Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001121619                                                           19     869
NP_000258                                                              19     869
NP_001035957                                                           19     869
XP_006721991                                                           19     869
XP_006721990                                                           19     869
XP_006721989                                                           19     869
XP_005258041                                                           19     869
XP_006721988                                                           19     869
XP_006721987                                                           19     869
XP_006721986                                                           19     869
XP_005258040                                                           19     869
XP_006721985                                                           19     869
NP_001243793                                                           18    1135
NP_001243794                                                           18    1135
NP_055602                                                              18    1135
NP_001004754                                                           18    1482
NP_055568                                                              17    4312
NP_056509                                                              17    4312
XP_005271906                                                           17    4312
XP_006718144                                                           17    4312
XP_005271905                                                           17    4312
XP_005271904                                                           17    4312
XP_005271903                                                           17    4312
XP_005250038                                                           17    4312
XP_005250037                                                           17    4312
NP_150253                                                              16    5631
NP_150242                                                              16    5631
NP_001229760                                                           16    5631
NP_001153797                                                           16    5631
NP_056150                                                              16    7355
NP_036234                                                              16    7355
NP_001036147                                                           16    7355
NP_001036146                                                           16    7355
NP_001009921                                                           16    7355
XP_006719370                                                           16    7355
XP_006719369                                                           16    7355
XP_006719368                                                           16    7355
XP_006713619                                                           16    7355
XP_005247308                                                           16    7355
XP_006710717                                                           16    7355
XP_005263523                                                           16    7355
XP_005263522                                                           16    7355
XP_006710716                                                           16    7355
XP_005263521                                                           16    7355
NP_056118                                                              16    7355
NP_057520                                                              15    9605
NP_001008563                                                           15    9605
NP_006667                                                              15    9605
NP_001103773                                                           15    9605
NP_005782                                                              15    9605
NP_060587                                                              15    9605
NP_938056                                                              15    9605
NP_001243543                                                           15    9605
NP_938055                                                              15    9605
NP_001243542                                                           15    9605
NP_055616                                                              15    9605
NP_872395                                                              15    9605
NP_570126                                                              15    9605
XP_005260478                                                           15    9605
XP_005260766                                                           15    9605
XP_005260765                                                           15    9605
XP_005255201                                                           15    9605
XP_006720914                                                           15    9605
XP_005270020                                                           15    9605
XP_005270019                                                           15    9605
XP_005251723                                                           15    9605
XP_006717001                                                           15    9605
XP_005251722                                                           15    9605
XP_005247433                                                           15    9605
XP_005273329                                                           15    9605
NP_631909                                                              15    9605
>NP_001121619
          Length = 593

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   AIRMAPSL 8
           AIRMAPSL
Sbjct: 459 AIRMAPSL 466
>NP_000258
          Length = 2818

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   AIRMAPSL 8
           AIRMAPSL
Sbjct: 459 AIRMAPSL 466
>NP_001035957
          Length = 2839

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   AIRMAPSL 8
           AIRMAPSL
Sbjct: 459 AIRMAPSL 466
>XP_006721991
          Length = 1632

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   AIRMAPSL 8
           AIRMAPSL
Sbjct: 469 AIRMAPSL 476
>XP_006721990
          Length = 2823

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   AIRMAPSL 8
           AIRMAPSL
Sbjct: 469 AIRMAPSL 476
>XP_006721989
          Length = 2823

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   AIRMAPSL 8
           AIRMAPSL
Sbjct: 469 AIRMAPSL 476
>XP_005258041
          Length = 2836

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   AIRMAPSL 8
           AIRMAPSL
Sbjct: 459 AIRMAPSL 466
>XP_006721988
          Length = 2846

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   AIRMAPSL 8
           AIRMAPSL
Sbjct: 469 AIRMAPSL 476
>XP_006721987
          Length = 2849

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   AIRMAPSL 8
           AIRMAPSL
Sbjct: 469 AIRMAPSL 476
>XP_006721986
          Length = 2854

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   AIRMAPSL 8
           AIRMAPSL
Sbjct: 456 AIRMAPSL 463
>XP_005258040
          Length = 2857

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   AIRMAPSL 8
           AIRMAPSL
Sbjct: 459 AIRMAPSL 466
>XP_006721985
          Length = 2867

