202
          Length = 972

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   AKCMAFLAS 9
           A+ MAFLAS
Sbjct: 763 AQGMAFLAS 771
>NP_001275634
          Length = 972

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   AKCMAFLAS 9
           A+ MAFLAS
Sbjct: 763 AQGMAFLAS 771
>NP_001726
          Length = 1676

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    AKCMAFLAS 9
            + C AFLA+
Sbjct: 1655 SSCQAFLAN 1663
>NP_001007526
          Length = 1432

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    CMAFLAS 9
            CMA LAS
Sbjct: 1005 CMAVLAS 1011
>NP_001277284
          Length = 1429

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   CMAFLAS 9
           CMA LAS
Sbjct: 870 CMAVLAS 876
>NP_653267
          Length = 4753

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2    KCMAF 6
            KCMAF
Sbjct: 1036 KCMAF 1040
>XP_006717373
          Length = 1087

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  CMAFLA 8
          C+AFLA
Sbjct: 6  CLAFLA 11
>XP_005265662
          Length = 529

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   CMAFLA 8
           C+AFLA
Sbjct: 501 CLAFLA 506
>NP_001239
          Length = 529

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   CMAFLA 8
           C+AFLA
Sbjct: 501 CLAFLA 506
>NP_005290
          Length = 319

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  AKCMAFLAS 9
          A C+ FLA+
Sbjct: 64 AACLPFLAA 72
>NP_006019
          Length = 441

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 3   CMAFL 7
           CMAFL
Sbjct: 309 CMAFL 313
>NP_073751
          Length = 472

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  CMAFLAS 9
          C AF+AS
Sbjct: 59 CAAFIAS 65
>NP_060004
          Length = 1941

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   AKCMAFLA 8
           A+C  FLA
Sbjct: 796 ARCRGFLA 803
>NP_808211
          Length = 309

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3   CMAFLA 8
           CM FLA
Sbjct: 196 CMVFLA 201
>NP_803545
          Length = 232

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3   CMAFLA 8
           CM FLA
Sbjct: 119 CMVFLA 124
>NP_001093582
          Length = 1941

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   AKCMAFLA 8
           A+C  FLA
Sbjct: 796 ARCRGFLA 803
>NP_003703
          Length = 288

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3   CMAFLA 8
           CM FLA
Sbjct: 175 CMVFLA 180
>XP_006726450
          Length = 661

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  AKCMAFLA 8
          ++CM FLA
Sbjct: 39 SQCMYFLA 46
>XP_005258189
          Length = 360

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  CMAFLAS 9
          C AF+AS
Sbjct: 59 CAAFIAS 65
>XP_006722402
          Length = 419

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  CMAFLAS 9
          C AF+AS
Sbjct: 59 CAAFIAS 65
>XP_006712223
          Length = 661

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  AKCMAFLA 8
          ++CM FLA
Sbjct: 39 SQCMYFLA 46
>XP_006710190
          Length = 603

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  AKCMAFLA 8
          ++CM FLA
Sbjct: 39 SQCMYFLA 46
>NP_001129386
          Length = 1503

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1    AKCMAF 6
            A CMAF
Sbjct: 1148 ASCMAF 1153
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.339    0.125    0.393 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 518,817
Number of extensions: 605
Number of successful extensions: 39
Number of sequences better than 10000.0: 39
Number of HSP's gapped: 39
Number of HSP's successfully gapped: 39
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.7 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package