Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_733751                                                              20     299
XP_006716142                                                           20     299
XP_005250088                                                           20     299
XP_006716141                                                           20     299
XP_005250085                                                           20     299
XP_006716140                                                           20     299
XP_005250084                                                           20     299
XP_005250083                                                           20     299
XP_005250082                                                           20     299
NP_001138355                                                           19     869
NP_001138353                                                           19     869
NP_694571                                                              19     869
NP_001138354                                                           19     869
NP_076918                                                              17    2528
NP_071351                                                              17    2528
NP_067091                                                              17    2528
NP_002166                                                              17    2528
NP_002160                                                              17    2528
NP_066282                                                              17    2528
NP_008831                                                              17    2528
NP_066546                                                              17    2528
NP_057272                                                              17    3301
XP_006716083                                                           17    3301
NP_116212                                                              17    4312
NP_001180260                                                           17    4312
NP_001180258                                                           17    4312
XP_006717370                                                           17    4312
XP_005252341                                                           17    4312
XP_006717369                                                           17    4312
NP_002162                                                              16    5631
NP_078913                                                              16    5631
NP_001273574                                                           16    7355
NP_150375                                                              16    7355
NP_775099                                                              16    7355
NP_001177716                                                           16    7355
XP_005247994                                                           16    7355
XP_005247993                                                           16    7355
XP_005247992                                                           16    7355
XP_005247991                                                           16    7355
XP_005247990                                                           16    7355
NP_036546                                                              15    9605
NP_003001                                                              15    9605
NP_001268364                                                           15    9605
NP_001136326                                                           15    9605
NP_055987                                                              15    9605
XP_006725462                                                           15    9605
XP_005261245                                                           15    9605
XP_005259798                                                           15    9605
XP_006722711                                                           15    9605
XP_005257805                                                           15    9605
XP_006722205                                                           15    9605
XP_006722204                                                           15    9605
XP_005256812                                                           15    9605
XP_006721631                                                           15    9605
XP_005256810                                                           15    9605
XP_005245087                                                           15    9605
XP_005245086                                                           15    9605
XP_005245085                                                           15    9605
XP_005245084                                                           15    9605
XP_006711302                                                           15    9605
XP_005245083                                                           15    9605
XP_005245082                                                           15    9605
XP_005245081                                                           15    9605
XP_005245080                                                           15    9605
XP_005245079                                                           15    9605
XP_005245077                                                           15    9605
XP_005245076                                                           15    9605
XP_006711301                                                           15    9605
XP_005245075                                                           15    9605
XP_005245074                                                           15    9605
XP_005245073                                                           15    9605
XP_005245072                                                           15    9605
NP_003623                                                              15    9605
NP_001290                                                              15    9605
>NP_733751
          Length = 4911

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   AITERKFSP 9
           AIT+RKFSP
Sbjct: 829 AITKRKFSP 837
>XP_006716142
          Length = 4927

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   AITERKFSP 9
           AIT+RKFSP
Sbjct: 830 AITKRKFSP 838
>XP_005250088
          Length = 4928

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   AITERKFSP 9
           AIT+RKFSP
Sbjct: 830 AITKRKFSP 838
>XP_006716141
          Length = 4959

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   AITERKFSP 9
           AIT+RKFSP
Sbjct: 830 AITKRKFSP 838
>XP_005250085
          Length = 4979

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   AITERKFSP 9
           AIT+RKFSP
Sbjct: 830 AITKRKFSP 838
>XP_006716140
          Length = 4982

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   AITERKFSP 9
           AIT+RKFSP
Sbjct: 830 AITKRKFSP 838
>XP_005250084
          Length = 4982

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   AITERKFSP 9
           AIT+RKFSP
Sbjct: 830 AITKRKFSP 838
>XP_005250083
          Length = 4982

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   AITERKFSP 9
           AIT+RKFSP
Sbjct: 829 AITKRKFSP 837
>XP_005250082
          Length = 4983

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   AITERKFSP 9
           AIT+RKFSP
Sbjct: 830 AITKRKFSP 838
>NP_001138355
          Length = 831

 Score = 18.9 bits (37), Expect =   869
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   ITERKFSP 9
           +TERK+SP
Sbjct: 690 VTERKYSP 697
>NP_001138353
          Length = 831

 Score = 18.9 bits (37), Expect =   869
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   ITERKFSP 9
           +TERK+SP
Sbjct: 690 VTERKYSP 697
>NP_694571
          Length = 831