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   AIRMAPSL 8
           AIRMAPSL
Sbjct: 469 AIRMAPSL 476
>NP_001243793
          Length = 970

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   IRMAPSLH 9
           IR APSLH
Sbjct: 189 IRQAPSLH 196
>NP_001243794
          Length = 900

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   IRMAPSLH 9
           IR APSLH
Sbjct: 119 IRQAPSLH 126
>NP_055602
          Length = 913

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   IRMAPSLH 9
           IR APSLH
Sbjct: 132 IRQAPSLH 139
>NP_001004754
          Length = 312

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  AIRMAPSLH 9
          A+R+ PSLH
Sbjct: 48 AVRVEPSLH 56
>NP_055568
          Length = 1282

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  AIRMAPSLH 9
          A+RMA S H
Sbjct: 50 AVRMARSFH 58
>NP_056509
          Length = 831

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RMAPSLH 9
           R+APS+H
Sbjct: 515 RLAPSVH 521
>XP_005271906
          Length = 879

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  AIRMAPSLH 9
          A+RMA S H
Sbjct: 50 AVRMARSFH 58
>XP_006718144
          Length = 886

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  AIRMAPSLH 9
          A+RMA S H
Sbjct: 50 AVRMARSFH 58
>XP_005271905
          Length = 1219

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  AIRMAPSLH 9
          A+RMA S H
Sbjct: 50 AVRMARSFH 58
>XP_005271904
          Length = 1219

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  AIRMAPSLH 9
          A+RMA S H
Sbjct: 50 AVRMARSFH 58
>XP_005271903
          Length = 1282

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  AIRMAPSLH 9
          A+RMA S H
Sbjct: 50 AVRMARSFH 58
>XP_005250038
          Length = 831

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RMAPSLH 9
           R+APS+H
Sbjct: 515 RLAPSVH 521
>XP_005250037
          Length = 875

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RMAPSLH 9
           R+APS+H
Sbjct: 559 RLAPSVH 565
>NP_150253
          Length = 781

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   AIRMAPSLH 9
           A+R+ P LH
Sbjct: 623 ALRLHPQLH 631
>NP_150242
          Length = 829

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   AIRMAPSLH 9
           A+R+ P LH
Sbjct: 671 ALRLHPQLH 679
>NP_001229760
          Length = 88

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  IRMAPSLH 9
          +RM P LH
Sbjct: 26 LRMGPPLH 33
>NP_001153797
          Length = 317

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  IRMAPSLH 9
          I +APSLH
Sbjct: 49 IWLAPSLH 56
>NP_056150
          Length = 2210

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   MAPSLH 9
           +APSLH
Sbjct: 803 LAPSLH 808
>NP_036234
          Length = 1566

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IRMAPSLH 9
           I+ AP+LH
Sbjct: 800 IQQAPALH 807
>NP_001036147
          Length = 1012

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IRMAPSLH 9
           I+ AP+LH
Sbjct: 246 IQQAPALH 253
>NP_001036146
          Length = 1566

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IRMAPSLH 9
           I+ AP+LH
Sbjct: 800 IQQAPALH 807
>NP_001009921
          Length = 1428

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    IRMAPSLH 9
            ++M+PS H
Sbjct: 1335 VKMSPSYH 1342
>XP_006719370
          Length = 2076

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   MAPSLH 9
           +APSLH
Sbjct: 669 LAPSLH 674
>XP_006719369
          Length = 2200

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   MAPSLH 9
           +APSLH
Sbjct: 793 LAPSLH 798
>XP_006719368
          Length = 2209

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   MAPSLH 9
           +APSLH
Sbjct: 803 LAPSLH 808
>XP_006713619
          Length = 856

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   IRMAPSLH 9
           ++M+PS H
Sbjct: 763 VKMSPSYH 770
>XP_005247308
          Length = 1428

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    IRMAPSLH 9
            ++M+PS H
Sbjct: 1335 VKMSPSYH 1342
>XP_006710717
          Length = 1171

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IRMAPSLH 9
           I+ AP+LH
Sbjct: 405 IQQAPALH 412
>XP_005263523
          Length = 1298

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IRMAPSLH 9
           I+ AP+LH
Sbjct: 532 IQQAPALH 539
>XP_005263522
          Length = 1524

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IRMAPSLH 9
           I+ AP+LH
Sbjct: 758 IQQAPALH 765
>XP_006710716
          Length = 1566

