Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000258                                                              19     665
NP_001035957                                                           19     665
XP_006721990                                                           19     665
XP_006721989                                                           19     665
XP_005258041                                                           19     665
XP_006721988                                                           19     665
XP_006721987                                                           19     665
XP_006721986                                                           19     665
XP_005258040                                                           19     665
XP_006721985                                                           19     665
NP_001709                                                              17    2528
NP_057288                                                              17    2528
NP_861525                                                              17    2528
NP_001711                                                              17    2528
XP_006717824                                                           17    2528
NP_066551                                                              17    2528
NP_001007594                                                           17    3301
NP_000534                                                              17    3301
NP_006729                                                              17    3301
NP_001257475                                                           17    3301
NP_009131                                                              17    3301
NP_055297                                                              17    3301
XP_005254913                                                           17    3301
XP_005254912                                                           17    3301
XP_005254911                                                           17    3301
XP_005254910                                                           17    3301
XP_005254909                                                           17    3301
XP_005254908                                                           17    3301
XP_005254907                                                           17    3301
XP_005254906                                                           17    3301
XP_005254905                                                           17    3301
XP_005254904                                                           17    3301
XP_005254903                                                           17    3301
XP_005254902                                                           17    3301
XP_005254901                                                           17    3301
XP_005254900                                                           17    3301
XP_005254899                                                           17    3301
XP_005254898                                                           17    3301
XP_005254897                                                           17    3301
XP_006720441                                                           17    3301
XP_006720440                                                           17    3301
XP_006720439                                                           17    3301
XP_005254896                                                           17    3301
XP_005253132                                                           17    3301
NP_001710                                                              17    4312
XP_005262769                                                           16    7355
NP_001229792                                                           15    9605
NP_060463                                                              15    9605
NP_057712                                                              15    9605
NP_567823                                                              15    9605
NP_060925                                                              15    9605
NP_001257403                                                           15    9605
NP_001094094                                                           15    9605
NP_001094095                                                           15    9605
NP_001257402                                                           15    9605
NP_001121087                                                           15    9605
XP_003960549                                                           15    9605
XP_006721299                                                           15    9605
XP_006719905                                                           15    9605
XP_006719904                                                           15    9605
XP_005266496                                                           15    9605
XP_005266495                                                           15    9605
XP_005252516                                                           15    9605
XP_005252514                                                           15    9605
XP_005252511                                                           15    9605
>NP_000258
          Length = 2818

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    AIVQSIIHM 9
            AIVQSIIH+
Sbjct: 1798 AIVQSIIHI 1806
>NP_001035957
          Length = 2839

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    AIVQSIIHM 9
            AIVQSIIH+
Sbjct: 1819 AIVQSIIHI 1827
>XP_006721990
          Length = 2823

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    AIVQSIIHM 9
            AIVQSIIH+
Sbjct: 1829 AIVQSIIHI 1837
>XP_006721989
          Length = 2823

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    AIVQSIIHM 9
            AIVQSIIH+
Sbjct: 1829 AIVQSIIHI 1837
>XP_005258041
          Length = 2836

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    AIVQSIIHM 9
            AIVQSIIH+
Sbjct: 1798 AIVQSIIHI 1806
>XP_006721988
          Length = 2846

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    AIVQSIIHM 9
            AIVQSIIH+
Sbjct: 1808 AIVQSIIHI 1816
>XP_006721987
          Length = 2849

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    AIVQSIIHM 9
            AIVQSIIH+
Sbjct: 1829 AIVQSIIHI 1837
>XP_006721986
          Length = 2854

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    AIVQSIIHM 9
            AIVQSIIH+
Sbjct: 1816 AIVQSIIHI 1824
>XP_005258040
          Length = 2857

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    AIVQSIIHM 9
            AIVQSIIH+
Sbjct: 1819 AIVQSIIHI 1827
>XP_006721985
          Length = 2867

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    AIVQSIIHM 9
            AIVQSIIH+
Sbjct: 1829 AIVQSIIHI 1837
>NP_001709
          Length = 513

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   AIVQSIIHM 9
           AIVQ+++H+
Sbjct: 459 AIVQTLVHL 467
>NP_057288
          Length = 429