 Score = 18.9 bits (37), Expect =   869
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   ITERKFSP 9
           +TERK+SP
Sbjct: 690 VTERKYSP 697
>NP_001138354
          Length = 831

 Score = 18.9 bits (37), Expect =   869
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   ITERKFSP 9
           +TERK+SP
Sbjct: 690 VTERKYSP 697
>NP_076918
          Length = 189

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ITERKFSP 9
           +TE+K+SP
Sbjct: 154 LTEKKYSP 161
>NP_071351
          Length = 2752

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    ITERKFS 8
            +TERKFS
Sbjct: 2281 VTERKFS 2287
>NP_067091
          Length = 189

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ITERKFSP 9
           +TE+K+SP
Sbjct: 154 LTEKKYSP 161
>NP_002166
          Length = 189

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ITERKFSP 9
           +TE+K+SP
Sbjct: 154 LTEKKYSP 161
>NP_002160
          Length = 189

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ITERKFSP 9
           +TE+K+SP
Sbjct: 154 LTEKKYSP 161
>NP_066282
          Length = 189

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ITERKFSP 9
           +TE+K+SP
Sbjct: 154 LTEKKYSP 161
>NP_008831
          Length = 190

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ITERKFSP 9
           +TE+K+SP
Sbjct: 155 LTEKKYSP 162
>NP_066546
          Length = 189

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ITERKFSP 9
           +TE+K+SP
Sbjct: 154 LTEKKYSP 161
>NP_057272
          Length = 426

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   ERKFSP 9
           ERKFSP
Sbjct: 385 ERKFSP 390
>XP_006716083
          Length = 474

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   ERKFSP 9
           ERKFSP
Sbjct: 433 ERKFSP 438
>NP_116212
          Length = 720

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   TERKFSP 9
           TER FSP
Sbjct: 361 TERPFSP 367
>NP_001180260
          Length = 566

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   TERKFSP 9
           TER FSP
Sbjct: 361 TERPFSP 367
>NP_001180258
          Length = 819

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   TERKFSP 9
           TER FSP
Sbjct: 361 TERPFSP 367
>XP_006717370
          Length = 569

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   TERKFSP 9
           TER FSP
Sbjct: 361 TERPFSP 367
>XP_005252341
          Length = 760

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   TERKFSP 9
           TER FSP
Sbjct: 361 TERPFSP 367
>XP_006717369
          Length = 819

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   TERKFSP 9
           TER FSP
Sbjct: 361 TERPFSP 367
>NP_002162
          Length = 189

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ITERKFSP 9
           + ERK+SP
Sbjct: 154 LIERKYSP 161
>NP_078913
          Length = 486

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ITERKFSP 9
           IT+R+F P
Sbjct: 419 ITDRRFRP 426
>NP_001273574
          Length = 662

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ITERKFSP 9
           +TE+ FSP
Sbjct: 551 LTEQTFSP 558
>NP_150375
          Length = 1196

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    TERKFSP 9
            T+R FSP
Sbjct: 1099 TDRSFSP 1105
>NP_775099
          Length = 2595

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  AITERKFSP 9
          AIT  KF P
Sbjct: 41 AITRTKFPP 49
>NP_001177716
          Length = 385

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  ERKFSP 9
          ERKF+P
Sbjct: 38 ERKFAP 43
>XP_005247994
          Length = 662

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ITERKFSP 9
           +TE+ FSP
Sbjct: 551 LTEQTFSP 558
>XP_005247993
          Length = 693

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ITERKFSP 9
           +TE+ FSP
Sbjct: 582 LTEQTFSP 589
>XP_005247992
          Length = 768

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ITERKFSP 9
           +TE+ FSP
Sbjct: 551 LTEQTFSP 558
>XP_005247991
          Length = 799

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ITERKFSP 9
           +TE+ FSP
Sbjct: 582 LTEQTFSP 589
>XP_005247990
          Length = 799

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ITERKFSP 9
           +TE+ FSP
Sbjct: 582 LTEQTFSP 589
>NP_036546
          Length = 1393

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ITERKFS 8
           +TE+KFS
Sbjct: 855 MTEKKFS 861
>NP_003001
          Length = 399

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   ERKFSP 9
           ER+FSP
Sbjct: 333 EREFSP 338
>NP_001268364
          Length = 410

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   ERKFSP 9
           ER+FSP
Sbjct: 344 EREFSP 349
>NP_001136326
          Length = 340