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IRMAPSLH 9
           I+ AP+LH
Sbjct: 800 IQQAPALH 807
>XP_005263521
          Length = 1566

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IRMAPSLH 9
           I+ AP+LH
Sbjct: 800 IQQAPALH 807
>NP_056118
          Length = 1426

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    IRMAPSLH 9
            ++M+PS H
Sbjct: 1333 VKMSPSYH 1340
>NP_057520
          Length = 1012

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2   IRMAPSLH 9
           + M+P LH
Sbjct: 587 VHMSPQLH 594
>NP_001008563
          Length = 914

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   IRMAPS 7
           +RMAPS
Sbjct: 415 VRMAPS 420
>NP_006667
          Length = 914

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   IRMAPS 7
           +RMAPS
Sbjct: 415 VRMAPS 420
>NP_001103773
          Length = 914

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   IRMAPS 7
           +RMAPS
Sbjct: 415 VRMAPS 420
>NP_005782
          Length = 681

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   AIRMAP 6
           A+RMAP
Sbjct: 410 AVRMAP 415
>NP_060587
          Length = 1224

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   AIRMAPSL 8
           AIRM P L
Sbjct: 469 AIRMCPPL 476
>NP_938056
          Length = 456

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AIRMAPSLH 9
           AIR  PSL+
Sbjct: 242 AIRRRPSLY 250
>NP_001243543
          Length = 482

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AIRMAPSLH 9
           AIR  PSL+
Sbjct: 268 AIRRRPSLY 276
>NP_938055
          Length = 441

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AIRMAPSLH 9
           AIR  PSL+
Sbjct: 227 AIRRRPSLY 235
>NP_001243542
          Length = 456

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AIRMAPSLH 9
           AIR  PSL+
Sbjct: 242 AIRRRPSLY 250
>NP_055616
          Length = 2137

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    AIRMAPSLH 9
            AIRM+  LH
Sbjct: 1690 AIRMSLKLH 1698
>NP_872395
          Length = 471

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AIRMAPSLH 9
           AIR  PSL+
Sbjct: 257 AIRRRPSLY 265
>NP_570126
          Length = 447

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AIRMAPSLH 9
           AIR  PSL+
Sbjct: 242 AIRRRPSLY 250
>XP_005260478
          Length = 609

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2   IRMAPSLH 9
           + M+P LH
Sbjct: 184 VHMSPQLH 191
>XP_005260766
          Length = 250

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 3   RMAPSLH 9
           RM P LH
Sbjct: 227 RMLPGLH 233
>XP_005260765
          Length = 348

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 3   RMAPSLH 9
           RM P LH
Sbjct: 325 RMLPGLH 331
>XP_005255201
          Length = 382

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 3   RMAPSLH 9
           RM PS H
Sbjct: 164 RMVPSAH 170
>XP_006720914
          Length = 543

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 3   RMAPSLH 9
           RM PS H
Sbjct: 325 RMVPSAH 331
>XP_005270020
          Length = 965

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   AIRMAPSL 8
           AIRM P L
Sbjct: 210 AIRMCPPL 217
>XP_005270019
          Length = 965

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   AIRMAPSL 8
           AIRM P L
Sbjct: 210 AIRMCPPL 217
>XP_005251723
          Length = 675

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   IRMAPS 7
           +RMAPS
Sbjct: 176 VRMAPS 181
>XP_006717001
          Length = 914

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   IRMAPS 7
           +RMAPS
Sbjct: 415 VRMAPS 420
>XP_005251722
          Length = 914

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   IRMAPS 7
           +RMAPS
Sbjct: 415 VRMAPS 420
>XP_005247433
          Length = 374

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AIRMAPSLH 9
           AIR  PSL+
Sbjct: 160 AIRRRPSLY 168
>XP_005273329
          Length = 1934

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    AIRMAPSLH 9
            AIRM+  LH
Sbjct: 1487 AIRMSLKLH 1495
>NP_631909
          Length = 520

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 3   RMAPSLH 9
           RM PS H
Sbjct: 302 RMVPSAH 308
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.331    0.131    0.390 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 694,207
Number of extensions: 942
Number of successful extensions: 71
Number of sequences better than 10000.0: 71
Number of HSP's gapped: 71
Number of HSP's successfully gapped: 71
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.3 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package