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   AIVQSIIHM 9
           AIVQ+++H+
Sbjct: 374 AIVQTLVHL 382
>NP_861525
          Length = 402

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   AIVQSIIHM 9
           AI+QS++H+
Sbjct: 348 AILQSLVHL 356
>NP_001711
          Length = 402

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   AIVQSIIHM 9
           AI+QS++H+
Sbjct: 348 AILQSLVHL 356
>XP_006717824
          Length = 417

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   AIVQSIIHM 9
           AIVQ+++H+
Sbjct: 374 AIVQTLVHL 382
>NP_066551
          Length = 454

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   AIVQSIIHM 9
           AIVQ+++H+
Sbjct: 400 AIVQTLVHL 408
>NP_001007594
          Length = 630

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   AIVQSIIHM 9
           A+ QSI+H+
Sbjct: 130 AVCQSIVHL 138
>NP_000534
          Length = 631

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   AIVQSIIHM 9
           A+ QSI+H+
Sbjct: 131 AVCQSIVHL 139
>NP_006729
          Length = 2817

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    IVQSIIHM 9
            +VQS++H+
Sbjct: 2525 VVQSVVHL 2532
>NP_001257475
          Length = 1434

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    IVQSIIHM 9
            +VQS++H+
Sbjct: 1142 VVQSVVHL 1149
>NP_009131
          Length = 2813

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    IVQSIIHM 9
            +VQS++H+
Sbjct: 2521 VVQSVVHL 2528
>NP_055297
          Length = 424

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   AIVQSIIHM 9
           AI+Q+++H+
Sbjct: 370 AIIQALVHL 378
>XP_005254913
          Length = 1441

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    IVQSIIHM 9
            +VQS++H+
Sbjct: 1149 VVQSVVHL 1156
>XP_005254912
          Length = 1442

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    IVQSIIHM 9
            +VQS++H+
Sbjct: 1150 VVQSVVHL 1157
>XP_005254911
          Length = 1473

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    IVQSIIHM 9
            +VQS++H+
Sbjct: 1181 VVQSVVHL 1188
>XP_005254910
          Length = 1523

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    IVQSIIHM 9
            +VQS++H+
Sbjct: 1231 VVQSVVHL 1238
>XP_005254909
          Length = 1536

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    IVQSIIHM 9
            +VQS++H+
Sbjct: 1244 VVQSVVHL 1251
>XP_005254908
          Length = 1536

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    IVQSIIHM 9
            +VQS++H+
Sbjct: 1244 VVQSVVHL 1251
>XP_005254907
          Length = 2590

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    IVQSIIHM 9
            +VQS++H+
Sbjct: 2298 VVQSVVHL 2305
>XP_005254906
          Length = 2675

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    IVQSIIHM 9
            +VQS++H+
Sbjct: 2383 VVQSVVHL 2390
>XP_005254905
          Length = 2793

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    IVQSIIHM 9
            +VQS++H+
Sbjct: 2501 VVQSVVHL 2508
>XP_005254904
          Length = 2802

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    IVQSIIHM 9
            +VQS++H+
Sbjct: 2510 VVQSVVHL 2517
>XP_005254903
          Length = 2820

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    IVQSIIHM 9
            +VQS++H+
Sbjct: 2528 VVQSVVHL 2535
>XP_005254902
          Length = 2835

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    IVQSIIHM 9
            +VQS++H+
Sbjct: 2543 VVQSVVHL 2550
>XP_005254901
          Length = 2842

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    IVQSIIHM 9
            +VQS++H+
Sbjct: 2550 VVQSVVHL 2557
>XP_005254900
          Length = 2843

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    IVQSIIHM 9
            +VQS++H+
Sbjct: 2551 VVQSVVHL 2558
>XP_005254899
          Length = 2861

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    IVQSIIHM 9
            +VQS++H+
Sbjct: 2569 VVQSVVHL 2576
>XP_005254898
          Length = 2874

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    IVQSIIHM 9
            +VQS++H+
Sbjct: 2582 VVQSVVHL 2589
>XP_005254897
          Length = 2876