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   TERKFSP 9
           T+RK SP
Sbjct: 129 TDRKLSP 135
>NP_055987
          Length = 2817

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4    ERKFSP 9
            ERKF P
Sbjct: 1410 ERKFDP 1415
>XP_006725462
          Length = 340

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   TERKFSP 9
           T+RK SP
Sbjct: 129 TDRKLSP 135
>XP_005261245
          Length = 340

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   TERKFSP 9
           T+RK SP
Sbjct: 129 TDRKLSP 135
>XP_005259798
          Length = 247

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   ERKFSP 9
           ERKF P
Sbjct: 99  ERKFEP 104
>XP_006722711
          Length = 257

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   ERKFSP 9
           ERKF P
Sbjct: 149 ERKFEP 154
>XP_005257805
          Length = 1308

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    ITERKFS 8
            +TE+KFS
Sbjct: 1088 LTEQKFS 1094
>XP_006722205
          Length = 1384

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    ITERKFS 8
            +TE+KFS
Sbjct: 1164 LTEQKFS 1170
>XP_006722204
          Length = 1384

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    ITERKFS 8
            +TE+KFS
Sbjct: 1164 LTEQKFS 1170
>XP_005256812
          Length = 253

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   ERKFSP 9
           ER+FSP
Sbjct: 187 EREFSP 192
>XP_006721631
          Length = 281

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   ERKFSP 9
           ER+FSP
Sbjct: 215 EREFSP 220
>XP_005256810
          Length = 281

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   ERKFSP 9
           ER+FSP
Sbjct: 215 EREFSP 220
>XP_005245087
          Length = 2708

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4    ERKFSP 9
            ERKF P
Sbjct: 1412 ERKFDP 1417
>XP_005245086
          Length = 2714

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4    ERKFSP 9
            ERKF P
Sbjct: 1412 ERKFDP 1417
>XP_005245085
          Length = 2718

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4    ERKFSP 9
            ERKF P
Sbjct: 1412 ERKFDP 1417
>XP_005245084
          Length = 2719

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4    ERKFSP 9
            ERKF P
Sbjct: 1412 ERKFDP 1417
>XP_006711302
          Length = 2754

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4    ERKFSP 9
            ERKF P
Sbjct: 1412 ERKFDP 1417
>XP_005245083
          Length = 2774

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4    ERKFSP 9
            ERKF P
Sbjct: 1412 ERKFDP 1417
>XP_005245082
          Length = 2779

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4    ERKFSP 9
            ERKF P
Sbjct: 1412 ERKFDP 1417
>XP_005245081
          Length = 2819

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4    ERKFSP 9
            ERKF P
Sbjct: 1412 ERKFDP 1417
>XP_005245080
          Length = 2824

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4    ERKFSP 9
            ERKF P
Sbjct: 1412 ERKFDP 1417
>XP_005245079
          Length = 2838

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4    ERKFSP 9
            ERKF P
Sbjct: 1412 ERKFDP 1417
>XP_005245077
          Length = 2858

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4    ERKFSP 9
            ERKF P
Sbjct: 1412 ERKFDP 1417
>XP_005245076
          Length = 2869

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4    ERKFSP 9
            ERKF P
Sbjct: 1412 ERKFDP 1417
>XP_006711301
          Length = 2896

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4    ERKFSP 9
            ERKF P
Sbjct: 1410 ERKFDP 1415
>XP_005245075
          Length = 2898

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4    ERKFSP 9
            ERKF P
Sbjct: 1407 ERKFDP 1412
>XP_005245074
          Length = 2898

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4    ERKFSP 9
            ERKF P
Sbjct: 1412 ERKFDP 1417
>XP_005245073
          Length = 2901

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4    ERKFSP 9
            ERKF P
Sbjct: 1410 ERKFDP 1415
>XP_005245072
          Length = 2903

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4    ERKFSP 9
            ERKF P
Sbjct: 1412 ERKFDP 1417
>NP_003623
          Length = 1384

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    ITERKFS 8
            +TE+KFS
Sbjct: 1164 LTEQKFS 1170
>NP_001290
          Length = 297

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   ERKFSP 9
           ERKF P
Sbjct: 149 ERKFEP 154
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.317    0.129    0.356 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 526,337
Number of extensions: 981
Number of successful extensions: 74
Number of sequences better than 10000.0: 74
Number of HSP's gapped: 74
Number of HSP's successfully gapped: 74
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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