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    IVQSIIHM 9
            +VQS++H+
Sbjct: 2584 VVQSVVHL 2591
>XP_006720441
          Length = 2881

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    IVQSIIHM 9
            +VQS++H+
Sbjct: 2589 VVQSVVHL 2596
>XP_006720440
          Length = 2882

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    IVQSIIHM 9
            +VQS++H+
Sbjct: 2590 VVQSVVHL 2597
>XP_006720439
          Length = 2882

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    IVQSIIHM 9
            +VQS++H+
Sbjct: 2590 VVQSVVHL 2597
>XP_005254896
          Length = 2883

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    IVQSIIHM 9
            +VQS++H+
Sbjct: 2591 VVQSVVHL 2598
>XP_005253132
          Length = 508

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   AIVQSIIHM 9
           A+ QSI+H+
Sbjct: 131 AVCQSIVHL 139
>NP_001710
          Length = 431

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   AIVQSIIH 8
           AIVQ+++H
Sbjct: 377 AIVQTLVH 384
>XP_005262769
          Length = 1034

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AIVQSIIHM 9
           AIVQ  +HM
Sbjct: 392 AIVQEKLHM 400
>NP_001229792
          Length = 643

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   AIVQSIIH 8
           A+V+ IIH
Sbjct: 109 AVVKEIIH 116
>NP_060463
          Length = 643

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   AIVQSIIH 8
           A+V+ IIH
Sbjct: 109 AVVKEIIH 116
>NP_057712
          Length = 647

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AIVQSIIH 8
           A +QSIIH
Sbjct: 397 ASLQSIIH 404
>NP_567823
          Length = 544

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AIVQSIIH 8
           A +QSIIH
Sbjct: 294 ASLQSIIH 301
>NP_060925
          Length = 204

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  AIVQSIIHM 9
          ++VQ +IH+
Sbjct: 47 SVVQHLIHL 55
>NP_001257403
          Length = 305

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  AIVQSIIHM 9
          ++VQ +IH+
Sbjct: 47 SVVQHLIHL 55
>NP_001094094
          Length = 339

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  AIVQSIIHM 9
          ++VQ +IH+
Sbjct: 47 SVVQHLIHL 55
>NP_001094095
          Length = 353

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  AIVQSIIHM 9
          ++VQ +IH+
Sbjct: 47 SVVQHLIHL 55
>NP_001257402
          Length = 319

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  AIVQSIIHM 9
          ++VQ +IH+
Sbjct: 47 SVVQHLIHL 55
>NP_001121087
          Length = 643

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   AIVQSIIH 8
           A+V+ IIH
Sbjct: 109 AVVKEIIH 116
>XP_003960549
          Length = 248

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   VQSIIHM 9
           VQS++H+
Sbjct: 238 VQSVLHL 244
>XP_006721299
          Length = 339

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  AIVQSIIHM 9
          ++VQ +IH+
Sbjct: 47 SVVQHLIHL 55
>XP_006719905
          Length = 643

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   AIVQSIIH 8
           A+V+ IIH
Sbjct: 109 AVVKEIIH 116
>XP_006719904
          Length = 643

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   AIVQSIIH 8
           A+V+ IIH
Sbjct: 109 AVVKEIIH 116
>XP_005266496
          Length = 643

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   AIVQSIIH 8
           A+V+ IIH
Sbjct: 109 AVVKEIIH 116
>XP_005266495
          Length = 678

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   AIVQSIIH 8
           A+V+ IIH
Sbjct: 144 AVVKEIIH 151
>XP_005252516
          Length = 550

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AIVQSIIH 8
           A +QSIIH
Sbjct: 300 ASLQSIIH 307
>XP_005252514
          Length = 602

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AIVQSIIH 8
           A +QSIIH
Sbjct: 352 ASLQSIIH 359
>XP_005252511
          Length = 653

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AIVQSIIH 8
           A +QSIIH
Sbjct: 403 ASLQSIIH 410
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.341    0.139    0.363 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 347,455
Number of extensions: 440
Number of successful extensions: 65
Number of sequences better than 10000.0: 65
Number of HSP's gapped: 65
Number of HSP's successfully gapped: 65
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.6 bits)
S2: 28 (15.4 bits)

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